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Yanıt Yüzey Metodolojisi Şartlarında Karabaş Otu Yağının Kompleks Koaservasyon Yöntemi İle Enkapsülasyonu

Year 2020, , 508 - 515, 26.08.2020
https://doi.org/10.19113/sdufenbed.687943

Abstract

Çalışmamızda karabaş otu yağı yanıt yüzey metodolojisi (YYM) ile oluşturulan bir deney setinde kompleks koaservasyon yöntemi ile enkapsülasyon yapılmıştır. Deney seti YYM’e üç bağımsız değişken (çekirdek maddesi miktarı, surfaktan konsantrasyonu, karıştırma hızı) girilerek oluşturulmuştur. Üretilen numunelerden enkapsülasyon verimi (%EV) hesaplanmıştır. Bulunan deneysel verimler YYM’e cevap yanıtı olarak girilerek analiz edilmiştir. YYM analizi sonucunda ulaşılan model önemlidir (p<0,05), R2 değeri %99,15, uyum eksikliğinin p değeri 0,217 (p>0,05) bulunmuştur. Elde edilen verilerden YYM’e girilen üç bağımsız değişkenin cevap yanıtı olan %EV’yi etkilediği sonucuna ulaşılmıştır. Deney setinden üretilen numuneler optik mikroskop ve taramalı elektron mikroskobu (SEM) altında karakterize edilmiştir. Elde edilen görüntülerde kapsüller, büyük çoğunluğu mikron (10-6), az miktarda nano (10-9) boyutunda gözlenmiştir. Yapılan çalışmanın kullanım alanlarının geniş, ekonomik değeri yüksek olan karabaş otu yağının enkapsülasyonunda ve farklı uygulama alanlarında değerlendirilmesinde önemli bir adım olacağı düşünülmektedir.

