Şap Hastalığında Klinik Bulgular, Tanı Yaklaşımları ve Tedavi Stratejileri: Türkiye Örneği Güncel Bir Derleme

Öz

Şap hastalığı (FMD), sığır, koyun, keçi ve domuz gibi çift tırnaklı hayvanları etkileyen, dünya genelinde en yıkıcı ekonomik sonuçlara yol açan sınır aşan hayvan hastalıklarından biri olmaya devam etmektedir. Avrupa ve Asya arasında stratejik bir köprü konumunda bulunan Türkiye, dönemsel olarak şap salgınlarıyla karşı karşıya kalmaktadır. Bu derleme çalışması, Türkiye’de şap hastalığına karşı kullanılan klinik bulgular, tanı yöntemleri, tedavi protokolleri ve korunma stratejilerine kapsamlı bir bakış sunmayı amaçlamaktadır. Çalışmada özellikle türlere özgü klinik tablolar, ayırıcı tanının önemi ve RT-PCR ile ELISA gibi moleküler tanı yöntemlerinin hızlı hastalık doğrulamasındaki yeri vurgulanmıştır. Destekleyici tedavi seçenekleri arasında anti-enflamatuvar uygulamalar, beslenme desteği ve sekonder enfeksiyon kontrolü saha koşulları ışığında tartışılmıştır. Ayrıca, Türkiye’nin aşılama stratejileri ve bölgesel kontrol programlarının güncel etkinliği değerlendirilmiştir. Bulgular, veteriner hekimlerin sürekli eğitimi, sürveyans sistemlerinin güçlendirilmesi ve yetiştiricilerin farkındalığının artırılmasının, hızlı müdahale ve şap hastalığının sosyoekonomik yükünün azaltılması açısından hayati önem taşıdığını ortaya koymaktadır.

Anahtar Kelimeler

• Şap hastalığı (FMD)
• Türkiye
• ELISA
• RT-PCR

Clinical Manifestations, Diagnostic Approaches and Preventive Strategies for Foot-and-Mouth Disease (FMD) in Türkiye: A Contemporary Review*

Öz

Foot and mouth disease (FMD) remains one of the most economically devastating transboundary animal diseases worldwide, affecting cloven hoofed animals including cattle, sheep, goats and pigs. Türkiye, due to its strategic geographical position bridging Europe and Asia, continues to face periodic challenges from FMD outbreaks. This review based study aims to provide a comprehensive overview of the clinical symptoms, diagnostic procedures, treatment protocols and prevention strategies currently employed against FMD in Türkiye. Emphasis is placed on the species specific clinical presentations, the importance of differential diagnosis and the integration of molecular diagnostics such as RT-PCR and ELISA in rapid disease confirmation. Supportive treatment options, including anti-inflammatory therapy, nutritional support and secondary infection control are discussed in light of field realities. Furthermore, Türkiye’s vaccination strategies and regional control programs are evaluated for their current effectiveness. The findings underscore the need for continuous veterinary training, improved surveillance systems and enhanced awareness among livestock owners to ensure timely response and reduce the socioeconomic burden of FMD.

