The Protective Effect of Melatonin on Plasma Lipid Profile in Rats with Cerulein-induced Acute Pancreatitis

Year 2019, Volume: 21 Issue: 2, 332 - 336, 15.09.2019

Ercan Keskin Deniz Uluışık

https://doi.org/10.15314/tsed.541829

Cited By: 2

Abstract

ABSTRACT

The objective of this study was to assessment
the effect of melatonin on lipid profile in rats with experimentally induced
acute pancreatitis. In this study, 32 adult, male, healthy Wistar Abino rats were
used. Group I animals was no applied.
Group II animals was intraperitoneally administered 50 mg/kg melatonin
per rat twice for two hours intervals. Animals
of group III received two intraperitoneal injections of cerulein (50 µg/kg and
25 µg/kg bw, respectively) at two hours
intervals. Animals of group IV
received two intraperitoneal injections of cerulein (50 µg/kg and 25 µg/kg bw,
respectively) at two hours intervals and
the rats received an intraperitoneal injection of 50 mg/kg melatonin 30 min
before each cerulein injection. After 12
hours from the last cerulein injection, total cholesterol, triglyceride, LDL, HDL
levels was determined. In this study,
experimentally induced acute pancreatitis resulted in significantly increase in
levels of total cholesterol, triglyceride and LDL (p<0.05), while HDL level
significantly decreased compared with control group level (p<0.05). Pretreatment of melatonin
to the rats with acute pancreatitis importantly reduced triglyceride and LDL
levels compared to pancreatitis group (p<0.05). In conclusion, melatonin pretreatment may alleviate
the abnormalities in plasma lipid profile caused by acute pancreatitis.

Keywords

Cerulein, melatonin, acute pancreatitis, lipid profile

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