References

  • [1] Tutin, T. G., Heywood, V. H., Burges, N. A., Valentine, D. H. (Eds.). 1964. Flora Europaea: Plantaginaceae to Compositae (and Rubiaceae) (Vol. 4). Cambridge University Press.
  • [2] Carrasco, A., Ortiz-Ruiz, V., Martinez-Gutierrez, R., Tomas, V., Tudela, J. 2015. Lavandula stoechas Essential Oil From Spain: Aromatic Profile Determined By Gas Chromatography–Mass Spectrometry, Antioxidant And Lipoxygenase Inhibitory Bioactivities. Industrial Crops And Products, 73, 16-27.
  • [3] Tanker, M., Tanker, N., Sarer, E., Atasü, E., Sener, B., Kurucu, S., Meriçli, F. 1993. Results Of Certain Investigations On The Volatile Oil Containing Plants Of Turkey. In Proceedings of an International Conference on Essential Oils for Petfumery and Flavors, Edits. KHC Baser and N. Giiler, 16-29.
  • [4] Adaşoğlu, N., Dinçer, S., Bolat, E. 1994. Supercritical-fluid Extraction Of Essential Oil From Turkish Lavender Flowers. The Journal of Supercritical Fluids, 7(2), 93-99.
  • [5] Akgün, N. A., Akgün, M., Dinçer, S., Akgerman, A. 2001. Supercritical Fluid Extraction Of Lavandula stoechas L. ssp. cariensis (Boiss.) Rozeira. Journal of Essential Oil Research, 13(3), 143-148.
  • [6] Lawless, J. 1992. Enciclopedia Degli Olii Essenziali. Tecniche nuove. 321s.
  • [7] Atzei, A. D. 2003. Le Piante Nella Tradizione Popolare Della Sardegna: Documentazione Sugli Usi Alimentari, Aromatizzanti, Profumieri, Artigianali, Cosmetici, Medicinali, Veterinari, Magici, Ornamentali, Rituali, Religiosi, Tintori, Antiparassitari E Vari, Delle Piante. Delfino Carlo Editore.
  • [8] Angioni, A., Barra, A., Coroneo, V., Dessi, S., Cabras, P. 2006. Chemical Composition, Seasonal Variability, And Antifungal Activity Of Lavandula stoechas L. ssp. stoechas Essential Oils From Stem/Leaves And Flowers. Journal Of Agricultural And Food Chemistry, 54(12), 4364-4370.
  • [9] Sheikhan, F., Jahdi, F., Khoei, E. M., Shamsalizadeh, N., Sheikhan, M., Haghani, H. 2012. Episiotomy Pain Relief: Use Of Lavender Oil Essence In Primiparous Iranian Women. Complementary Therapies In Clinical Practice, 18(1), 66-70.
  • [10] Vakilian, K., Atarha, M., Bekhradi, R., Chaman, R. 2011. Healing Advantages Of Lavender Essential Oil During Episiotomy Recovery: A Clinical Trial. Complementary Therapies In Clinical Practice, 17(1), 50-53.
  • [11] Kadoglidou, K., Lagopodi, A., Karamanoli, K., Vokou, D., Bardas, G. A., Menexes, G., Constantinidou, H. I. A. 2011. Inhibitory And Stimulatory Effects Of Essential Oils And Individual Monoterpenoids On Growth And Sporulation Of Four Soil-Borne Fungal Isolates Of Aspergillus Terreus, Fusarium Oxysporum, Penicillium Expansum, And Verticillium Dahliae. European Journal Of Plant Pathology, 130(3), 297-309.
  • [12] Dadalioǧlu, I., Evrendilek, G. A. 2004. Chemical Compositions And Antibacterial Effects Of Essential Oils Of Turkish Oregano (Origanum minutiflorum), bay Laurel (Laurus nobilis), Spanish Lavender (Lavandula stoechas L.), And Fennel (Foeniculum vulgare) On Common Foodborne Pathogens. Journal Of Agricultural And Food Chemistry, 52(26), 8255-8260.
  • [13] Hui, L., He, L., Huan, L., XiaoLan, L., AiGuo, Z. 2010. Chemical Composition Of Lavender Essential Oil And Its Antioxidant Activity And Inhibition Against Rhinitis Related Bacteria. African Journal Of Microbiology Research, 4(4), 309-313.
  • [14] Wells, R., Truong, F., Adal, A. M., Sarker, L. S., Mahmoud, S. S. 2018. Lavandula Essential Oils: A Current Review Of Applications In Medicinal, Food, And Cosmetic Industries Of Lavender. Natural Product Communications, 13(10),
  • [15] Timilsena, Y. P., Akanbi, T. O., Khalid, N., Adhikari, B., Barrow, C. J. 2019. Complex Coacervation: Principles, Mechanisms And Applications In Microencapsulation. International Journal Of Biological Macromolecules, 121, 1276-1286.
  • [16] Lam, K. H., Cheng, S. Y., Lam, P. L., Yuen, M. C. W., Wong, R. S. M., Lau, F. Y., Lai, P. B. S., Gambari, R., Chui, C. H. 2010. Microencapsulation: Past, Present And Future. Minerva Biotecnologica, 22(1), 23.
