Nazal Kavite ve Paranazal Sinüs Tümörlerinde Radyoterapinin Sağkalıma Etkisi

Abstract

Amaç: Nazal kavite ve paranazal bölge tümörleri nadir görülen ve genellikle ileri evrede tanı konulan tümörlerdir. Bu çalışma sinonazal bölge tümörlerinde histopatolojik tanının,  boyun lenf nodu tutulumunun ve tedavi modalitelerinin sağkalıma etkisini  araştırmak amacıyla retrospektif olarak yapılmıştır.

Materyal ve metod:1991-2002 yılları arasında kliniğimize paranazal sinüs kanseri tanısıyla başvuran ve tedaviye alınan 47 hastadan 37’si çalışmaya dahil edilmiştir. Hastaların 24’ü erkek, 13’ü kadındır. Medyan yaş 55’tir.Hastaların histopatolojik tanılarının çoğunluğunu sırasıyla yassı hücreli kanser, adenoidkistik karsinom ve baş – boyun sarkomu oluşturmaktadır.T3-T4 hasta sayısı 23 (%76.6)’dü. Beş hastanın boyun lenf nodu tutulmuştur. Hastaların 16’sına (%43.24)  cerrahi + postoperatif radyoterapi(port), 6’sına (%16.21) cerrahi + port + kemoterapi (kt), 11’ine (%29.72) definitif radyoterapi (rt), 4 hastaya  (10.81) rt ardından kt uygulanmıştır.

Sonuçlar: Takip süremiz 22 aydır. 5 yıllık sağkalım oranı % 43.69 olarak bulunmuştur.Çalışmamızda boyun lenf nodu tutulumunun sağkalımı olumsuz etkilediğini (p=0.03) , adenoidkistik karsinomun yassı hücreli kanser ve  baş boyun sarkomuna göre sağkalımı arttırdığını gösterdik (sırasıyla p=0.01, p=0.03 ). İstatistiksel anlam içermese de  seçilen tedavi  modalitesinin sağkalıma etkili olduğunu  düşündürecek sonuçlara vardık.

Tartışma: Çalışmamızın tek merkezli bir çalışma olması zaten paranazal sinüs kanserli hasta sayısının az olmasıyla birleştiğinde yeterli hasta sayısına ulaşmayı ve homojen hasta dağılımını engellemiştir.

Keywords

• radyoterapi,sağkalım,paranazal sinüs tümörleri

The Effect Of Radiotherapy On Survival In Nasal Cavity And Paranasal Sinus Tumors

Abstract

Aim: Nasal cavity and paranasal tumors are rare and usually diagnosed in advanced stage. This study was retrospectively designed to investigate the survival effect of histopathological diagnosis,  lymph node involvement and treatment modalities in sinonasal  tumors.

Material and Method :, 37 patients out of 47 who had referred to our clinic with paranasal sinus cancer between 1991-2002 were included in the study. Twenty-four patients were male and thirteen were female. Median age was 55 years .Most  seen histopathological diagnoses were squamous cell cancer, adenoidcystic  carcinoma, and head and neck sarcoma, respectively. The number of patients with t3-t4  was 23 (76.6%).  There was lymph nodes involvement in five patients. Surgical treatment + postoperative radiotherapy (port) was performed in 16 patients (%43.24%) , surgical treatment + chemotherapy (kt) was performed in 6 patients (16.21 %),  and definitive radiotherapy (RT), was performed in 4 patients (10.81%)

Results: Our follow-up period was 22 months. Five-year survival rate was 43.69%. In our study , we showed that neck lymph node involvement negatively affects survival (p=0.03), adenoidcystic carcinoma increases survival compared  to squamous cell cancer and head and neck sarcoma (p=0.01, p=0.03, respectively ).  Although it is not statistically significant, we have concluded that the chosen treatment modality is effective on survival

Conclusion: The fact that our study being single centered combined with the low number of patients with paranasal sinus cancer prevented the number of patients and the distribution of homogenous patients.

 

 

 

 

Keywords

• paranasal sinus cancer,radiotherapy

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