Anahtar Kelimeler

• Foot and mouth disease (FMD)
• Türkiye
• ELISA
• RT-PCR

Kaynakça

1. Albayrak, H., Ozan, E., & Cavunt, A. (2013). A serological survey of selected pathogens in wild boar (Sus scrofa) in northern Türkeye. European Journal of Wildlife Research, 59(6), 893–897. https://doi.org/10.1007/s10344-013-0743-6 Accessed 15.06.2025
2. Alexandersen, S., Zhang, Z., Donaldson, A. I., & Garland, A. J. (2003). The pathogenesis and diagnosis of foot-and-mouth disease. Journal of Comparative Pathology, 129(1), 1–36. https://doi.org/10.1016/S0021-9975(03)00041-0 Accessed 15.06.2025
3. Alexandrov, T., et al. (2013). Surveillance of foot-and-mouth disease (FMD) in susceptible wildlife and domestic ungulates in Southeast of Bulgaria following a FMD case in wild boar. Veterinary Microbiology, 166(1–2), 84–90. https://doi.org/10.1016/j.vetmic.2013.05.016 Accessed 15.06.2025
4. Alkhamis MA, Perez AM, Yadin H, Knowles NJ (2009) Temporospatial clustering of foot-and-mouth Disease outbreaks in Israel and Palestine, 2006–2007. Transbound Emerg Dis56(3):99–107.https://doi.org/10.1111/j.1865-1682.2009.01066.xAccessed 27.10.2025
5. Anonymous (2025). Republic of Türkiye, Ministry of Agriculture and Forestry, Foot-and-Mouth Disease Institute (Şap Institute) https://vetkontrol.tarimorman.gov.tr/sap Accessed 08.12.2025
6. Arzt, J., Juleff, N., Zhang, Z., & Rodriguez, L. L. (2011). The pathogenesis of foot-and-mouth disease I: Viral pathways in cattle. Transboundary and Emerging Diseases, 58(4), 291–304. https://doi.org/10.1111/j.1865-1682.2011.01204.x Accessed 15.06.2025
7. Bastos, A. D., Haydon, D. T., Forsberg, R., Knowles, N. J., Anderson, E. C., Bengis, R. G., Nel, L. H., & Thomson, G. R. (2001). Genetic heterogeneity of SAT-1 type foot-and-mouth disease viruses in southern Africa. Archives of Virology, 146(8), 1537–1551. https://doi.org/10.1007/s007050170077 Accessed 15.06.2025
8. Brown, C. C., & Torres, A. (2008). Foreign animal diseases. USAHA, Richmond, VA. Retrieved from https://homepage.uludag.edu.tr/~mufitk/op120072008guz/thegraybookanimald.pdf Accessed 15.06.2025

