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The Investigation of Effect Mechanism, Chemical Structure and Toxicokinetics Properties of Dioxins Compounds

Year 2010, Volume: 17 Issue: 4, 413 - 422, 01.08.2010

Abstract

Dioxin compounds are environmental pollutants that have a wide range of diffusion and that are harmful for human and animal health. The dioxin compounds are formed by some chemical process and high temperature. They are taken by human beings through animal products and then stored in fat tissues. The dioxin compounds have many side effects including immune system disrupts, chloracne, wasting syndrome, endocrine and reproductive toxicity as well as cancer. As considered the risks of dioxins which may affect the public health, it is important to learn about the sources, chemical structures, effect mechanisms, toxicity, the daily intake rates, and toxicokinetics properties of dioxins. Key words: Dioxin; 2,3,7,8-TCDD; PCDD; PCDF; PCB.

References

  • McKay G. Dioxin characterization, formation and minimization during municipal solid waste (MSW) incineration: Rev Chem Engineer Jour. 2002;86:343-68.
  • Ministry of Health and Welfare (Japan) Interin Report of Studies on Dioxsin Risk Assessment (in japanese), 1996.
  • Pohjanvirta R, Tuomisto J. Short-term toxicity of 2,3,7,8- tetrachlorodibenzo-p-dioxin in laboratory animals: effects, mechanisms and animal models. Pharmacol Rev 1994;46:483- 549.
  • WHO Executive Summary Report of ‘ Assessment of health risks of dioxins; re-evaluation of the tolerable daily intake (TDI), 1998.
  • Environment Agency (Japan) Dioxin Risk assessment Committee Report (in japanese), 1997.
  • Dioxins FactSheet Published by The Instituation of Electirical Engineers Savoy Place (IEE). London WC2R 0BL November 2001, Second edition January 2003.
  • Lavric ED, Konnov AA, Ruyck JD. Surrogate Compounds for Dioxins in Incineration. Rev. Waste Management, 2005;25:755- 65.
  • Siewers S, Schact U. Untersuchungen zur dioxinne-bildungbeim compostierungprozess-unter realen bedingungen, Organohalogen Comp 1994;18:180-5.
  • Beukens A, Huang H, Stieglitz L. Dioxins from the sintering process. 1. particle charecteristation and SEM/ wet analysis of samples. Organohalogen Comp 1999;41:109-12.
  • Papadopoulos A, Vassiliadou I, Costopoulos D, Papanicolaou C, Leondiadis L. Levels of dioxins and dioxin like PCBs in food simples on the greek market. Chemosphere 2003;57:5:413-9.
  • European Commission meeting at Brussels july. Fact Sheet on dioxin in feed and food. Publishedon 2001.
  • IARC (ed) IARC Working Group on the evaluation carcinogenic risks to humans: Polychlorinated dibenzo-para- dioxins an dibenzofurans. Lyon, France, 4-11 February 1997 vol. 69. IARC Monogr Eval Carcinog Risks Hum 1997.
  • Mimura J, Yamashita K, Nakamura K, Morita M, Takagi TN, Nakao K, Ema M, Sogawa K, Yasuda M, Katsuki M, Fuji- Kuriyama Y. Loss of teratogenic response to 2,3,7,8-TCDD in mice lacking the Ah receptor. Genes to Cells 1997;2:645-54.
  • Hahn ME. Aryl Hidrocarbon receptors: diversty and evaluation. Chem Biol Interact 2002;141:131-160.
  • Okey AB, Franc MA, Moffat ID, Tijet N, Boutros PC, Korkalainen M, Tuomisto J, Pohjanvirta R. Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: The case aryl hydrocarbon receptor. Toxicol App Pharmacol 2005; 207:43-51.
  • Jonosek J, Hilscherova K, Blaha L, Holoubek I. Environmental xenobiotics and nuclear receptors- Interactions, effects and in vitro assessment. Toxicology in vitro. 2005.
  • Riddick DS, Lee C, Bhathena A, Timsit YE, Cheng PY, Morgan ET, Prough RA, Ripp SL, Miller KK, Jahan A, Chiang JY. Transcriptional suppression of cytochrome P450 genes by endogeneous and exogeneous chemicals. Drug Metab Dispos 2004;32:367-75. 1 PCDD
  • (Poliklorlu dibenzo-para dioksinler) 1 0.1 0.1 0.1 0.01 0.0001 0.1 0.05 0.5 0.1 0.1 0.1 0.1 0.01 0.01 0.0001 0.0001 0.0001 0.1 0.01 0.0001 0.0005 0.0001 0.0001 0.0005 0.0001 0.00001 0.0001

