FONKSİYONEL BİR ÜRÜN OLAN PROPOLİSİN SAĞLIK ÜZERİNE ETKİSİ

Year 2020, Volume: 20 Issue: 2, 189 - 208, 09.11.2020

Sultan Acun , Hülya Gül

https://doi.org/10.31467/uluaricilik.770477

Cited By: 5

Abstract

Propolis bal arıları tarafından çam, okaliptüs, akçaağaç, kavak, kestane, erik gibi ağaçların tomurcuk, yaprak ya da kabuk çatlaklarından topladığı bitki reçinelerinin mum ile karıştırılmasıyla üretilen ve kovanda çeşitli amaçlarla kullanılan bir arı ürünüdür. Yapısında bulunan galangin, luteolin, kafeik asit fenil ester, krisin, ferulik asit gibi biyolojik aktiviteye sahip bileşenler insan sağlığının korunmasında büyük öneme sahiptir. Günümüzde her altı kişiden birinin ölümüne sebep olan kanserin tedavisi ve iyileşme sürecinin desteklenmesinde propolisin faydası kanıtlanmıştır. Bunun yanında antimikrobiyal, antiviral, antifungal, antioksidan özelliği ile gıdaların korunması ve fonksiyonel özelliğinin arttırılmasına yardımcı olmaktadır. Bu faydalı özellikleri nedeniyle fonksiyonel gıda üretiminde, kozmetik sanayinde, ilaç sanayinde ve destekleyici bir tedavi olan apiterapide kullanılmaktadır.

Keywords

propolis, kanser, apiterapi, antimikrobiyal, antifungal

Supporting Institution

Süleyman Demirel Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

FDK-2019-6924

Thanks

Bu çalışma Süleyman Demirel Üniversitesi Bilimsel Araştırma Projeleri (SDÜ-BAP) Koordinasyon Birimi tarafından FDK-2019-6924 No’lu proje ile doktora tez çalışması kapsamında desteklenmiştir. Desteklerinden dolayı SDÜ-BAP birimine teşekkür ederiz.

The Effect of Propolis as a Functional Product on Health

Abstract

Propolis is used plant resins collected by honey bees from the buds, leaves or shell cracks of trees such as pine, eucalyptus, maple, poplar, chestnut, plum; wax is a bee product produced by mixing bees with various secretions and partially with pollen and used for various purposes in the hive. The components in its structure gave the propolis antimicrobial, antitumoral, antifungal and antiseptic properties. For this reason, it has been used for the healing of wounds, the treatment of dental caries or disinfection since ancient times. Today, the use of propolis, which is determined to support the immune system, has become more common. The availability of many products produced using propolis has also facilitated its usability. Products such as cream, lotion, and toothpaste produced in recent years contribute positively to the treatment of various diseases. Especially in recent years, the use of propolis in the treatment and recovery of cancer that causes the death of one out of every six people has drawn attention and many studies have been conducted on this subject. Propolis is also used in different areas such as healing wounds, eliminating dermatological problems, protecting oral and dental health. In this review, the healing and preventive effects of propolis are mentioned.

