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Diş Hekimliğinde Aromaterapi

Year 2023, , 118 - 123, 27.04.2023
https://doi.org/10.15311/selcukdentj.1097018

Abstract

Aromaterapi; bitkisel uçucu yağların ve aromatik bitkisel bileşiklerin hastalıkların önlenmesinde ya da tedavisinde topikal olarak veya inhalasyon yolu ile uygulanan tedavi yaklaşımıdır. Geçmişten günümüze kadar geleneksel, alternatif veya tamamlayıcı tedavi yaklaşımları olarak tıp ve diş hekimliğinin çeşitli alanlarında kullanılması önerilen uçucu yağların antibakteriyel, antiviral, antifungal, analjezik, sedatif gibi farklı etkiler gösterdiği bildirilmektedir. Bu derleme, diş hekimliğinde kullanılabileceği belirtilen uçucu yağların tanımlanması, uygulanma alanlarının ve tedavi etkinliklerinin incelenmesi amacı ile gerçekleştirilmiştir. Aromaterapiye ilişkin dental literatürler değerlendirildiğinde; uçucu yağların oral mukoza ve dişeti hastalıklarının tedavisinde, diş çürüğünün önlenmesinde, remineralizasyonda, endodontik ve restoratif tedavide, halitoziste, anksiyete kontrolünde kullanılabileceğinin önerildiği görülmektedir. Çay ağacı, karanfil, lavanta, kekik, tarçın, okaliptüs, nane ve limon uçucu yağları ise diş hekimliğinde en çok uygulanan uçucu yağlar olarak belirtilmektedir. Candida enfeksiyonunda çay ağacı, kekik, tarçın, nane, limon; stomatitiste okaliptüs, lavanta; dişeti hastalıklarında çay ağacı, tarçın, okaliptüs; ağız çalkalama solüsyonu olarak çay ağacı yağı, nane; diş çürüğünün önlenmesinde ve remineralizasyonunda çay ağacı yağı, karanfil, kekik, tarçın, limon; pulpa tedavilerinde karanfil, kanal patlarında karanfil, kekik; restoratif materyallerin antimikrobiyal özelliklerinin artırılmasında kekik, tarçın; halitoziste tarçın, okaliptus, nane; dental anksiyete kontrolünde lavanta ve topikal anestezide karanfil uçucu yağlarının kullanılabileceği bildirilmektedir. Kullanım güvenirliliklerine ilişkin deneysel çalışmaların artırılması ve tedavide etkili minimum dozlarının belirlenmesi ile uçucu yağların diş hekimliği klinik uygulamalarında kullanımının gelecekte artacağı öngörülmektedir.

