The Investigation of Effect Mechanism, Chemical Structure and Toxicokinetics Properties of Dioxins Compounds
Öz
Dioxin compounds are environmental pollutants that have a wide range of diffusion and that are harmful for human and animal health. The dioxin compounds are formed by some chemical process and high temperature. They are taken by human beings through animal products and then stored in fat tissues. The dioxin compounds have many side effects including immune system disrupts, chloracne, wasting syndrome, endocrine and reproductive toxicity as well as cancer. As considered the risks of dioxins which may affect the public health, it is important to learn about the sources, chemical structures, effect mechanisms, toxicity, the daily intake rates, and toxicokinetics properties of dioxins. Key words: Dioxin; 2,3,7,8-TCDD; PCDD; PCDF; PCB.
Anahtar Kelimeler
Kaynakça
- McKay G. Dioxin characterization, formation and minimization during municipal solid waste (MSW) incineration: Rev Chem Engineer Jour. 2002;86:343-68.
- Ministry of Health and Welfare (Japan) Interin Report of Studies on Dioxsin Risk Assessment (in japanese), 1996.
- Pohjanvirta R, Tuomisto J. Short-term toxicity of 2,3,7,8- tetrachlorodibenzo-p-dioxin in laboratory animals: effects, mechanisms and animal models. Pharmacol Rev 1994;46:483- 549.
- WHO Executive Summary Report of ‘ Assessment of health risks of dioxins; re-evaluation of the tolerable daily intake (TDI), 1998.
- Environment Agency (Japan) Dioxin Risk assessment Committee Report (in japanese), 1997.
- Dioxins FactSheet Published by The Instituation of Electirical Engineers Savoy Place (IEE). London WC2R 0BL November 2001, Second edition January 2003.
- Lavric ED, Konnov AA, Ruyck JD. Surrogate Compounds for Dioxins in Incineration. Rev. Waste Management, 2005;25:755- 65.
- Siewers S, Schact U. Untersuchungen zur dioxinne-bildungbeim compostierungprozess-unter realen bedingungen, Organohalogen Comp 1994;18:180-5.
- Beukens A, Huang H, Stieglitz L. Dioxins from the sintering process. 1. particle charecteristation and SEM/ wet analysis of samples. Organohalogen Comp 1999;41:109-12.
- Papadopoulos A, Vassiliadou I, Costopoulos D, Papanicolaou C, Leondiadis L. Levels of dioxins and dioxin like PCBs in food simples on the greek market. Chemosphere 2003;57:5:413-9.
- European Commission meeting at Brussels july. Fact Sheet on dioxin in feed and food. Publishedon 2001.
- IARC (ed) IARC Working Group on the evaluation carcinogenic risks to humans: Polychlorinated dibenzo-para- dioxins an dibenzofurans. Lyon, France, 4-11 February 1997 vol. 69. IARC Monogr Eval Carcinog Risks Hum 1997.
- Mimura J, Yamashita K, Nakamura K, Morita M, Takagi TN, Nakao K, Ema M, Sogawa K, Yasuda M, Katsuki M, Fuji- Kuriyama Y. Loss of teratogenic response to 2,3,7,8-TCDD in mice lacking the Ah receptor. Genes to Cells 1997;2:645-54.
- Hahn ME. Aryl Hidrocarbon receptors: diversty and evaluation. Chem Biol Interact 2002;141:131-160.
- Okey AB, Franc MA, Moffat ID, Tijet N, Boutros PC, Korkalainen M, Tuomisto J, Pohjanvirta R. Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: The case aryl hydrocarbon receptor. Toxicol App Pharmacol 2005; 207:43-51.
- Jonosek J, Hilscherova K, Blaha L, Holoubek I. Environmental xenobiotics and nuclear receptors- Interactions, effects and in vitro assessment. Toxicology in vitro. 2005.
- Riddick DS, Lee C, Bhathena A, Timsit YE, Cheng PY, Morgan ET, Prough RA, Ripp SL, Miller KK, Jahan A, Chiang JY. Transcriptional suppression of cytochrome P450 genes by endogeneous and exogeneous chemicals. Drug Metab Dispos 2004;32:367-75. 1 PCDD
- (Poliklorlu dibenzo-para dioksinler) 1 0.1 0.1 0.1 0.01 0.0001 0.1 0.05 0.5 0.1 0.1 0.1 0.1 0.01 0.01 0.0001 0.0001 0.0001 0.1 0.01 0.0001 0.0005 0.0001 0.0001 0.0005 0.0001 0.00001 0.0001
Dioksinli Bileşiklerin Etki Mekanizması, Kimyasal Yapısı ve Toksikokinetik Özelliklerinin İncelenmesi
Öz
Dioksinli bileşikler geniş yayılım alanına sahip, doğada kararlı durumda bulunan, insan ve hayvan sağlığı açısından son derece zehirli çevresel kirleticilerdir. Kimyasal olaylara ve yüksek ısıya bağlı olarak oluşan dioksinli bileşikler özellikle hayvansal gıdalar aracılığı ile insanlar tarafından alınmakta ve yağ dokuda depolanmaktadır. Bu bileşikler, insanlarda kanser başta olmak üzere immunsistem bozuklukları, kloroakne, Wasting sendromu, hormon ve üreme sistemi fonksiyon bozuklukları gibi birçok yan etkiye neden olmaktadır. Toplum sağlığı açısından oluşturabilecekleri riskler göz önüne alınarak, dioksinli bileşiklerin kaynakları, kimyasal yapıları, etki mekanizmaları, zehirlilikleri, kabul edilebilir günlük alım miktarları ve bazı toksikokinetik özelliklerinin bilinmesi oldukça önemlidir. Anahtar kelimeler: Dioksin; 2,3,7,8-TCDD; PCDD; PCDF; PCB.