9. DEFRA (UK Department for Environment, Food and Rural Affairs). (2023). Foot-and-mouth disease in Türkeye – March 2023 Rapid Risk Assessment. Retrieved from https://assets.publishing.service.gov.uk/media/6414302f8fa8f5556a0d698b/foot-and-mouth-disease-in- Türkeye -march-2023.pdf Accessed 15.06.2025
10. Di Nardo, A., Knowles, N. J., & Paton, D. J. (2011). Combining livestock trade patterns with phylogenetics to help understand the spread of foot-and-mouth disease in the Middle East. Transboundary and Emerging Diseases, 58(4), 356–362. https://doi.org/10.1111/j.1865-1682.2011.01221.x Accessed 15.06.2025
11. Dinçel, D., Ardıçlı, S., & Şamlı, H. (2019). Şap hastalığında genetik direnç mekanizmaları. In 6th International Multidisciplinary Studies Congress (pp. 611–619). Gaziantep, Türkeye.
12. Domingo, E., Baranowski, E., Escarmís, C., & Sobrino, F. (2002). Foot-and-mouth disease virus. Comparative Immunology, Microbiology and Infectious Diseases, 25(5–6), 297–308. https://doi.org/10.1016/S0147-9571(02)00027-9 Accessed 15.06.2025
13. European Union. (2016). Regulation (EU) 2016/429 of the European Parliament and of the Council of 9 March 2016 on transmissible animal diseases (“Animal Health Law”). Official Journal of the European Union, L84, 1–208. https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32016R0429 Accessed 15.06.2025
14. FAO (2021). (Food and Agriculture Organization) FMD situation reports and regional strategy updates. Rome: FAO. Retrieved from https://www.fao.org/newsroom/detail/fao-warns--enhanced-awareness-and-action-needed-amid-foot-and-mouth-disease-outbreaks-in-europe-and-the-near-east/en Accessed 15.06.2025
15. Golde, W. T., Nfon, C. K., & Toka, F. N. (2008). Immune evasion during foot-and-mouth disease virus infection of swine. Immunological Reviews, 225(1), 85–95. https://doi.org/10.1111/j.1600-065X.2008.00672.x Accessed 15.06.2025
16. Grubman, M. J., & Baxt, B. (2004). Foot-and-mouth disease. Clinical Microbiology Reviews, 17(2), 465–493. https://doi.org/10.1128/CMR.17.2.465-493.2004 Accessed 15.06.2025
17. Hardham, J. M., Krug, P., Pacheco, J. M., Thompson, J., Domanowski, P., Gay, C. G., Rodriguez, L. L., & Rieder, A. E. (2020). Novel foot-and-mouth disease vaccine platform: Formulations for safe and DIVA-compatible FMD vaccines with improved potency. Frontiers in Veterinary Science, 7, 554305. https://doi.org/10.3389/fvets.2020.554305 Accessed 15.06.2025
18. İnce, Ö. B., and Kanat, Ö. (2015). Şap hastalığı: Etiyoloji, Türkiye’de dağılımı ve kontrol stratejileri. Veteriner Mikrobiyoloji Dergisi, 45–51. https://doi.org/10.35864/evmd.513381 Accessed 15.06.2025
19. İnce, Ö. B., Şefik, M. and Şener R. (2023). Spatiotemporal analysis of foot and mouth disease outbreaks in cattle and small ruminants in Türkiye between 2010 and 2019 Veterinary Research Communications https://doi.org/10.1007/s11259-023-10269-w Accessed 27.10.2025
20. Jackson, T., Sheppard, D., Denyer, M., Blakemore, W., & King, A. M. (2000). The epithelial integrin αvβ6 is a receptor for foot-and-mouth disease virus. Journal of Virology, 74(11), 4949–4956. https://doi.org/10.1128/jvi.74.11.4949-4956.2000 Accessed 15.06.2025
21. Jamal, S. M., & Belsham, G. J. (2013). Foot-and-mouth disease: Past, present and future. Veterinary Research, 44, 116. https://doi.org/10.1186/1297-9716-44-116 Accessed 15.06.2025
22. Kim, H. W., Shin, S., Park, S. H., Park, J. H., Kim, S. M., Lee, Y. H., & Lee, M. J. (2024). Next-generation adjuvant systems containing furfurman drives potent adaptive immunity and host defense as a foot-and-mouth disease vaccine adjuvant. Frontiers in Immunology, 15, 1491043. https://doi.org/10.3389/fimmu.2024.1491043