Keywords

Propolis, Cancer,, Apitherapy,, Antimicrobial,, Antifungal,

Project Number

FDK-2019-6924

References

• Abdelrazeg, S., Hussin, H., Salih, M., Shaharuddin, B. 2020. Propolis composition and applications in medicine and health, International Medical Journal, 25(3), 1505-1542.
• Akçora, B., Altuğ, ME., Hakverdi, S., Kontaş, S., Öztürk, A., Bayraktar S. 2010. Kısmi üreter obstrüksiyonu oluşturulan tavşanlara kafeik asit fenil ester’in böbrek hasarlanması üzerine etkileri. Journal of Experimental and Clinical Medicine,26, 163-168.
• Albayrak, S., Albayrak, S. 2008. Propolis: doğal antimikrobiyal madde. Ankara Eczacılık Fakültesi Dergisi, 37(3), 201-215.
• Alday, E., Valencia, D., Carreno, AL., Picerno, P., Piccinelli, AL., Rastrelli, L., Roblez-zepeda, R., Hernandez, J., Velazquez, C. 2015. Apoptotic induction by pinobanksin and some of its ester derivates from Sonoran propolisin a-B-Cell lymphoma cell line. Chemico-Biological Interactions, 242, 35-44. https://doi.org/10.1016/j.cbi.2015.09.013
• Aly, SA., Elewa, NA. 2007. The effect of Egyptian honeybee propolis on the growth of Aspergillus versicolor and sterigmatocystin biosynthesis in Ras cheese. The Journal of dairy research, 74(1), 74.
• Anjum, SI., Ullah, A., Khan, K., Attaullah, M., Khan, H., Ali, H., Bashir, MA., Tahir, M., Ansari, MJ., Ghramh, HA., Adgaba, N., Dash. C. K. 2019. Composition and functional properties of propolis (Bee Glue): A review. Saudi Journal of Biological Sciences, 26(7), 1695-1703. https://doi.org/10.1016/j.sjbs.2018.08.013
• Anonim, 2014. Geleneksel ve Tamamlayıcı Tıp Uygulamaları Yönetmeliği. TC Resmi Gazete. 29158. 27 Ekim 2014.
• Anonim, 2019. Türkiye’de kalp ve damar hastalıkları. TC Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü Bilgi Notu. 21 Haziran 2019.
• Apaydın, H. 2015. Propolisin Hazır çorbalardan elde edilen Staphylococcus aureus üzerine inhibisyon etkisi. Fen Bilimleri Enstitüsü. Yüksek Lisans Tezi. 67s. Tekirdağ.
• Arslan, AS., Birben, N., Seven, PT., Seven, İ. 2017. Arı ürünleri ve hayvan beslemede kullanımı. Uludağ Arıcılık Dergisi, 17(2),93-104. https://doi.org/10.31467/uluaricilik.372898
• Arslan, S., Perçin, D., Silici, S., Koç, AN., Er, Ö. 2010. Farklı çözücülerde hazırlanan propolis özütlerinin mutans streptokoklar üzerine in vitro antimikrobiyal etkisi, Sağlık Bilimleri Dergisi, 19(1), 68-73.
• Atik, A., Gümüş, T. 2017. Propolisin gıda endüstrisinde kullanım olanakları. Akademik Gıda, 15(1), 60-65. https://doi.org/10.24323/akademik-gida.306066
• Aydın, HE. 2013. Deneysel omurilik yaralanmasında metilprednizalon ve propolis etkinliğinin karşılaştırılması. Tıpta Uzmanlık Tezi, 65s. Eskişehir.
• Aydın, Y., Tekeoğlu, İ. 2018. Tamamlayıcı tıp ve güncel apiterapi uygulamaları. Journal of Biotechnology and Strategic Health Research, 2(2), 64-73.
• Bağdatlı, MN. 2019. Enkapsüle propolisin fonksiyonel gıda üretiminde kullanılması. Fen Bilimleri Enstitüsü. Yüksek Lisans Tezi. 76s. Malatya.
• Bahtiti, NH. 2013. Study of preservative effect of "propolis" on the storage quality of mashed potatoes. Food Science and Technology, 1(2), 17–20.
• Bakkaloğlu, Z., Arıcı, M. 2019. Farklı çözücülerle propolis ekstraksiyonunun toplam fenolik içeriği, antioksidan kapasite ve antimikrobiyal aktivite üzerine etkileri. Akademik Gıda, 17(4), 538-545. https://doi.org/10.24323/akademik-gida.667272
• Baltaş, N., Karaoğlu, AA., Tarakçı, C., Kolaylı S. 2016. Effect of propolis in gastric disorders: inhibition studies on the growth of Helicobacter pylori and production of its urease. Journal of Enzyme Inhibition and Medical Chemistry, 31(2), 46-50. https://doi.org/10.1080/14756366.2016.1186023
• Barroso, MV., Cattani-Cavalieri, I., Brito-Gtirana, L., Fautel, A., Lagente, V., Schmidt, M., Porto, LC., Romana-Souza, B., Valença, SS., Lanzetti, M. 2017. Propolis reserved cigarette smoke-induced emphysema through macrophage alternative activation independent of Nrf2. Bioorganic and Medicinal Chemistry, 25,5557-5568. https://doi.org/10.1016/j.bmc.2017.08.026
• Bayram, NE. 2015. Hakkari Bölgesi propolislerinin botanik orijininin ve kimyasal içeriğinin saptanması, Biyoloji Anabilim Dalı, İstanbul Üniversitesi Fen Bilimleri Enstitüsü, Doktora Tezi, 222 s., İstanbul.