References

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  • 2. Groppo FC, Bergamaschi CC, Cogo K, Franz-Montan M, Motta RHL, Andrade ED. Use of phytotherapy in dentistry. Phytother Res. 2008;8:993-998.
  • 3. Arada GJM, Perez CZ. Phytotherapy in dentistry: survey of products of plant origin for health oral. Braz. J. Implantol. Health Sci. 2019;1:2-17.
  • 4. Farrar AJ, Farrar FC. Clinical aromatherapy. Nurs Clin North Am. 2020;55(4):489–504.
  • 5. Lis-Balchin M. Aromatherapy Science: a guide for Healthcare professionals. 1st ed. London: Pharmaceutical press; 2006. p.462.
  • 6. Gültekin E. Türkiye’deki Aromaterapi Eğitimlerinde Karşılaşılan Bazı Etik Sorunlar [Ethical Issues in Aromatherapy Courses in Turkey]. Turkiye Klinikleri J Med Ethics. 2020;28(2):273-8
  • 7. Lapinska B, Szram A, Zarzycka B, Grzegorczyk J, Hardan L, Sokolowski J, et al. In vitro study on the antimicrobial properties of essential oil modified resin composite against oral pathogens. Materials (Basel). 2020;13(19):4383.
  • 8. Carson CF, Hammer KA, Riley TV. Melaleuca alternifolia (Tea Tree) Oil: A review of antimicrobial and other medicinal properties. Clin Microbiol Rev. 2006;19(1):50–62.
  • 9. Kulik E, Lenkeit K, Meyer J. Antimicrobial effects of tea tree oil (Melaleuca alternifolia) on oral microorganisms. Schweiz Monatsschr Zahnmed. 2000;110(11):125-30.
  • 10. Hammer KA, Carson CF, Riley TV. In-vitro activity of essential oils, in particular Melaleuca alternifolia (tea tree) oil and tea tree oil products, against Candida spp. J Antimicrob Chemother. 1998;42(5):591-5.
  • 11. Hammer KA, Dry L, Johnson M, Michalak EM, Carson CF, Riley TV. Susceptibility of oral bacteria to Melaleuca alternifolia (tea tree) oil in vitro. Oral Microbiol Immunol. 2003;18(6):389-92.
  • 12. Thosar N, Basak S, Bahadure RN, Rajurkar M. Antimicrobial efficacy of five essential oils against oral pathogens: An in vitro study. Eur J Dent. 2013;7(Suppl 1):S71–S77.
  • 13. Ripari F, Cera A, Freda M, Zumbo G, Zara F, Vozza I. Tea tree oil versus chlorhexidine mouthwash in treatment of gingivitis: A pilot randomized, double blinded clinical trial. Eur J Dent. 2020;14(1):55-62.
  • 14. Kamath NP, Tandon S, Nayak R, Naidu S, Anand PS, Kamath YS. The effect of aloe vera and tea tree oil mouthwashes on the oral health of school children. Eur Arch Paediatr Dent. 2020;21(1):61-66.
  • 15. Taher YA, Samud AM, El-Taher FE, Ben-Hussin G, Elmezogi JS, Al-Mehdawi BF, et al. Experimental evaluation of anti-inflammatory, antinociceptive and antipyretic activities of clove oil in mice. Libyan J Med. 2015;10:28685.
  • 16. Jadhav BK, Khandelwal KR, Ketkar AR, Pisal SS. Formulation and evaluation of mucoadhesive tablets containing eugenol for the treatment of periodontal diseases. Drug Dev Ind Pharm. 2004;30(2):195-203.
  • 17. Milind P, Deepa K. Clove: A Champion Spice. IJRAP 2011;2(1):47-54.
  • 18. Marya CM, Satija G, Avinash J, Nagpal R, Kapoor R, Ahmad A. In vitro inhibitory effect of clove essential oil and its two active principles on tooth decalcification by apple juice. Int J Dent. 2012;2012:759618.
  • 19. Alqareer A, Alyahya A, Andersson L. The effect of clove and benzocaine versus placebo as topical anesthetics. J Dent. 2006;34(10):747-50.
  • 20. Havale R, Rao DG, Shrutha SP, Tuppadmath KM, Tharay N, Mathew I, et al. Comparative evaluation of pain perception following topical application of clove oil, betel leaf extract, lignocaine gel, and ice prior to intraoral injection in children aged 6–10 years: a randomized control study. J Dent Anesth Pain Med. 2021;21(4):329–336.
  • 21. Markowitz K, Moynihan M, Liu M, Kim S. Biologic properties of eugenol and zinc oxide-eugenol. A clinically oriented review. Oral Surg Oral Med Oral Pathol. 1992;73(6):729-37.
  • 22. Martínez-Herrera A, Pozos-Guillén A, Ruiz-Rodríguez S, Garrocho-Rangel A, Vértiz-Hernández A, Escobar-García DM. Effect of 4-Allyl-1-hydroxy-2-methoxybenzene (Eugenol) on inflammatory and apoptosis processes in dental pulp fibroblasts. Mediators Inflamm. 2016;2016:9371403.
  • 23. Chen X, Lin B, Zhong J, Ge L. Degradation evaluation and success of pulpectomy with a modified primary root canal filling in primary molars. Beijing Da Xue Xue Bao Yi Xue Ban. 2015;47(3):529-35.
  • 24. Pires CW, Lenzi TL, Soares FZM, Rocha RO. Zinc oxide eugenol paste jeopardises the adhesive bonding to primary dentine. Eur Arch Paediatr Dent. 2018;19(3):163-169.
