Leptin ve İmmün Sistem

Demircan Özbalcı; Mehmet Şahin

doi:10.17343/sdutfd.70320

Leptin ve İmmün Sistem

Öz

SüleymanDemirel Üniversitesi TIP FAKÜLTESİ DERGİSİ: 2007 Haziran; 14(2) Leptin ve İmmün Sistem Demircan Özbalcı, Mehmet Şahin Süleyman Demirel Üniversitesi Tıp Fakültesi İç Hastalıkları Bilim Dalı Özet Leptin, hipotalamustaki reseptörüne bağlanıp, Interlökin-1 üzerinden yaptığı etkiyle insanlarda yemek yeme hissini azaltarak kilo alımını engelleyen, sitokinlere benzer yapıda bir hormondur. Kandaki düzeyi vücut yağ dokusu ile doğru orantılıdır. Son zamanlarda yapılan çalışmalarda leptinin organizmada birçok sistem üzerinde etkilerinin olduğu ortaya çıkarılmıştır. Leptin hematopoez, sitokin sentezi, anjiogenez ve hipotalamus-hipofiz-adrenal aksta görevlidir. Yeni yapılan çalışmalarda immun düzenleyici etkileri de ortaya çıkmıştır. Obezitede etkin olan mekanizmanın , sekonder leptin yetmezliği olduğu görüşü ağırlık kazanmaya başlamıştır. Bu derlemede immün sistem üzerine olan etkileri ve kısaca obesitedeki rolü tartışılmıştır. Anahtar kelimeler: leptin, immün sistem, sitokin, obezite Abstract Leptin and Immune System Leptin is a cytokine-like hormone that makes an effect on decreasing the appetite via on Interleukin-1 after it bounds to its receptor in hypothalamus. The level of the hormone is directly proportional with the body fat tissue. Recent studies showed that Leptin has effects on multiple systems of organisms. Leptin has effects on hematopoesis, synthesis of cytokines, angiogenesis and hypothalamus- pituitary-adrenal axis. Immune regulatory functions of leptin are found in recent studies. The mechanism responsible in obesity is thought to be secondary leptin deficiency. In this review, its effects on immune system and briefly its role in obesity is discussed. Key words: leptin, immune system, cytokine, obesity

Anahtar Kelimeler

leptin, immün sistem, sitokin, obezite

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

-

Yazarlar

Demircan Özbalcı Bu kişi benim

Mehmet Şahin Bu kişi benim

Yayımlanma Tarihi

30 Nisan 2009

Gönderilme Tarihi

30 Nisan 2009

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2007 Cilt: 14 Sayı: 2

DOI

https://doi.org/10.17343/sdutfd.70320

IZ

https://izlik.org/JA24ZP87DL

Kaynak Göster

RIS / Bibtex

APA

Özbalcı, D., & Şahin, M. (2009). Leptin ve İmmün Sistem. Medical Journal of Süleyman Demirel University, 14(2), 51-55. https://doi.org/10.17343/sdutfd.70320

AMA

1.Özbalcı D, Şahin M. Leptin ve İmmün Sistem. SDÜ Tıp Fak Derg. 2009;14(2):51-55. doi:10.17343/sdutfd.70320

Chicago

Özbalcı, Demircan, ve Mehmet Şahin. 2009. “Leptin ve İmmün Sistem”. Medical Journal of Süleyman Demirel University 14 (2): 51-55. https://doi.org/10.17343/sdutfd.70320.

EndNote

Özbalcı D, Şahin M (01 Nisan 2009) Leptin ve İmmün Sistem. Medical Journal of Süleyman Demirel University 14 2 51–55.

IEEE

[1]D. Özbalcı ve M. Şahin, “Leptin ve İmmün Sistem”, SDÜ Tıp Fak Derg, c. 14, sy 2, ss. 51–55, Nis. 2009, doi: 10.17343/sdutfd.70320.

ISNAD

Özbalcı, Demircan - Şahin, Mehmet. “Leptin ve İmmün Sistem”. Medical Journal of Süleyman Demirel University 14/2 (01 Nisan 2009): 51-55. https://doi.org/10.17343/sdutfd.70320.

JAMA

1.Özbalcı D, Şahin M. Leptin ve İmmün Sistem. SDÜ Tıp Fak Derg. 2009;14:51–55.

MLA

Özbalcı, Demircan, ve Mehmet Şahin. “Leptin ve İmmün Sistem”. Medical Journal of Süleyman Demirel University, c. 14, sy 2, Nisan 2009, ss. 51-55, doi:10.17343/sdutfd.70320.

Vancouver

1.Demircan Özbalcı, Mehmet Şahin. Leptin ve İmmün Sistem. SDÜ Tıp Fak Derg. 01 Nisan 2009;14(2):51-5. doi:10.17343/sdutfd.70320