Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi

Cihan Gür; Fatih Kandemir; Aydın Genç

doi:10.46810/tdfd.809220

Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi

Abstract

Bortezomib (BTZ), proteazom sistemini bloke ederek hücresel protein yıkımını engelleyen yeni nesil bir antineoplastik ilaçtır. Bu çalışmada BTZ kaynaklı kalp hasarına karşı bir izokinolin alkaloid olan berberinin (BBR) koruyucu etkileri araştırılmıştır. Çalışmada erkek Sprague Dawley cinsi ratlara 1., 3., 5. ve 7. günlerde periton içi 0,2 mg kg-1 BTZ ve 10 gün boyunca her gün 50 ve 100 mg kg-1 dozlarda BBR verildi. Ratların kalp dokularında malondialdehit (MDA), glutatyon (GSH), total antioksidan kapasite (TAK), total oksidan kapasite (TOK) ve nitrik oksit (NO) seviyeleri ile süperoksit dismutaz (SOD), katalaz (KAT), glutatyon peroksidaz (GPx) ve laktat dehidrogenaz (LDH) aktiviteleri biyokimyasal yöntemler ile analiz edildi. Veriler BTZ’nin kalp dokusunda MDA, NO ve TOK seviyelerini, serumda LDH aktivelerini ve oksidatif stres indeksini (OSI) önemli ölçüde arttırdığını, GSH ve TAK seviyeleri ile SOD, KAT ve GPx aktivitelerini azaltarak oksidatif stresi tetiklediğini buna bağlı olarak dokuda hasar oluşturduğunu gösterdi. Buna karşın BBR, BTZ’nin neden olduğu oksidatif stresi ve nitrozatif stresi hafifleterek kalp hasarına karşı koruyucu etki gösterdi. Sonuçlara göre BBR’nin, BTZ ile indüklenen kardiyak toksisiteye karşı daha ileri çalışmalardan sonra koruyucu olarak kullanılabileceğini gösterdi.

Keywords

References

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Details

Primary Language

Turkish

Subjects

Veterinary Surgery

Journal Section

Research Article

Authors

Cihan Gür ^*
0000-0001-6775-7858
Türkiye

Fatih Kandemir
0000-0002-8490-2479
Türkiye

Aydın Genç This is me
0000-0001-5367-0743
Türkiye

Publication Date

December 30, 2020

Submission Date

October 12, 2020

Acceptance Date

December 14, 2020

Published in Issue

Year 2020 Volume: 9 Number: 2

DOI

https://doi.org/10.46810/tdfd.809220

IZ

https://izlik.org/JA58TD65ZT

Cite

RIS / Bibtex

APA

Gür, C., Kandemir, F., & Genç, A. (2020). Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. Türk Doğa Ve Fen Dergisi, 9(2), 118-126. https://doi.org/10.46810/tdfd.809220

AMA

1.Gür C, Kandemir F, Genç A. Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. TJNS. 2020;9(2):118-126. doi:10.46810/tdfd.809220

Chicago

Gür, Cihan, Fatih Kandemir, and Aydın Genç. 2020. “Bortezomib Ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif Ve Nitrozatif Stres Üzerine Etkisi”. Türk Doğa Ve Fen Dergisi 9 (2): 118-26. https://doi.org/10.46810/tdfd.809220.

EndNote

Gür C, Kandemir F, Genç A (December 1, 2020) Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. Türk Doğa ve Fen Dergisi 9 2 118–126.

IEEE

[1]C. Gür, F. Kandemir, and A. Genç, “Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi”, TJNS, vol. 9, no. 2, pp. 118–126, Dec. 2020, doi: 10.46810/tdfd.809220.

ISNAD

Gür, Cihan - Kandemir, Fatih - Genç, Aydın. “Bortezomib Ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif Ve Nitrozatif Stres Üzerine Etkisi”. Türk Doğa ve Fen Dergisi 9/2 (December 1, 2020): 118-126. https://doi.org/10.46810/tdfd.809220.

JAMA

1.Gür C, Kandemir F, Genç A. Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. TJNS. 2020;9:118–126.

MLA

Gür, Cihan, et al. “Bortezomib Ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif Ve Nitrozatif Stres Üzerine Etkisi”. Türk Doğa Ve Fen Dergisi, vol. 9, no. 2, Dec. 2020, pp. 118-26, doi:10.46810/tdfd.809220.

Vancouver

1.Cihan Gür, Fatih Kandemir, Aydın Genç. Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. TJNS. 2020 Dec. 1;9(2):118-26. doi:10.46810/tdfd.809220