  • [17] Oliveira, W. D., Araújo, A. D. O., Wurlitzer, N., Bastos, M., Furtado, R. 2019. Effect Of The Reaction Volume On The Formation Of Microparticles Of The Pequi Oil (Caryocar coriaceum Wittm.) By Complex Coacervation. Embrapa Agroindústria Tropical-Artigo Em Periódico Indexado (ALICE).
  • [18] Eghbal, N., Choudhary, R. 2018. Complex Coacervation: Encapsulation And Controlled Release Of Active Agents In Food Systems. Lwt, 90, 254-264.
  • [19] Silva, V., Rouboa, A. 2015. Combining A 2-D Multiphase CFD Model With A Response Surface Methodology To Optimize The Gasification Of Portuguese Biomasses. Energy Conversion And Management, 99, 28-40.
  • [20] Köksal, E. 2016. Kompleks Koaservasyon Yöntemi İle E Vitamini İçeren Mikrokapsül Üretimi. Süleyman Demirel Üniversitesi, Fen Bilimleri Enstitüsü, Yüksek Lisans Tezi, 69s, Isparta.
  • [21] Ahn, J. H., Kim, Y. P., Lee, Y. M., Seo, E. M., Lee, K. W., Kim, H. S. 2008. Optimization Of Microencapsulation Of Seed Oil By Response Surface Methodology. Food Chemistry, 107(1), 98-105.
  • [22] Hu, L., Zhang, J., Hu, Q., Gao, N., Wang, S., Sun, Y., Yang, X. 2016. Microencapsulation Of Brucea Javanica Oil: Characterization, Stability And Optimization Of Spray Drying Conditions. Journal of Drug Delivery Science and Technology, 36, 46-54.
  • [23] Li, K., Woo, M. W., Patel, H., Selomulya, C. 2017. Enhancing The Stability Of Protein-Polysaccharides Emulsions Via Maillard Reaction For Better Oil Encapsulation In Spray-Dried Powders By pH Adjustment. Food Hydrocolloids, 69, 121-131.
  • [24] Ghasemi, S., Jafari, S. M., Assadpour, E., Khomeiri, M. 2017. Production Of Pectin-Whey Protein Nano-Complexes As Carriers Of Orange Peel Oil. Carbohydrate Polymers, 177, 369-377.
  • [25] Patrickab, K.E., Abbasa, S., Lva, Y., Ntsamacd, I.S.B., Zhanga, X. 2013. Microencapsulation By Complex Coacervation Of Fish Oil Using Gelatin/SDS/NaCMC. Pakistan Journal of Food Sciences, 23(1), 17-25.
  • [26] Velasco, J., Marmesat, S., Dobarganes, C., Márquez-Ruiz, G. 2006. Heterogeneous Aspects Of Lipid Oxidation In Dried Microencapsulated Oils. Journal Of Agricultural And Food Chemistry, 54(5), 1722-1729.
  • [27] Aziz, S., Gill, J., Dutilleul, P., Neufeld, R., Kermasha, S. 2014. Microencapsulation Of Krill Oil Using Complex Coacervation. Journal Of Microencapsulation, 31(8), 774-784.
  • [28] Gören, A.C., Topçu, G., Bilsel, G., Bilsel, M., Aydoğmuş, Z., Pezzuto, J.M. 2002. The Chemical Constituents And Biological Activity Of Essential Oil Of Lavandula stoechas ssp. stoechas. Zeitschrift für Naturforschung C, 57(9-10), 797-800.
  • [29] Öztürk, B., Konyalıoğlu, S., Kantarcı, G., Çetinkol, D. 2005. İzmir Yöresindeki Yabani Lavandula stoechas L. subsp. stoechas Taksonundan Elde Edilen Uçucu Yağın Bileşimi, Antibakteriyel, Antifungal Ve Antioksidan Kapasitesi. Anadolu Ege Tarımsal Araştırma Enstitüsü Dergisi, 15(1), 61-72.
  • [30] Mancer, D., Allemann, E., Daoud, K. 2018. Metformin Hydrochloride Microencapsulation By Complex Coacervation: Study Of Size Distribution And Encapsulation Yield Using Response Surface Methodology. Journal Of Drug Delivery Science And Technology, 45, 184-195.
  • [31] Mendanha, D. V., Ortiz, S. E. M., Favaro-Trindade, C. S., Mauri, A., Monterrey-Quintero, E. S., Thomazini, M. 2009. Microencapsulation Of Casein Hydrolysate By Complex Coacervation With SPI/pectin. Food Research International, 42(8), 1099-1104.
  • [32] Sharifi, F., Hadizadeh, F., Sadeghi, F., Hamed Mosavian, M. T., Zarei, C. 2016. Process Optimization, Physical Properties, And Environmental Stability Of An α-Tocopherol Nanocapsule Preparation Using Complex Coacervation Method and Full Factorial Design. Chemical Engineering Communications, 203(1), 64-74.
  • [33] Bayram O., Köksal E., Danaş F., Göde F., Erzengin Ö. U. 2019. A Statistical Investigation Of The Effects Of Different Surfactant Concentrations On The Capsule Size In The Encapsulation Of Grapefruit (Citrus Paradisi Macf.) Peel Oil By Complex Coacervation Method. 2rd International Health Science And Life Congress, 24–27 April, Burdur, 486-497.