Dioksinli Bileşiklerin Etki Mekanizması, Kimyasal Yapısı ve Toksikokinetik Özelliklerinin İncelenmesi

Year 2010, Volume: 17 Issue: 4, 413 - 422, 01.08.2010

Abstract

Dioksinli bileşikler geniş yayılım alanına sahip, doğada kararlı durumda bulunan, insan ve hayvan sağlığı açısından son derece zehirli çevresel kirleticilerdir. Kimyasal olaylara ve yüksek ısıya bağlı olarak oluşan dioksinli bileşikler özellikle hayvansal gıdalar aracılığı ile insanlar tarafından alınmakta ve yağ dokuda depolanmaktadır. Bu bileşikler, insanlarda kanser başta olmak üzere immunsistem bozuklukları, kloroakne, Wasting sendromu, hormon ve üreme sistemi fonksiyon bozuklukları gibi birçok yan etkiye neden olmaktadır. Toplum sağlığı açısından oluşturabilecekleri riskler göz önüne alınarak, dioksinli bileşiklerin kaynakları, kimyasal yapıları, etki mekanizmaları, zehirlilikleri, kabul edilebilir günlük alım miktarları ve bazı toksikokinetik özelliklerinin bilinmesi oldukça önemlidir. Anahtar kelimeler: Dioksin; 2,3,7,8-TCDD; PCDD; PCDF; PCB.

References

  • McKay G. Dioxin characterization, formation and minimization during municipal solid waste (MSW) incineration: Rev Chem Engineer Jour. 2002;86:343-68.
  • Ministry of Health and Welfare (Japan) Interin Report of Studies on Dioxsin Risk Assessment (in japanese), 1996.
  • Pohjanvirta R, Tuomisto J. Short-term toxicity of 2,3,7,8- tetrachlorodibenzo-p-dioxin in laboratory animals: effects, mechanisms and animal models. Pharmacol Rev 1994;46:483- 549.
  • WHO Executive Summary Report of ‘ Assessment of health risks of dioxins; re-evaluation of the tolerable daily intake (TDI), 1998.
  • Environment Agency (Japan) Dioxin Risk assessment Committee Report (in japanese), 1997.
  • Dioxins FactSheet Published by The Instituation of Electirical Engineers Savoy Place (IEE). London WC2R 0BL November 2001, Second edition January 2003.
  • Lavric ED, Konnov AA, Ruyck JD. Surrogate Compounds for Dioxins in Incineration. Rev. Waste Management, 2005;25:755- 65.
  • Siewers S, Schact U. Untersuchungen zur dioxinne-bildungbeim compostierungprozess-unter realen bedingungen, Organohalogen Comp 1994;18:180-5.
  • Beukens A, Huang H, Stieglitz L. Dioxins from the sintering process. 1. particle charecteristation and SEM/ wet analysis of samples. Organohalogen Comp 1999;41:109-12.
  • Papadopoulos A, Vassiliadou I, Costopoulos D, Papanicolaou C, Leondiadis L. Levels of dioxins and dioxin like PCBs in food simples on the greek market. Chemosphere 2003;57:5:413-9.
  • European Commission meeting at Brussels july. Fact Sheet on dioxin in feed and food. Publishedon 2001.
  • IARC (ed) IARC Working Group on the evaluation carcinogenic risks to humans: Polychlorinated dibenzo-para- dioxins an dibenzofurans. Lyon, France, 4-11 February 1997 vol. 69. IARC Monogr Eval Carcinog Risks Hum 1997.
  • Mimura J, Yamashita K, Nakamura K, Morita M, Takagi TN, Nakao K, Ema M, Sogawa K, Yasuda M, Katsuki M, Fuji- Kuriyama Y. Loss of teratogenic response to 2,3,7,8-TCDD in mice lacking the Ah receptor. Genes to Cells 1997;2:645-54.
  • Hahn ME. Aryl Hidrocarbon receptors: diversty and evaluation. Chem Biol Interact 2002;141:131-160.
  • Okey AB, Franc MA, Moffat ID, Tijet N, Boutros PC, Korkalainen M, Tuomisto J, Pohjanvirta R. Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: The case aryl hydrocarbon receptor. Toxicol App Pharmacol 2005; 207:43-51.
  • Jonosek J, Hilscherova K, Blaha L, Holoubek I. Environmental xenobiotics and nuclear receptors- Interactions, effects and in vitro assessment. Toxicology in vitro. 2005.
  • Riddick DS, Lee C, Bhathena A, Timsit YE, Cheng PY, Morgan ET, Prough RA, Ripp SL, Miller KK, Jahan A, Chiang JY. Transcriptional suppression of cytochrome P450 genes by endogeneous and exogeneous chemicals. Drug Metab Dispos 2004;32:367-75. 1 PCDD
  • (Poliklorlu dibenzo-para dioksinler) 1 0.1 0.1 0.1 0.01 0.0001 0.1 0.05 0.5 0.1 0.1 0.1 0.1 0.01 0.01 0.0001 0.0001 0.0001 0.1 0.01 0.0001 0.0005 0.0001 0.0001 0.0005 0.0001 0.00001 0.0001
There are 18 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Osman Çiftçi This is me

