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Şap Hastalığında Klinik Bulgular, Tanı Yaklaşımları ve Tedavi Stratejileri: Türkiye Örneği Güncel Bir Derleme

Year 2025, Issue: 9, 98 - 119, 23.12.2025

Abstract

Şap hastalığı (FMD), sığır, koyun, keçi ve domuz gibi çift tırnaklı hayvanları etkileyen, dünya genelinde en yıkıcı ekonomik sonuçlara yol açan sınır aşan hayvan hastalıklarından biri olmaya devam etmektedir. Avrupa ve Asya arasında stratejik bir köprü konumunda bulunan Türkiye, dönemsel olarak şap salgınlarıyla karşı karşıya kalmaktadır. Bu derleme çalışması, Türkiye’de şap hastalığına karşı kullanılan klinik bulgular, tanı yöntemleri, tedavi protokolleri ve korunma stratejilerine kapsamlı bir bakış sunmayı amaçlamaktadır. Çalışmada özellikle türlere özgü klinik tablolar, ayırıcı tanının önemi ve RT-PCR ile ELISA gibi moleküler tanı yöntemlerinin hızlı hastalık doğrulamasındaki yeri vurgulanmıştır. Destekleyici tedavi seçenekleri arasında anti-enflamatuvar uygulamalar, beslenme desteği ve sekonder enfeksiyon kontrolü saha koşulları ışığında tartışılmıştır. Ayrıca, Türkiye’nin aşılama stratejileri ve bölgesel kontrol programlarının güncel etkinliği değerlendirilmiştir. Bulgular, veteriner hekimlerin sürekli eğitimi, sürveyans sistemlerinin güçlendirilmesi ve yetiştiricilerin farkındalığının artırılmasının, hızlı müdahale ve şap hastalığının sosyoekonomik yükünün azaltılması açısından hayati önem taşıdığını ortaya koymaktadır.