23. Klein, J., Parlak, Ü., Özyörük, F., et al. (2006). The molecular epidemiology of foot-and-mouth disease virus serotypes A and O from 1998 to 2004 in Türkeye. BMC Veterinary Research, 2, 35. https://doi.org/10.1186/1746-6148-2-35 Accessed 15.06.2025
24. Knight-Jones, T. J. D., & Rushton, J. (2013). The economic impacts of foot and mouth disease – What are they, how big are they and where do they occur? Preventive Veterinary Medicine, 112(3–4), 161–173. https://doi.org/10.1016/j.prevetmed.2013.07.013 Accessed 15.06.2025
25. Knight-Jones, T. J. D., Bulut, A. N., Gubbins, S., Stärk, K. D. C., Pfeiffer, D. U., Sumption, K. J., & Paton, D. J. (2014). Retrospective evaluation of foot-and-mouth disease vaccine effectiveness in Türkeye. Vaccine, 32(16), 1848–1855. https://doi.org/10.1016/j.vaccine.2014.01.071 Accessed 15.06.2025
26. Knight-Jones, T. J. D., Paton, D. J., Gubbins, S., & Woolhouse, M. E. J. (2016). Mass vaccination, immunity and coverage: Modelling population protection against foot-and-mouth disease in Turkish cattle. Scientific Reports, 6, 22121. https://doi.org/10.1038/srep22121 Accessed 15.06.2025
27. Knowles, N. J., & Samuel, A. R. (2003). Molecular epidemiology of foot-and-mouth disease virus. Virus Research, 91(1), 65–80. https://doi.org/10.1016/S0168-1702(02)00260-5
28. Li, Y., Zeng, W., Niu, X., Yuan, Z., Li, S., Lin, J., Xie, K., Zhu, Z., Yi, L., Ding, H., Zhao, M., Fan, S., & Chen, J. (2025). Foot-and-mouth disease virus-like particle vaccine incorporating dominant T and B cell epitopes: Enhanced immune response in piglets with CD154 molecules. Frontiers in Veterinary Science, 12, 1540102. https://doi.org/10.3389/fvets.2025.1540102 Accessed 15.06.2025
29. Lu, B., Ru, Y., Hao, R., et al. (2024). A ferritin-based nanoparticle displaying a neutralizing epitope for foot-and-mouth disease virus (FMDV) confers partial protection in guinea pigs. BMC Veterinary Research, 20, 301. https://doi.org/10.1186/s12917-024-04159-9 Accessed 15.06.2025
30. Ludi, A. B., Reeve, R., Horsington, J., Wilsden, G., Brouwer, A., Morgan, K. L., Paton, D. J., & Knight-Jones, T. J. D. (2022). PRAGMATIST: A semi-quantitative FMD vaccine strain selection tool combining risk estimates, lineage distribution and vaccine coverage. Frontiers in Veterinary Science, 9, 1029075. https://doi.org/10.3389/fvets.2022.1029075 Accessed 15.06.2025
31. Mahapatra, M., Statham, B., Li, Y., Hammond, J., Paton, D., & Parida, S. (2016). Emergence of antigenic variants within serotype A FMDV in the Middle East with antigenically critical amino acid substitutions. Vaccine, 34(27), 3199–3206. https://doi.org/10.1016/j.vaccine.2016.02.057 Accessed 15.06.2025
32. Ministry of Agriculture and Forestry, Directorate General of Food and Control. (20 February 2025). Circular No. 2025/1 on combating animal diseases and controlling animal movements in 2025. Ankara: Ministry of Agriculture and Forestry of the Republic of Türkeye. Retrieved from https://www.tarimorman.gov.tr/Konu/2304/hayvan-hastaliklari-mucadele-hayvan-hareketleri-kontrolu-genelgesi-2025-1 Accessed 15 June 2025
33. Nature Association (2021). Türkeye wildlife observation report 2021. Ankara: Nature Association Publications. Retrieved from https://www.dogadernegi.org/ Accessed 15 June 2025
34. Radostits, O. M., Gay, C. C., Hinchcliff, K. W., & Constable, P. D. (2007). Veterinary medicine: A textbook of the diseases of cattle, horses, sheep, pigs and goats (10th ed.). London: Elsevier Saunders.
35. Rweyemamu, M. M., Roeder, P. L., Mackay, D. K., Sumption, K. J., Brownlie, J., & Leforban, Y. (2008). Planning for the progressive control of foot-and-mouth disease worldwide. Transboundary and Emerging Diseases, 55(1), 73–87. https://doi.org/10.1111/j.1865-1682.2007.01016.x Accessed 15.06.2025
36. Salt, J. S. (1993). The carrier state in foot and mouth disease—An immunological review. The British Veterinary Journal, 149(3), 207–223. https://doi.org/10.1016/S0007-1935(05)80168-X Accessed 15.06.2025
