Amin Grupları ile Fonksiyonelleştirilmiş Poli(vinil alkol) Aşı Kopolimerinin İlaç Salım Sistemlerinde Kullanımının İncelenmesi

Year 2018, Volume: 22 Issue: 2, 954 - 960, 15.08.2018

Zehra Özbaş

https://doi.org/10.19113/sdufbed.84289

Cited By: 1

Abstract

Bu çalışmada, çapraz bağlı poli(vinil alkol), CPVA üzerine glisidil metakrilat (GMA) monomerinin aşı polimerizasyonu gerçekleştirildikten sonra amin grupları ile modifiye edilerek fonksiyonelleştirilmesi amaçlanmıştır. Elde edilen ürünlerin karakterizasyonu Fourier dönüşümlü infrared spektroskopisi (FT-IR) ve taramalı elektron mikroskobu (SEM) ile gerçekleştirilmiştir.  Fonksiyonelleştirilmiş ürünün farklı pH’larda farklı şişme denge değerlerine (SDD) sahip olduğu bulunmuştur, en yüksek SDD değeri pH 2,1’de elde edilmiştir. Yapılan ilaç yükleme ve salım çalışmalarında anyonik yapıdaki tripan mavisi (TB) ve iyonik olmayan yapıdaki 5-flurasil (5-FU) model ilaç olarak seçilmiştir. Sonuç olarak, elde edilen ürünler ile ilaçların farklı yük gruplarına sahip olması nedeni ile ürünlere yüklenen ilaç miktarları ve dolayısıyla salım miktarlarının farklı olduğu görülmüştür.

Keywords

Poli(vinil alkol), Glisidil metakrilat; Aşı polimerizasyonu; Aminasyon; İlaç salımı

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