References

  • Albayrak, H., Ozan, E., & Cavunt, A. (2013). A serological survey of selected pathogens in wild boar (Sus scrofa) in northern Türkeye. European Journal of Wildlife Research, 59(6), 893–897. https://doi.org/10.1007/s10344-013-0743-6 Accessed 15.06.2025
  • Alexandersen, S., Zhang, Z., Donaldson, A. I., & Garland, A. J. (2003). The pathogenesis and diagnosis of foot-and-mouth disease. Journal of Comparative Pathology, 129(1), 1–36. https://doi.org/10.1016/S0021-9975(03)00041-0 Accessed 15.06.2025
  • Alexandrov, T., et al. (2013). Surveillance of foot-and-mouth disease (FMD) in susceptible wildlife and domestic ungulates in Southeast of Bulgaria following a FMD case in wild boar. Veterinary Microbiology, 166(1–2), 84–90. https://doi.org/10.1016/j.vetmic.2013.05.016 Accessed 15.06.2025
  • Alkhamis MA, Perez AM, Yadin H, Knowles NJ (2009) Temporospatial clustering of foot-and-mouth Disease outbreaks in Israel and Palestine, 2006–2007. Transbound Emerg Dis56(3):99–107.https://doi.org/10.1111/j.1865-1682.2009.01066.xAccessed 27.10.2025
  • Anonymous (2025). Republic of Türkiye, Ministry of Agriculture and Forestry, Foot-and-Mouth Disease Institute (Şap Institute) https://vetkontrol.tarimorman.gov.tr/sap Accessed 08.12.2025
  • Arzt, J., Juleff, N., Zhang, Z., & Rodriguez, L. L. (2011). The pathogenesis of foot-and-mouth disease I: Viral pathways in cattle. Transboundary and Emerging Diseases, 58(4), 291–304. https://doi.org/10.1111/j.1865-1682.2011.01204.x Accessed 15.06.2025
  • Bastos, A. D., Haydon, D. T., Forsberg, R., Knowles, N. J., Anderson, E. C., Bengis, R. G., Nel, L. H., & Thomson, G. R. (2001). Genetic heterogeneity of SAT-1 type foot-and-mouth disease viruses in southern Africa. Archives of Virology, 146(8), 1537–1551. https://doi.org/10.1007/s007050170077 Accessed 15.06.2025
  • Brown, C. C., & Torres, A. (2008). Foreign animal diseases. USAHA, Richmond, VA. Retrieved from https://homepage.uludag.edu.tr/~mufitk/op120072008guz/thegraybookanimald.pdf Accessed 15.06.2025
  • DEFRA (UK Department for Environment, Food and Rural Affairs). (2023). Foot-and-mouth disease in Türkeye – March 2023 Rapid Risk Assessment. Retrieved from https://assets.publishing.service.gov.uk/media/6414302f8fa8f5556a0d698b/foot-and-mouth-disease-in- Türkeye -march-2023.pdf Accessed 15.06.2025
  • Di Nardo, A., Knowles, N. J., & Paton, D. J. (2011). Combining livestock trade patterns with phylogenetics to help understand the spread of foot-and-mouth disease in the Middle East. Transboundary and Emerging Diseases, 58(4), 356–362. https://doi.org/10.1111/j.1865-1682.2011.01221.x Accessed 15.06.2025
  • Dinçel, D., Ardıçlı, S., & Şamlı, H. (2019). Şap hastalığında genetik direnç mekanizmaları. In 6th International Multidisciplinary Studies Congress (pp. 611–619). Gaziantep, Türkeye.
  • Domingo, E., Baranowski, E., Escarmís, C., & Sobrino, F. (2002). Foot-and-mouth disease virus. Comparative Immunology, Microbiology and Infectious Diseases, 25(5–6), 297–308. https://doi.org/10.1016/S0147-9571(02)00027-9 Accessed 15.06.2025
  • European Union. (2016). Regulation (EU) 2016/429 of the European Parliament and of the Council of 9 March 2016 on transmissible animal diseases (“Animal Health Law”). Official Journal of the European Union, L84, 1–208. https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32016R0429 Accessed 15.06.2025
  • FAO (2021). (Food and Agriculture Organization) FMD situation reports and regional strategy updates. Rome: FAO. Retrieved from https://www.fao.org/newsroom/detail/fao-warns--enhanced-awareness-and-action-needed-amid-foot-and-mouth-disease-outbreaks-in-europe-and-the-near-east/en Accessed 15.06.2025
  • Golde, W. T., Nfon, C. K., & Toka, F. N. (2008). Immune evasion during foot-and-mouth disease virus infection of swine. Immunological Reviews, 225(1), 85–95. https://doi.org/10.1111/j.1600-065X.2008.00672.x Accessed 15.06.2025
  • Grubman, M. J., & Baxt, B. (2004). Foot-and-mouth disease. Clinical Microbiology Reviews, 17(2), 465–493. https://doi.org/10.1128/CMR.17.2.465-493.2004 Accessed 15.06.2025
  • Hardham, J. M., Krug, P., Pacheco, J. M., Thompson, J., Domanowski, P., Gay, C. G., Rodriguez, L. L., & Rieder, A. E. (2020). Novel foot-and-mouth disease vaccine platform: Formulations for safe and DIVA-compatible FMD vaccines with improved potency. Frontiers in Veterinary Science, 7, 554305. https://doi.org/10.3389/fvets.2020.554305 Accessed 15.06.2025