Encapsulation of Karabas Herb Oil with Complex Coacervation Method in Response Surface Methodology Conditions

Year 2020, , 508 - 515, 26.08.2020
https://doi.org/10.19113/sdufenbed.687943

Abstract

In our study, encapsulation was performed with complex coacervation method in an experimental set created with Karabas herb oil response surface methodology (RSM). The experiment set was created by entering three independent variables (core material amount, surfactant concentration, stirring speed) in RSM. The encapsulation efficiency (EV%) was calculated from the produced samples. The experimental efficiencies found were analyzed by entering RSM as a response response. The model reached as a result of RSM analysis was significant (p <0,05), R2 value was 99,15%, and lack-of-fit p value was found as 0,217 (p>0,05). The collected data indicated that three independent variables entered in RSM affect the response response EV%. Samples produced from the experimental set were characterized under optical microscope and scanning electron microscope (SEM). The vast majority of the images obtained were observed in micron (10-6) and a small amount of nano (10-9) in size. It is believed that the study will be an important step in the encapsulation of karabaş herb oil, which has a wide range of economic value, and different application areas.

References

  • [1] Tutin, T. G., Heywood, V. H., Burges, N. A., Valentine, D. H. (Eds.). 1964. Flora Europaea: Plantaginaceae to Compositae (and Rubiaceae) (Vol. 4). Cambridge University Press.
  • [2] Carrasco, A., Ortiz-Ruiz, V., Martinez-Gutierrez, R., Tomas, V., Tudela, J. 2015. Lavandula stoechas Essential Oil From Spain: Aromatic Profile Determined By Gas Chromatography–Mass Spectrometry, Antioxidant And Lipoxygenase Inhibitory Bioactivities. Industrial Crops And Products, 73, 16-27.
  • [3] Tanker, M., Tanker, N., Sarer, E., Atasü, E., Sener, B., Kurucu, S., Meriçli, F. 1993. Results Of Certain Investigations On The Volatile Oil Containing Plants Of Turkey. In Proceedings of an International Conference on Essential Oils for Petfumery and Flavors, Edits. KHC Baser and N. Giiler, 16-29.
  • [4] Adaşoğlu, N., Dinçer, S., Bolat, E. 1994. Supercritical-fluid Extraction Of Essential Oil From Turkish Lavender Flowers. The Journal of Supercritical Fluids, 7(2), 93-99.
  • [5] Akgün, N. A., Akgün, M., Dinçer, S., Akgerman, A. 2001. Supercritical Fluid Extraction Of Lavandula stoechas L. ssp. cariensis (Boiss.) Rozeira. Journal of Essential Oil Research, 13(3), 143-148.
  • [6] Lawless, J. 1992. Enciclopedia Degli Olii Essenziali. Tecniche nuove. 321s.
  • [7] Atzei, A. D. 2003. Le Piante Nella Tradizione Popolare Della Sardegna: Documentazione Sugli Usi Alimentari, Aromatizzanti, Profumieri, Artigianali, Cosmetici, Medicinali, Veterinari, Magici, Ornamentali, Rituali, Religiosi, Tintori, Antiparassitari E Vari, Delle Piante. Delfino Carlo Editore.
  • [8] Angioni, A., Barra, A., Coroneo, V., Dessi, S., Cabras, P. 2006. Chemical Composition, Seasonal Variability, And Antifungal Activity Of Lavandula stoechas L. ssp. stoechas Essential Oils From Stem/Leaves And Flowers. Journal Of Agricultural And Food Chemistry, 54(12), 4364-4370.