  • 25. Altmann ASP, Leitune VCB, Collares FM. Influence of eugenol-based sealers on push-out bond strength of fiber post luted with resin cement: Systematic review and meta-analysis. J Endod. 2015;41(9):1418-23.
  • 26. Sarrami N, Pemberton MN, Thornhill MH, Theaker ED. Adverse reactions associated with the use of eugenol in dentistry. Br Dent J. 2002;193(5):257-9.
  • 27. Cavanagh HMA, Wilkinson JM. Biological activities of lavender essential oil. Phytother Res. 2002;16(4):301-8.
  • 28. Dagli N, Dagli R, Mahmoud RS, Baroudi K. Essential oils, their therapeutic properties, and implication in dentistry: A review. J Int Soc Prev Community Dent. 2015;5(5):335–340.
  • 29. Arslan I, Aydinoglu S, Karan NB. Can lavender oil inhalation help to overcome dental anxiety and pain in children? A randomized clinical trial. Eur J Pediatr. 2020;179(6):985-992.
  • 30. Karan NB. Influence of lavender oil inhalation on vital signs and anxiety: A randomized clinical trial. Physiol Behav. 2019;211:112676.
  • 31. Kim S, Kim H, Yeo J, Hong S, Lee J, Jeon Y. The effect of lavender oil on stress, bispectral index values, and needle insertion pain in volunteers. J Altern Complement Med. 2011;17(9):823-6.
  • 32. Altaei DT. Topical lavender oil for the treatment of recurrent aphthous ulceration. Am J Dent. 2012;25(1):39-43.
  • 33. Salehi B, Mishra AP, Shukla I, Sharifi-Rad M, Del Mar Contreras M, Segura-Carretero A, et al. Thymol, thyme, and other plant sources: Health and potential uses. Phytother Res. 2018;32(9):1688-1706.
  • 34. Manconi M, Petretto G, D'hallewin G, Escribano E, Milia E, Pinna R, et al. Thymus essential oil extraction, characterization and incorporation in phospholipid vesicles for the antioxidant/antibacterial treatment of oral cavity diseases. Colloids Surf B Biointerfaces. 2018;171:115-122.
  • 35. Hammad M, Sallal AK, Darmani H. Inhibition of Streptococcus mutans adhesion to buccal epithelial cells by an aqueous extract of Thymus vulgaris. Int J Dent Hyg. 2007;5(4):232-5.
  • 36. Rezaeian Z, Beigi-Boroujeni S, Atai M, Ebrahimibagha M, Özcan M. A novel thymol-doped enamel bonding system: Physico-mechanical properties, bonding strength, and biological activity. J Mech Behav Biomed Mater. 2019;100:103378.
  • 37. Jafri H, Ahmad I. Thymus vulgaris essential oil and thymol inhibit biofilms and interact synergistically with antifungal drugs against drug resistant strains of Candida albicans and Candida tropicalis. J Mycol Med. 2020;30(1):100911.
  • 38. Thosar NR, Chandak M, Bhat M, Basak S. Evaluation of antimicrobial activity of two endodontic sealers: Zinc oxide with thyme oil and zinc oxide eugenol against root canal microorganisms- An in vitro study. Int J Clin Pediatr Dent. 2018;11(2):79-82.
  • 39. Jayaprakasha GK, Rao LJ. Chemistry, biogenesis, and biological activities of Cinnamomum zeylanicum. Crit Rev Food Sci Nutr. 2011;51:547–562. 40. Yanakiev S. Effects of Cinnamon ( Cinnamomum spp.) in Dentistry: A Review. Molecules. 2020;25(18):4184.
  • 41. Elgamily H, Safy R, Makharita R. Influence of medicinal plant extracts on the growth of oral pathogens Streptococcus mutans and Lactobacillus acidophilus: An in-vitro study. Open Access Maced J Med Sci. 2019;7:2328–2334.
  • 42. Wang Y, Zhang Y, Shi Y, Pan X, Lu Y, Cao P. Antibacterial effects of cinnamon (Cinnamomum zeylanicum) bark essential oil on Porphyromonas gingivalis. Microb Pathog. 2018;116:26-32.
  • 43. Lapinska B, Szram A, Zarzycka B, Grzegorczyk J, Hardan L, Sokolowski J, et al. In vitro study on the antimicrobial properties of essential oil modified resin composite against oral pathogens. Materials (Basel). 2020;13(19):4383.
  • 44. Sherief DI, Fathi MS, El Fadl RKA. Antimicrobial properties, compressive strength and fluoride release capacity of essential oil-modified glass ionomer cements-an in vitro study. Clin Oral Investig. 2021;25(4):1879-1888.
  • 45. Ranasinghe P, Jayawardana R, Galappaththy P, Constantine GR, de Vas Gunawardana N, Katulanda P. Efficacy and safety of ‘true’ cinnamon (cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med. 2012;29:1480–1492.
  • 46. Kumar Yadav H, Kumar Yadav R, Chandra A, Thakkar RR. The effectiveness of eucalyptus oil, orange oil, and xylene in dissolving different endodontic sealers. J Conserv Dent. 2016;19(4):332-7.
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Aromatherapy in Dentistry