  • İnce, Ö. B., and Kanat, Ö. (2015). Şap hastalığı: Etiyoloji, Türkiye’de dağılımı ve kontrol stratejileri. Veteriner Mikrobiyoloji Dergisi, 45–51. https://doi.org/10.35864/evmd.513381 Accessed 15.06.2025
  • İnce, Ö. B., Şefik, M. and Şener R. (2023). Spatiotemporal analysis of foot and mouth disease outbreaks in cattle and small ruminants in Türkiye between 2010 and 2019 Veterinary Research Communications https://doi.org/10.1007/s11259-023-10269-w Accessed 27.10.2025
  • Jackson, T., Sheppard, D., Denyer, M., Blakemore, W., & King, A. M. (2000). The epithelial integrin αvβ6 is a receptor for foot-and-mouth disease virus. Journal of Virology, 74(11), 4949–4956. https://doi.org/10.1128/jvi.74.11.4949-4956.2000 Accessed 15.06.2025
  • Jamal, S. M., & Belsham, G. J. (2013). Foot-and-mouth disease: Past, present and future. Veterinary Research, 44, 116. https://doi.org/10.1186/1297-9716-44-116 Accessed 15.06.2025
  • Kim, H. W., Shin, S., Park, S. H., Park, J. H., Kim, S. M., Lee, Y. H., & Lee, M. J. (2024). Next-generation adjuvant systems containing furfurman drives potent adaptive immunity and host defense as a foot-and-mouth disease vaccine adjuvant. Frontiers in Immunology, 15, 1491043. https://doi.org/10.3389/fimmu.2024.1491043
  • Klein, J., Parlak, Ü., Özyörük, F., et al. (2006). The molecular epidemiology of foot-and-mouth disease virus serotypes A and O from 1998 to 2004 in Türkeye. BMC Veterinary Research, 2, 35. https://doi.org/10.1186/1746-6148-2-35 Accessed 15.06.2025
  • Knight-Jones, T. J. D., & Rushton, J. (2013). The economic impacts of foot and mouth disease – What are they, how big are they and where do they occur? Preventive Veterinary Medicine, 112(3–4), 161–173. https://doi.org/10.1016/j.prevetmed.2013.07.013 Accessed 15.06.2025
  • Knight-Jones, T. J. D., Bulut, A. N., Gubbins, S., Stärk, K. D. C., Pfeiffer, D. U., Sumption, K. J., & Paton, D. J. (2014). Retrospective evaluation of foot-and-mouth disease vaccine effectiveness in Türkeye. Vaccine, 32(16), 1848–1855. https://doi.org/10.1016/j.vaccine.2014.01.071 Accessed 15.06.2025
  • Knight-Jones, T. J. D., Paton, D. J., Gubbins, S., & Woolhouse, M. E. J. (2016). Mass vaccination, immunity and coverage: Modelling population protection against foot-and-mouth disease in Turkish cattle. Scientific Reports, 6, 22121. https://doi.org/10.1038/srep22121 Accessed 15.06.2025
  • Knowles, N. J., & Samuel, A. R. (2003). Molecular epidemiology of foot-and-mouth disease virus. Virus Research, 91(1), 65–80. https://doi.org/10.1016/S0168-1702(02)00260-5
  • Li, Y., Zeng, W., Niu, X., Yuan, Z., Li, S., Lin, J., Xie, K., Zhu, Z., Yi, L., Ding, H., Zhao, M., Fan, S., & Chen, J. (2025). Foot-and-mouth disease virus-like particle vaccine incorporating dominant T and B cell epitopes: Enhanced immune response in piglets with CD154 molecules. Frontiers in Veterinary Science, 12, 1540102. https://doi.org/10.3389/fvets.2025.1540102 Accessed 15.06.2025
  • Lu, B., Ru, Y., Hao, R., et al. (2024). A ferritin-based nanoparticle displaying a neutralizing epitope for foot-and-mouth disease virus (FMDV) confers partial protection in guinea pigs. BMC Veterinary Research, 20, 301. https://doi.org/10.1186/s12917-024-04159-9 Accessed 15.06.2025
  • Ludi, A. B., Reeve, R., Horsington, J., Wilsden, G., Brouwer, A., Morgan, K. L., Paton, D. J., & Knight-Jones, T. J. D. (2022). PRAGMATIST: A semi-quantitative FMD vaccine strain selection tool combining risk estimates, lineage distribution and vaccine coverage. Frontiers in Veterinary Science, 9, 1029075. https://doi.org/10.3389/fvets.2022.1029075 Accessed 15.06.2025
  • Mahapatra, M., Statham, B., Li, Y., Hammond, J., Paton, D., & Parida, S. (2016). Emergence of antigenic variants within serotype A FMDV in the Middle East with antigenically critical amino acid substitutions. Vaccine, 34(27), 3199–3206. https://doi.org/10.1016/j.vaccine.2016.02.057 Accessed 15.06.2025
  • Ministry of Agriculture and Forestry, Directorate General of Food and Control. (20 February 2025). Circular No. 2025/1 on combating animal diseases and controlling animal movements in 2025. Ankara: Ministry of Agriculture and Forestry of the Republic of Türkeye. Retrieved from https://www.tarimorman.gov.tr/Konu/2304/hayvan-hastaliklari-mucadele-hayvan-hareketleri-kontrolu-genelgesi-2025-1 Accessed 15 June 2025
  • Nature Association (2021). Türkeye wildlife observation report 2021. Ankara: Nature Association Publications. Retrieved from https://www.dogadernegi.org/ Accessed 15 June 2025
