Egzersiz-Kaynaklı BDNF'nin Mental Sağlık Üzerindeki Etkisinin Değerlendirilmesi: Sistematik Derleme

Yıl 2023, , 115 - 124, 09.06.2023

Yakup Zühtü Birinci , Engin Sagdilek , Şenay Şahin

https://doi.org/10.32708/uutfd.1223655

Cited By: 1

Öz

Yaşam süresi uzadıkça mental hastalıklar daha yaygın sağlık sorunları haline gelerek hastaların ve ailelerinin refahını ve yaşam kalitesini oldukça azaltmaktadır. Bu patolojilerin başlamasını önlemek veya geciktirmek için etkili bir strateji olan düzenli egzersizin beyin-kaynaklı nörotrofik faktör (BDNF) gibi nöroprotektif nitelikli hücresel ve moleküler dolaşım faktörleri yoluyla beyin sağlığı üzerindeki faydaları tetiklediği düşünülmektedir. Bu nedenle, bu sistematik derleme, egzersiz kaynaklı BDNF’nin mental hastalıklar üzerindeki etkisine ilişkin güncel bilgileri özetlemeyi ve bu hastalıklara optimum fayda sağlayacak egzersiz programları oluşturmak için öneriler sunmayı amaçlamaktadır. Sistematik inceleme stratejisi, elektronik veri tabanı sistematik araştırmalarında bir metodoloji olarak spor bilimine uyarlanan raporlama maddeler bildirisi PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) yönergelerine uygun şekilde yürütülmüştür. Bu kapsamda oluşturulan dışlama ve dahil edilme kriterleri göz önünde bulundurularak sekiz tam metin çalışma değerlendirilmiştir. Bu çalışmadan elde edilen bulgular, en az dört hafta boyunca ve haftada 150 dakika orta şiddetli aerobik ve direnç egzersizlerinin ya da bu egzersizlerin halihazırda devam eden tedavilerle veya bilişsel egzersizlerle birlikte kullanılmasının mental sağlık üzerindeki olumlu etkilerine BDNF'deki artışların aracılık edebileceğini göstermektedir. Bu durum egzersizin, düşük BDNF seviyelerine sahip mental hastalığı olan bireyleri hedefleyebileceği hipotezlerini desteklemektedir. Sonuç olarak egzersiz kaynaklı BDNF düzeylerinin mental sağlıkla ilişkili standart tedavi müdahalelerinin etkinliğini geliştirebileceği ve klinik iyileşmeyle ilişkili potansiyel bir biyobelirteç olabileceği düşünülmektedir. Buna rağmen özellikle farklı şiddet ve sıklıklarda planlanan egzersiz türlerinin ya da kombinasyonlarının BDNF salınımını farklı şekilde etkiliyor oluşu bu çalışma sonuçlarına dayanarak mental sağlığı BDNF kaynaklı geliştirebilecek standart bir egzersiz programı oluşturmayı oldukça zorlaştırmaktadır.

Anahtar Kelimeler

BDNF, Depresyon, Egzersiz, Kaygı, Mental Sağlık

Destekleyen Kurum

Çalışma için destek alınmamıştır.

Teşekkür

Msc. Kadir Keskin, Dr. Hüseyin Topçu ve Dr. Serkan Pancar’ a teşekkür ederiz.

Assessing the Effect of Exercise-induced BDNF on Mental Health: A Systematic Review

Öz

As life expectancy increases, mental illnesses become more common health problems, significantly reducing patients' and their families' well-being and quality of life. Regular exercise is an effective strategy to prevent or delay the onset of these pathologies. It is thought to trigger benefits on brain health through neuroprotective cellular and molecular circulatory factors such as brain-derived neurotrophic factor (BDNF). Therefore, this systematic review aims to summarize the current literature on the effect of exercise-induced BDNF on mental disorders and provide recommendations for creating exercise programs to ensure optimum benefit. The systematic review strategy was conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines adapted for sports science. It was reported as a methodology in electronic database systematic research. Eight full-text studies were evaluated after the exclusion and inclusion criteria were conducted. Findings from this study suggest that increases in BDNF may mediate the positive effects on the mental health of 150 minutes of moderate-intensity aerobic and resistance exercise per week for at least four weeks or the use of these exercises in combination with ongoing treatments or cognitive exercises. It can support the hypothesis that exercise may target individuals with mental disorders who exhibit reduced BDNF production. In conclusion, exercise-induced BDNF levels may improve the effectiveness of standard treatment interventions related to mental health and may be a potential biomarker associated with clinical improvement. However, to the results of this study, the fact that exercise types or combinations planned at different intensities and frequencies affect BDNF release differently makes it very difficult to create a standard exercise program that can improve mental health on BDNF based.

