Case Report
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COVID-19 İlişkili Akut İmmün Trombositopenik Purpura: Sıradışı Pediatrik Bir Olgu

Year 2023, Volume: 17 Issue: 4, 324 - 327, 25.07.2023
https://doi.org/10.12956/tchd.1113184

Abstract

İmmün trombositopenik purpura (İTP), izole trombositopeni ile kendini gösteren hematolojik bir hastalıktır. Etiyolojisinde son bir aydaki viral enfeksiyonlar sıklıkla bulunur. COVİD-19 enfeksiyonu sonrası çeşitli hematolojik komplikasyonların yanı sıra ITP gelişimi de görülebilmektedir. Bu yazıda COVİD-19 enfeksiyonu sırasında teşhis edilen ve kanama bulgusu olmayan bir çocuk akut ITP olgusu sunulmaktadır.

References

  • Kühne T, Buchanan GR, Zimmerman S, Michaels LA, Kohan R, Berchtold W, et al. Intercontinental Childhood ITP Study Group; Intercontinental Childhood ITP Study Group. A prospective comparative study of 2540 infants and children with newly diagnosed idiopathic thrombocytopenic purpura (ITP) from the Intercontinental Childhood ITP Study Group. J Pediatr 2003;143:605-8.
  • Zeller B, Rajantie J, Hedlund-Treutiger I, Tedgård U, Wesenberg F, Jonsson OG, et al. NOPHO ITP. Childhood idiopathic thrombocytopenic purpura in the Nordic countries: epidemiology and predictors of chronic disease. Acta Paediatr 2005;94:178-4.
  • Zulfiqar AA, Lorenzo-Villalba N, Hassler P, Andrès E. Immune Thrombocytopenic Purpura in a Patient with Covid-19. N Engl J Med 2020;382:e43.
  • Lévesque V, Millaire É, Corsilli D, Rioux-Massé B, Carrier FM. Severe immune thrombocytopenic purpura in critical COVID-19. Int J Hematol 2020;112:746-50.
  • Bomhof G, Mutsaers PGNJ, Leebeek FWG, Te Boekhorst PAW, Hofland J, Croles FN, et al. COVID-19-associated immune thrombocytopenia. Br J Haematol 2020;190:e61-4.
  • D’Orazio JA, Neely J, Farhoudi N. ITP in children: pathophysiology and current treatment approaches. J Pediatr Hematol Oncol 2013;35:1-13.
  • O’Leary ST, Glanz JM, McClure DL, Akhtar A, Daley MF, Nakasato C, et al. The risk of immune thrombocytopenic purpura after vaccination in children and adolescents. Pediatrics 2012;129:248-55.
  • British Committee for Standards in Haematology General Haematology Task Force. Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy. Br J Haematol 2003;120:574-96.
  • Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel JB, et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 2010;115:168-86.
  • Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. China Medical Treatment Expert Group for Covid-19. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med 2020;382:1708-20.
  • Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin Chim Acta 2020;506:145-8.
  • Tsao HS, Chason HM, Fearon DM. Immune Thrombocytopenia (ITP) in a Pediatric Patient Positive for SARS-CoV-2. Pediatrics 2020;146:e20201419.
  • Rosenzweig JD, McThenia SS, Kaicker S. SARS-CoV-2 infection in two pediatric patients with immune cytopenias: A single institution experience during the pandemic. Pediatr Blood Cancer 2020;67:e28503.
  • Patel PA, Chandrakasan S, Mickells GE, Yildirim I, Kao CM, Bennett CM. Severe pediatric COVID-19 presenting with respiratory failure and severe thrombocytopenia. Pediatrics 2020;146:e20201437.
  • Bhattacharjee S, Banerjee M. Immune Thrombocytopenia Secondary to COVID-19: a Systematic Review. SN Compr Clin Med 2020;2:2048-58.
  • Ceglie G, De Ioris MA, Mercadante S, Olivini N, Del Bufalo F, Marchesani S, et al. Immune thrombocytopenia in a child with COVID-19: Is it the calm after the (cytokine) storm? Pediatr Blood Cancer 2022;69:e29326.
  • Vadakkekara J, Mathew R, Khera S. COVID-19-Associated Immune Thrombocytopenia in a Toddler. Indian J Pediatr 2022;89:623.
  • Saad MA, Alfishawy M, Nassar M, Mohamed M, Esene IN, Elbendary A. COVID-19 and Autoimmune Diseases: A Systematic Review of Reported Cases. Curr Rheumatol Rev 2021;17:193-204.

COVID-19-Associated Acute Immune Thrombocytopenic Purpura: An Unusual Pediatric Case

Year 2023, Volume: 17 Issue: 4, 324 - 327, 25.07.2023
https://doi.org/10.12956/tchd.1113184

Abstract

Immune thrombocytopenic purpura (ITP) is a hematological disease manifested by isolated thrombocytopenia. Viral infections in the last month are often found in its etiology. After COVID-19 infection, various hematological complications can be seen, as well as the development of ITP. In this article, a case of pediatric acute ITP who was diagnosed during COVID-19 infection and had no signs of bleeding is presented.