  • Radostits, O. M., Gay, C. C., Hinchcliff, K. W., & Constable, P. D. (2007). Veterinary medicine: A textbook of the diseases of cattle, horses, sheep, pigs and goats (10th ed.). London: Elsevier Saunders.
  • Rweyemamu, M. M., Roeder, P. L., Mackay, D. K., Sumption, K. J., Brownlie, J., & Leforban, Y. (2008). Planning for the progressive control of foot-and-mouth disease worldwide. Transboundary and Emerging Diseases, 55(1), 73–87. https://doi.org/10.1111/j.1865-1682.2007.01016.x Accessed 15.06.2025
  • Salt, J. S. (1993). The carrier state in foot and mouth disease—An immunological review. The British Veterinary Journal, 149(3), 207–223. https://doi.org/10.1016/S0007-1935(05)80168-X Accessed 15.06.2025
  • Samuel, A. R., & Knowles, N. J. (2001). Foot-and-mouth disease type O viruses exhibit genetically and geographically distinct evolutionary lineages. Journal of General Virology, 82(3), 609–621. https://doi.org/10.1099/0022-1317-82-3-609
  • Sareyyüpoğlu, B. (2022). Şap hastalığında taşıyıcılık. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 19(3), 233–240. https://doi.org/10.32707/ercivet.1205687 Accessed 15.06.2025
  • Şevik, M., & Öztürk, F. F. (2013). Comparative evaluation of liquid-phase blocking ELISA and solid-phase competition ELISA methods for the detection of antibodies to the structural proteins of foot-and-mouth disease types O and A viruses. Turkish Journal of Veterinary and Animal Sciences, 37(5), Article 7.
  • Thomson, G. R., Vosloo, W., & Bastos, A. D. S. (2003). Foot and mouth disease in wildlife. Virus Research, 91(1), 145–161. https://doi.org/10.1016/S0168-1702(02)00263-0 Accessed 15.06.2025
  • TÜSEDAD (2025). Bitmeyen Salgın: Şap – TÜSEDAD Bilim Danışma Kurulu Raporu. https://www.tusedad.org/wp-content/uploads/2025/08/Bitmeyen-Salgin-Sap-TUSEDAD-Bilim-Danisma-Kurulu-Raporu.pdf Accessed 08.12.2025
  • Vosloo, W., Bastos, A. D., Sangare, O., Hargreaves, S. K., & Thomson, G. R. (2002). Review of the status and control of foot and mouth disease in sub-Saharan Africa. Revue Scientifique et Technique (OIE), 21(3), 437–449. https://doi.org/10.20506/rst.21.3.1349 Accessed 15.06.2025
  • Wasfy, M., Bazid, A. H., Nayel, M., et al. (2025). Immunogenicity of a foot-and-mouth disease (FMD) vaccine against serotypes O, A, SAT-2, and Asia-1 in the Middle East and many parts of Africa, Southeast Asia and Europe. Virology Journal, 22, 98. https://doi.org/10.1186/s12985-025-02698-7 Accessed 15.06.2025
  • Wilson, R. T., & Yilmaz, O. (2020). The domestic livestock resources of Türkeye: The biodiversity of species and breeds and its conservation. Page 201-244 ResearchGate.DOI:10.13140/RG.2.2.19668.55682
  • WOAH (World Organisation for Animal Health). (2021). Foot-and-Mouth Disease: Technical Disease Card WOAH 2021. Retrieved January 2025, https://www.woah.org/app/uploads/2021/09/202501-fmd-diseasecard.pdf? Accessed 15.06.2025
  • WOAH (World Organisation for Animal Health). (2022). World Animal Health Information System (WAHIS): Foot-and-mouth disease reports. Paris: WOAH. Retrieved from https://wahis.woah.org/ Accessed 15.06.2025
  • WOAH (World Organisation for Animal Health). (2023). Foot-and-mouth disease factsheet. Retrieved from https://www.woah.org/app/uploads/2021/09/foot-and-mouth-disease-1.pdf Accessed 15.06.2025
  • WOAH (World Organisation for Animal Health). (2024). Foot and mouth disease. Retrieved July 2025 from https://www.woah.org/en/disease/foot-and-mouth-disease Accessed 15.06.2025
  • WRLFMD (World Reference Laboratory for FMD). (2016). Genotyping report: FMDV type O in Lao PDR (WRLFMD Ref. No. LAO/2/2016; Batch No. WRLFMD/2016/00014). The Pirbright Institute.
  • WRLFMD (World Reference Laboratory for FMD). (2023). Regional serotype reports – Türkiye. Retrieved from https://www.wrlfmd.org/western-and-central-asia/turkiye Accessed 15.06.2025
  • Wubshet, A. K., Werid, G. M., Teklue, T., Zhou, L., Bayasgalan, C., Tserendorj, A., Liu, J., Heath, L., Sun, Y., Ding, Y., Wang, W., Zaberezhny, A. D., Liu, Y., & Zhang, J. (2024). Foot and mouth disease vaccine efficacy in Africa: A systematic review and meta-analysis. Frontiers in Veterinary Science, 11, 1360256. https://doi.org/10.3389/fvets.2024.1360256 Accessed 15.06.2025
  • Zhao, X., Xiao, X., Xin, Z., Zhu, W., Wang, H., Xiao, Y., & Gao, L. (2025). Preliminary evaluation of a serotype O FMD mRNA vaccine in pigs and guinea pigs. Vaccine Development Journal.

