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Isparta bölgesinde mide kanserli hastalarda helikobakter pilori sıklığı

Year 2005, Volume 12, Issue 2, 30 - 33, 08.04.2009

Abstract

SüleymanDemirel Üniversitesi TIP FAKÜLTESİ DERGİSİ: 2005 Haziran; 12(2) Isparta bölgesinde mide kanserli hastalarda helikobakter pilori sıklığı Nermin Karahan, Sema Bircan,Nilgün Kapucuoğlu, Şirin Başpınar, Özden Çandır, Ersin Uskun Özet Helikobakter pilori (HP) ilk kez 1983 yılında Warren ve Marshall tarafından kültürü yapılan gram negatif bakteridir. Helikobakter pilori'nin mide karsinom gelişmesinde prekürsör lezyon olan kronik atrofik gastrit ve intestinal metaplaziye neden olması, gastrik karsinomların patogenezinde olası rolünü gündeme getirmiştir. Çalışmamızda mide karsinomlarında histolojik olarak gastrit, intestinal metaplazi ile helikobakter pilori arasındaki ilişkiyi araştırmayı amaçladık. Bu çalışmada son 5 yılda mide kanseri nedeniyle total yada subtotal gastrektomi yapılan 34 olgu incelenerek histolojik tiplerine ayrıldı. Helikobakter pilori'yi araştırmak için Toluidin mavisi boyama yöntemi kullanıldı. 34 mide karsinomlu olgunun 30'u intestinal tip (%88.2) 4'ü diffüz tip (%11.8) idi. Olguların tümünde kronik gastirit vardı. Aktif kronik gastrit 22 olguda (%64.7) inaktif gastrit 12'sinde (%35.3) vardı. İntestinal tip mide adenokarsinomlarının 23'ünde (%76.6), 4 diffüz tip karsinomun 4'ünde (%100) intestinal metaplazi izlendi. Helikobakter pilori 34 olgunun 24'ünde (%70.6) pozitif bulundu. Helikobakter pilori enfeksiyonu diffüz tipe göre intestinal tipde daha sıktı (p>0.05). Aktif kronik gastritlerin 22'sinde (%72.7) inaktif kronik gastritlerin 5'inde (%35.7) Helikobakter pilori pozitif bulundu. Helikobakter pilori varlığı aktif gastritlerde inaktif gastritlere göre daha sık gibi görülmesine karşın istatistiksel olarak anlamlı değildi (p>0.05). Anahtar kelimeler: Helikobakter pilori, mide adenokarsinomu Abstract Prevalence of helıcobacter pylorı ın patıents wıth gastrıc carcınoma ın Isparta regıon Helicobacter plyori is the gram negative bacteria which was cultured by Warren and Marshall first in 1983. Helicobacter pylori was frequently observed in patients with chronic gastritis. Chronic atrofic gastritis is defined as precursor lesion in the development of gastric carcinoma . Therefore, H.Pylori has an important role in pathogenesis of gastric carcinoma . Our study aimed to examine the association between helicobacter and gastritis, intestinal metaplasia in gastric carcinomas of different histological types. In this study, 34 patients who underwent total or subtotal gastrectomy due to gastric carcinoma in last five years were examined and histologically defined . Helicobacter pylori status was evaluated by toluidine blue . Intestinal type carcinoma was observed in 30 cases out of 34 (%88.2), diffuse type was found in 4 cases (%11.8). Chronic gastritis was diagnosed in all cases. There were active chronic gastrtis in 22 cases ( % 64.7) and inactive gastritis in 12 cases ( %35). Intestinal metaplasia was observed in 23 of 30 ( % 76.6) with intestinal type carcinomas, 4 of 4 (%100) with diffuse type carcinoma. The prevalance of helicobacter was positive in 24 ( %70.6) cases out of 34. The helicobacter pylori infection was higher in intestinal type carcinoma than diffuse type (p>0.05). Helicobacter pylori was positive in 22 cases ( % 72.2) with active gastritis and in 5 cases ( % 35.7) with inactive gastritis. Despite the frequent existence of helicobacter pylori in active gastritis when compared to inactive gastritis, it was not statically significant (p>0.05). Key words: Helicobacter Pylori,gastric adenocarcinoma