37. Samuel, A. R., & Knowles, N. J. (2001). Foot-and-mouth disease type O viruses exhibit genetically and geographically distinct evolutionary lineages. Journal of General Virology, 82(3), 609–621. https://doi.org/10.1099/0022-1317-82-3-609
38. Sareyyüpoğlu, B. (2022). Şap hastalığında taşıyıcılık. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 19(3), 233–240. https://doi.org/10.32707/ercivet.1205687 Accessed 15.06.2025
39. Şevik, M., & Öztürk, F. F. (2013). Comparative evaluation of liquid-phase blocking ELISA and solid-phase competition ELISA methods for the detection of antibodies to the structural proteins of foot-and-mouth disease types O and A viruses. Turkish Journal of Veterinary and Animal Sciences, 37(5), Article 7.
40. Thomson, G. R., Vosloo, W., & Bastos, A. D. S. (2003). Foot and mouth disease in wildlife. Virus Research, 91(1), 145–161. https://doi.org/10.1016/S0168-1702(02)00263-0 Accessed 15.06.2025
41. TÜSEDAD (2025). Bitmeyen Salgın: Şap – TÜSEDAD Bilim Danışma Kurulu Raporu. https://www.tusedad.org/wp-content/uploads/2025/08/Bitmeyen-Salgin-Sap-TUSEDAD-Bilim-Danisma-Kurulu-Raporu.pdf Accessed 08.12.2025
42. Vosloo, W., Bastos, A. D., Sangare, O., Hargreaves, S. K., & Thomson, G. R. (2002). Review of the status and control of foot and mouth disease in sub-Saharan Africa. Revue Scientifique et Technique (OIE), 21(3), 437–449. https://doi.org/10.20506/rst.21.3.1349 Accessed 15.06.2025
43. Wasfy, M., Bazid, A. H., Nayel, M., et al. (2025). Immunogenicity of a foot-and-mouth disease (FMD) vaccine against serotypes O, A, SAT-2, and Asia-1 in the Middle East and many parts of Africa, Southeast Asia and Europe. Virology Journal, 22, 98. https://doi.org/10.1186/s12985-025-02698-7 Accessed 15.06.2025
44. Wilson, R. T., & Yilmaz, O. (2020). The domestic livestock resources of Türkeye: The biodiversity of species and breeds and its conservation. Page 201-244 ResearchGate.DOI:10.13140/RG.2.2.19668.55682
45. WOAH (World Organisation for Animal Health). (2021). Foot-and-Mouth Disease: Technical Disease Card WOAH 2021. Retrieved January 2025, https://www.woah.org/app/uploads/2021/09/202501-fmd-diseasecard.pdf? Accessed 15.06.2025
46. WOAH (World Organisation for Animal Health). (2022). World Animal Health Information System (WAHIS): Foot-and-mouth disease reports. Paris: WOAH. Retrieved from https://wahis.woah.org/ Accessed 15.06.2025
47. WOAH (World Organisation for Animal Health). (2023). Foot-and-mouth disease factsheet. Retrieved from https://www.woah.org/app/uploads/2021/09/foot-and-mouth-disease-1.pdf Accessed 15.06.2025
48. WOAH (World Organisation for Animal Health). (2024). Foot and mouth disease. Retrieved July 2025 from https://www.woah.org/en/disease/foot-and-mouth-disease Accessed 15.06.2025
49. WRLFMD (World Reference Laboratory for FMD). (2016). Genotyping report: FMDV type O in Lao PDR (WRLFMD Ref. No. LAO/2/2016; Batch No. WRLFMD/2016/00014). The Pirbright Institute.
50. WRLFMD (World Reference Laboratory for FMD). (2023). Regional serotype reports – Türkiye. Retrieved from https://www.wrlfmd.org/western-and-central-asia/turkiye Accessed 15.06.2025
51. Wubshet, A. K., Werid, G. M., Teklue, T., Zhou, L., Bayasgalan, C., Tserendorj, A., Liu, J., Heath, L., Sun, Y., Ding, Y., Wang, W., Zaberezhny, A. D., Liu, Y., & Zhang, J. (2024). Foot and mouth disease vaccine efficacy in Africa: A systematic review and meta-analysis. Frontiers in Veterinary Science, 11, 1360256. https://doi.org/10.3389/fvets.2024.1360256 Accessed 15.06.2025
52. Zhao, X., Xiao, X., Xin, Z., Zhu, W., Wang, H., Xiao, Y., & Gao, L. (2025). Preliminary evaluation of a serotype O FMD mRNA vaccine in pigs and guinea pigs. Vaccine Development Journal.