INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT
Abstract
Gastric cancers continues to be one of the most important health problems in our society with high morbidity and mortality rates. Based on genomic characterization, gastric cancer has recently been defined as a heterogeneous disease consisting of different subtypes, each with unique molecular features and specific clinics. In this study, we tried to investigate the frequency of microsatellite instability in gastric cancers and its effects on the disease. In our study, microsatellite instability results of the patients were seen as microsatellite stable (MSS) in 45 (90%) patients, microsatellite instability high (MSI-H) in 2 (4%) patients and microsatellite instability low (MSI-L) in 3 (6%) patients. It was observed that microsatellite stability was an independent risk factor for mortality. (p=0.035). As a result, it was seen that microsatellite stability was a negative risk factor for mortality in gastric cancer, however, it was concluded that microsatellite instability should be evaluated together with other risk factors that may have an effect on the disease.
Keywords
References
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Details
Primary Language
English
Subjects
Pathology
Journal Section
Research Article
Publication Date
April 30, 2025
Submission Date
December 26, 2024
Acceptance Date
March 27, 2025
Published in Issue
Year 2025 Volume: 7 Number: 1
APA
Kiziltunc, H. S., & Tekin, S. B. (2025). INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT. Sabuncuoglu Serefeddin Health Sciences, 7(1), 17-21. https://doi.org/10.55895/sshs.1688217
AMA
1.Kiziltunc HS, Tekin SB. INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT. SSHS. 2025;7(1):17-21. doi:10.55895/sshs.1688217
Chicago
Kiziltunc, Husnu Serdar, and Salim Başol Tekin. 2025. “INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT”. Sabuncuoglu Serefeddin Health Sciences 7 (1): 17-21. https://doi.org/10.55895/sshs.1688217.
EndNote
Kiziltunc HS, Tekin SB (April 1, 2025) INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT. Sabuncuoglu Serefeddin Health Sciences 7 1 17–21.
IEEE
[1]H. S. Kiziltunc and S. B. Tekin, “INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT”, SSHS, vol. 7, no. 1, pp. 17–21, Apr. 2025, doi: 10.55895/sshs.1688217.
ISNAD
Kiziltunc, Husnu Serdar - Tekin, Salim Başol. “INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT”. Sabuncuoglu Serefeddin Health Sciences 7/1 (April 1, 2025): 17-21. https://doi.org/10.55895/sshs.1688217.
JAMA
1.Kiziltunc HS, Tekin SB. INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT. SSHS. 2025;7:17–21.
MLA
Kiziltunc, Husnu Serdar, and Salim Başol Tekin. “INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT”. Sabuncuoglu Serefeddin Health Sciences, vol. 7, no. 1, Apr. 2025, pp. 17-21, doi:10.55895/sshs.1688217.
Vancouver
1.Husnu Serdar Kiziltunc, Salim Başol Tekin. INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT. SSHS. 2025 Apr. 1;7(1):17-21. doi:10.55895/sshs.1688217