Leptin ve İmmün Sistem

Demircan Özbalcı; Mehmet Şahin

doi:10.17343/sdutfd.70320

Leptin ve İmmün Sistem

Abstract

SüleymanDemirel Üniversitesi TIP FAKÜLTESİ DERGİSİ: 2007 Haziran; 14(2) Leptin ve İmmün Sistem Demircan Özbalcı, Mehmet Şahin Süleyman Demirel Üniversitesi Tıp Fakültesi İç Hastalıkları Bilim Dalı Özet Leptin, hipotalamustaki reseptörüne bağlanıp, Interlökin-1 üzerinden yaptığı etkiyle insanlarda yemek yeme hissini azaltarak kilo alımını engelleyen, sitokinlere benzer yapıda bir hormondur. Kandaki düzeyi vücut yağ dokusu ile doğru orantılıdır. Son zamanlarda yapılan çalışmalarda leptinin organizmada birçok sistem üzerinde etkilerinin olduğu ortaya çıkarılmıştır. Leptin hematopoez, sitokin sentezi, anjiogenez ve hipotalamus-hipofiz-adrenal aksta görevlidir. Yeni yapılan çalışmalarda immun düzenleyici etkileri de ortaya çıkmıştır. Obezitede etkin olan mekanizmanın , sekonder leptin yetmezliği olduğu görüşü ağırlık kazanmaya başlamıştır. Bu derlemede immün sistem üzerine olan etkileri ve kısaca obesitedeki rolü tartışılmıştır. Anahtar kelimeler: leptin, immün sistem, sitokin, obezite Abstract Leptin and Immune System Leptin is a cytokine-like hormone that makes an effect on decreasing the appetite via on Interleukin-1 after it bounds to its receptor in hypothalamus. The level of the hormone is directly proportional with the body fat tissue. Recent studies showed that Leptin has effects on multiple systems of organisms. Leptin has effects on hematopoesis, synthesis of cytokines, angiogenesis and hypothalamus- pituitary-adrenal axis. Immune regulatory functions of leptin are found in recent studies. The mechanism responsible in obesity is thought to be secondary leptin deficiency. In this review, its effects on immune system and briefly its role in obesity is discussed. Key words: leptin, immune system, cytokine, obesity

Keywords

leptin, immün sistem, sitokin, obezite

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Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Demircan Özbalcı This is me

Mehmet Şahin This is me

Publication Date

April 30, 2009

Submission Date

April 30, 2009

Acceptance Date

-

Published in Issue

Year 2007 Volume: 14 Number: 2

DOI

https://doi.org/10.17343/sdutfd.70320

IZ

https://izlik.org/JA24ZP87DL

Cite

RIS / Bibtex

APA

Özbalcı, D., & Şahin, M. (2009). Leptin ve İmmün Sistem. Medical Journal of Süleyman Demirel University, 14(2), 51-55. https://doi.org/10.17343/sdutfd.70320

AMA

1.Özbalcı D, Şahin M. Leptin ve İmmün Sistem. Med J SDU. 2009;14(2):51-55. doi:10.17343/sdutfd.70320

Chicago

Özbalcı, Demircan, and Mehmet Şahin. 2009. “Leptin Ve İmmün Sistem”. Medical Journal of Süleyman Demirel University 14 (2): 51-55. https://doi.org/10.17343/sdutfd.70320.

EndNote

Özbalcı D, Şahin M (April 1, 2009) Leptin ve İmmün Sistem. Medical Journal of Süleyman Demirel University 14 2 51–55.

IEEE

[1]D. Özbalcı and M. Şahin, “Leptin ve İmmün Sistem”, Med J SDU, vol. 14, no. 2, pp. 51–55, Apr. 2009, doi: 10.17343/sdutfd.70320.

ISNAD

Özbalcı, Demircan - Şahin, Mehmet. “Leptin Ve İmmün Sistem”. Medical Journal of Süleyman Demirel University 14/2 (April 1, 2009): 51-55. https://doi.org/10.17343/sdutfd.70320.

JAMA

1.Özbalcı D, Şahin M. Leptin ve İmmün Sistem. Med J SDU. 2009;14:51–55.

MLA

Özbalcı, Demircan, and Mehmet Şahin. “Leptin Ve İmmün Sistem”. Medical Journal of Süleyman Demirel University, vol. 14, no. 2, Apr. 2009, pp. 51-55, doi:10.17343/sdutfd.70320.

Vancouver

1.Demircan Özbalcı, Mehmet Şahin. Leptin ve İmmün Sistem. Med J SDU. 2009 Apr. 1;14(2):51-5. doi:10.17343/sdutfd.70320