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Kronik Hastalığı Olmayan Varikosel Tanılı Genç Erkek Hastalarda Kan Sayım Parametrelerinin Değerlendirilmesi

Year 2020, Volume: 10 Issue: 4, 587 - 591, 15.12.2020
https://doi.org/10.31832/smj.770022

Abstract

Amaç: Varikosel pleksus pampiniformis içerisindeki testikuler venlerin anormal dilatasyonu olarak tanımlanan ve günümüzde erkeklerde infertiliteye neden olan en sık görülen hastalıklardan biridir. Çalışmamızın amacı varikosel tanısı alan hastalarda kan sayım parametrelerinin sağlıklı bireylerle karşılaştırılmasıdır.
Gereç ve Yöntem: Ordu Üniversitesi Eğitim ve Araştırma Hastanesi üroloji polikliniğine Nisan 2014-Nisan 2019 tarihleri arasında müracaat eden hastalar retrospektif olarak değerlendirildi. Fizik muayenesinde Grade 3 varikosel tanısı konulan 163 hasta saptandı. Dahil etme kriterlerini karşılayan toplam 112 hasta kontrol grubu olarak çalışmaya alındı. Varikosel fizik muayene ile değerlendirildi. Elde edilen hemogram sonuçlarındaki beyaz kan hücresi, hemoglobin, Hematokrit, Platelet, Eritrosit, Nötrofil, Lenfosit, Monosit, Ortalama hemoglobin miktarı, Ortalama eritrosit hacmi (OEH), Eritrosit dağılım genişliği (EDG), Trombosit dağılım genişliği (TDG), Ortalama trombosit hacmi (OTH) değerleri karşılaştırıldı.
Bulgular: Her iki grup arasında yaş ortalamaları açısından istatistiksel farklılık saptanmamıştır (p=0,370). Her iki grup arasında istatistiksel olarak anlamlı çıkan parametreler sırasıyla eritrosit (p=0,027), OEH (p=0,038), EDG (p=0,013) ve TDG (p=0,000)’dır. OTH değeri kontrol grubuna göre varikosel grubunda istatistiksel anlamlılık olmasa da rakamsal olarak kontrol grubuna göre yüksek bulunmuştur. Diğer parametreler ve oranlar arasında istatistiksel açıdan anlamlı bir farklılık saptanmamıştır.
Sonuç: Çalışmamız varikoseli olan hastalarda eritrosit, TDG ve EDG değerlerinin daha yüksek olduğunu göstermektedir. Trombosit ve eritrosit aktivasyonunun, varikoselin patofizyolojik temelinde önemli bir rol oynayabileceğini düşünmekteyiz.

