Neuroprotective Effects of Dexpanthenol Against Chest Trauma-Induced Brain Injury in Rats

Year 2025, Volume: 32 Issue: 3, 184 - 190, 09.09.2025

Şerife Taşan , Sanem Aşcı , Halil Aşçı

https://doi.org/10.17343/sdutfd.1629663

Abstract

Objective: Chest trauma-induced brain injury (CTB) occurs as a result of the formation of inflammatory markers in the lung and blood. Vitamin B5, derived from dexpanthenol (DEX), has antioxidant, anti-inflammatory, and antiapoptotic properties. This study aimed to investigate the protective effects of DXP on CTB.
Materials and methods: Forty Wistar Albino males were divided into four groups as sham, CTB (Dropping a 200g weight from a height of 1 meter onto the anterior chest wall), CTB+DXP (500mg/kg, ip), and DXP. After 48 hours, rats were sacrificed under anesthesia, and the brain tissues were put into 10% formaldehyde solution for histopathological and immunohistochemical examination.
Results: In the CTB group, rats exhibited significant hemorrhage, increased TNF-α, Cas-3, and decreased MBP expressions in the brain compared to the control group. DXP treatment significantly reducted hemorrhage areas and reversed immunoexpressions.
Conclusion: CTB may develop in brain tissue by causing inflammation, apoptosis, and myelin sheath damage. These adverse effects can be reversed with DXP treatment.

Keywords

acute cheast trauma , brain , dexpanthenol , inflammation , apoptosis

Ethical Statement

In this study, all experiments were performed under the guidelines for animal research from the National Institutes of Health and were approved by the Committee on Animal Research of Suleyman Demirel University, Isparta (Ethic No:09.05.2024/300).

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