Publication Date August 1, 2010
Published in Issue Year 2010 Volume: 17 Issue: 4

Cite

APA Çiftçi, O. (2010). Dioksinli Bileşiklerin Etki Mekanizması, Kimyasal Yapısı ve Toksikokinetik Özelliklerinin İncelenmesi. Journal of Turgut Ozal Medical Center, 17(4), 413-422.
AMA Çiftçi O. Dioksinli Bileşiklerin Etki Mekanizması, Kimyasal Yapısı ve Toksikokinetik Özelliklerinin İncelenmesi. J Turgut Ozal Med Cent. August 2010;17(4):413-422.
Chicago Çiftçi, Osman. “Dioksinli Bileşiklerin Etki Mekanizması, Kimyasal Yapısı Ve Toksikokinetik Özelliklerinin İncelenmesi”. Journal of Turgut Ozal Medical Center 17, no. 4 (August 2010): 413-22.
EndNote Çiftçi O (August 1, 2010) Dioksinli Bileşiklerin Etki Mekanizması, Kimyasal Yapısı ve Toksikokinetik Özelliklerinin İncelenmesi. Journal of Turgut Ozal Medical Center 17 4 413–422.
IEEE O. Çiftçi, “Dioksinli Bileşiklerin Etki Mekanizması, Kimyasal Yapısı ve Toksikokinetik Özelliklerinin İncelenmesi”, J Turgut Ozal Med Cent, vol. 17, no. 4, pp. 413–422, 2010.
ISNAD Çiftçi, Osman. “Dioksinli Bileşiklerin Etki Mekanizması, Kimyasal Yapısı Ve Toksikokinetik Özelliklerinin İncelenmesi”. Journal of Turgut Ozal Medical Center 17/4 (August 2010), 413-422.
JAMA Çiftçi O. Dioksinli Bileşiklerin Etki Mekanizması, Kimyasal Yapısı ve Toksikokinetik Özelliklerinin İncelenmesi. J Turgut Ozal Med Cent. 2010;17:413–422.
MLA Çiftçi, Osman. “Dioksinli Bileşiklerin Etki Mekanizması, Kimyasal Yapısı Ve Toksikokinetik Özelliklerinin İncelenmesi”. Journal of Turgut Ozal Medical Center, vol. 17, no. 4, 2010, pp. 413-22.
Vancouver Çiftçi O. Dioksinli Bileşiklerin Etki Mekanizması, Kimyasal Yapısı ve Toksikokinetik Özelliklerinin İncelenmesi. J Turgut Ozal Med Cent. 2010;17(4):413-22.