Preterm Bebeklerde Antenatal Betametazon Tedavisinin Serum Tiroid Hormon Düzeylerine Etkisi

Abstract

Amaç: Yenidoğan ölümleri ve ağır morbiditelerini azaltan antenatal betametazon tedavisinin preterm bebeklerdeki serum tiroid hormonlarına etkisinin araştırılması amaçlanmıştır. Gereç ve

Yöntemler: 2013-2019 yılları arasında doğan ve gebelik haftası 32 hafta ve altında olan ve çalışmaya alınma kriterlerini karşılayan toplam 156 bebek bu retrospektif çalışmaya alındı. Bebeklerin bilgilerine hastane kayıt sisteminden ulaşıldı. Bebekler hiç steroid almayan, tek doz alan ve tam doz alan olmak üzere üç gruba ayrıldı. Yaşamın 30. gününden önce bakılan tiroid fonksiyon testleri karşılaştırıldı.

Bulgular: Doğum haftası, doğum şekli, doğum ağırlığı, çoğul gebelik durumu, cinsiyet, anne yaşı, preeklampsi, erken membran rüptürü, koriyoamniyonit, annede tiroid hastalığı, bebeğin hastanede kalma süresi, tiroid testi örneklem zamanı, Apgar skoru, patent duktus arteriyozus, nekrotizan enterokolit, intraventriküler kanama, prematüre retinopatisi ve bronkopulmoner displazi oranı açısından her üç grup arasında fark saptanmadı. Tam doz steroid alanlarda surfaktan ihtiyacı anlamlı olarak düşüktü. Serum serbest tiroksin (sT4) ve tiroid uyarıcı hormon (TSH) düzeyleri açısından her üç grup arasında fark saptanmadı.

Sonuç: Bu çalışmada preterm bebeklerde antenatal betametazon profilaksisinin serum tiroid hormonlarına etkisinin olmadığı görülmüştür.

Keywords

• Antenatal steroid
• tiroksin
• tiroid uyarıcı hormon

The Effect of Antenatal Betamethasone Treatment On Serum Thyroid Hormone Levels of Preterm Infants

Abstract

Objective: In this study, we aimed to investigate the effect of antenatal betamethasone treatment on serum thyroid hormones in preterm infants.

Material and Methods: A total of 156 babies born between 2013-2019 with gestational age of ≤32 weeks were included in this retrospective study. Information of the babies was accessed from the hospital records. Infants were divided into 3 groups according to betamethasone treatment: no treatment, partial dose, and complete dose. Thyroid function tests were compared between the groups before 30th days of life.

Results: There was no difference between the three groups in terms of gestational age, route of delivery, birth weight, rate of multiple pregnancy, gender, maternal age, premature rupture of membranes, chorioamnionitis, maternal thyroid disease, hospital stay, sampling time of serum thyroid hormones, Apgar score, patent ductus arteriosus, necrotizing enterocolitis, intraventricular hemorrhage, retinopathy of prematurity and bronchopulmonary dysplasia. The surfactant treatment was significantly low in the patients receiving complete dose of steroid. There was no difference between the three groups in terms of serum free thyroxine (fT4) and thyroid stimulating hormone (TSH) levels.

Conclusion: It has been shown that antenatal betamethasone treatment has no effect on serum thyroid hormones in preterm infants.

Keywords

• Antenatal steroid
• thyroxine
• thyroid stimulating hormone

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