Clinical Manifestations, Diagnostic Approaches and Preventive Strategies for Foot-and-Mouth Disease (FMD) in Türkiye: A Contemporary Review*

Year 2025, Issue: 9, 98 - 119, 23.12.2025

Abstract

Foot and mouth disease (FMD) remains one of the most economically devastating transboundary animal diseases worldwide, affecting cloven hoofed animals including cattle, sheep, goats and pigs. Türkiye, due to its strategic geographical position bridging Europe and Asia, continues to face periodic challenges from FMD outbreaks. This review based study aims to provide a comprehensive overview of the clinical symptoms, diagnostic procedures, treatment protocols and prevention strategies currently employed against FMD in Türkiye. Emphasis is placed on the species specific clinical presentations, the importance of differential diagnosis and the integration of molecular diagnostics such as RT-PCR and ELISA in rapid disease confirmation. Supportive treatment options, including anti-inflammatory therapy, nutritional support and secondary infection control are discussed in light of field realities. Furthermore, Türkiye’s vaccination strategies and regional control programs are evaluated for their current effectiveness. The findings underscore the need for continuous veterinary training, improved surveillance systems and enhanced awareness among livestock owners to ensure timely response and reduce the socioeconomic burden of FMD.

References

  • Albayrak, H., Ozan, E., & Cavunt, A. (2013). A serological survey of selected pathogens in wild boar (Sus scrofa) in northern Türkeye. European Journal of Wildlife Research, 59(6), 893–897. https://doi.org/10.1007/s10344-013-0743-6 Accessed 15.06.2025
  • Alexandersen, S., Zhang, Z., Donaldson, A. I., & Garland, A. J. (2003). The pathogenesis and diagnosis of foot-and-mouth disease. Journal of Comparative Pathology, 129(1), 1–36. https://doi.org/10.1016/S0021-9975(03)00041-0 Accessed 15.06.2025
  • Alexandrov, T., et al. (2013). Surveillance of foot-and-mouth disease (FMD) in susceptible wildlife and domestic ungulates in Southeast of Bulgaria following a FMD case in wild boar. Veterinary Microbiology, 166(1–2), 84–90. https://doi.org/10.1016/j.vetmic.2013.05.016 Accessed 15.06.2025
  • Alkhamis MA, Perez AM, Yadin H, Knowles NJ (2009) Temporospatial clustering of foot-and-mouth Disease outbreaks in Israel and Palestine, 2006–2007. Transbound Emerg Dis56(3):99–107.https://doi.org/10.1111/j.1865-1682.2009.01066.xAccessed 27.10.2025
  • Anonymous (2025). Republic of Türkiye, Ministry of Agriculture and Forestry, Foot-and-Mouth Disease Institute (Şap Institute) https://vetkontrol.tarimorman.gov.tr/sap Accessed 08.12.2025
  • Arzt, J., Juleff, N., Zhang, Z., & Rodriguez, L. L. (2011). The pathogenesis of foot-and-mouth disease I: Viral pathways in cattle. Transboundary and Emerging Diseases, 58(4), 291–304. https://doi.org/10.1111/j.1865-1682.2011.01204.x Accessed 15.06.2025
  • Bastos, A. D., Haydon, D. T., Forsberg, R., Knowles, N. J., Anderson, E. C., Bengis, R. G., Nel, L. H., & Thomson, G. R. (2001). Genetic heterogeneity of SAT-1 type foot-and-mouth disease viruses in southern Africa. Archives of Virology, 146(8), 1537–1551. https://doi.org/10.1007/s007050170077 Accessed 15.06.2025
  • Brown, C. C., & Torres, A. (2008). Foreign animal diseases. USAHA, Richmond, VA. Retrieved from https://homepage.uludag.edu.tr/~mufitk/op120072008guz/thegraybookanimald.pdf Accessed 15.06.2025
  • DEFRA (UK Department for Environment, Food and Rural Affairs). (2023). Foot-and-mouth disease in Türkeye – March 2023 Rapid Risk Assessment. Retrieved from https://assets.publishing.service.gov.uk/media/6414302f8fa8f5556a0d698b/foot-and-mouth-disease-in- Türkeye -march-2023.pdf Accessed 15.06.2025