• Bayram, R., Benek, BS., Gümüştekin, K., Yavuz, MZ., Benek, Ü., Kaya, E. 2015. Propolis tıbbi tedaviye destek olabilir mi? European Journal of Health Sciences, 1(3), 92-95.
• Bazmandegan, G., Boroushaki, MT., Shamsizadeh, A., Ayoobi, F., Hakimizadeh, E., Allahtavakoli, M. 2017. Brown propolis attenuates cerebral ischemia-induced oxidative damage via affecting antioxidant enzyme system in mice. Biomedicine and Pharmacotherapy, 85(2017), 503-510. http://dx.doi.org/10.1016/j.biopha.2016.11.057
• Bazmandegan, G., Shamsizadeh, A., FathiNajafi, M., Assadollahi, Z., Allahtavakoli, M., Kamiab, Z., Vakilian, A., Moghadam-Ahmadi, A., Amirteimoury, M., Boroushaki, MT. 2020. Iranian Brown propolis possesses neuroprotective effect aganist ischemic neuronal damage in mice. Journal of Herbmed Pharmacology, 9(2), 121-129. http://dx.doi.org/10.34172/jhp.2020.16
• Bhat, N., Bapat, S., Asawa, K., Tak, M., Chaturvedi, P., Gupta, VV., George, PP. 2015. The antiplaque efficacy of propolis-based herbal toothpaste: A crossover clinical study. Journal of Naturel Science, Biology and Medicine, 6(2), 364. https://doi.org/10.4103/0976-9668.160007
• Bigliardi, B., Galati, F. 2013. Innovation trends in the food industry: the case of functional foods. Trends in Food Science and Technology, 31(2), 118-129. https://doi.org/10.1016/j.tifs.2013.03.006
• Biray, Ç., Gündüz, C., Yılmaz, B., Şahin, F., Topçuoğlu, N. 2006. Propolis ve etken maddeleri olan Kafeik Asit Fenetil Ester (CAPE) ve Sinnamik Asitin, insan T hücreli akut lenfoblastik lösemi hücre dizisi (CCRF-CEM)’de sitotoksik ve apoptotik etkinliğinin değerlendirilmesi. Ege Tıp Dergisi, 45(2), 83-92.
• Bogdanov, S. 2017. Propolis. Composition, health, medicine. A Review. Bee Product Science. Chapter 1.
• Braakhuis, A. 2019. Evidence on the health benefits of suplemental propolis. Nutrients, 11(11), 2705. https://doi.org/ 10.3390/nu11112705
• Budisan, L., Gulei, D., Jurj, A., Braicu, C., Zanoaga, O., Cojocneanu, R., Pop, L., Raduly, L., Barbat, A., Moldovan, A., Moldovan, C., Tigu, AB., Ionescu, C., Atanasov, AG., Irimie, A., Berindan-Neagoe, I. 2019. Inhibitory effects of CAPE and Kaempferol in colon cancer cell lines-possible implications in new therapeutic strategies. International Journal of Molecular Science, 20(5). 1199. https://doi.org/10.3390/ijms20051199
• Burdock, GA, 1998. Review of the biological properties and toxicity of bee propolis (propolis). Food and Chemical Toxicology, 36(4), 347-363. https://doi.org/10.1016/S0278-6915(97)00145-2
• Cao, G., Ying, P., Yan, B., Xue, W., Li, K., Shi, A., Sun, T., Yan, J., Hu, X., 2015. Pharmocokinetics, safety, and tolarability of single and multiple doses of pinocembrin injection administered intravenous in healthy subjects. Journal of Ethnopharmacology, 168, 31-36. https://doi.org/10.1016/j.jep.2015.03.041
• Castaldo, S., Capasso, F. 2002. Propolis, an old remedy used in modern medicine. Fitoterapia, 73 (1), 1-6. https://doi.org/10.1016/S0367-326X(02)00185-5
• Catchpole, O., Mitchell, K., Bloor, S., Davis, P., Suddes, A. 2018. Anti-gastrointestinal cancer activity of cyclodextrin-encapsulated propolis. Journal of Functional Foods, 41,1-8. https://doi.org/10.1016/j.jff.2017.12.023
• Cavacante de Farias, JH., Reis, AS., Araujo, AR., Araujo, MJAM., Assunçao, AKM., Cavacante de Farias, J., Fialho, EMS., Silva, LA., Costa, GC., Guerra, RNM., Riberio., MNS., Fernandes do Nascimento, FR. 2014. Effects of stigless bee propolis on experimental asthma. Evidence -Based Complementary and Alternative Medicine, 2014, 951478. https://doi.org/10.1155/2014/951478
• Celinska-Janowicz, K., Zareba, I., Lazarek, U., Teul, J., Tomczyk, M., Palka, J., Mityk, W. 2018. Constituents of propolis: chrysin, caffeic acid, p-coumaric acid, and ferulic acid induce PRODH/POX dependent apoptosis in human tongu squamous cell carcinoma cell (CAL-27). Frontiers in Pharmacology, 9, 336. https://doi.org/10.3389/fphar.2018.00336
• Chen, YW., Ye, SR., Ting, C., Yu, YH. 2018. Antibacterial activity of propolins from Taiwanese green propolis. Journal of Food and Drug Analysis, 26(2), 761-768. https://doi.org/10.1016/j.jfda.2017.10.002