References

  • 1. Noske HD, Weidner W. Varicocele--a historical perspective. World journal of urology 1999;17:151-7.
  • 2. Beddy P, Geoghegan T, Browne RF, Torreggiani WC. Testicular varicoceles. Clinical radiology 2005;60:1248-55.
  • 3. Zucchi A, Mearini L, Mearini E, Fioretti F, Bini V, Porena M. Varicocele and fertility: relationship between testicular volume and seminal parameters before and after treatment. Journal of andrology 2006;27:548-51.
  • 4. Gonda RL, Jr., Karo JJ, Forte RA, O'Donnell KT. Diagnosis of subclinical varicocele in infertility. AJR American journal of roentgenology 1987;148:71-5.
  • 5. Semba RD, Patel KV, Ferrucci L, et al. Serum antioxidants and inflammation predict red cell distribution width in older women: the Women's Health and Aging Study I. Clin Nutr 2010;29:600-4.
  • 6. Tsuboi S, Miyauchi K, Kasai T, et al. Impact of red blood cell distribution width on long-term mortality in diabetic patients after percutaneous coronary intervention. Circulation journal : official journal of the Japanese Circulation Society 2013;77:456-61.
  • 7. Coban S, Keles I, Biyik I, et al. Is there any relationship between mean platelet volume and varicocele? Andrologia 2015;47:37-41.
  • 8. Bozkurt Y, Soylemez H, Sancaktutar AA, et al. Relationship between mean platelet volume and varicocele: a preliminary study. Urology 2012;79:1048-51.
  • 9. Hong H, Xiao W, Maitta RW. Steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage. PloS one 2014;9:e85465.
  • 10. Nena E, Papanas N, Steiropoulos P, et al. Mean Platelet Volume and Platelet Distribution Width in non-diabetic subjects with obstructive sleep apnoea syndrome: new indices of severity? Platelets 2012;23:447-54.
  • 11. Dubin L, Amelar RD. Varicocele size and results of varicocelectomy in selected subfertile men with varicocele. Fertility and sterility 1970;21:606-9.
  • 12. Huczek Z, Kochman J, Kowara MK, et al. Baseline platelet indices and bleeding after transcatheter aortic valve implantation. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2015;26:527-32.
  • 13. Icli A, Aksoy F, Nar G, et al. Increased Mean Platelet Volume in Familial Hypercholesterolemia. Angiology 2016;67:146-50.
  • 14. Arica S, Ozer C, Arica V, Karakus A, Celik T, Gunesacar R. Evaluation of the mean platelet volume in children with familial Mediterranean fever. Rheumatology international 2012;32:3559-63.
  • 15. Yesil Y, Kuyumcu ME, Cankurtaran M, et al. Increased mean platelet volume (MPV) indicating the vascular risk in Alzheimer's disease (AD). Archives of gerontology and geriatrics 2012;55:257-60.
  • 16. Cuce F, Demiray O, Kucuk U, Olgun Kucuk H. Varicocele: tissue stress in the etiology. Turkish journal of medical sciences 2016;46:1014-7.
  • 17. Pyo JS, Cho WJ. Mean Platelet Volume, Platelet Distribution Width, and Platelet Count in Varicocele: A Systematic Review and Meta-Analysis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;38:2239-46.
  • 18. Polat H, Gulpinar MT, Sarica MA, Benlioglu C. Relationship between mean platelet volume, platelet distribution width, plateletcrit and varicocele. Andrologia 2017;49.
  • 19. May JE, Marques MB, Reddy VVB, Gangaraju R. Three neglected numbers in the CBC: The RDW, MPV, and NRBC count. Cleveland Clinic journal of medicine 2019;86:167-72.
  • 20. King GL, Loeken MR. Hyperglycemia-induced oxidative stress in diabetic complications. Histochemistry and cell biology 2004;122:333-8.
  • 21. Friedman JS, Lopez MF, Fleming MD, et al. SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness. Blood 2004;104:2565-73.
  • 22. Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Archives of pathology & laboratory medicine 2009;133:628-32.
  • 23. Patel KV, Ferrucci L, Ershler WB, Longo DL, Guralnik JM. Red blood cell distribution width and the risk of death in middle-aged and older adults. Archives of internal medicine 2009;169:515-23.
  • 24. Perlstein TS, Weuve J, Pfeffer MA, Beckman JA. Red blood cell distribution width and mortality risk in a community-based prospective cohort. Archives of internal medicine 2009;169:588-94.
  • 25. Malandrino N, Wu WC, Taveira TH, Whitlatch HB, Smith RJ. Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes. Diabetologia 2012;55:226-35.

Evaluation of Biochemical Parameters in Young Male Patients with Varicocele without Chronic Disease

Year 2020, Volume: 10 Issue: 4, 587 - 591, 15.12.2020
https://doi.org/10.31832/smj.770022

Abstract

Objective: Varicocele is one of the most common causes of infertility in men today, which is defined as abnormal dilatation of testicular veins in plexus pampiniformis. The aim of our study was to compare blood count parameters with healthy subjects in patients with varicocele.
Materials and Methods: Patients who applied to Ordu University Training and Research Hospital Urology Policlinic between April 2014 and April 2019 were evaluated retrospectively. In the physical examination, 163 patients with Grade 3 varicocele were diagnosed. A total of 112 patients who met the inclusion criteria were included as a control group in the study. Varicocele was evaluated by physical examination. Obtained hemogram results in white blood cell, hemoglobin, hematocrit, platelet, erythrocyte, neutrophil, lymphocyte, Monocyte, mean erythrocyte volume, average hemoglobin amount, erythrocyte distribution width (RDW), platelet distribution width (PDW), mean platelet volume (MPV) values were compared.
Results: There is no statistically significant difference was found between the two groups in terms of the mean age (p = 0.370). The statistically significant parameters between the two groups were erythrocyte (p = 0.027), MCV (p = 0.038), RDW (p = 0.013) and PDW (p = 0.000), respectively. MPV values were higher in the varicocele group than the control group. There is no statistically significant difference was found between other parameters and rates.
Conclusion: Our study shows that erythrocyte, PDW and RDW values are higher in patients with varicocele. We think that platelet and erythrocyte activation may play an important role in the pathophysiological basis of varicocele.

