Modifiye Grafit Elektrotlar Kullanılarak Bazı Tetrasiklinlerin Elektrokimyasal Davranışlarının İncelenmesi

Year 2021, Volume 25, Issue 3, 513 - 518, 30.12.2021

Berrin GÜRLER AKYÜZ Sabriye PERÇİN ÖZKORUCUKLU Esengül KIR

https://doi.org/10.19113/sdufenbed.852801

Abstract

Bu çalışmada, Tetrasiklin (TC), Klortetrasiklin (CTC) ve Oksitetrasiklin’in (OTC) elektrokimyasal davranışları % 20; 30 ve 40 asetonitril-su karışımlarında hazırlanan Britton-Robinson (BR) tamponlarında pH 1,5; 2; 2,5; 3 ve 4’ te diferansiyel puls voltametri yöntemiyle incelenmiştir. TC, CTC ve OTC’nin voltametrik çalışmaları moleküler baskılı (MIP) ve baskısız (NIP) polimer modifiye grafit elektrotlar kullanılarak gerçekleştirilmiştir. Her iki tür elektrot da dönüşümlü voltametri yöntemiyle hazırlanmıştır. Asetonitril-su oranı ve pH’nın modifiye grafit elektrodun performansı üzerine olan etkisi incelenmiş ve optimize edilmiştir. TC, CTC ve OTC için modifiye grafit elektrot ile en yüksek anodik sinyaller %20 asetonitril-su karışımında hazırlanan BR tamponu ile pH 2’de elde edilmiştir.

Keywords

Polipirol, Tetrasiklin, Klortetrasiklin, Oksitetrasiklin, Modifiye grafit, Diferansiyel puls

Investigation of Electrohemical Behaviors of Some Tetracyclines Using Modified Graphite Electrodes

Abstract

In this study, electrochemical behavior of tetracycline (TC), chlortetracycline (CTC) and oxytetracycline (OTC) were investigated in 20; 30 and 40% acetonitrile-water mixture at the pH of 1.5; 2; 2.5; 3; 4 prepared Britton-Robinson (BR) buffers, by the differential pulse voltammetric method. Voltammetric determinations of TC, CTC and OTC were carried out using molecularly imprinted (MIP) and non-imprinted polypyrrole (NIP) modified graphite electrodes. Both types of electrode were prepared by the cyclic voltammetric method. The effect of the asetonitrile–water ratio and pH, on the performance of the modified graphite electrode (MIP) was investigated and optimized. The highest anodic signals of TC, CTC and OTC with modified graphite electrode were obtained in BR buffer solution were prepared in 20% asetonitrile-water at pH 2.

Keywords

Polypyrrole, Tetracycline, Chlortetracycline, Oxytetracycline, Modified graphite, Differential pulse

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