Chemotherapy-Induced Cellular Senescence: A Comprehensive Review of Clinical Methodologies and Treatment Outcomes

Fatma Özge Yağbasan; Yaprak Dilber Şimay Demir; Mustafa Ark

doi:10.18663/tjcl.1745156

Review

Chemotherapy-Induced Cellular Senescence: A Comprehensive Review of Clinical Methodologies and Treatment Outcomes

Year 2025, Volume: 16 Issue: 3, 653 - 664, 30.09.2025

Fatma Özge Yağbasan , Yaprak Dilber Şimay Demir , Mustafa Ark

https://doi.org/10.18663/tjcl.1745156

Abstract

The phenomenon of cellular senescence, which inevitably occurs as a result of chemotherapy, which is the basis of today's cancer treatment, has been a subject of increasing interest in recent years. This article aims to methodologically examine how cellular senescence is induced by chemotherapeutic agents and how this condition is detected in patients who are receiving or have received treatment. How senescent cells induced by chemotherapy during cancer treatment are determined, which biomarkers are used to detect senescence, and the methods used to detect these markers are discussed. In addition, the effects of senescent cells on the tumor microenvironment and the important clinical outcomes that may occur in patients with treatment are examined. In conclusion, in this review, we aimed to examine the clinical importance of cellular senescence induced by chemotherapy in cancer patients, how it may affect the response to chemotherapy, the side effects and long-term clinical outcomes it may cause in patients and possible new treatment methods to prevent potential adverse consequences.

Keywords

senescence , cancer , chemotherapy , biomarker , clinic , tumor

Ethical Statement

Not applicable.

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Kemoterapi ile İndüklenen Hücresel Senesens: Klinik Yöntemler ve Tedavi Sonuçlarının Kapsamlı Bir İncelemesi

Year 2025, Volume: 16 Issue: 3, 653 - 664, 30.09.2025

Fatma Özge Yağbasan , Yaprak Dilber Şimay Demir , Mustafa Ark

https://doi.org/10.18663/tjcl.1745156

Abstract

Günümüz kanser tedavisinin temelini oluşturan kemoterapinin kaçınılmaz bir sonucu olarak ortaya çıkan hücresel senesens olgusu, son yıllarda artan bir ilgiyle araştırılmaktadır. Bu makalede, kemoterapötik ajanlar tarafından hücresel senesens'in nasıl indüklendiği ve bu durumun tedavi almakta olan ya da tedavi almış hastalarda nasıl tespit edildiği yöntemsel olarak incelenmiştir. Kanser tedavisi sırasında kemoterapiye bağlı olarak gelişen senesens hücrelerin nasıl belirlendiği, senesens'in tespitinde kullanılan biyobelirteçler ve bu belirteçleri saptamada kullanılan yöntemler tartışılmıştır. Ayrıca, senesens hücrelerin tümör mikroçevresi üzerindeki etkileri ve tedavi gören hastalarda ortaya çıkabilecek önemli klinik sonuçlar değerlendirilmiştir. Sonuç olarak, bu derlemede kemoterapiye bağlı olarak gelişen hücresel senesens'in kanser hastalarındaki klinik önemini, kemoterapiye yanıtı nasıl etkileyebileceğini, hastalarda oluşturabileceği yan etkiler ile uzun vadeli klinik sonuçlarını ve potansiyel olumsuz sonuçları önlemeye yönelik yeni tedavi yöntemlerini incelemeyi amaçladık.

Keywords

senesens , kanser , kemoterapi , biyobelirteç , klinik , tümör

Ethical Statement

Not applicable

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Primary Language	English
Subjects	Clinical Pharmacology and Therapeutics, Cancer Cell Biology, Cancer Diagnosis, Predictive and Prognostic Markers
Journal Section	Revıew Artıcle
Authors	Fatma Özge Yağbasan 0000-0002-5289-9949 Yaprak Dilber Şimay Demir 0000-0002-8248-0268 Mustafa Ark 0000-0003-2707-5531
Publication Date	September 30, 2025
Submission Date	July 17, 2025
Acceptance Date	September 21, 2025
Published in Issue	Year 2025 Volume: 16 Issue: 3

Cite

APA	Yağbasan, F. Ö., Şimay Demir, Y. D., & Ark, M. (2025). Chemotherapy-Induced Cellular Senescence: A Comprehensive Review of Clinical Methodologies and Treatment Outcomes. Turkish Journal of Clinics and Laboratory, 16(3), 653-664. https://doi.org/10.18663/tjcl.1745156
AMA	Yağbasan FÖ, Şimay Demir YD, Ark M. Chemotherapy-Induced Cellular Senescence: A Comprehensive Review of Clinical Methodologies and Treatment Outcomes. TJCL. September 2025;16(3):653-664. doi:10.18663/tjcl.1745156
Chicago	Yağbasan, Fatma Özge, Yaprak Dilber Şimay Demir, and Mustafa Ark. “Chemotherapy-Induced Cellular Senescence: A Comprehensive Review of Clinical Methodologies and Treatment Outcomes”. Turkish Journal of Clinics and Laboratory 16, no. 3 (September 2025): 653-64. https://doi.org/10.18663/tjcl.1745156.
EndNote	Yağbasan FÖ, Şimay Demir YD, Ark M (September 1, 2025) Chemotherapy-Induced Cellular Senescence: A Comprehensive Review of Clinical Methodologies and Treatment Outcomes. Turkish Journal of Clinics and Laboratory 16 3 653–664.
IEEE	F. Ö. Yağbasan, Y. D. Şimay Demir, and M. Ark, “Chemotherapy-Induced Cellular Senescence: A Comprehensive Review of Clinical Methodologies and Treatment Outcomes”, TJCL, vol. 16, no. 3, pp. 653–664, 2025, doi: 10.18663/tjcl.1745156.
ISNAD	Yağbasan, Fatma Özge et al. “Chemotherapy-Induced Cellular Senescence: A Comprehensive Review of Clinical Methodologies and Treatment Outcomes”. Turkish Journal of Clinics and Laboratory 16/3 (September2025), 653-664. https://doi.org/10.18663/tjcl.1745156.
JAMA	Yağbasan FÖ, Şimay Demir YD, Ark M. Chemotherapy-Induced Cellular Senescence: A Comprehensive Review of Clinical Methodologies and Treatment Outcomes. TJCL. 2025;16:653–664.
MLA	Yağbasan, Fatma Özge et al. “Chemotherapy-Induced Cellular Senescence: A Comprehensive Review of Clinical Methodologies and Treatment Outcomes”. Turkish Journal of Clinics and Laboratory, vol. 16, no. 3, 2025, pp. 653-64, doi:10.18663/tjcl.1745156.
Vancouver	Yağbasan FÖ, Şimay Demir YD, Ark M. Chemotherapy-Induced Cellular Senescence: A Comprehensive Review of Clinical Methodologies and Treatment Outcomes. TJCL. 2025;16(3):653-64.

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