  • [9] Sheikhan, F., Jahdi, F., Khoei, E. M., Shamsalizadeh, N., Sheikhan, M., Haghani, H. 2012. Episiotomy Pain Relief: Use Of Lavender Oil Essence In Primiparous Iranian Women. Complementary Therapies In Clinical Practice, 18(1), 66-70.
  • [10] Vakilian, K., Atarha, M., Bekhradi, R., Chaman, R. 2011. Healing Advantages Of Lavender Essential Oil During Episiotomy Recovery: A Clinical Trial. Complementary Therapies In Clinical Practice, 17(1), 50-53.
  • [11] Kadoglidou, K., Lagopodi, A., Karamanoli, K., Vokou, D., Bardas, G. A., Menexes, G., Constantinidou, H. I. A. 2011. Inhibitory And Stimulatory Effects Of Essential Oils And Individual Monoterpenoids On Growth And Sporulation Of Four Soil-Borne Fungal Isolates Of Aspergillus Terreus, Fusarium Oxysporum, Penicillium Expansum, And Verticillium Dahliae. European Journal Of Plant Pathology, 130(3), 297-309.
  • [12] Dadalioǧlu, I., Evrendilek, G. A. 2004. Chemical Compositions And Antibacterial Effects Of Essential Oils Of Turkish Oregano (Origanum minutiflorum), bay Laurel (Laurus nobilis), Spanish Lavender (Lavandula stoechas L.), And Fennel (Foeniculum vulgare) On Common Foodborne Pathogens. Journal Of Agricultural And Food Chemistry, 52(26), 8255-8260.
  • [13] Hui, L., He, L., Huan, L., XiaoLan, L., AiGuo, Z. 2010. Chemical Composition Of Lavender Essential Oil And Its Antioxidant Activity And Inhibition Against Rhinitis Related Bacteria. African Journal Of Microbiology Research, 4(4), 309-313.
  • [14] Wells, R., Truong, F., Adal, A. M., Sarker, L. S., Mahmoud, S. S. 2018. Lavandula Essential Oils: A Current Review Of Applications In Medicinal, Food, And Cosmetic Industries Of Lavender. Natural Product Communications, 13(10),
  • [15] Timilsena, Y. P., Akanbi, T. O., Khalid, N., Adhikari, B., Barrow, C. J. 2019. Complex Coacervation: Principles, Mechanisms And Applications In Microencapsulation. International Journal Of Biological Macromolecules, 121, 1276-1286.
  • [16] Lam, K. H., Cheng, S. Y., Lam, P. L., Yuen, M. C. W., Wong, R. S. M., Lau, F. Y., Lai, P. B. S., Gambari, R., Chui, C. H. 2010. Microencapsulation: Past, Present And Future. Minerva Biotecnologica, 22(1), 23.
  • [17] Oliveira, W. D., Araújo, A. D. O., Wurlitzer, N., Bastos, M., Furtado, R. 2019. Effect Of The Reaction Volume On The Formation Of Microparticles Of The Pequi Oil (Caryocar coriaceum Wittm.) By Complex Coacervation. Embrapa Agroindústria Tropical-Artigo Em Periódico Indexado (ALICE).
  • [18] Eghbal, N., Choudhary, R. 2018. Complex Coacervation: Encapsulation And Controlled Release Of Active Agents In Food Systems. Lwt, 90, 254-264.
  • [19] Silva, V., Rouboa, A. 2015. Combining A 2-D Multiphase CFD Model With A Response Surface Methodology To Optimize The Gasification Of Portuguese Biomasses. Energy Conversion And Management, 99, 28-40.
  • [20] Köksal, E. 2016. Kompleks Koaservasyon Yöntemi İle E Vitamini İçeren Mikrokapsül Üretimi. Süleyman Demirel Üniversitesi, Fen Bilimleri Enstitüsü, Yüksek Lisans Tezi, 69s, Isparta.
  • [21] Ahn, J. H., Kim, Y. P., Lee, Y. M., Seo, E. M., Lee, K. W., Kim, H. S. 2008. Optimization Of Microencapsulation Of Seed Oil By Response Surface Methodology. Food Chemistry, 107(1), 98-105.