• Chopra, S., Pillai, KK., Husain, SZ., Girl, DK. 1995. Propolis protects aganist Doxorubicin-induced myocardiopathy in rats. Experimental and Molecular Pathology, 62(3), 190-198. https://doi.org/10.1006/exmp.1995.1021
• Chu, K., Lu, W., Zhu, L., Shen, X., Huang, J. 2013. Cafeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pylori prptide deformylase activity. Biochemical and Biopysical Rresearch Communications, 435, 289-294 http://dx.doi.org/10.1016/j.bbrc.2013.04.026
• Cornara, L., Biagi, M., Xiao, J., Burlando, B. 2017. Therapeutic properties of bioactive compounds from different honeybee products. Frontiers in Pharmacology, 8. https://doi.org/10.3389/fphar.2017.00412
• Çağlayan, HZB., Ataoğlu, EE., Kibaroğlu, S. 2017. Nörolojide geleneksel ve tamamlayıcı tıp uygulamalarının etkinliğinin değerlendirilmesi. Turkish Journal Neurology, 24, 111-116. https://doi.org/10.4274/tnd.83357
• Çelik, G. 2016. Fonksiyonel yeni süt ürünleri; Propolis katkılı yoğurt ve ayran. Fen Bilimleri Enstitüsü. Yüksek Lisans Tezi, 75s. Tunceli.
• Doğan, N., Hayoğlu, İ. 2012. Propolis ve kullanım alanları. Harran Tarım ve Gıda Bilimleri Dergisi, 16(3), 39-48.
• Durmuş, M., Yılmaz, HR., Uz, E., Özçelik, N. 2008. The Effect of Caffeic Acid Phenethyl Ester (CAPE) treatment on levels of MDA, NO and antioxidant enzyme activities in retinas of Streptozotocin-induced diabetic rats. Turkish Journal of Medical Science, 38(6), 525-530.
• Ebeid, SA., El Moneim, NAA., El Benhawy, SA., Hussain, NG., Hussein, MI. 2016. Assessment of the radioprotective erffect of propolis in breast cancer patients undergoing radiotherapy. New perspective for an old honey bee product. Journal of Radiation Research and Applied Sciences, 9, 431-440. https://doi.org/10.1016/j.jrras.2016.06.001
• El-Demery, M., Elsebaie, EM., Zidan, N., Essa, R. 2016. Effıcıency of propolis and turmeric powders as natural preservatıves ın mınced beef. Journal of Food and Dairy Sciences, 7(1), 45-50.
• Elfiky, AA. 2020. Natural products may interfere with SARS-CoV-2 attachment to the host cell. Journal of Biomolecular Structure and Dynamics, 1-10.
• El-Seedi, HR., Khalifa, SAM., El-Wahed, AA., Gao, R., Guo, Z., Elrasheid, T., Zhao, C., Du, M., Farag, MA., Musharraf, SG., Abbas, G. 2020. Honeybee products: An updated rewiew of neurological actions. Trends in Food Science and Technology, 101,17-27. https://doi.org/10.1016/j.tifs.2020.04.026
• Escriche, I., Juan-Borrás, M. 2018. Standardizing the analysis of phenolic profile in propolis. Food Research International, 106, 834-841. https://doi.org/10.1016/j.foodres.2018.01.055
• Farooqui, T., Farooqui, AA. 2012. Beneficial effects of propolis on human health and neurological diseases. Front Biosci (Elite Ed), 4, 779-793.
• Folic, M., Nesic, V., Arsovic, N. 2020. Efficiancy of propolis N-acetylsistein on reduction on sypmtom severity of respiratory infection in children with adenoid hypertrophy. Journal of Pharmacy and Pharmacology, 8, 91-98. https://doi.org 10.17265/2328-2150/2020.04.001
• Fuliang, HU., Hepburn, HR., Xuan, H., Chen, M., Daya, S., Radloff, SE. 2005. Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabets mellitus. Pharmological Research, 51(2), 147-152. https://doi.org/10.1016/j.phrs.2004.06.011
• Gao, JX., Chen, HY., Lu, ZY. 2011. The Influence of Propolis on Bifidobacteria And Lactobacillus in Yogurt. Chinese Journal of Disinfection, (2), 21.
• Gargouri, W., Oses, SM., Fernandez-Muino, MA., Sancho, MT. 2019. Evaluation of bioactive compounds and biological activities of Tunusian propolis. Food Science and Technoloogy, 111, 328-336. https://doi.org/10.1016/j.lwt.2019.05.044
• Gargouri, W., Kammiun, R., Elleuche, M., Tlili, M., Kechaou, N., Ghoul-Mazgar, S. 2020. Effect of xylitol chewing gum enriched with propolis on dentin remineralization in vitro. Archives of Oral Biology, 112. https://doi.org/10.1016/j.archoralbio.2020.104684
• Ghebleh, F. 2019. Propolis ve kekik yağı katkılı kitosan kaplamanın tavuk göğüs eti kalitesi üzerine etkisi. Sağlık Billimleri Enstitüsü, Doktora Tezi. 65s. Erzurum.
