HEARING LOSS IN PATIENTS WITH COVID-19

Abstract

Objective Worldwide, scientists continue to follow-up on patients recovered from COVID-19 and have published the long-term persistent symptoms and permanent damage observed in various tissues. The present study aimed to evaluate hearing loss in patients with COVID-19 on the basis of pure tone averages measured using pure tone audiometry. Material and Method In this retrospective data analysis study, pure tone averages of non-hospitalised patients with COVID-19 were compared over 1 year before and after contracting COVID-19. Continuous variables were presented as mean ± Standard deviation (SD) and categorical variables were presented as number (n) and percentage (%). All data showed normal distribution. Therefore, paired t-test, a type of parametric test, was used to identify the significant differences between the measurements. Results The pure tone threshold values of patients increased significantly after COVID-19 (p0.001 for all) based on puretone averages measured in the bones and airways of theleftandrightears. Olderadults (41–64 yearsold) had a greater difference in puretone averages of the left ear airway before and after COVID-19 (p=0.040) than younger adults (18–40 yearsold). Conclusion COVID-19 affects both ears' bones and airways, causing varying degrees of hearing loss at different frequencies. Hearing loss tests should be included in COVID-19 complications research, and clinicians should be given advice on how to avoid hearing loss.

Keywords

• COVID-19
• hearing loss
• pandemic

COVİD-19 HASTALARINDA İŞİTME KAYBI

Abstract

Amaç Dünya çapında bilim insanları, COVID-19'dan iyileşen hastaları takip etmeye devam ediyorlar. Bu hastalarda gözlemlenen uzun süreli kalıcı semptomları ve kalıcı hasarları yayınlıyorlar. Bu çalışma, saf ses odyometrisi kullanılarak ölçülen saf ses ortalamaları temelinde COVID-19 hastalarında işitme kaybını değerlendirmeyi amaçladı. Gereç ve Yöntem Bu geriye dönük veri analizi çalışmasında, COVID- 19'lu hastaneye yatırılmamış hastaların saf ses ortalamaları, COVID-19'a yakalanmadan 1 yıl önce ve sonra karşılaştırıldı. Sürekli değişkenler ortalama ± standart sapma (SD) olarak, kategorik değişkenler ise sayı (n) ve yüzde (%) olarak sunuldu. Tüm veriler normal dağılım gösterdi. Bu nedenle, ölçümler arasındaki anlamlı farklılıkları belirlemek için bir parametrik test türü olan eşleştirilmiş t testi kullanılmıştır. Bulgular Sol ve sağ kulakların kemik ve hava yollarında ölçülen saf ses ortalamalarına göre, COVID-19 sonrası hastaların saf ses eşik değerlerinde anlamlı bir artış bulundu (tümü için p<0,001). COVID-19 öncesi ve sonrası sol kulak hava yolunun saf ton ortalamaları yaşlı erişkinlerde (41-64 yaş) genç yetişkinlere (18-40 yaş) göre daha yüksekti (p=0.040). Sonuç COVID-19 her iki kulağın kemik ve hava yollarını etkileyerek farklı frekanslarda farklı düzeylerde işitme kaybına neden olmaktadır. COVID-19'un komplikasyonları üzerine yapılan araştırmalar, işitme kaybı testlerini içermeli ve olası işitme kaybını önlemek için çalışmalar yapılmalıdır.

Keywords

• Covid-19
• işitme kaybı
• pandemi

References

1. 1. Li K, Wu J, Wu F, et al. The Clinical and Chest CT Features Associated with Severe and Critical COVID-19 Pneumonia. Invest Radiol.2020;55(6):327-31. doi:10.1097/RLI.0672
2. 2. Ahmad I, Rathore FA. Neurological manifestations and comp- lications of COVID-19: A Literature Review. J ClinNeurosci. 2020;13(5):667-73.doi: 10.1016/j.jiph.2020.03.019
3. 3. Leonardi M, Padovani A, McArthur JC. Neurological manifestations associated with COVID19: a review and a call for action. J Neurol. 2020;267(6):1573-6.
4. 4. Li B, Yang J, Zhao F, et al. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. ClinRes- Cardiol. 2020;109(5):531‐8. doi:10.1007/s00392-020-01626-9
5. 5. Hunt RH, East JE, Lanas A, et al. COVID-19 and Gastrointestinal Disease: Implications for the Gastroenterologist. Dig- Dis2021;39:119-39. doi: 10.1159/000512152
6. 6. TR. Ministry of Health Covid-19 patients follow-up guide, 2021. Accessed from::https://toraks.org.tr/site/sf/nmf/pre_migration/ 0cd6655ae86e94eec61e88ab75cc757d8eaa1df39ce- 43d3c871b3d715afde5b6.pdf. Accessed time: 05.06.2021
7. 7. Chen X, Fu YY, Zhang TY. Role of Viral infection in sudden hearing loss. J IntMedRes. 2019;47(7):2865–72. doi: 10.1177/0300060519847860.
8. 8. TR. Ministry of Family, Laborand Social Security. Health and surve illance guide in working life, 2018. Accessed from: https:// www.ailevecalisma.gov.tr/medias/4591/rehber03.pdf. Accessed time: 05.06.2021