  • [22] Hu, L., Zhang, J., Hu, Q., Gao, N., Wang, S., Sun, Y., Yang, X. 2016. Microencapsulation Of Brucea Javanica Oil: Characterization, Stability And Optimization Of Spray Drying Conditions. Journal of Drug Delivery Science and Technology, 36, 46-54.
  • [23] Li, K., Woo, M. W., Patel, H., Selomulya, C. 2017. Enhancing The Stability Of Protein-Polysaccharides Emulsions Via Maillard Reaction For Better Oil Encapsulation In Spray-Dried Powders By pH Adjustment. Food Hydrocolloids, 69, 121-131.
  • [24] Ghasemi, S., Jafari, S. M., Assadpour, E., Khomeiri, M. 2017. Production Of Pectin-Whey Protein Nano-Complexes As Carriers Of Orange Peel Oil. Carbohydrate Polymers, 177, 369-377.
  • [25] Patrickab, K.E., Abbasa, S., Lva, Y., Ntsamacd, I.S.B., Zhanga, X. 2013. Microencapsulation By Complex Coacervation Of Fish Oil Using Gelatin/SDS/NaCMC. Pakistan Journal of Food Sciences, 23(1), 17-25.
  • [26] Velasco, J., Marmesat, S., Dobarganes, C., Márquez-Ruiz, G. 2006. Heterogeneous Aspects Of Lipid Oxidation In Dried Microencapsulated Oils. Journal Of Agricultural And Food Chemistry, 54(5), 1722-1729.
  • [27] Aziz, S., Gill, J., Dutilleul, P., Neufeld, R., Kermasha, S. 2014. Microencapsulation Of Krill Oil Using Complex Coacervation. Journal Of Microencapsulation, 31(8), 774-784.
  • [28] Gören, A.C., Topçu, G., Bilsel, G., Bilsel, M., Aydoğmuş, Z., Pezzuto, J.M. 2002. The Chemical Constituents And Biological Activity Of Essential Oil Of Lavandula stoechas ssp. stoechas. Zeitschrift für Naturforschung C, 57(9-10), 797-800.
  • [29] Öztürk, B., Konyalıoğlu, S., Kantarcı, G., Çetinkol, D. 2005. İzmir Yöresindeki Yabani Lavandula stoechas L. subsp. stoechas Taksonundan Elde Edilen Uçucu Yağın Bileşimi, Antibakteriyel, Antifungal Ve Antioksidan Kapasitesi. Anadolu Ege Tarımsal Araştırma Enstitüsü Dergisi, 15(1), 61-72.
  • [30] Mancer, D., Allemann, E., Daoud, K. 2018. Metformin Hydrochloride Microencapsulation By Complex Coacervation: Study Of Size Distribution And Encapsulation Yield Using Response Surface Methodology. Journal Of Drug Delivery Science And Technology, 45, 184-195.
  • [31] Mendanha, D. V., Ortiz, S. E. M., Favaro-Trindade, C. S., Mauri, A., Monterrey-Quintero, E. S., Thomazini, M. 2009. Microencapsulation Of Casein Hydrolysate By Complex Coacervation With SPI/pectin. Food Research International, 42(8), 1099-1104.
  • [32] Sharifi, F., Hadizadeh, F., Sadeghi, F., Hamed Mosavian, M. T., Zarei, C. 2016. Process Optimization, Physical Properties, And Environmental Stability Of An α-Tocopherol Nanocapsule Preparation Using Complex Coacervation Method and Full Factorial Design. Chemical Engineering Communications, 203(1), 64-74.
  • [33] Bayram O., Köksal E., Danaş F., Göde F., Erzengin Ö. U. 2019. A Statistical Investigation Of The Effects Of Different Surfactant Concentrations On The Capsule Size In The Encapsulation Of Grapefruit (Citrus Paradisi Macf.) Peel Oil By Complex Coacervation Method. 2rd International Health Science And Life Congress, 24–27 April, Burdur, 486-497.
There are 33 citations in total.