• Granados-Pineda, J., Uribe-Uribe, N., Garcia-Lopez, P., Ramos-Godinez, MDP., Rivero-Cruz, JF., Perez-Rojas, JM. 2018. Effects of pinocembrin isolated from Mexican Brown propolis on diabetic nephropathy. Molecules, 23(4), 852. https://doi.org/10.3390/molecules23040852
• Güney, F. 2016. Bazı propolis özütlerinin meyveli yoğurtların biyokimyasal, fizikokimyasal ve raf ömrü üzerine etkilerinin araştırılması. Fen Bilimleri Enstitüsü, 85s, Ordu.
• Hochheim, S., Guedes, A., Faccin-Galhardi, L., Rechenchoski, DZ., Nozowa, C., Linhares, RE., da Silva Filho, HH., Rau, M., Siebert, DA., Micke, G., Cordova, CMM. 2019. Determination of phenolic profile by HPLC-ESI-MS/MS, antioxidant activity, in vitro cytotoxicity and anti-herpetic activity of propolis from the Brazilan native bee Melipona quadrifasciata. Brazilian Journal of Pharmacognosy, Revista Brasileira de Farmacognosia, 29,339-350. https://doi.org /10.1016/j.bjp.2018.12.010
• Imhof, M., Lipovac, M., Kurz, CH., Barta, J., Verhoeven, HC., Huber, JC. 2005. Propolis solution fort the treatment of chronic vaginitis. International Journal of Gynocology and Obstetrics. 89, 127-132. https://doi.org/10.1016/j.ijgo.2005.01.033
• İlhan, A., Koltuksuz, U, Özen, Uz, S., Ciralik, H., Akyol, O. 1999. The effects of caffeic acid phenethyl ester (CAPE) on spinal cord ischema/reperfusion injury in rabbits. European Journal of Cardio-Thoracic Surgery, 16(4), 458-463. https://doi.org /10.1016/s1010-7940(99)00246-8.
• Kabala-Dzik, A., Rzepecka-Stojko, A., Kubina, R., Jastrzebska-Stojko, Z., Stojko, R., Wojtyczka, RD., Stojko, J. 2017. Comparison of two components of propolis: caffeic acid (CA) and Caffeic Acid Phenethyl Ester (CAPE) induce apoptosis and cell cycle arrest od breast cancer cells MDA-MB-231. Molecules, 22(9), 1554. https://doi.org/10.3390/molecules22091554
• Kakoolaki, S., Talaş, ZS., Çakır, O., Çiftçi, O., Özdemir, İ. 2013. Role of propolis on oxidative stress in fish brain. Basic and Clinical Neuroscience, 4(2), 153-158.
• Kaldır, HM., Tatlı, E., Turgut, B., Vural, Ö. 2002. Doksorubisin’e bağlı kardiyotoksisite. Türkiye Klinikleri Kardiyoloji. 15 (6), 416-421.
• Kamatou, G., Sandasi, M., Tankeu, S., Vuuren, SV., Viljoen, A. 2019. Headspace analysis and characterisation of South African propolis volatile compounds using GCxGC–ToF–MS. Revista Brasileira de Farmacognosia, 29(3), 351-357. https://doi.org/10.1016/j.bjp.2018.12.002
• Katırcıoğlu, H., Mercan, N. 2006. Antimicrobial activity and chemical compositions of Turkish propolis from different regions. African Journal of Biotechnology, 5(11), 1151-1153.
• Keskin, M. 2018. Propolis ve özütlerinin kalite parametrelerinin belirlenmesi ve enkapsülasyonu, Fen Bilimleri Enstitüsü, Doktora Tezi, 100s, Trabzon.
• Keskin, M., Kolaylı, S. 2019. Propolis ekstraktlarının kalite parametreleri açısından karşılaştırılması. Uludağ Bee Journal, 19(1), 43-49. https://doi.org/10.31467/uluaricilik.568302
• Keskin, Ş., Yatanaslan, L., Karlıdağ, S. 2020. Anadolu’nun farklı illerinden toplanan propolis örneklerinin kimyasal karakterizasyonu. Uludag Bee Journal, 20(1). 81-88. https://doi.org/10.31467/uluaricilik.714317
• Kimoto, N., Hirose, M., Kawabe, M., Satot, T., Miyataka, H., Shirai, T. 1999. Post-initation effects of a super critical extract of propolis in a rat two-stage carcinogenesis model in female F344 rats. Cancer Letters, 147(1-2), 221-227.
• Koo, HJ., Lee, KR., Kim, HS., Lee, BM. 2019. Detoxification effects of aloe polysaccaride and propolis on the urinary excretion of metabolites in smokers. Food and Chemical Technology, 130, 99-108. https://doi.org/10.1016/j.fct.2019.05.029
• Kouidhi, B., Zmantar, T., Bakhrouf, A. 2010. Anti-cariogenic and anti-biofilms activity of Tunusian propolis extract and its potential protective effect aganist cancer cells proliferation. Anaerobe, 16, 566-571. https://doi.org/10.1016/j.anaerobe.2010.09.005
• Kumar, V., Dhanjal, JK., Kaul, SC., Wadhwa, R., Sundar, D. 2020. Withanone and caffeic acid phenethyl ester are predicted to interact with main protease (Mpro) of SARS-CoV-2 and inhibit its activity. Journal of Biomolecular Structure and Dynamics, (just-accepted), 1-17. https://doi.org/10.1080/07391102.2020.1772108