  • Di Nardo, A., Knowles, N. J., & Paton, D. J. (2011). Combining livestock trade patterns with phylogenetics to help understand the spread of foot-and-mouth disease in the Middle East. Transboundary and Emerging Diseases, 58(4), 356–362. https://doi.org/10.1111/j.1865-1682.2011.01221.x Accessed 15.06.2025
  • Dinçel, D., Ardıçlı, S., & Şamlı, H. (2019). Şap hastalığında genetik direnç mekanizmaları. In 6th International Multidisciplinary Studies Congress (pp. 611–619). Gaziantep, Türkeye.
  • Domingo, E., Baranowski, E., Escarmís, C., & Sobrino, F. (2002). Foot-and-mouth disease virus. Comparative Immunology, Microbiology and Infectious Diseases, 25(5–6), 297–308. https://doi.org/10.1016/S0147-9571(02)00027-9 Accessed 15.06.2025
  • European Union. (2016). Regulation (EU) 2016/429 of the European Parliament and of the Council of 9 March 2016 on transmissible animal diseases (“Animal Health Law”). Official Journal of the European Union, L84, 1–208. https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32016R0429 Accessed 15.06.2025
  • FAO (2021). (Food and Agriculture Organization) FMD situation reports and regional strategy updates. Rome: FAO. Retrieved from https://www.fao.org/newsroom/detail/fao-warns--enhanced-awareness-and-action-needed-amid-foot-and-mouth-disease-outbreaks-in-europe-and-the-near-east/en Accessed 15.06.2025
  • Golde, W. T., Nfon, C. K., & Toka, F. N. (2008). Immune evasion during foot-and-mouth disease virus infection of swine. Immunological Reviews, 225(1), 85–95. https://doi.org/10.1111/j.1600-065X.2008.00672.x Accessed 15.06.2025
  • Grubman, M. J., & Baxt, B. (2004). Foot-and-mouth disease. Clinical Microbiology Reviews, 17(2), 465–493. https://doi.org/10.1128/CMR.17.2.465-493.2004 Accessed 15.06.2025
  • Hardham, J. M., Krug, P., Pacheco, J. M., Thompson, J., Domanowski, P., Gay, C. G., Rodriguez, L. L., & Rieder, A. E. (2020). Novel foot-and-mouth disease vaccine platform: Formulations for safe and DIVA-compatible FMD vaccines with improved potency. Frontiers in Veterinary Science, 7, 554305. https://doi.org/10.3389/fvets.2020.554305 Accessed 15.06.2025
  • İnce, Ö. B., and Kanat, Ö. (2015). Şap hastalığı: Etiyoloji, Türkiye’de dağılımı ve kontrol stratejileri. Veteriner Mikrobiyoloji Dergisi, 45–51. https://doi.org/10.35864/evmd.513381 Accessed 15.06.2025
  • İnce, Ö. B., Şefik, M. and Şener R. (2023). Spatiotemporal analysis of foot and mouth disease outbreaks in cattle and small ruminants in Türkiye between 2010 and 2019 Veterinary Research Communications https://doi.org/10.1007/s11259-023-10269-w Accessed 27.10.2025
  • Jackson, T., Sheppard, D., Denyer, M., Blakemore, W., & King, A. M. (2000). The epithelial integrin αvβ6 is a receptor for foot-and-mouth disease virus. Journal of Virology, 74(11), 4949–4956. https://doi.org/10.1128/jvi.74.11.4949-4956.2000 Accessed 15.06.2025
  • Jamal, S. M., & Belsham, G. J. (2013). Foot-and-mouth disease: Past, present and future. Veterinary Research, 44, 116. https://doi.org/10.1186/1297-9716-44-116 Accessed 15.06.2025
  • Kim, H. W., Shin, S., Park, S. H., Park, J. H., Kim, S. M., Lee, Y. H., & Lee, M. J. (2024). Next-generation adjuvant systems containing furfurman drives potent adaptive immunity and host defense as a foot-and-mouth disease vaccine adjuvant. Frontiers in Immunology, 15, 1491043. https://doi.org/10.3389/fimmu.2024.1491043
  • Klein, J., Parlak, Ü., Özyörük, F., et al. (2006). The molecular epidemiology of foot-and-mouth disease virus serotypes A and O from 1998 to 2004 in Türkeye. BMC Veterinary Research, 2, 35. https://doi.org/10.1186/1746-6148-2-35 Accessed 15.06.2025
  • Knight-Jones, T. J. D., & Rushton, J. (2013). The economic impacts of foot and mouth disease – What are they, how big are they and where do they occur? Preventive Veterinary Medicine, 112(3–4), 161–173. https://doi.org/10.1016/j.prevetmed.2013.07.013 Accessed 15.06.2025
