Birinci Mesajcılar ve Reseptörlerine Genel Bakış

Yıl 2022, , 559 - 566, 20.12.2022

Esma Selçuk , Nilüfer Şahin Calapoğlu

https://doi.org/10.22312/sdusbed.1208717

Öz

Sinyal molekülleri, hücreler arasında biyolojik bilginin taşınmasında ve uygun yanıtın oluşmasında kilit rol oynamaktadır. Bir sinyal molekülü reseptörüne bağlandığında hücre çoğalması, farklılaşması, hareketi, metabolizması ve davranışı gibi hayati olayların düzenlenmesi için hücre içi yanıtlar başlatır. Hücre içi sinyal moleküllerinin etki mekanizması reseptörlerin lokalizasyonundan etkilenir. Reseptörler, hedef hücrenin zarında, sitoplazmasında veya nukleusunda yer alan, istenen etkinin oluşmasını sağlayan proteinlerdir. Sinyalizasyon için sentezlenen birinci mesajcılar yapılarına göre hücre içinde veya hücre membranında yer alan reseptörlerine bağlanır. Ligand reseptöre bağlandığında reseptörün özelliklerini değiştirerek hücrede gerekli uyarının oluşmasını sağlar.

Anahtar Kelimeler

reseptör, ligand, hidrofilik, receptor, hydrophilic, : receptor

Destekleyen Kurum

YOK

Proje Numarası

YOK

Overview of Primary Messengers and Their Receptors

Öz

Signaling molecules play a key role in the transport of biological information between cells and in the formation of an appropriate response. When a signal molecule binds to its receptor, it initiates intracellular responses for the regulation of vital events such as cell proliferation, differentiation, movement, metabolism and behavior. The mechanism of action of intracellular signaling molecules is affected by the localization of the receptors. Receptors are proteins located in the membrane, cytoplasm or nucleus of the target cell, enabling the desired effect to occur. The first messengers synthesized for signaling bind to their receptors located in the cell or on the cell membrane, depending on their structure.When the ligand binds to the receptor, it changes the properties of the receptor and provides the necessary stimulation in the cell.

Anahtar Kelimeler

receptor, ligand, hydrophilic

Proje Numarası

YOK

Kaynakça

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