9. 9. Mustafa MW. Audiological profile of asymptomatic Covid-19 PCR-positive cases. Am J Otolaryngol. 2020;41(3) doi: 10.1016/j.amjoto.2020.102483.
10. 10. Karimi-Galougahi M, Naeini AS, Raad N, et al. Vertigo and hearing loss during the COVID-19 pandemic - is there an association? ActaOtorhinolaryngolItal. 2020;40:463-5. doi: 10.14639/0392-100X-N0820
11. 11. Koumpa FS, Forde CT, Manjaly JG. Sudden irreversible hearing loss post COVID-19. BMJ Case Reports CP 2020;13,13(11):e238419 doi:10.1136/bcr-2020-238419.
12. 12. Sriwijitalai W, Wiwanitkit V. Hearing loss and COVID-19: A note. AmericanJournal of Otolaryngology -Head and Neck Medicine and Surgery;2020;41(3). doi:10.1016/j.amjoto.2020.102473
13. 13. Han W, Quan B, Guo Y, et al. The course of clinical diagnosis and treatment of a case infected with coronavirus disease 2019. Journal of Medical Virology.2020;92(5):461-3. doi:10.1002/ jmv.25711
14. 14. Kim J, Jung J, Moon IS, Lee HK, Lee WS. Statistical analysis of puretone audiometry and caloric test in herpes zosteroticus. ClinExpOtorhinolaryngol. 2008;1(1):15-9.
15. 15. Kim CH, Choi H, Shin JE. Characteristics of hearing loss in patients with herpes zosteroticus. Medicine (Baltimore). 2016;95(46):e5438.
16. 16. Acharya A, Kevadiya BD, Gendelman HE, Byrareddy SN. SARSCoV- 2 Infection Leads to Neurological Dysfunction. J NeuroimmunePharmacol2020; 15:167–73.
17. 17. Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, vanGoor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004;203(2):631-7. doi: 10.1002/ path.1570.
18. 18. Iroegbu JD, Ifenatuoha CW. Ijomone OM. Potential neurological impact of coronaviruses: implications for the novel SARSCoV- 2. NeurolSci. 2020;41(6):1329-37.
19. 19. Kalcioglu MT, Cag Y, Kilic O, Tuysuz O. COVID-19 cause sudden sensorineural hearing loss? Int J Infect Dis.2020;101:205 doi:10.1016/j.ijid.2020.09.1468.
20. 20. Maharaj S, BelloAlvarez M, Mungul S, Hari K. Otologic dysfunction in patients with COVID-19: a systematic review. LaryngoscopeInvestigOtolaryngol.2020;5(6):1192–6. doi: 10.1002/ lio2.498.
21. 21. Saniasiaya J. Hearing loss in SARS-CoV-2: What do we know? EarNoseThroat J. 2020;100(2):152-4. doi: 10.1177/0145561320946902.
22. 22. Taneja MK. Deafness in COVID-19. Indian J Otol. 2020;26(2):68- 70 doi:10.4103/indianjotol.INDIANJOTOL_83_20
23. 23. Yaseen N K, Al-Ani R M, Ali Rashid R. COVID-19-related sudden sensorineural hearing loss. Qatar medical journal, 2021(3), 58. https://doi.org/10.5339/qmj.2021.58
24. 24. Edwards M, Muzaffar J, Naik P, Coulson C. Catastrophic bilateral sudden sensorineural hearing loss following COVID-19. BMJ Case Rep. 2021 ;14(6):e243157. doi: 10.1136/bcr-2021- 243157.
25. 25. 25. Koumpa F S, Forde C T, Manjaly J G. Sudden irreversible hearing loss post COVID-19. BMJ case reports 2020;13(11); e238419. https://doi.org/10.1136/bcr-2020-238419