Miroparçacıkların Boyutlarına Göre Verimli Ayrıştırılması İçin Eğimli Eliptik Engeller İçeren Bir Deterministik Yanal Yerdeğiştirme Sistemi

Abstract

Deterministic Lateral Displacement System with Inclined Elliptical Obstacles for Efficient Size-Based Separation of Microparticles

Abstract

A deterministic lateral displacement system with inclined elliptical posts is demonstrated to sort spherical micrometer-sized solid particles. Numerical simulations via the finite-element method are performed to investigate the microfluidic system performance. Soft microparticles undergo deformations in designs with cylindrical posts or posts with sharp corners. Such deformations occur due to particle clogging between obstacles, which can disrupt the flow lanes. The proposed approach aims to eliminate these challenges. The calculations reveal a much-reduced rate of change in flow velocity between vertically inclined elliptical posts, compared to circular posts. The calculated critical particle sizes are more likely to follow the equation associated with the first flow lane width derived from a parabolic velocity profile at high fluid inlet rates, rather than the two semi-analytical models proposed for circular posts. The experimental and theoretical critical diameter data exhibited greater agreement with the critical diameter equation obtained using the curve-fitting method at lower fluid inlet rates. Overall, the minimum particle size decreased as the rate of flow increased. When assessing the connection between the two, a smaller critical diameter is achieved by decreasing the inclination angle. The adjustability of the system by rotating the posts is a major advantage of the proposed approach.

Keywords

• Microfluidics
• deterministic lateral displacement (DLD)
• particle separation

References

1. Whitesides GM. The origins and the future of microfluidics. Nature. 2006;442(7101):368-73.
2. Yager P, Edwards T, Fu E, Helton K, Nelson K, Tam MR, Weigl BH. Microfluidic diagnostic technologies for global public health. Nature. 2006;442(7101):412-8.
3. Salafi T, Zeming KK, Zhang Y. Advancements in microfluidics for nanoparticle separation. Lab on a Chip. 2017;17(1):11-33.
4. Xu X, Sarder P, Kotagiri N, Achilefu S, Nehorai A. Performance analysis and design of position-encoded microsphere arrays using the Ziv-Zakai bound. IEEE Transactions on Nanobioscience. 2012;12(1):29-40.
5. Choi J-W, Oh KW, Thomas JH, Heineman WR, Halsall HB, Nevin JH, et al. An integrated microfluidic biochemical detection system for protein analysis with magnetic bead-based sampling capabilities. Lab on a Chip. 2002;2(1):27-30.
6. Dittrich PS, Schwille P. An integrated microfluidic system for reaction, high-sensitivity detection, and sorting of fluorescent cells and particles. Analytical chemistry. 2003;75(21):5767-74.
7. Munaz A, Shiddiky MJ, Nguyen N-T. Recent advances and current challenges in magnetophoresis based micro magnetofluidics. Biomicrofluidics. 2018;12(3).
8. Jubery TZ, Srivastava SK, Dutta P. Dielectrophoretic separation of bioparticles in microdevices: A review. Electrophoresis. 2014;35(5):691-713.

9. Connacher W, Zhang N, Huang A, Mei J, Zhang S, Gopesh T, Friend J. Micro/nano acoustofluidics: materials, phenomena, design, devices, and applications. Lab on a Chip. 2018;18(14):1952-96.
10. Vigolo D, Rusconi R, Stone HA, Piazza R. Thermophoresis: microfluidics characterization and separation. Soft Matter. 2010;6(15):3489-93.
11. Debnath N, Sadrzadeh M. Microfluidic mimic for colloid membrane filtration: a review. Journal of the Indian Institute of Science. 2018;98(2):137-57.
12. Lenshof A, Laurell T. Continuous separation of cells and particles in microfluidic systems. Chemical Society Reviews. 2010;39(3):1203-17.
13. Zhang J, Yan S, Yuan D, Alici G, Nguyen N-T, Warkiani ME, Li W. Fundamentals and applications of inertial microfluidics: A review. Lab on a Chip. 2016;16(1):10-34.
14. Lu X, Liu C, Hu G, Xuan X. Particle manipulations in non-Newtonian microfluidics: A review. Journal of colloid and interface science. 2017;500:182-201.
15. McGrath J, Jimenez M, Bridle H. Deterministic lateral displacement for particle separation: a review. Lab on a Chip. 2014;14(21):4139-58.
16. Huang LR, Cox EC, Austin RH, Sturm JC. Continuous particle separation through deterministic lateral displacement. Science. 2004;304(5673):987-90.
17. Inglis DW, Davis JA, Austin RH, Sturm JC. Critical particle size for fractionation by deterministic lateral displacement. Lab on a Chip. 2006;6(5):655-8.
18. Davis JA. Microfluidic separation of blood components through deterministic lateral displacement: Princeton University; 2008.
19. Beech JP. SEPARATION AND ANALYSIS OF BIOLOGICAL PARTICLES.
20. Al-Fandi M, Al-Rousan M, Jaradat MA, Al-Ebbini L. New design for the separation of microorganisms using microfluidic deterministic lateral displacement. Robotics and computer-integrated manufacturing. 2011;27(2):237-44.
21. Dincau BM, Aghilinejad A, Chen X, Moon SY, Kim J-H. Vortex-free high-Reynolds deterministic lateral displacement (DLD) via airfoil pillars. Microfluidics and Nanofluidics. 2018;22:1-9.
22. Liu L, Loutherback K, Liao D, Yeater D, Lambert G, Estévez-Torres A, et al. A microfluidic device for continuous cancer cell culture and passage with hydrodynamic forces. Lab on a Chip. 2010;10(14):1807-13.
23. Zeming KK, Ranjan S, Zhang Y. Rotational separation of non-spherical bioparticles using I- pillar arrays in a microfluidic device. Nature communications. 2013;4(1):1625.
24. Hyun J-c, Hyun J, Wang S, Yang S. Improved pillar shape for deterministic lateral displacement separation method to maintain separation efficiency over a long period of time. Separation and Purification Technology. 2017;172:258-67
25. Burlington MA. Multiphysics, C. O. M. S. O. L. Introduction to comsol multiphysics®. COMSOL Multiphysics, 1998. accessed Feb, 9(2018), 32.
26. Bruus H. Theoretical microfluidis (Vol. 18): Oxford University Press; 2007
27. Batchelor GK. An introduction to fluid dynamics: Cambridge University Press; 2000
28. Beech J. Microfluidics separation and analysis of biological particles: Lund University; 2011.