  • Knight-Jones, T. J. D., Bulut, A. N., Gubbins, S., Stärk, K. D. C., Pfeiffer, D. U., Sumption, K. J., & Paton, D. J. (2014). Retrospective evaluation of foot-and-mouth disease vaccine effectiveness in Türkeye. Vaccine, 32(16), 1848–1855. https://doi.org/10.1016/j.vaccine.2014.01.071 Accessed 15.06.2025
  • Knight-Jones, T. J. D., Paton, D. J., Gubbins, S., & Woolhouse, M. E. J. (2016). Mass vaccination, immunity and coverage: Modelling population protection against foot-and-mouth disease in Turkish cattle. Scientific Reports, 6, 22121. https://doi.org/10.1038/srep22121 Accessed 15.06.2025
  • Knowles, N. J., & Samuel, A. R. (2003). Molecular epidemiology of foot-and-mouth disease virus. Virus Research, 91(1), 65–80. https://doi.org/10.1016/S0168-1702(02)00260-5
  • Li, Y., Zeng, W., Niu, X., Yuan, Z., Li, S., Lin, J., Xie, K., Zhu, Z., Yi, L., Ding, H., Zhao, M., Fan, S., & Chen, J. (2025). Foot-and-mouth disease virus-like particle vaccine incorporating dominant T and B cell epitopes: Enhanced immune response in piglets with CD154 molecules. Frontiers in Veterinary Science, 12, 1540102. https://doi.org/10.3389/fvets.2025.1540102 Accessed 15.06.2025
  • Lu, B., Ru, Y., Hao, R., et al. (2024). A ferritin-based nanoparticle displaying a neutralizing epitope for foot-and-mouth disease virus (FMDV) confers partial protection in guinea pigs. BMC Veterinary Research, 20, 301. https://doi.org/10.1186/s12917-024-04159-9 Accessed 15.06.2025
  • Ludi, A. B., Reeve, R., Horsington, J., Wilsden, G., Brouwer, A., Morgan, K. L., Paton, D. J., & Knight-Jones, T. J. D. (2022). PRAGMATIST: A semi-quantitative FMD vaccine strain selection tool combining risk estimates, lineage distribution and vaccine coverage. Frontiers in Veterinary Science, 9, 1029075. https://doi.org/10.3389/fvets.2022.1029075 Accessed 15.06.2025
  • Mahapatra, M., Statham, B., Li, Y., Hammond, J., Paton, D., & Parida, S. (2016). Emergence of antigenic variants within serotype A FMDV in the Middle East with antigenically critical amino acid substitutions. Vaccine, 34(27), 3199–3206. https://doi.org/10.1016/j.vaccine.2016.02.057 Accessed 15.06.2025
  • Ministry of Agriculture and Forestry, Directorate General of Food and Control. (20 February 2025). Circular No. 2025/1 on combating animal diseases and controlling animal movements in 2025. Ankara: Ministry of Agriculture and Forestry of the Republic of Türkeye. Retrieved from https://www.tarimorman.gov.tr/Konu/2304/hayvan-hastaliklari-mucadele-hayvan-hareketleri-kontrolu-genelgesi-2025-1 Accessed 15 June 2025
  • Nature Association (2021). Türkeye wildlife observation report 2021. Ankara: Nature Association Publications. Retrieved from https://www.dogadernegi.org/ Accessed 15 June 2025
  • Radostits, O. M., Gay, C. C., Hinchcliff, K. W., & Constable, P. D. (2007). Veterinary medicine: A textbook of the diseases of cattle, horses, sheep, pigs and goats (10th ed.). London: Elsevier Saunders.
  • Rweyemamu, M. M., Roeder, P. L., Mackay, D. K., Sumption, K. J., Brownlie, J., & Leforban, Y. (2008). Planning for the progressive control of foot-and-mouth disease worldwide. Transboundary and Emerging Diseases, 55(1), 73–87. https://doi.org/10.1111/j.1865-1682.2007.01016.x Accessed 15.06.2025
  • Salt, J. S. (1993). The carrier state in foot and mouth disease—An immunological review. The British Veterinary Journal, 149(3), 207–223. https://doi.org/10.1016/S0007-1935(05)80168-X Accessed 15.06.2025
  • Samuel, A. R., & Knowles, N. J. (2001). Foot-and-mouth disease type O viruses exhibit genetically and geographically distinct evolutionary lineages. Journal of General Virology, 82(3), 609–621. https://doi.org/10.1099/0022-1317-82-3-609
  • Sareyyüpoğlu, B. (2022). Şap hastalığında taşıyıcılık. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 19(3), 233–240. https://doi.org/10.32707/ercivet.1205687 Accessed 15.06.2025