Anahtar Kelimeler

anxiety, BDNF, Depression, Exercise, Mental Health

Kaynakça

• 1. Dishman RK, Berthoud HR, Booth FW, et al. Neurobiology of exercise. Obesity 2006;14(3):345-56.
• 2. Birinci YZ. Veteran sporcularda farklı tip akut egzersizin serum beyin kaynaklı nörotrofik faktör (BDNF) düzeyleri ve nörobilişsel işlevler üzerine etkisi (Doktora Tezi). Bursa: Bursa Uludağ Üniversitesi; 2021.
• 3. Sallis RE. Exercise is medicine and physicians need to prescribe it!. Br. J. Sport Med 2009;43(1):3-4.
• 4. Deslandes AC. Exercise and mental health: what did we learn in the last 20 years?. Front. Psychiatry 2014;5:66.
• 5. Albagmi FM, Alansari A, Al Shawan DS, AlNujaidi HY, Olatunji SO. Prediction of generalized anxiety levels during the Covid-19 pandemic: A machine learning-based modeling approach. Inform. Med. Unlocked 2022;28:100854.
• 6. Carmassi C, Dell’Osso L, Bertelloni CA et al. Three-Month Follow-up Study of Mental Health Outcomes after a National COVID-19 Lockdown: Comparing Patients with Mood or Anxiety Disorders Living in an Area with a Higher Versus Lower Infection Incidence. J Clin. Psychiatry 2022;83(2):39558.
• 7. Sothmann MS, Buckworth J, Claytor RP, et al. Exercise training and the cross-stressor adaptation hypothesis. Exerc. Sport Sci. Rev 1996;24(1):267-88.
• 8. Schuch FB, Vancampfort D, Firth J, et al. Physical activity and incident depression: a meta-analysis of prospective cohort studies. Am. J. Psychiatry, 2018;175(7):631-48.
• 9. McDowell CP, Dishman RK, Gordon BR. Herring MP. Physical activity and anxiety: a systematic review and meta-analysis of prospective cohort studies. Am. J. Prev. Med. 2019;57(4):545-56.
• 10. Blumenthal JA, Babyak MA, Moore KA, et al. Effects of exercise training on older patients with major depression. Arc. Intern. Med. 1999;159(19):2349-56.
• 11. Blumenthal JA, Babyak MA, Doraiswamy PM, et al. Exercise and pharmacotherapy in the treatment of major depressive disorder. Psychosomatic Med. 2007;69(7):587.
• 12. Jacob L, Tully MA, Barnett Y et al. The relationship between physical activity and mental health in a sample of the UK public: A cross-sectional study during the implementation of COVID-19 social distancing measures. Ment. Health Phys. Act. 2020;19:100345
• 13. Van Praag H, Kempermann G, Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 1999;2(3):266-70.
• 14. Gillan CM, Rutledge RB. Smartphones and the neuroscience of mental health. Annu. Rev. Neurosci. 2021;44:129-51.
• 15. Schuch FB, Deslandes AC, Stubbs B, et al. Neurobiological effects of exercise on major depressive disorder: a systematic review. Neurosci. Biobehav. Rev. 2016;61: 1-11.
• 16. Birinci YZ, Sagdilek E, Taymur I et al. Acute effects of different types of exercises on insulin-like growth factor-1, homocysteine and cortisol levels in veteran athletes. Medicine 2022;11(3):968-74.
• 17. Birinci YZ, Şahin Ş, Vatansever Ş, Pancar S. Yaşlılarda fiziksel egzersizin beyin kaynaklı nörotrofik faktör (bdnf) üzerine etkisi: deneysel çalışmaların sistematik derlemesi. Turk. J. Sports Med. 2019;54(4):276-87.
• 18. Birinci YZ. Spor Bilimlerinde Uluslararası Araştırmalar II. Egzersiz ve Beyin Sağlığı: Egzersiz-kaynaklı Nöroprotektif Hücresel ve Moleküler Mekanizmalar. Konya: Eğitim Yayınevi; 2022;25-50
• 19. Dinoff A, Herrmann N, Swardfager W, Lanctot KL.The effect of acute exercise on blood concentrations of brain‐derived neurotrophic factor in healthy adults: a meta‐analysis. Eur. J. Neurosci. 2017;46(1):1635-46.
• 20. Nagahara AH, Tuszynski MH. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat. Rev. Drug Discov 2011;10(3):209-19.