• Kumova, U., Korkmaz, A., Avcı, BC., Ceyran, G. 2002. Önemli bir arı ürünü: Propolis. Uludağ Arıcılık Dergisi, 2(2), 10-24.
• Kunrath, CA., Savoldi, DC., Mileski, JPF., Novello, CR., Alfaro, AT., Marchi, JF., Tonial, IB. 2017. Application and evaluation of propolis, the natural antioxidant in ıtalian type salami. Brazilan Journal Food Technology,20. http://dx.doi.org/10.1590/1981-6723.3516
• Kuropatnicki, AK., Szliszka, E., Krol, W. 2013. Historical aspects of propolis research in modern times. Evidence -Based Complementary and Alternative Medicine, 1, 964149. https://doi.org/ https://doi.org/
• Lavigne, JP., Vitrac, X., Bernard, L., Bruyere, F., Sotto, A. 2011. Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infections. Biomed Central Research Notes, 4(1), 522.
• Li, YJ., Lin, L., Yang, CW., Yu, CC. 2005. Acute renal failure induced by a Brazilian variety of propolis. American Journal of Kidney Diseases, 46(6), 125-129. https://doi.org/10.1053/j.ajkd.2005.08.028
• Liu, Y., Liang, X., Zhang, G., Kong, L., Peng, W., Zhang, H. 2018. Galangin and pinocembrin from propolis ameliorate insülin resistance in HepG2 cells via regulating Akt/mTOR signaling. Evidence -Based Complementary and Alternative Medicine, 7971842. https://doi.org/10.1155/2018/7971842
• Lotfy, M. 2006. Biological activity of bee propolis in health and disease. Asian Pacific Journal of Cancer Prevention, 7, 22-31.
• Ma, YZ., Li, L., Kong, LL., Zhu, ZM., Zhang, W., Song, JK., Chang, J., Du, GH. 2018 Pinocembrin protects blood-brain barrier function and expands the therapeutic time window for tissue-type plasminogen activator treatment in a rat thromboembolic stroke model. BioMed Research International, 2018, 8943210. https://doi.org/10.1155/2018/8943210
• Maaroufi, H. 2020. LxxIxE-like Motif in Spike Protein of SARS-CoV-2 that is Known to Recruit the Host PP2A-B56 Phosphatase Mimics Artepillin C, an Immunomodulator, of Brazilian Green Propolis. Biorewiev. https://doi.org/10.1101/2020.04.01.020941
• Mehmetoğlu, S. 2019. Propolis katkılı dondurmaların depolama süresince fizikokimyasal yapısının incelenmesi. Fen Bilimleri Enstitüsü, Yüksek Lisans Tezi, 75s. Ordu.
• Mehmetoğlu, S., Tarakçı, Z., Demirkol, M., Çakıcı, N., Güney, F. 2017. Gıda katkı maddesi olarak propolis. Arıcılık Araştırma Dergisi, 9(1), 32-39.
• Mirsadraee, M., Azmoon, B., Ghaffari, S., Abdolsamadi, A., Khazdair, MR. 2019. Effects of propolis on moderate persistent asthma: a phase two randomized, double blind, controlled clinical trial. Avicenna Journal of Phytoedicine. https://doi.org/10.22038/AJP.2020.15777
• Mohammad Ali, BM., Ghoname, NF., Hodeib, AA., Elbadawy, MA. 2015. Significance of topical propolis in the treatment of facial acne vulgaris. Egyptian Journal of Dermatology and Venereology, 35, 29-36. https://doi.org/10.4103/1110-6530.162468
• Mojarab, S., Shahbazzadeh, D., Moghbeli, M., Eshraghi, Y., Bagheri, KP., Rahimi, Savoji, MA., Mahdavi, M. 2020. Immune responses to HIV-1 polytope vaccine candidate formulated in aqueous and alcoholic extracts of Propolis: Comparable immune responses to Alum and Freund adjuvants. Microbial Pathogenesis, 140, 103932. https://doi.org/10.1016/j.micpath.2019.103932
• Mollahaliloğlu, S., Uğurlu, FG., Kalaycı, M., Öztaş, D. 2015. Geleneksel ve tamamlayıcı tıp uygulamalarında yeni dönem. Ankara Medikal Journal,15(2), 102-105. https://doi.org/10.17098/amj.44789
• Moreno, MA., Vallejo, AM., Ballester, AR., Zampini, C., Isla, MI., López-Rubio, A., Fabra, MJ. 2020. Antifungal edible coatings containing Argentinian propolis extract and their application in raspberries. Food Hydrocolloids, 105973. https://doi.org/10.1016/j.foodhyd.2020.105973
• Naz, S., Imran, M., Rauf, A., Orhan, IE., Shariati, MA., Ul-Haq, I., Yasmin, I., Shahbaz, M., Qaisrani, TB., Shah, ZA., Plygun, S., Heydari, M. 2019. Chrysin: Pharmacological and therapeutic properties. Life Sciences, 235, 116797. https://doi.org/10.1016/j.lfs.2019.116797
