EFFICACY OF OZONE THERAPY IN THE TREATMENT OF LUMBAR DISC HERNIATION: A SYSTEMATIC REVIEW OF 1098 PATIENTS' RESULTS

Abstract

Ozone therapy is widely used in the treatment of lumbar disc herniation with intradiscal injection and paravertebral intramuscular injection routes. This study aims to evaluate the efficacy of ozone therapy in the treatment of lumbar disc herniation according to the results of randomized controlled trials. 105 articles obtained as a result of a search in Pubmed, Google Scholar and Science Direct databases were examined, and 9 randomized controlled studies were included in the systematic review. In studies, it has been observed that ozone is used in concentrations ranging from 20 μg/ml to 60 μg/ml by intradiscal or paravertebral route. While only ozone application can be done in studies, it has been determined that some studies use the effect of ozone injection in combination with other treatment methods. It was seen that pain was measured with a visual analog scale as the primary output criterion of the studies. The results of randomized controlled studies show that ozone therapy gives more effective results in the treatment of lumbar disc herniation compared to conventional drug therapy, and increases the effectiveness of treatment when added to other minimally invasive treatments. It also leads to less hospital stay and lower treatment costs compared to surgery.

Keywords

• low back pain
• ozone
• intervertebral disc herniation

LOMBER DİSK HERNİSİ TEDAVİSİNDE OZON TERAPİNİN ETKİNLİĞİ: 1098 HASTANIN SONUÇLARININ SİSTEMATİK DERLEMESİ

Abstract

Ozon terapi, lomber disk hernisi tedavisinde, intradiskal enjeksiyon ve paravertebral kas içi enjeksiyon şeklinde yaygın olarak kullanılmaktadır. Bu sistematik derlemenin amacı, lomber disk herniasyonu tedavisinde ozon tedavisinin etkinliğinin randomize kontrollü çalışma sonuçlarına göre değerlendirilmesidir. Pubmed, Google Akademik ve Science Direct veritabanlarında yapılan arama sonucunda elde edilen 105 makale incelenerek 9 adet randomize kontrollü araştırma sistematik derleme kapsamına alınmıştır. Araştırmalarda ozonun intradiskal ya da paravertebral yolla, 20 μg/ml ile 60 μg/ml arasında değişen konsantrasyonlarda kullanıldığı görülmüştür. Araştırmalarda sadece ozon uygulaması yapılabildiği gibi, bazı araştırmalar ozon enjeksiyonunun etkisini başka tedavi yöntemleriyle kombinasyon halinde kullandığı saptanmıştır. Araştırmalarda değerlendirme parametresi olarak genelde ağrının görsel analog skala (GAS) ile ölçüldüğü görülmüştür. Randomize kontrollü çalışma sonuçları, ozon terapinin lomber disk hernisi tedavisinde konvansiyonel ilaç tedavisine kıyasla daha etkili olduğu ve minimal invaziv tedavilere eklendiğinde ise tedavi etkinliğini artırdığı görülmüştür. Ayrıca cerrahiye kıyasla daha az hastanede yatış süresine ve daha düşük tedavi maliyetine yol açmaktadır.

Keywords

• bel ağrısı
• ozon
• Lomber disk hernisi

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