Details

Primary Language Turkish
Subjects Engineering
Journal Section Articles
Authors

Okan Bayram 0000-0002-1748-9354

Elif Köksal 0000-0001-5131-3531

Fethiye Göde 0000-0002-3008-1353

Publication Date August 26, 2020
Published in Issue Year 2020

Cite

APA Bayram, O., Köksal, E., & Göde, F. (2020). Yanıt Yüzey Metodolojisi Şartlarında Karabaş Otu Yağının Kompleks Koaservasyon Yöntemi İle Enkapsülasyonu. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 24(2), 508-515. https://doi.org/10.19113/sdufenbed.687943
AMA Bayram O, Köksal E, Göde F. Yanıt Yüzey Metodolojisi Şartlarında Karabaş Otu Yağının Kompleks Koaservasyon Yöntemi İle Enkapsülasyonu. Süleyman Demirel Üniv. Fen Bilim. Enst. Derg. August 2020;24(2):508-515. doi:10.19113/sdufenbed.687943
Chicago Bayram, Okan, Elif Köksal, and Fethiye Göde. “Yanıt Yüzey Metodolojisi Şartlarında Karabaş Otu Yağının Kompleks Koaservasyon Yöntemi İle Enkapsülasyonu”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 24, no. 2 (August 2020): 508-15. https://doi.org/10.19113/sdufenbed.687943.
EndNote Bayram O, Köksal E, Göde F (August 1, 2020) Yanıt Yüzey Metodolojisi Şartlarında Karabaş Otu Yağının Kompleks Koaservasyon Yöntemi İle Enkapsülasyonu. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 24 2 508–515.
IEEE O. Bayram, E. Köksal, and F. Göde, “Yanıt Yüzey Metodolojisi Şartlarında Karabaş Otu Yağının Kompleks Koaservasyon Yöntemi İle Enkapsülasyonu”, Süleyman Demirel Üniv. Fen Bilim. Enst. Derg., vol. 24, no. 2, pp. 508–515, 2020, doi: 10.19113/sdufenbed.687943.
ISNAD Bayram, Okan et al. “Yanıt Yüzey Metodolojisi Şartlarında Karabaş Otu Yağının Kompleks Koaservasyon Yöntemi İle Enkapsülasyonu”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 24/2 (August 2020), 508-515. https://doi.org/10.19113/sdufenbed.687943.
JAMA Bayram O, Köksal E, Göde F. Yanıt Yüzey Metodolojisi Şartlarında Karabaş Otu Yağının Kompleks Koaservasyon Yöntemi İle Enkapsülasyonu. Süleyman Demirel Üniv. Fen Bilim. Enst. Derg. 2020;24:508–515.
MLA Bayram, Okan et al. “Yanıt Yüzey Metodolojisi Şartlarında Karabaş Otu Yağının Kompleks Koaservasyon Yöntemi İle Enkapsülasyonu”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol. 24, no. 2, 2020, pp. 508-15, doi:10.19113/sdufenbed.687943.
Vancouver Bayram O, Köksal E, Göde F. Yanıt Yüzey Metodolojisi Şartlarında Karabaş Otu Yağının Kompleks Koaservasyon Yöntemi İle Enkapsülasyonu. Süleyman Demirel Üniv. Fen Bilim. Enst. Derg. 2020;24(2):508-15.

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