References

  • ) Lauren P. The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 1965; 64: 31- 49.
  • ) Hu PK, Chan WY, Cheung PY, et al. Pathologic changes of gastric mucosa colonised by Helicobacter pylori. Hum Pathol 1992; 25: 548-556.
  • ) Ohata H, Kitauchi S, Yoshimura N. et al. Progression of chronic atrophic gastritis associated with . Helicobacter pylori infection increases risk of gastric cancer. Int J Cancer 2004; 109: 138-143.
  • ) Frenck Jr RW, Clemens J. Helicobacter in the developing world. Microbes and Infection 2003; 5: 705-713.
  • ) Craanen ME, Blok P, Dekker W, et al. Subtypes of intestinal metaplasia and Helicobacter pylori. Gut 1992; 33: 597-600.
  • ) Sipponen P, Kosman TU, Valle J, et al. Helicobacter pylori infection and chronic gastritis in gastric cancer. J Clin Pathol 1992; 45: 319-323.
  • ) Turhanoðlu M, Göral V, Arýkan E, et al. Çeþitli üst gastrointestinal sistem hastalýklarýnda Helicobacter pylori sýklýðý. Klinik Dergisi1992; 5:19-21.
  • ) Kelley JR, Duggan JM. Gastric cancer epidemiology and risk factors. Journal of Clinical Epidemiology 2003; 56: 1-9.
  • ) Kikuchi S. Epidemiology of . Helicobacter pylori and gastric cancer. Gastric Cancer 2002; 5: 6-15.
  • )Khanna AK, Seth P, Nath G, et al Correlation of. Helicobacter pylori and gastric carcinoma. J Postgrad Med 2002; 48: 27-28.
  • )Sepulveda AR, Graham DY. Role of . Helicobacter pylori in gastric carcinogenesis. Gastroenterol Clin N Am 2002; 31: 517-535.
  • )Versalovic J. Helicobacter pylori Pathology and diagnostic strategies. Am J Clin Pathol 2003; 119: 403- 412.
  • )Ponce-de-Leon S, Leal JE, Cortes R. . Helicobacter pylori and gastric carcinoma: potential carcinogen, cancer sentinel, or both? Br J Cancer 2000; 83(7): 969- 970.
  • )Bjorkholm B, Falk P, Engstrand L, et al. .Helicobacter pylori: resurrection of the cancer link. J Intern Med 2003; 253: 102-119.
  • )Blaser MJ. Polymorphic bacteria persisting in polymorphic hosts: Assessing . Helicobacter pylori- related risks for gastric cancer. Journal of the National Cancer Institute 2002; 94(22): 1662-1663.
  • )Tseng H, Hsu P, Chen H, et al. Compartment Theory in. Helicobacter pylori-associated gastric carcinogenesis. Anticancer Research 2003; 23: 3223-3230.
  • )Craanen ME, Blok P, Dekker W, Typgat GN. Helicobacter pylori and early gastric cancer. Gut 1994; 35: 1372-1374.
  • )El-Omar EM, Rabkin CS, Gammon MD, et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2003; 124: 1193-1201.
  • )Machado JC, Figueiredo C, Canedo P, et al. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology 2003; 125: 364-371.
  • )Correa P, Fox J, Fontham E, et al. Helicobacter pylori and gastric carcinoma. Serum antibody prevelance in poplations with contrasting cancer risks. Cancer 1990; 66: 2569-2574.
  • )Correa P. Chronic gastritis. A clinico-pathological classification. Am J Gastroenterol 1998; 83: 504-509.
  • )Parsonnet J, Vandersteen D, Goates J, et al. Helicobacter pylori infection in intestinal and diffuse type gastric adenocarcinoma. J Nathl Cancer Inst 1991; 83: 640- 643.
  • )Avellini C, Cocchi V, Pagonelli GM, Biasco G. Evaluation of presence and amount of Helicobacter pylori in early gastric cancer. Rev Esp. Enferm Dig 1990; 78 (Suppl 1): 92-98.