References

  • 1. Noske HD, Weidner W. Varicocele--a historical perspective. World journal of urology 1999;17:151-7.
  • 2. Beddy P, Geoghegan T, Browne RF, Torreggiani WC. Testicular varicoceles. Clinical radiology 2005;60:1248-55.
  • 3. Zucchi A, Mearini L, Mearini E, Fioretti F, Bini V, Porena M. Varicocele and fertility: relationship between testicular volume and seminal parameters before and after treatment. Journal of andrology 2006;27:548-51.
  • 4. Gonda RL, Jr., Karo JJ, Forte RA, O'Donnell KT. Diagnosis of subclinical varicocele in infertility. AJR American journal of roentgenology 1987;148:71-5.
  • 5. Semba RD, Patel KV, Ferrucci L, et al. Serum antioxidants and inflammation predict red cell distribution width in older women: the Women's Health and Aging Study I. Clin Nutr 2010;29:600-4.
  • 6. Tsuboi S, Miyauchi K, Kasai T, et al. Impact of red blood cell distribution width on long-term mortality in diabetic patients after percutaneous coronary intervention. Circulation journal : official journal of the Japanese Circulation Society 2013;77:456-61.
  • 7. Coban S, Keles I, Biyik I, et al. Is there any relationship between mean platelet volume and varicocele? Andrologia 2015;47:37-41.
  • 8. Bozkurt Y, Soylemez H, Sancaktutar AA, et al. Relationship between mean platelet volume and varicocele: a preliminary study. Urology 2012;79:1048-51.
  • 9. Hong H, Xiao W, Maitta RW. Steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage. PloS one 2014;9:e85465.
  • 10. Nena E, Papanas N, Steiropoulos P, et al. Mean Platelet Volume and Platelet Distribution Width in non-diabetic subjects with obstructive sleep apnoea syndrome: new indices of severity? Platelets 2012;23:447-54.
  • 11. Dubin L, Amelar RD. Varicocele size and results of varicocelectomy in selected subfertile men with varicocele. Fertility and sterility 1970;21:606-9.
  • 12. Huczek Z, Kochman J, Kowara MK, et al. Baseline platelet indices and bleeding after transcatheter aortic valve implantation. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2015;26:527-32.
  • 13. Icli A, Aksoy F, Nar G, et al. Increased Mean Platelet Volume in Familial Hypercholesterolemia. Angiology 2016;67:146-50.
  • 14. Arica S, Ozer C, Arica V, Karakus A, Celik T, Gunesacar R. Evaluation of the mean platelet volume in children with familial Mediterranean fever. Rheumatology international 2012;32:3559-63.
  • 15. Yesil Y, Kuyumcu ME, Cankurtaran M, et al. Increased mean platelet volume (MPV) indicating the vascular risk in Alzheimer's disease (AD). Archives of gerontology and geriatrics 2012;55:257-60.
  • 16. Cuce F, Demiray O, Kucuk U, Olgun Kucuk H. Varicocele: tissue stress in the etiology. Turkish journal of medical sciences 2016;46:1014-7.
  • 17. Pyo JS, Cho WJ. Mean Platelet Volume, Platelet Distribution Width, and Platelet Count in Varicocele: A Systematic Review and Meta-Analysis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;38:2239-46.
  • 18. Polat H, Gulpinar MT, Sarica MA, Benlioglu C. Relationship between mean platelet volume, platelet distribution width, plateletcrit and varicocele. Andrologia 2017;49.
  • 19. May JE, Marques MB, Reddy VVB, Gangaraju R. Three neglected numbers in the CBC: The RDW, MPV, and NRBC count. Cleveland Clinic journal of medicine 2019;86:167-72.
  • 20. King GL, Loeken MR. Hyperglycemia-induced oxidative stress in diabetic complications. Histochemistry and cell biology 2004;122:333-8.
  • 21. Friedman JS, Lopez MF, Fleming MD, et al. SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness. Blood 2004;104:2565-73.
  • 22. Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Archives of pathology & laboratory medicine 2009;133:628-32.
  • 23. Patel KV, Ferrucci L, Ershler WB, Longo DL, Guralnik JM. Red blood cell distribution width and the risk of death in middle-aged and older adults. Archives of internal medicine 2009;169:515-23.
  • 24. Perlstein TS, Weuve J, Pfeffer MA, Beckman JA. Red blood cell distribution width and mortality risk in a community-based prospective cohort. Archives of internal medicine 2009;169:588-94.
  • 25. Malandrino N, Wu WC, Taveira TH, Whitlatch HB, Smith RJ. Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes. Diabetologia 2012;55:226-35.
There are 25 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Ali Aslan 0000-0002-9674-5618

Abullah Çırakoğlu 0000-0002-8602-5836

Publication Date December 15, 2020
Submission Date July 16, 2020
Published in Issue Year 2020 Volume: 10 Issue: 4

Cite

AMA Aslan A, Çırakoğlu A. Kronik Hastalığı Olmayan Varikosel Tanılı Genç Erkek Hastalarda Kan Sayım Parametrelerinin Değerlendirilmesi. Sakarya Tıp Dergisi. December 2020;10(4):587-591. doi:10.31832/smj.770022

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