Year 2023, , 118 - 123, 27.04.2023
https://doi.org/10.15311/selcukdentj.1097018

Abstract

Aromatherapy is a therapeutic approach that uses herbal essential oils and aromatic herbal components applied topically or through inhalation to prevent or treat diseases. The essential oils recommended in various fields of medicine and dentistry as traditional, alternative, or complementary treatment approaches from past to present have been reported as to have various effects such as antibacterial, antiviral, antifungal, analgesic, or sedative. This review aims to define the essential oils used in dentistry as well as to analyse the application areas and efficiency of treatments. When dental literatures on aromatherapy have been evaluated, it is seen that essential oils are recommended to be used in treatment of gingival diseases and oral mucosa, preventing dental caries, remineralisation, endodontic-restorative treatment, halitosis, and anxiety control. Tea tree, clove, lavender, thyme, cinnamon, eucalyptus, mint, and lemon are reported as the most frequently used essential oils in dentistry. It has been reported that tea tree, thyme, cinnamon, mint, lemon can be used for candida infection; eucalyptus, lavender for stomatitis; tea tree, cinnamon, eucalyptus for gingival diseases; tea tree oil, mint as mouthwash; tea tree oil, clove, thyme, cinnamon, lemon for preventing tooth decay and remineralisation; clove for pulp treatments; thyme, cinnamon to increase antimicrobial properties of restorative materials; cinnamon, eucalyptus, mint for halitosis; lavender in controlling dental anxiety and clove for topical anaesthesia. It is predicted that as studies on usage reliability increase and minimum doses efficient for treatments are identified, the use of essential oils in clinical dentistry will be increased in the future.

