Parkinson Hastalığında Nöroinflamasyonun Rolü

Elif Taşdemir

doi:10.17343/sdutfd.447542

Parkinson Hastalığında Nöroinflamasyonun Rolü

Öz

Parkinson Hastalığı (PH), 65 yaş üzeri kişilerde en sık görülen ikinci nörodejeneratif bozukluktur (1). Bu hastalık, substantia nigra pars compacta’daki dopaminerjik nöronların progresif kaybı (2-4), striatal dopamin seviyesinde azalma ve dopaminerjik liflerin kaybıyla karakterizedir (5). PH’ndaki nöron dejenerasyon sürecinde; oksidatif stresin, aktive edilmiş mikroglia hücrelerinin ve nöroinflamasyonun olduğu bilinmektedir (6). PH, yoğun araştırma konusu olmasına rağmen hastalığın patogenezinde yatan mekanizmalar tam olarak anlaşılamamıştır (7-8). Dolayısıyla, bu süreci tamamen önleyen bir tedavi de bulunamamıştır. Bu derlemede, PH patogenezinde yer alan nöroinflamasyon süreçleri incelenmiştir.

Anahtar Kelimeler

Parkinson hastalığı,nöroinflamasyon,mikroglia

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Eczacılık ve İlaç Bilimleri, Klinik Tıp Bilimleri

Bölüm

Derleme

Yazarlar

Elif Taşdemir ^*
Türkiye

Yayımlanma Tarihi

1 Eylül 2019

Gönderilme Tarihi

25 Temmuz 2018

Kabul Tarihi

18 Eylül 2018

Yayımlandığı Sayı

Yıl 2019 Cilt: 26 Sayı: 3

DOI

https://doi.org/10.17343/sdutfd.447542

IZ

https://izlik.org/JA43LT89PU

Kaynak Göster

RIS / Bibtex

APA

Taşdemir, E. (2019). Parkinson Hastalığında Nöroinflamasyonun Rolü. Medical Journal of Süleyman Demirel University, 26(3), 348-352. https://doi.org/10.17343/sdutfd.447542

AMA

1.Taşdemir E. Parkinson Hastalığında Nöroinflamasyonun Rolü. SDÜ Tıp Fak Derg. 2019;26(3):348-352. doi:10.17343/sdutfd.447542

Chicago

Taşdemir, Elif. 2019. “Parkinson Hastalığında Nöroinflamasyonun Rolü”. Medical Journal of Süleyman Demirel University 26 (3): 348-52. https://doi.org/10.17343/sdutfd.447542.

EndNote

Taşdemir E (01 Eylül 2019) Parkinson Hastalığında Nöroinflamasyonun Rolü. Medical Journal of Süleyman Demirel University 26 3 348–352.

IEEE

[1]E. Taşdemir, “Parkinson Hastalığında Nöroinflamasyonun Rolü”, SDÜ Tıp Fak Derg, c. 26, sy 3, ss. 348–352, Eyl. 2019, doi: 10.17343/sdutfd.447542.

ISNAD

Taşdemir, Elif. “Parkinson Hastalığında Nöroinflamasyonun Rolü”. Medical Journal of Süleyman Demirel University 26/3 (01 Eylül 2019): 348-352. https://doi.org/10.17343/sdutfd.447542.

JAMA

1.Taşdemir E. Parkinson Hastalığında Nöroinflamasyonun Rolü. SDÜ Tıp Fak Derg. 2019;26:348–352.

MLA

Taşdemir, Elif. “Parkinson Hastalığında Nöroinflamasyonun Rolü”. Medical Journal of Süleyman Demirel University, c. 26, sy 3, Eylül 2019, ss. 348-52, doi:10.17343/sdutfd.447542.

Vancouver

1.Elif Taşdemir. Parkinson Hastalığında Nöroinflamasyonun Rolü. SDÜ Tıp Fak Derg. 01 Eylül 2019;26(3):348-52. doi:10.17343/sdutfd.447542

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