B12 VİTAMİN EKSİKLİĞİ OLAN ÇOCUKLARDA HEMATOLOJİK BULGULAR

Abstract

Amaç Vitamin B12 eksikliği çocukluk çağında sık görülen bir durumdur ve eksikliğine bağlı olarak çeşitli nörolojik, hematolojik ve dermatolojik bulgular görülebilmektedir. Çalışmanın amacı B12 vitamini eksikliği tanısı alan çocuklarda hematolojik bulguları değerlendirmektir. Gereç ve Yöntem Çocuk Hematoloji Bölümü'nde B12 eksikliği tanısı ile izlenen hastaların hematolojik verileri geriye dönük olarak incelendi. Bulgular Çalışmamızda yüz yirmi dört hastanın hematolojik verileri değerlendirildi. Kırksekiz hastada anemi, 8 hastada trombositopeni ve 6 hastada lökopeni tespit edildi. İki süt çocuğu uzamış sarılık ve hemolitik anemi ile başvurdu. Hastaların ortalama vitamin B12 düzeyleri 97.3±30.6 (5-140) pg/ml idi. Sonuç Vitamin B12 eksikliği gelişmekte olan ülkelerde sık görülen bir hastalıktır ve çoğunlukla annedeki eksiklikten kaynaklanır. Çalışmamızda 52 bebekten 42'sinin (%80) annesinde B12 vitamini eksikliği saptandı. Buda gebelerde B12 vitamini düzeyinin belirlenmesinin ve eksiklik durumunda tedavisinin önemini açıkça göstermektedir. B12 vitamini eksikliği olan hastalar çeşitli nedenlerle hastaneye başvurabilirler. Bu nedenle özellikle uzamış sarılık ve hemolitik anemi ile başvuran hastalarda B12 vitamini eksikliğinin neden olabileceği akılda tutulmalıdır.

Keywords

• Vitamin B12 eksikliği
• hematolojik bulgular
• çocuklar

HEMATOLOGICAL FINDINGS IN CHILDREN WITH VITAMIN B12 DEFICIENCY

Abstract

Objective Vitamin B12 deficiency is a common condition in childhood and various neurological, hematological, and dermatological findings could be seen due to its deficiency. The aim of the study is to evaluate the hematological findings in children diagnosed with vitamin B12 deficiency. Materials and Methods Hematological data of children with B12 deficiency who were examined in Pediatric Hematology Department were retrospectively reviewed. Results Hematological data of one hundred twenty-four patients were assessed in our study. Anemia, thrombocytopenia and leucopenia were detected in 48 patients, 8 patients and 6 patients, respectively. Two infants presented with prolonged jaundice and hemolytic anemia. The mean vitamin B12 levels of the patients were 97.3±30.6 (5-140) pg/ml. Conclusion Vitamin B12 deficiency is a common disease in developing countries and it is mostly of maternal origin. In our study, vitamin B12 deficiency in mothers of 42 out of 52 infants (80%) were discovered. This percentage clearly shows the importance of the vitamin B12 level determination in pregnant women and its treatment in case of deficiency. Patients with vitamin B12 deficiency might be admitted to the hospital for various reasons. Therefore, it is recommended to keep in mind that vitamin B12 deficiency might be the base of various diseases, especially for patients presenting prolonged jaundice and hemolytic anemia.

Keywords

• Vitamin B12deficiency
• hematological findings
• children

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