  • Şevik, M., & Öztürk, F. F. (2013). Comparative evaluation of liquid-phase blocking ELISA and solid-phase competition ELISA methods for the detection of antibodies to the structural proteins of foot-and-mouth disease types O and A viruses. Turkish Journal of Veterinary and Animal Sciences, 37(5), Article 7.
  • Thomson, G. R., Vosloo, W., & Bastos, A. D. S. (2003). Foot and mouth disease in wildlife. Virus Research, 91(1), 145–161. https://doi.org/10.1016/S0168-1702(02)00263-0 Accessed 15.06.2025
  • TÜSEDAD (2025). Bitmeyen Salgın: Şap – TÜSEDAD Bilim Danışma Kurulu Raporu. https://www.tusedad.org/wp-content/uploads/2025/08/Bitmeyen-Salgin-Sap-TUSEDAD-Bilim-Danisma-Kurulu-Raporu.pdf Accessed 08.12.2025
  • Vosloo, W., Bastos, A. D., Sangare, O., Hargreaves, S. K., & Thomson, G. R. (2002). Review of the status and control of foot and mouth disease in sub-Saharan Africa. Revue Scientifique et Technique (OIE), 21(3), 437–449. https://doi.org/10.20506/rst.21.3.1349 Accessed 15.06.2025
  • Wasfy, M., Bazid, A. H., Nayel, M., et al. (2025). Immunogenicity of a foot-and-mouth disease (FMD) vaccine against serotypes O, A, SAT-2, and Asia-1 in the Middle East and many parts of Africa, Southeast Asia and Europe. Virology Journal, 22, 98. https://doi.org/10.1186/s12985-025-02698-7 Accessed 15.06.2025
  • Wilson, R. T., & Yilmaz, O. (2020). The domestic livestock resources of Türkeye: The biodiversity of species and breeds and its conservation. Page 201-244 ResearchGate.DOI:10.13140/RG.2.2.19668.55682
  • WOAH (World Organisation for Animal Health). (2021). Foot-and-Mouth Disease: Technical Disease Card WOAH 2021. Retrieved January 2025, https://www.woah.org/app/uploads/2021/09/202501-fmd-diseasecard.pdf? Accessed 15.06.2025
  • WOAH (World Organisation for Animal Health). (2022). World Animal Health Information System (WAHIS): Foot-and-mouth disease reports. Paris: WOAH. Retrieved from https://wahis.woah.org/ Accessed 15.06.2025
  • WOAH (World Organisation for Animal Health). (2023). Foot-and-mouth disease factsheet. Retrieved from https://www.woah.org/app/uploads/2021/09/foot-and-mouth-disease-1.pdf Accessed 15.06.2025
  • WOAH (World Organisation for Animal Health). (2024). Foot and mouth disease. Retrieved July 2025 from https://www.woah.org/en/disease/foot-and-mouth-disease Accessed 15.06.2025
  • WRLFMD (World Reference Laboratory for FMD). (2016). Genotyping report: FMDV type O in Lao PDR (WRLFMD Ref. No. LAO/2/2016; Batch No. WRLFMD/2016/00014). The Pirbright Institute.
  • WRLFMD (World Reference Laboratory for FMD). (2023). Regional serotype reports – Türkiye. Retrieved from https://www.wrlfmd.org/western-and-central-asia/turkiye Accessed 15.06.2025
  • Wubshet, A. K., Werid, G. M., Teklue, T., Zhou, L., Bayasgalan, C., Tserendorj, A., Liu, J., Heath, L., Sun, Y., Ding, Y., Wang, W., Zaberezhny, A. D., Liu, Y., & Zhang, J. (2024). Foot and mouth disease vaccine efficacy in Africa: A systematic review and meta-analysis. Frontiers in Veterinary Science, 11, 1360256. https://doi.org/10.3389/fvets.2024.1360256 Accessed 15.06.2025
  • Zhao, X., Xiao, X., Xin, Z., Zhu, W., Wang, H., Xiao, Y., & Gao, L. (2025). Preliminary evaluation of a serotype O FMD mRNA vaccine in pigs and guinea pigs. Vaccine Development Journal.
There are 52 citations in total.

Details

Primary Language English
Subjects Agricultural Engineering (Other)
Journal Section Review
Authors

Ayşe Özge Demir 0000-0001-7203-4734

Sinan Hakan 0009-0001-0468-2091

Submission Date September 10, 2025
Acceptance Date November 8, 2025
Publication Date December 23, 2025
Published in Issue Year 2025 Issue: 9

Cite

APA Demir, A. Ö., & Hakan, S. (2025). Clinical Manifestations, Diagnostic Approaches and Preventive Strategies for Foot-and-Mouth Disease (FMD) in Türkiye: A Contemporary Review*. Şırnak Üniversitesi Fen Bilimleri Dergisi(9), 98-119.

Sirnak University Journal of Science licensed under a Creative Commons Attribution-NonCommercial-Non-Derivatives 4.0 International Licence (CC BY-NC-ND 4.0).