The Role of Oxidative Stress in Recurrent Pregnancy Loss

Abstract

Objective: To determine the role of oxidative stress in recurrent pregnancy loss by using using a novel automated method Material and Method: Thirty first trimester pregnant women with history of recurrent pregnancy loss (RPL) and 30 healthy pregnant women were enrolled in this prospective controlled study. The levels of total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) in maternal serum were measured by using the more recently designated Erel method. Results: We observed statistically significant increased TOS and OSI levels in patient group (p=0.032, p=0.007 respectively). We also demonstrated statistically significant decreased TAS level in pregnant women who had history of RPL (p=0.013). Conclusion: Our results support the concept that oksidative stress plays a central role in the etiopathogenesis of RPL. Further studies to evaluate the predictive role of TAS, TOS, OSI level by using Erel method are needed. Key words: Recurrent Pregnancy Loss, Oxidative Stress.

Keywords

• Recurrent Pregnancy Loss, Oxidative Stress.

Tekrarlayan Gebelik Kayıplarının Etyopatogenezinde Oksidatif Stresin Rolü

Öz

Amaç: Tekrarlayan Gebelik Kaybı (TGK) etyopatogenezinde oksidatif stresin rolünün değerlendirilmesi. Gereç ve Yöntem: TGK izlenen 30 gebe ve sağlıklı 30 gebede Total Oksidan Seviye (TOS), Total Antioksidan Kapasite (TAK) ve Oksidatif Stres İndeksi (OSI) değerleri özgün, tam otomatik bir ölçüm yöntemi olan Erel metoduyla ölçülmüştür. Bulgular: TGK izlenen hasta grubunda TOS ve OSI değerleri istatistiksel olarak anlamlı ölçüde yüksek izlenirken (p=0.032, p=007), TAK değeri anlamlı ölçüde düşük olarak gözlenmiştir (p=0.013). Sonuç: TGK etypatogenezinde artmış oksidan seviye ve azalmış antioksidan kapasitenin rolü bulunmaktadır. Gelecekte TAK, TOS, OSI değerlerinin TGK prediksiyonundaki yerini ortaya koyabilecek yeni prospektif çalışmalara ihtiyaç vardır. Anahtar kelimeler: Tekrarlayan Gebelik Kaybı; Oksidatif Stres.

Anahtar Kelimeler

• Tekrarlayan Gebelik Kaybı; Oksidatif Stres.

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