Parkinson Hastalığında Nöroinflamasyonun Rolü

Elif Taşdemir

doi:10.17343/sdutfd.447542

Parkinson Hastalığında Nöroinflamasyonun Rolü

Abstract

Parkinson Hastalığı (PH), 65 yaş üzeri kişilerde en sık görülen ikinci nörodejeneratif bozukluktur (1). Bu hastalık, substantia nigra pars compacta’daki dopaminerjik nöronların progresif kaybı (2-4), striatal dopamin seviyesinde azalma ve dopaminerjik liflerin kaybıyla karakterizedir (5). PH’ndaki nöron dejenerasyon sürecinde; oksidatif stresin, aktive edilmiş mikroglia hücrelerinin ve nöroinflamasyonun olduğu bilinmektedir (6). PH, yoğun araştırma konusu olmasına rağmen hastalığın patogenezinde yatan mekanizmalar tam olarak anlaşılamamıştır (7-8). Dolayısıyla, bu süreci tamamen önleyen bir tedavi de bulunamamıştır. Bu derlemede, PH patogenezinde yer alan nöroinflamasyon süreçleri incelenmiştir.

Keywords

Parkinson hastalığı,nöroinflamasyon,mikroglia

References

1. Phani S, Loike JD, Przedborski S. Neurodegeneration and inflammation in Parkinson's disease. Parkinsonism & related disorders 2012;18(1):207-9.
2. Episcopo FL, Tirolo C, Testa N, Caniglia S, Morale MC, Marchetti B. Reactive astrocytes are key players in nigrostriatal dopaminergic neurorepair in the MPTP mouse model of Parkinson's disease: focus on endogenous neurorestoration. Current aging science 2013;6(1):45-55.
3. Hernandes MS, Santos GD, Cafe-Mendes CC, Lima LS, Scavone C, Munhoz CD, et al. Microglial cells are involved in the susceptibility of NADPH oxidase knockout mice to 6-hydroxy-dopamine-induced neurodegeneration. PloS one 2013;8(9):e75532.
4. Holmqvist S, Chutna O, Bousset L, Aldrin-Kirk P, Li W, Bjorklund T. Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats. Act Neuropathol 2014;128(6):805-20.
5. Schober A. Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell Tissue Res 2004;318(1):215-24.
6. Hirsch EC, Vyas S, Hunot S. Neuroinflammation in Parkinson's disease. Parkinsonism & related disorders 2012;18(1):210-2.
7. Chao Y, Wong SC, Tan EK. Evidence of inflammatory system involvement in Parkinson's disease. BioMed research international 2014;2014:308654.
8. Jackson-Lewis V, Smeyne RJ. MPTP and SNpc DA neuronal vulnerability: role of dopamine, superoxide and nitric oxide in neurotoxicity. Minireview. Neurotoxicity research 2005;7(3):193-202.