References

  • 1. Taheri JB, Azimi S, Rafieian N, Zanjani HA. Herbs in Dentistry. Int Dent J. 2011;61:287–296.
  • 2. Groppo FC, Bergamaschi CC, Cogo K, Franz-Montan M, Motta RHL, Andrade ED. Use of phytotherapy in dentistry. Phytother Res. 2008;8:993-998.
  • 3. Arada GJM, Perez CZ. Phytotherapy in dentistry: survey of products of plant origin for health oral. Braz. J. Implantol. Health Sci. 2019;1:2-17.
  • 4. Farrar AJ, Farrar FC. Clinical aromatherapy. Nurs Clin North Am. 2020;55(4):489–504.
  • 5. Lis-Balchin M. Aromatherapy Science: a guide for Healthcare professionals. 1st ed. London: Pharmaceutical press; 2006. p.462.
  • 6. Gültekin E. Türkiye’deki Aromaterapi Eğitimlerinde Karşılaşılan Bazı Etik Sorunlar [Ethical Issues in Aromatherapy Courses in Turkey]. Turkiye Klinikleri J Med Ethics. 2020;28(2):273-8
  • 7. Lapinska B, Szram A, Zarzycka B, Grzegorczyk J, Hardan L, Sokolowski J, et al. In vitro study on the antimicrobial properties of essential oil modified resin composite against oral pathogens. Materials (Basel). 2020;13(19):4383.
  • 8. Carson CF, Hammer KA, Riley TV. Melaleuca alternifolia (Tea Tree) Oil: A review of antimicrobial and other medicinal properties. Clin Microbiol Rev. 2006;19(1):50–62.
  • 9. Kulik E, Lenkeit K, Meyer J. Antimicrobial effects of tea tree oil (Melaleuca alternifolia) on oral microorganisms. Schweiz Monatsschr Zahnmed. 2000;110(11):125-30.
  • 10. Hammer KA, Carson CF, Riley TV. In-vitro activity of essential oils, in particular Melaleuca alternifolia (tea tree) oil and tea tree oil products, against Candida spp. J Antimicrob Chemother. 1998;42(5):591-5.
  • 11. Hammer KA, Dry L, Johnson M, Michalak EM, Carson CF, Riley TV. Susceptibility of oral bacteria to Melaleuca alternifolia (tea tree) oil in vitro. Oral Microbiol Immunol. 2003;18(6):389-92.
  • 12. Thosar N, Basak S, Bahadure RN, Rajurkar M. Antimicrobial efficacy of five essential oils against oral pathogens: An in vitro study. Eur J Dent. 2013;7(Suppl 1):S71–S77.
  • 13. Ripari F, Cera A, Freda M, Zumbo G, Zara F, Vozza I. Tea tree oil versus chlorhexidine mouthwash in treatment of gingivitis: A pilot randomized, double blinded clinical trial. Eur J Dent. 2020;14(1):55-62.
  • 14. Kamath NP, Tandon S, Nayak R, Naidu S, Anand PS, Kamath YS. The effect of aloe vera and tea tree oil mouthwashes on the oral health of school children. Eur Arch Paediatr Dent. 2020;21(1):61-66.
  • 15. Taher YA, Samud AM, El-Taher FE, Ben-Hussin G, Elmezogi JS, Al-Mehdawi BF, et al. Experimental evaluation of anti-inflammatory, antinociceptive and antipyretic activities of clove oil in mice. Libyan J Med. 2015;10:28685.
  • 16. Jadhav BK, Khandelwal KR, Ketkar AR, Pisal SS. Formulation and evaluation of mucoadhesive tablets containing eugenol for the treatment of periodontal diseases. Drug Dev Ind Pharm. 2004;30(2):195-203.
  • 17. Milind P, Deepa K. Clove: A Champion Spice. IJRAP 2011;2(1):47-54.
  • 18. Marya CM, Satija G, Avinash J, Nagpal R, Kapoor R, Ahmad A. In vitro inhibitory effect of clove essential oil and its two active principles on tooth decalcification by apple juice. Int J Dent. 2012;2012:759618.
  • 19. Alqareer A, Alyahya A, Andersson L. The effect of clove and benzocaine versus placebo as topical anesthetics. J Dent. 2006;34(10):747-50.
  • 20. Havale R, Rao DG, Shrutha SP, Tuppadmath KM, Tharay N, Mathew I, et al. Comparative evaluation of pain perception following topical application of clove oil, betel leaf extract, lignocaine gel, and ice prior to intraoral injection in children aged 6–10 years: a randomized control study. J Dent Anesth Pain Med. 2021;21(4):329–336.
  • 21. Markowitz K, Moynihan M, Liu M, Kim S. Biologic properties of eugenol and zinc oxide-eugenol. A clinically oriented review. Oral Surg Oral Med Oral Pathol. 1992;73(6):729-37.
  • 22. Martínez-Herrera A, Pozos-Guillén A, Ruiz-Rodríguez S, Garrocho-Rangel A, Vértiz-Hernández A, Escobar-García DM. Effect of 4-Allyl-1-hydroxy-2-methoxybenzene (Eugenol) on inflammatory and apoptosis processes in dental pulp fibroblasts. Mediators Inflamm. 2016;2016:9371403.
  • 23. Chen X, Lin B, Zhong J, Ge L. Degradation evaluation and success of pulpectomy with a modified primary root canal filling in primary molars. Beijing Da Xue Xue Bao Yi Xue Ban. 2015;47(3):529-35.
  • 24. Pires CW, Lenzi TL, Soares FZM, Rocha RO. Zinc oxide eugenol paste jeopardises the adhesive bonding to primary dentine. Eur Arch Paediatr Dent. 2018;19(3):163-169.
  • 25. Altmann ASP, Leitune VCB, Collares FM. Influence of eugenol-based sealers on push-out bond strength of fiber post luted with resin cement: Systematic review and meta-analysis. J Endod. 2015;41(9):1418-23.