• Olegario, LS., Andrade, JKS., Andrade, GRS., Denadal, M., Cavalcanti, RL., Silva, MAAP., Narain, N. 2019. Chemical characterization of four brazilian brown propolis: an insight in tracking of its geographical location of production and quality control. Food Research International, 123, 481-502. https://doi.org/10.1016/j.foodres.2019.04.004
• Onur, E, Nalbantsoy, A., Kışla, D. 2018. İmmünoterapi ve propolisin kanser immünoterapisinde kullanım potansiyeli. Food and Health, 4(4), 231-246. https://doi.org/10.3153/FH18023
• Orsolic, N., Jurcevic, IL., Dikic, D., Rogic, DD., Odeh, D., Balta, V., Junakovic, EP., Terzic, S., Jutric, D. 2019. Effects of propolis on diet-induced hyperlipidemia and atherogenic indices in mice. Antioxidants, 8(6), 156. https://doi.org/10.3390/antiox8060156
• Padmavathi, R., Senthilnathan, P., Sakthisekaran, D. 2006. Therapeutic effect of propolis and propolis and paclitaxel on hepatic phase I and II enzymes and marker enzymes in Dimethylbenz(a)anthracene-Induced breast cancer in female rats. Comperative Biochemistry and Psysiology, 143, 349-354. https://doi.org/10.1016/j.cbpc.2006.03.009
• Pahlavani, N., Sedaghat, A., Moghaddam, AB., Shabnam, S., Kiapey, M., Navashenaq, JG., Jarahi, L., Reazvani, R., Norouzy, A., Nematy, M., Safarian, M., Ghayour-Mobarhan, M. 2019. Effect of propolis and melatonin on oxidative stress, ınflammation, and clinical status in patients with primary sepsis: study protocol and review on previous studies. Clinical Nutrition ESPEN, 33, 125-131. https://doi.org/10.1016/j.clnesp.2019.06.007
• Palaz, MN., Akçay, E., 2020. The impact of propolis factor caffeic acid phenethyl-ester on the cerebral vasospasm and early brain damage in the experimental induced subarachnoid herrhage on rats. World Neurosurgery, 138, 736-742. https://doi.org/10.1016/j.wneu.2020.03.058
• Patel, S. 2016. Emerging adjuvant therapy for cancer: Propolis and its constituents. Journal of Dietary Supplements, 13(3), 245-268. https://doi.org/10.3109/19390211.2015.1008614
• Pineros, AR., Lima, MHF., Rodrigues, T., Gembre, AF., Bertolini, TB., Fonseca, MD., Bernetta, AA., Ramalho LNZ., Cunha, FQ., Hori, JI., Bonato, VLD. 2020. Green propolis increases myeloid suppressor cells and CD4+ Foxp3+ cells and reduces Th2 inflammation in the lungs after allergen exposure. Journal of Ethnopharmacology, 252, 112496. https://doi.org/10.1016/j.jep.2019.112496
• Popova, M., Giannopoulou, E., Skalicka-Wo´zniak, K., Graikou, K., Widelski, J., Bankova, V., Kalofonos, H., Sivolapenko, G., Gawe-Beben, K, Antosiewicz, B., Chinou, I. 2017. Characterization and biological evaluation of propolis from Poland. Molecules, 22, 1159. https://doi.org/10.3390/molecules22071159
• Popova, M., Silici, S., Kaftanoğlu, O., Bankova, V. 2005. Antibacterial activity of Turkish propolis and its qualitative and quantitative chemical composition. Phytomedicine, 12, 221-228. https://doi:10.1016/j.phymed.2003.09.007
• Putra, RA., Prasetyo, DH., Pesik, RN. 2015. The effect of propolis’ ethanolic extract on serum malondialdehyde level of mice Balb/c induced by cigarette smoke. Nexus Biomedika, 4(1).
• Romeo, M., Freire, J., Pastene, E., Garcia, A., Aranda, M., Gonzales, C. 2019. Propolis phyphenolic compounds affect the viability and structure of Helicobacter pylori in vitro. Revista Brasilerira de Farmacognosia. 29(3), 325-332. https://doi.org/10.1016/j.bjp.2019.03.002
• Santos, DA., Munari, FM., Silva Frozza, CO., Moura, S., Barcellos, T., Henriques, JAP., Roesch-Ely, M. 2019. Brazilian red propolis extracts: study of chemical composition by ESI-MS/MS(ESI+) and cytotoxic profiles aganist colon cancer cell lines. Biotechnology Research and Innovation, 3, 120-130. https://doi.org/10.1016/j.biori.2019.02.001
• Seçilmiş Y., Silici, S. 2020. Bee product efficacy in children with upper respiratory tract infection. The Turkish Journal of Pediatrics, 62, 634-640. https://doi.org/10.24953/turkjped.2020.04.013
• Seven, PT., Baykalır, BG., Ak, TP., Seven, İ., Başak, N., Yaman, M. 2018. The protective effects of propolis aand flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues aganist excess copper in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 65, 395-406.
• Sforcin, JM. 2016. Biological propoerties and therapeutic applications of propolis. Phytotherapy Research, 30, 894-905. https://doi.org/10.1002/ptr.5605