9. Nolan YM, Sullivan AM, Toulouse A. Parkinson's disease in the nuclear age of neuroinflammation. Trends in molecular medicine 2013;19(3):187-96.
10. Şentürk E, Esen F. Sepsiste İmmunoglobülin Tedavisi ile Kompleman İnhibisyonu ve Nöroproteksiyon. Türk Anesteziyoloji Reanimasyon Dergisi 2012;40(4):184-92.
11. Laveti D, Kumar M, Hemalatha R, Sistla R, Naidu VG, Talla V, et al. Anti-inflammatory treatments for chronic diseases: a review. Inflammation & allergy drug targets 2013;12(5):349-61.
12. Gao HM, Liu B, Zhang W, Hong JS. Novel anti-inflammatory therapy for Parkinson's disease. Trends in pharmacological sciences 2003;24(8):395-401.
13. Mosley RL, Benner EJ, Kadiu I, Thomas M, Boska MD, Hasan K, et al. Neuroinflammation, Oxidative Stress and the Pathogenesis of Parkinson's Disease. Clinical neuroscience research 2006;6(5):261-81.
14. Wilms H, Zecca L, Rosenstiel P, Sievers J, Deuschl G, Lucius R. Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications. Current pharmaceutical design 2007;13(18):1925-8.
15. Hirsch EC, Hunot S. Neuroinflammation in Parkinson's disease: a target for neuroprotection? The Lancet Neurology 2009;8(4):382-97.
16. Qian L, Flood PM, Hong JS. Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. J Neural Transm 2010;117(8):971-9.
17. Duke DC, Moran LB, Pearce RK, Graeber MB. The medial and lateral substantia nigra in Parkinson's disease: mRNA profiles associated with higher brain tissue vulnerability. Neurogenetics 2007;8(2):83-94.
18. Lleo A, Galea E, Sastre M. Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases. Cell Mol Life Sci 2007;64(11):1403-18.
19. Zaminelli T, Gradowski RW, Bassani TB, Barbiero JK, Santiago RM, Maria-Ferreira D, et al. Antidepressant and antioxidative effect of Ibuprofen in the rotenone model of Parkinson's disease. Neurotoxicity research 2014;26(4):351-62.
20. Taylor JM, Main BS, Crack PJ. Neuroinflammation and oxidative stress: co-conspirators in the pathology of Parkinson's disease. Neurochem Int 2013;62(5):803-19.
21. Chung YC, Kim SR, Jin BK. Paroxetine prevents loss of nigrostriatal dopaminergic neurons by inhibiting brain inflammation and oxidative stress in an experimental model of Parkinson's disease. J Immunol 2010;185(2):1230-7.
22. Xing B, Liu M, Bing G. Neuroprotection with pioglitazone against LPS insult on dopaminergic neurons may be associated with its inhibition of NF-kappaB and JNK activation and suppression of COX-2 activity. J Neuroimmunol 2007;192(1-2):89-98.
23. Liberatore GT, Jackson-Lewis V, Vukosavic S, Mandir AS, Vila M, McAuliffe WG, et al. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med 1999;5(12):1403-9.
24. Yang X, Lou Y, Liu G, Wang X, Qian Y, Ding J, et al. Microglia P2Y6 receptor is related to Parkinson’s disease through neuroinflammatory process. Journal of neuroinflammation 2017;14(1):38.
25. Tansey MG, Goldberg MS. Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. Neurobiol Dis 2010;37:510-8.
26. Stojkovska I, Wagner BM, Morrison ME. Parkinson's disease and enhanced inflammatory response. Experimental biology and medicine 2015;240(11):1387-95.
27. Chung YC, Ko HW, Bok E, Park ES, Huh SH, Nam JH, et al. The role of neuroinflammation on the pathogenesis of Parkinson's disease. BMB reports 2010;43(4):225-32.
28. McGeer PL, Itagaki S, Boyes BE, McGeer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988;38(8):1285-91.
29. Jenner P, Olanow CW. The pathogenesis of cell death in Parkinson's disease. Neurology 2006;66:24-36.
30. Ramsey CP, Tansey MG. A survey from 2012 of evidence for the role of neuroinflammation in neurotoxin animal models of Parkinson's disease and potential molecular targets. Experimental neurology 2014;256:126-32.
31. Tiwari PC, Pal R. The potential role of neurıinflammation and transcription factors in Parkinson disease. Dialogues in clinical neuroscience 2017;19(1):71-80.
32. Nagatsu T, Sawada M. Inflammatory process in Parkinson's disease: role for cytokines. Current pharmaceutical design 2005;11(8):999-1016.
33. Rajasekar N, Dwivedi S, Nath C, Hanif K, Shukla R. Protection of streptozotocin induced insulin receptor dysfunction, neuroinflammation and amyloidogenesis in astrocytes by insulin. Neuropharmacology 2014;86:337-52.
34. Joe EH, Choi DJ, An J, Eun JH, Jou I, Park S. Astrocytes, Microglia, and Parkinson’s Disease. Experimental neurobiology 2018;27(2):77-87.
35. Lee E, Park HR, Ji ST, Lee Y, Lee J. Baicalein attenuates astroglial activation in the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model by downregulating the activations of nuclear factor-kappaB, ERK, and JNK. J Neurosci Res 2014;92(1):130-9.
36. Halliday GM, Stevens CH. Glia: initiators and progressors of pathology in Parkinson’s disease. Movement disorders: official journal of the movement disorder society 2011;26(1):6-17.

Details

Primary Language

Turkish

Subjects

Pharmacology and Pharmaceutical Sciences, Clinical Sciences

Journal Section

Review

Authors

Elif Taşdemir ^*
Türkiye

Publication Date

September 1, 2019

Submission Date

July 25, 2018

Acceptance Date

September 18, 2018

Published in Issue

Year 2019 Volume: 26 Number: 3

DOI

https://doi.org/10.17343/sdutfd.447542

IZ

https://izlik.org/JA43LT89PU

Cite

RIS / Bibtex

APA

Taşdemir, E. (2019). Parkinson Hastalığında Nöroinflamasyonun Rolü. Medical Journal of Süleyman Demirel University, 26(3), 348-352. https://doi.org/10.17343/sdutfd.447542

AMA

1.Taşdemir E. Parkinson Hastalığında Nöroinflamasyonun Rolü. Med J SDU. 2019;26(3):348-352. doi:10.17343/sdutfd.447542

Chicago

Taşdemir, Elif. 2019. “Parkinson Hastalığında Nöroinflamasyonun Rolü”. Medical Journal of Süleyman Demirel University 26 (3): 348-52. https://doi.org/10.17343/sdutfd.447542.

EndNote

Taşdemir E (September 1, 2019) Parkinson Hastalığında Nöroinflamasyonun Rolü. Medical Journal of Süleyman Demirel University 26 3 348–352.

IEEE

[1]E. Taşdemir, “Parkinson Hastalığında Nöroinflamasyonun Rolü”, Med J SDU, vol. 26, no. 3, pp. 348–352, Sept. 2019, doi: 10.17343/sdutfd.447542.

ISNAD

Taşdemir, Elif. “Parkinson Hastalığında Nöroinflamasyonun Rolü”. Medical Journal of Süleyman Demirel University 26/3 (September 1, 2019): 348-352. https://doi.org/10.17343/sdutfd.447542.

JAMA

1.Taşdemir E. Parkinson Hastalığında Nöroinflamasyonun Rolü. Med J SDU. 2019;26:348–352.

MLA

Taşdemir, Elif. “Parkinson Hastalığında Nöroinflamasyonun Rolü”. Medical Journal of Süleyman Demirel University, vol. 26, no. 3, Sept. 2019, pp. 348-52, doi:10.17343/sdutfd.447542.

Vancouver

1.Elif Taşdemir. Parkinson Hastalığında Nöroinflamasyonun Rolü. Med J SDU. 2019 Sep. 1;26(3):348-52. doi:10.17343/sdutfd.447542

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