  • 26. Sarrami N, Pemberton MN, Thornhill MH, Theaker ED. Adverse reactions associated with the use of eugenol in dentistry. Br Dent J. 2002;193(5):257-9.
  • 27. Cavanagh HMA, Wilkinson JM. Biological activities of lavender essential oil. Phytother Res. 2002;16(4):301-8.
  • 28. Dagli N, Dagli R, Mahmoud RS, Baroudi K. Essential oils, their therapeutic properties, and implication in dentistry: A review. J Int Soc Prev Community Dent. 2015;5(5):335–340.
  • 29. Arslan I, Aydinoglu S, Karan NB. Can lavender oil inhalation help to overcome dental anxiety and pain in children? A randomized clinical trial. Eur J Pediatr. 2020;179(6):985-992.
  • 30. Karan NB. Influence of lavender oil inhalation on vital signs and anxiety: A randomized clinical trial. Physiol Behav. 2019;211:112676.
  • 31. Kim S, Kim H, Yeo J, Hong S, Lee J, Jeon Y. The effect of lavender oil on stress, bispectral index values, and needle insertion pain in volunteers. J Altern Complement Med. 2011;17(9):823-6.
  • 32. Altaei DT. Topical lavender oil for the treatment of recurrent aphthous ulceration. Am J Dent. 2012;25(1):39-43.
  • 33. Salehi B, Mishra AP, Shukla I, Sharifi-Rad M, Del Mar Contreras M, Segura-Carretero A, et al. Thymol, thyme, and other plant sources: Health and potential uses. Phytother Res. 2018;32(9):1688-1706.
  • 34. Manconi M, Petretto G, D'hallewin G, Escribano E, Milia E, Pinna R, et al. Thymus essential oil extraction, characterization and incorporation in phospholipid vesicles for the antioxidant/antibacterial treatment of oral cavity diseases. Colloids Surf B Biointerfaces. 2018;171:115-122.
  • 35. Hammad M, Sallal AK, Darmani H. Inhibition of Streptococcus mutans adhesion to buccal epithelial cells by an aqueous extract of Thymus vulgaris. Int J Dent Hyg. 2007;5(4):232-5.
  • 36. Rezaeian Z, Beigi-Boroujeni S, Atai M, Ebrahimibagha M, Özcan M. A novel thymol-doped enamel bonding system: Physico-mechanical properties, bonding strength, and biological activity. J Mech Behav Biomed Mater. 2019;100:103378.
  • 37. Jafri H, Ahmad I. Thymus vulgaris essential oil and thymol inhibit biofilms and interact synergistically with antifungal drugs against drug resistant strains of Candida albicans and Candida tropicalis. J Mycol Med. 2020;30(1):100911.
  • 38. Thosar NR, Chandak M, Bhat M, Basak S. Evaluation of antimicrobial activity of two endodontic sealers: Zinc oxide with thyme oil and zinc oxide eugenol against root canal microorganisms- An in vitro study. Int J Clin Pediatr Dent. 2018;11(2):79-82.
  • 39. Jayaprakasha GK, Rao LJ. Chemistry, biogenesis, and biological activities of Cinnamomum zeylanicum. Crit Rev Food Sci Nutr. 2011;51:547–562. 40. Yanakiev S. Effects of Cinnamon ( Cinnamomum spp.) in Dentistry: A Review. Molecules. 2020;25(18):4184.
  • 41. Elgamily H, Safy R, Makharita R. Influence of medicinal plant extracts on the growth of oral pathogens Streptococcus mutans and Lactobacillus acidophilus: An in-vitro study. Open Access Maced J Med Sci. 2019;7:2328–2334.
  • 42. Wang Y, Zhang Y, Shi Y, Pan X, Lu Y, Cao P. Antibacterial effects of cinnamon (Cinnamomum zeylanicum) bark essential oil on Porphyromonas gingivalis. Microb Pathog. 2018;116:26-32.
  • 43. Lapinska B, Szram A, Zarzycka B, Grzegorczyk J, Hardan L, Sokolowski J, et al. In vitro study on the antimicrobial properties of essential oil modified resin composite against oral pathogens. Materials (Basel). 2020;13(19):4383.
  • 44. Sherief DI, Fathi MS, El Fadl RKA. Antimicrobial properties, compressive strength and fluoride release capacity of essential oil-modified glass ionomer cements-an in vitro study. Clin Oral Investig. 2021;25(4):1879-1888.
  • 45. Ranasinghe P, Jayawardana R, Galappaththy P, Constantine GR, de Vas Gunawardana N, Katulanda P. Efficacy and safety of ‘true’ cinnamon (cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med. 2012;29:1480–1492.
  • 46. Kumar Yadav H, Kumar Yadav R, Chandra A, Thakkar RR. The effectiveness of eucalyptus oil, orange oil, and xylene in dissolving different endodontic sealers. J Conserv Dent. 2016;19(4):332-7.
  • 47. Dhakad AK, Pandey VV, Beg S, Rawat JM, Singh A. Biological, medicinal and toxicological significance of Eucalyptus leaf essential oil: a review. J Sci Food Agric. 2018;98(3):833-848.
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There are 60 citations in total.

Details

Primary Language Turkish
Subjects Dentistry
Journal Section Review
Authors

Doğa Naz Açar 0000-0002-9932-3031

Oya Aktören 0000-0002-4005-5925

Publication Date April 27, 2023
Submission Date April 1, 2022
Published in Issue Year 2023

Cite

Vancouver Açar DN, Aktören O. Diş Hekimliğinde Aromaterapi. Selcuk Dent J. 2023;10(1):118-23.