• Silici, S., Güçlü, BK. 2018. Yumurtacı tavuk rasyonlarına propolis ve kafeik asit ilavesinin performans, yumurta kalitesi ve serum değişkenleri üzerine etkileri. Sağlık Bilimleri Dergisi, 27(3), 221-227.
• Silva Frozza, CO., Santos, DA., Rufatto, LC., Minetto, L., Scariot, FJ., Echeverrigaray, S., Pich, CT., Moura, S., Padilha, FF., Borsuk, S., Savegnago, L., Collares, T., Seixas, FK., Dellagostin, O., Roesch-Ely, M., Henriques, JAP. 2017. Antitumor activity of brazilian red propolis fractions hep-2 cancer cell line. Biomedicine and Pharmacotherapy, 91, 951-963. https://doi.org/10.1016/j.biopha.2017.05.027
• Spinelli, S., Conte, A., Lecce, L., Incoronato, L., Del Nobile, MA. 2015. Microencapsulated propolis to enhance the antioxidant properties of fresh fish burgers. Journal of Food Process Engineering, 38(6), 527-535. https://doi.org/10.1111/jfpe.12183
• Sun, G., Qiu, Z., Wang, W., Sui, X., Sui, D., 2016. Flavonoids extraction from propolis attenuates pathological cardiac hypertrophy through PI3K//AKT signaling pathway. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2016/6281376
• Sun, LP., Xu, X., Hwang, HH., Wang, X., Su, KY., Chen, YLS. 2016. Dichromethane extracts of propolis protect cell from oxygen-glucose deprivation-induced oxidative stress via reducing apoptosis. Food and Nutrition Research, 60(1), 1-10. https://doi.org/10.3402/fnr.v60.30081
• Sung, SH., Choi, GH., Lee, NW., Shin, BC 2017. External use of propolis oral, skin, and genital diseases: a systematic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine., 2017, 8025752. https://doi.org/10.1155/2017/8025752
• Tacconelli, E., Magrini, N., Singh, N. 2017. Global priority list of antibiotic-resistant bacteria. World Health Organization, Genece, 7s.
• Talaş, ZS., Özdemir, İ., Çiftçi, O., Çakır, O., Gülhan, MF., Paşaoğlu, OM. 2014. Role of propolis on biochemical parameters in kidney and heart tissues against l-NAME induced oxidative injury in rats. Clinical and Experimental Hypertension. 36 (7), 492-496. https://doi.org/10.3109/10641963.2013.863322
• Usman, ZU., Bakar, ABA., Mohamed, M. 2016. Phytochemical screening and comparison of antioxidant activity of water and ethanol extract propolis from Malaysia. International Journal of Pharmacy and Pharmaceutical Sciences, 8(5), 413-415.
• Vagish Kumar, LS. 2014. Propolis in Dentisry and oral cancer management. North American Journal of Medical Science. 6(6), 250-259. https://doi.org/10.4103/1947-2714.134369
• Vukovic, NL., Obradovic, AD., Vukic, MD., Jovanovic, D. 2018. Cytotoxic proapoptic and antioxidative potential of flavonoids isolated from propolis aganist colon (HTC-116) and breast (MDA-MB-231) cancer cell lines. Food Research International. 106, 71-80. https://doi.org/10.1016/j.foodres.2017.12.056
• Walgrave, SE., Warshaw, EM., Glesne, LA. 2005. Allergic contact dermatitis from propolis. Dermatitis, 16 (4), 209-215.
• Wu, JJ., Shen, CT., Jong, TT., Young, Chiu-Chung, Y., Yang, HL., Hsu, SL., Chang, CM., Shiesh, CJ. 2009. Supercritical carbon dioxide anti-solvent process for purification of micronized propolis particules and associated anti-cancer activity. Seperation and Purification Technology, 70, 190-198. https://doi.org/10.1016/j.seppur.2009.09.015
• Yang, W., Wu, Z., Huang, ZY., Miao, X. 2017. Preservation of orange juice using propolis. Journal of Food Science and Technology -Mysore- 54(11),1-9. https://doi.org/10.1007/s13197-017-2754-x
• Yılmaz, S., Kaya, E. 2018. Ratlarda siklofosfamid ile oluşturulmuş hemorajik sistitte propolis ve enginarın koruyucu etkileri. Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi. 32(2), 93-98
• Yücel, B., Topal, E., Akçiçek, E., Köseoğlu, M. 2014. Propolisin insan sağlığına etkisi. Anadolu Journal of Agean Agriculture Reserarch Institute, 24(2), 41-49.
• Zabaiou, N., Fouache, A., Trousson, A., Baron, S., Zellagui, A., Lahouel, M., Lobaccaro, JMA. 2017. Biological propoerties of propolis extrats: something new from an ancient product. Chemistry and Physics of Lipids, 207, 214-222. https://doi.org/10.1016/j.chemphyslip.2017.04.005