Serum Levels of Interleukin (IL)-lp, sIL-2R, IL-6, IL-8 and TNF-a in Chüdren with idiopatine Nephrotic Syndrome

Aydın Ece; Leyla Çolpan; Mehmet Yılmaz; Fuat Gürkan; Kenan Haspolat

doi:10.17343/sdutfd.72216

Serum Levels of Interleukin (IL)-lp, sIL-2R, IL-6, IL-8 and TNF-a in Chüdren with idiopatine Nephrotic Syndrome

Abstract

SüleymanDemirel Üniversitesi TIP FAKÜLTESİ DERGİSİ: 1999 Haziran; 6(2) Serum Levels of Interleukin (IL)-lp, sIL-2R, IL-6, IL-8 and TNF-a in Chüdren with idiopatine Nephrotic Syndrome Aydın Ece, Leyla Çolpan, Mehmet Emin Yılmaz, Fuat Gürkan, Kenan Haspolat Abstract The pathogenesis of idiopathic nephrotic syndrome (INS) is stili controversial. Lymphocytic dysfunction and increased cytokine prodıtction have been suggested to be pathogenetic mechanism for renal injury in childhood INS. in order to investigate the role of certain cytokines, 23 children with steroid sensitive INS, aged 2-8 years, and 29 healthy controls were included in the study. Blood samples ofpatients were taken both at remission and relapse phases of the disease. Cytokines were measured by the chemiluminescent immunometric assay. Interleukin (lL)-l/3 vvas undetectable in serum samples of ali children. Serum levels of soluble interleukin-2 receptor (sIL-2R), IL-6, IL-8, and tümör necrosis factor-alpha (TNF-a) vere signifıcantly higher in relapsing phase of INS compared to remission and controls. Signifıcant correlation wasfound between sIL-2R and 24-hour proteinuria. in conclusion, sIL-2R, IL-6, IL-8 and TNF-a may have a role in the pathogenesis of renal injury in childhood steroid sensitive INS. Key Words: Children, cytokines, nephrotic syndrome, pathogenesis

Keywords

-

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Aydın Ece This is me

Leyla Çolpan This is me

Mehmet Yılmaz This is me

Fuat Gürkan This is me

Kenan Haspolat This is me

Publication Date

March 10, 2009

Submission Date

March 9, 2009

Acceptance Date

-

Published in Issue

Year 1999 Volume: 6 Number: 2

DOI

https://doi.org/10.17343/sdutfd.72216

IZ

https://izlik.org/JA98NH96LM

Cite

RIS / Bibtex

APA

Ece, A., Çolpan, L., Yılmaz, M., Gürkan, F., & Haspolat, K. (2009). Serum Levels of Interleukin (IL)-lp, sIL-2R, IL-6, IL-8 and TNF-a in Chüdren with idiopatine Nephrotic Syndrome. Medical Journal of Süleyman Demirel University, 6(2). https://doi.org/10.17343/sdutfd.72216

AMA

1.Ece A, Çolpan L, Yılmaz M, Gürkan F, Haspolat K. Serum Levels of Interleukin (IL)-lp, sIL-2R, IL-6, IL-8 and TNF-a in Chüdren with idiopatine Nephrotic Syndrome. Med J SDU. 2009;6(2). doi:10.17343/sdutfd.72216

Chicago

Ece, Aydın, Leyla Çolpan, Mehmet Yılmaz, Fuat Gürkan, and Kenan Haspolat. 2009. “Serum Levels of Interleukin (IL)-Lp, SIL-2R, IL-6, IL-8 and TNF-a in Chüdren With Idiopatine Nephrotic Syndrome”. Medical Journal of Süleyman Demirel University 6 (2). https://doi.org/10.17343/sdutfd.72216.

EndNote

Ece A, Çolpan L, Yılmaz M, Gürkan F, Haspolat K (March 1, 2009) Serum Levels of Interleukin (IL)-lp, sIL-2R, IL-6, IL-8 and TNF-a in Chüdren with idiopatine Nephrotic Syndrome. Medical Journal of Süleyman Demirel University 6 2

IEEE

[1]A. Ece, L. Çolpan, M. Yılmaz, F. Gürkan, and K. Haspolat, “Serum Levels of Interleukin (IL)-lp, sIL-2R, IL-6, IL-8 and TNF-a in Chüdren with idiopatine Nephrotic Syndrome”, Med J SDU, vol. 6, no. 2, Mar. 2009, doi: 10.17343/sdutfd.72216.

ISNAD

Ece, Aydın - Çolpan, Leyla - Yılmaz, Mehmet - Gürkan, Fuat - Haspolat, Kenan. “Serum Levels of Interleukin (IL)-Lp, SIL-2R, IL-6, IL-8 and TNF-a in Chüdren With Idiopatine Nephrotic Syndrome”. Medical Journal of Süleyman Demirel University 6/2 (March 1, 2009). https://doi.org/10.17343/sdutfd.72216.

JAMA

1.Ece A, Çolpan L, Yılmaz M, Gürkan F, Haspolat K. Serum Levels of Interleukin (IL)-lp, sIL-2R, IL-6, IL-8 and TNF-a in Chüdren with idiopatine Nephrotic Syndrome. Med J SDU. 2009;6. doi:10.17343/sdutfd.72216.

MLA

Ece, Aydın, et al. “Serum Levels of Interleukin (IL)-Lp, SIL-2R, IL-6, IL-8 and TNF-a in Chüdren With Idiopatine Nephrotic Syndrome”. Medical Journal of Süleyman Demirel University, vol. 6, no. 2, Mar. 2009, doi:10.17343/sdutfd.72216.

Vancouver

1.Aydın Ece, Leyla Çolpan, Mehmet Yılmaz, Fuat Gürkan, Kenan Haspolat. Serum Levels of Interleukin (IL)-lp, sIL-2R, IL-6, IL-8 and TNF-a in Chüdren with idiopatine Nephrotic Syndrome. Med J SDU. 2009 Mar. 1;6(2). doi:10.17343/sdutfd.72216