Anahtar Kelimeler
Kaynakça
- McKay G. Dioxin characterization, formation and minimization during municipal solid waste (MSW) incineration: Rev Chem Engineer Jour. 2002;86:343-68.
- Ministry of Health and Welfare (Japan) Interin Report of Studies on Dioxsin Risk Assessment (in japanese), 1996.
- Pohjanvirta R, Tuomisto J. Short-term toxicity of 2,3,7,8- tetrachlorodibenzo-p-dioxin in laboratory animals: effects, mechanisms and animal models. Pharmacol Rev 1994;46:483- 549.
- WHO Executive Summary Report of ‘ Assessment of health risks of dioxins; re-evaluation of the tolerable daily intake (TDI), 1998.
- Environment Agency (Japan) Dioxin Risk assessment Committee Report (in japanese), 1997.
- Dioxins FactSheet Published by The Instituation of Electirical Engineers Savoy Place (IEE). London WC2R 0BL November 2001, Second edition January 2003.
- Lavric ED, Konnov AA, Ruyck JD. Surrogate Compounds for Dioxins in Incineration. Rev. Waste Management, 2005;25:755- 65.
- Siewers S, Schact U. Untersuchungen zur dioxinne-bildungbeim compostierungprozess-unter realen bedingungen, Organohalogen Comp 1994;18:180-5.
- Beukens A, Huang H, Stieglitz L. Dioxins from the sintering process. 1. particle charecteristation and SEM/ wet analysis of samples. Organohalogen Comp 1999;41:109-12.
- Papadopoulos A, Vassiliadou I, Costopoulos D, Papanicolaou C, Leondiadis L. Levels of dioxins and dioxin like PCBs in food simples on the greek market. Chemosphere 2003;57:5:413-9.
- European Commission meeting at Brussels july. Fact Sheet on dioxin in feed and food. Publishedon 2001.
- IARC (ed) IARC Working Group on the evaluation carcinogenic risks to humans: Polychlorinated dibenzo-para- dioxins an dibenzofurans. Lyon, France, 4-11 February 1997 vol. 69. IARC Monogr Eval Carcinog Risks Hum 1997.
- Mimura J, Yamashita K, Nakamura K, Morita M, Takagi TN, Nakao K, Ema M, Sogawa K, Yasuda M, Katsuki M, Fuji- Kuriyama Y. Loss of teratogenic response to 2,3,7,8-TCDD in mice lacking the Ah receptor. Genes to Cells 1997;2:645-54.
- Hahn ME. Aryl Hidrocarbon receptors: diversty and evaluation. Chem Biol Interact 2002;141:131-160.
- Okey AB, Franc MA, Moffat ID, Tijet N, Boutros PC, Korkalainen M, Tuomisto J, Pohjanvirta R. Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: The case aryl hydrocarbon receptor. Toxicol App Pharmacol 2005; 207:43-51.
- Jonosek J, Hilscherova K, Blaha L, Holoubek I. Environmental xenobiotics and nuclear receptors- Interactions, effects and in vitro assessment. Toxicology in vitro. 2005.
- Riddick DS, Lee C, Bhathena A, Timsit YE, Cheng PY, Morgan ET, Prough RA, Ripp SL, Miller KK, Jahan A, Chiang JY. Transcriptional suppression of cytochrome P450 genes by endogeneous and exogeneous chemicals. Drug Metab Dispos 2004;32:367-75. 1 PCDD
- (Poliklorlu dibenzo-para dioksinler) 1 0.1 0.1 0.1 0.01 0.0001 0.1 0.05 0.5 0.1 0.1 0.1 0.1 0.01 0.01 0.0001 0.0001 0.0001 0.1 0.01 0.0001 0.0005 0.0001 0.0001 0.0005 0.0001 0.00001 0.0001
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Ağustos 2010 |
| Yayımlandığı Sayı | Yıl 2010 Cilt: 17 Sayı: 4 |