Year 2005, Volume 12, Issue 2, 30 - 33, 08.04.2009

Abstract

References

  • ) Lauren P. The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 1965; 64: 31- 49.
  • ) Hu PK, Chan WY, Cheung PY, et al. Pathologic changes of gastric mucosa colonised by Helicobacter pylori. Hum Pathol 1992; 25: 548-556.
  • ) Ohata H, Kitauchi S, Yoshimura N. et al. Progression of chronic atrophic gastritis associated with . Helicobacter pylori infection increases risk of gastric cancer. Int J Cancer 2004; 109: 138-143.
  • ) Frenck Jr RW, Clemens J. Helicobacter in the developing world. Microbes and Infection 2003; 5: 705-713.
  • ) Craanen ME, Blok P, Dekker W, et al. Subtypes of intestinal metaplasia and Helicobacter pylori. Gut 1992; 33: 597-600.
  • ) Sipponen P, Kosman TU, Valle J, et al. Helicobacter pylori infection and chronic gastritis in gastric cancer. J Clin Pathol 1992; 45: 319-323.
  • ) Turhanoðlu M, Göral V, Arýkan E, et al. Çeþitli üst gastrointestinal sistem hastalýklarýnda Helicobacter pylori sýklýðý. Klinik Dergisi1992; 5:19-21.
  • ) Kelley JR, Duggan JM. Gastric cancer epidemiology and risk factors. Journal of Clinical Epidemiology 2003; 56: 1-9.
  • ) Kikuchi S. Epidemiology of . Helicobacter pylori and gastric cancer. Gastric Cancer 2002; 5: 6-15.
  • )Khanna AK, Seth P, Nath G, et al Correlation of. Helicobacter pylori and gastric carcinoma. J Postgrad Med 2002; 48: 27-28.
  • )Sepulveda AR, Graham DY. Role of . Helicobacter pylori in gastric carcinogenesis. Gastroenterol Clin N Am 2002; 31: 517-535.
  • )Versalovic J. Helicobacter pylori Pathology and diagnostic strategies. Am J Clin Pathol 2003; 119: 403- 412.
  • )Ponce-de-Leon S, Leal JE, Cortes R. . Helicobacter pylori and gastric carcinoma: potential carcinogen, cancer sentinel, or both? Br J Cancer 2000; 83(7): 969- 970.
  • )Bjorkholm B, Falk P, Engstrand L, et al. .Helicobacter pylori: resurrection of the cancer link. J Intern Med 2003; 253: 102-119.
  • )Blaser MJ. Polymorphic bacteria persisting in polymorphic hosts: Assessing . Helicobacter pylori- related risks for gastric cancer. Journal of the National Cancer Institute 2002; 94(22): 1662-1663.
  • )Tseng H, Hsu P, Chen H, et al. Compartment Theory in. Helicobacter pylori-associated gastric carcinogenesis. Anticancer Research 2003; 23: 3223-3230.
  • )Craanen ME, Blok P, Dekker W, Typgat GN. Helicobacter pylori and early gastric cancer. Gut 1994; 35: 1372-1374.
  • )El-Omar EM, Rabkin CS, Gammon MD, et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2003; 124: 1193-1201.
  • )Machado JC, Figueiredo C, Canedo P, et al. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology 2003; 125: 364-371.
  • )Correa P, Fox J, Fontham E, et al. Helicobacter pylori and gastric carcinoma. Serum antibody prevelance in poplations with contrasting cancer risks. Cancer 1990; 66: 2569-2574.
  • )Correa P. Chronic gastritis. A clinico-pathological classification. Am J Gastroenterol 1998; 83: 504-509.
  • )Parsonnet J, Vandersteen D, Goates J, et al. Helicobacter pylori infection in intestinal and diffuse type gastric adenocarcinoma. J Nathl Cancer Inst 1991; 83: 640- 643.
  • )Avellini C, Cocchi V, Pagonelli GM, Biasco G. Evaluation of presence and amount of Helicobacter pylori in early gastric cancer. Rev Esp. Enferm Dig 1990; 78 (Suppl 1): 92-98.

Details

Primary Language English
Journal Section Araştırma Makaleleri
Authors

Nermin Karahan This is me


Sema Bircan This is me


Nilgün Kapucuoğlu This is me


Şirin Başpınar This is me


Özden Çandır This is me


Ersin USKUN>

0000-0001-6446-0186

Publication Date April 8, 2009
Application Date April 6, 2009
Acceptance Date
Published in Issue Year 2005, Volume 12, Issue 2

Cite

Vancouver Karahan N. , Bircan S. , Kapucuoğlu N. , Başpınar Ş. , Çandır Ö. , Uskun E. Isparta bölgesinde mide kanserli hastalarda helikobakter pilori sıklığı. SDÜ Tıp Fakültesi Dergisi. 2009; 12(2): 30-33.

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