INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT
Öz
Gastric cancers continues to be one of the most important health problems in our society with high morbidity and mortality rates. Based on genomic characterization, gastric cancer has recently been defined as a heterogeneous disease consisting of different subtypes, each with unique molecular features and specific clinics. In this study, we tried to investigate the frequency of microsatellite instability in gastric cancers and its effects on the disease. In our study, microsatellite instability results of the patients were seen as microsatellite stable (MSS) in 45 (90%) patients, microsatellite instability high (MSI-H) in 2 (4%) patients and microsatellite instability low (MSI-L) in 3 (6%) patients. It was observed that microsatellite stability was an independent risk factor for mortality. (p=0.035). As a result, it was seen that microsatellite stability was a negative risk factor for mortality in gastric cancer, however, it was concluded that microsatellite instability should be evaluated together with other risk factors that may have an effect on the disease.
Anahtar Kelimeler
Kaynakça
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Ayrıntılar
Birincil Dil
İngilizce
Konular
Patoloji
Bölüm
Araştırma Makalesi
Yayımlanma Tarihi
30 Nisan 2025
Gönderilme Tarihi
26 Aralık 2024
Kabul Tarihi
27 Mart 2025
Yayımlandığı Sayı
Yıl 2025 Cilt: 7 Sayı: 1
APA
Kiziltunc, H. S., & Tekin, S. B. (2025). INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT. Sabuncuoglu Serefeddin Health Sciences, 7(1), 17-21. https://doi.org/10.55895/sshs.1688217
AMA
1.Kiziltunc HS, Tekin SB. INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT. Sabuncuoglu Serefeddin Health Sciences. 2025;7(1):17-21. doi:10.55895/sshs.1688217
Chicago
Kiziltunc, Husnu Serdar, ve Salim Başol Tekin. 2025. “INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT”. Sabuncuoglu Serefeddin Health Sciences 7 (1): 17-21. https://doi.org/10.55895/sshs.1688217.
EndNote
Kiziltunc HS, Tekin SB (01 Nisan 2025) INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT. Sabuncuoglu Serefeddin Health Sciences 7 1 17–21.
IEEE
[1]H. S. Kiziltunc ve S. B. Tekin, “INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT”, Sabuncuoglu Serefeddin Health Sciences, c. 7, sy 1, ss. 17–21, Nis. 2025, doi: 10.55895/sshs.1688217.
ISNAD
Kiziltunc, Husnu Serdar - Tekin, Salim Başol. “INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT”. Sabuncuoglu Serefeddin Health Sciences 7/1 (01 Nisan 2025): 17-21. https://doi.org/10.55895/sshs.1688217.
JAMA
1.Kiziltunc HS, Tekin SB. INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT. Sabuncuoglu Serefeddin Health Sciences. 2025;7:17–21.
MLA
Kiziltunc, Husnu Serdar, ve Salim Başol Tekin. “INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT”. Sabuncuoglu Serefeddin Health Sciences, c. 7, sy 1, Nisan 2025, ss. 17-21, doi:10.55895/sshs.1688217.
Vancouver
1.Husnu Serdar Kiziltunc, Salim Başol Tekin. INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT. Sabuncuoglu Serefeddin Health Sciences. 01 Nisan 2025;7(1):17-21. doi:10.55895/sshs.1688217