References

  • Kühne T, Buchanan GR, Zimmerman S, Michaels LA, Kohan R, Berchtold W, et al. Intercontinental Childhood ITP Study Group; Intercontinental Childhood ITP Study Group. A prospective comparative study of 2540 infants and children with newly diagnosed idiopathic thrombocytopenic purpura (ITP) from the Intercontinental Childhood ITP Study Group. J Pediatr 2003;143:605-8.
  • Zeller B, Rajantie J, Hedlund-Treutiger I, Tedgård U, Wesenberg F, Jonsson OG, et al. NOPHO ITP. Childhood idiopathic thrombocytopenic purpura in the Nordic countries: epidemiology and predictors of chronic disease. Acta Paediatr 2005;94:178-4.
  • Zulfiqar AA, Lorenzo-Villalba N, Hassler P, Andrès E. Immune Thrombocytopenic Purpura in a Patient with Covid-19. N Engl J Med 2020;382:e43.
  • Lévesque V, Millaire É, Corsilli D, Rioux-Massé B, Carrier FM. Severe immune thrombocytopenic purpura in critical COVID-19. Int J Hematol 2020;112:746-50.
  • Bomhof G, Mutsaers PGNJ, Leebeek FWG, Te Boekhorst PAW, Hofland J, Croles FN, et al. COVID-19-associated immune thrombocytopenia. Br J Haematol 2020;190:e61-4.
  • D’Orazio JA, Neely J, Farhoudi N. ITP in children: pathophysiology and current treatment approaches. J Pediatr Hematol Oncol 2013;35:1-13.
  • O’Leary ST, Glanz JM, McClure DL, Akhtar A, Daley MF, Nakasato C, et al. The risk of immune thrombocytopenic purpura after vaccination in children and adolescents. Pediatrics 2012;129:248-55.
  • British Committee for Standards in Haematology General Haematology Task Force. Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy. Br J Haematol 2003;120:574-96.
  • Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel JB, et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 2010;115:168-86.
  • Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. China Medical Treatment Expert Group for Covid-19. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med 2020;382:1708-20.
  • Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin Chim Acta 2020;506:145-8.
  • Tsao HS, Chason HM, Fearon DM. Immune Thrombocytopenia (ITP) in a Pediatric Patient Positive for SARS-CoV-2. Pediatrics 2020;146:e20201419.
  • Rosenzweig JD, McThenia SS, Kaicker S. SARS-CoV-2 infection in two pediatric patients with immune cytopenias: A single institution experience during the pandemic. Pediatr Blood Cancer 2020;67:e28503.
  • Patel PA, Chandrakasan S, Mickells GE, Yildirim I, Kao CM, Bennett CM. Severe pediatric COVID-19 presenting with respiratory failure and severe thrombocytopenia. Pediatrics 2020;146:e20201437.
  • Bhattacharjee S, Banerjee M. Immune Thrombocytopenia Secondary to COVID-19: a Systematic Review. SN Compr Clin Med 2020;2:2048-58.
  • Ceglie G, De Ioris MA, Mercadante S, Olivini N, Del Bufalo F, Marchesani S, et al. Immune thrombocytopenia in a child with COVID-19: Is it the calm after the (cytokine) storm? Pediatr Blood Cancer 2022;69:e29326.
  • Vadakkekara J, Mathew R, Khera S. COVID-19-Associated Immune Thrombocytopenia in a Toddler. Indian J Pediatr 2022;89:623.
  • Saad MA, Alfishawy M, Nassar M, Mohamed M, Esene IN, Elbendary A. COVID-19 and Autoimmune Diseases: A Systematic Review of Reported Cases. Curr Rheumatol Rev 2021;17:193-204.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section CASE REPORTS
Authors

Ömer GÜNEŞ 0000-0001-7121-3810

Ahmet Yasin GÜNEY 0000-0002-3446-7034

Latife GÜDER 0000-0003-4565-3665

Özlem MUSTAFAOĞLU 0000-0001-8915-6922

Pınar BAYRAKTAR 0000-0001-6408-1936

Seda ŞAHİN 0000-0002-8233-8659

Saliha KANIK YÜKSEK 0000-0002-2538-2872

Belgin GÜLHAN 0000-0003-0839-1301

Gülsüm İclal BAYHAN 0000-0002-1423-4348

Aslınur ÖZKAYA PARLAKAY 0000-0001-5691-2461

Early Pub Date May 3, 2023
Publication Date July 25, 2023
Submission Date May 10, 2022
Published in Issue Year 2023 Volume: 17 Issue: 4

Cite

Vancouver GÜNEŞ Ö, GÜNEY AY, GÜDER L, MUSTAFAOĞLU Ö, BAYRAKTAR P, ŞAHİN S, KANIK YÜKSEK S, GÜLHAN B, BAYHAN Gİ, ÖZKAYA PARLAKAY A. COVID-19-Associated Acute Immune Thrombocytopenic Purpura: An Unusual Pediatric Case. Türkiye Çocuk Hast Derg. 2023;17(4):324-7.


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