• 21. Molendijk ML, Spinhoven P, Polak, M et al. Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N= 9484). Mol. Psychiatry 2014;19(7):791-800.
• 22. Teche SP, Nuernberg GL, Sordi AO, et al. Measurement methods of BDNF levels in major depression: a qualitative systematic review of clinical trials. Psychiatric Q. 2013;84(4):485-97.
• 23. Fernandes BS, Gama CS, Ceresér KM, et al. Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis. J. Psychiatr. Res. 2011;45(8): 995-1004.
• 24. Fernandes BS, Steiner J, Berk M, et al. Peripheral brain-derived neurotrophic factor in schizophrenia and the role of antipsychotics: meta-analysis and implications. Mol. Psychiatry. 2015;20(9):1108-19.
• 25. Song X, Quan M, Lv L et al. Decreased cortical thickness in drug naive first episode schizophrenia: in relation to serum levels of BDNF. J. Psychiatr. Res. 2015;60:22-8.
• 26. Duman RS, Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol. Psychiatry 2006;59(12):1116-27.
• 27. Berton O, McClung CA, DiLeone RJ, et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 2006;311(5762):864-8.
• 28. Eisch AJ, Bolaños CA, De Wit J et al. Brain-derived neurotrophic factor in the ventral midbrain–nucleus accumbens pathway: a role in depression. Biol. Psychiatry, 2003;54(10):994-1005.
• 29. Schmitt K, Holsboer-Trachsler E, Eckert A. BDNF in sleep, insomnia, and sleep deprivation. Ann. Med. 2016;48(1-2):42-51.
• 30. Shirayama Y, Chen ACH, Nakagawa S, Russell DS, Duman RS. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J. Neurosci. 2002;22(8):3251-61.
• 31. Siuciak JA, Lewis DR, Wiegand SJ, Lindsay RM. Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav 1997;56(1):131-7.
• 32. Chen B, Dowlatshahi D, MacQueen GM, Wang JF, Young LT. Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol. Psychiatry 2001;50(4):260-5.
• 33. Martinowich K, Manji H, Lu B. New insights into BDNF function in depression and anxiety. Nat. Neurosci. 2007;10(9): 1089-93.
• 34. Green MJ, Matheson SL, Shepherd A, Weickert CS, Carr VJ. Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis. Mol. Psychiatry 2011;16(9):960-72.
• 35. Favalli G, Li J, Belmonte-de-Abreu P, Wong A H, Daskalakis ZJ. The role of BDNF in the pathophysiology and treatment of schizophrenia. J. Psychiatr. Res. 2012;46(1):1-11.
• 36. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst. Rev. 2021;10(1):1-11.
• 37. Rico-González M, Pino-Ortega J, Clemente F, Los Arcos A. Guidelines for performing systematic reviews in sports science. Biol. Sport 2022;39(2):463-71.
• 38. Liu Y, Yan T, Chu JMT et al. The beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases. Lab Invest. 2019; 99(7):943-57.
• 39. Krishnan V, Nestler EJ. The molecular neurobiology of depression. Nature 2008;455(7215):894-902.
• 40. Karege F, Perret G, Bondolfi G, et al. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res. 2002;109(2):143-8.
• 41. Polyakova M, Stuke K, Schuemberg K, et al. BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis. J. Affect. Disord. 2015;174:432-40.
• 42. Rantamäki T, Vesa L, Antila H, et al. Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. PloS one 2011;6(6):e20567.
• 43. Kurdi FN, Flora R. Physical exercise increased brain-derived neurotrophic factor in elderly population with depression. Open access Maced. J. Med. Sci. 2019;7(13):2057-61.
• 44. Hartmann TE, Robertson CV, Miller TD, Hunter JR, Skein M. Associations between exercise, inflammation and symptom severity in those with mental health disorders. Cytokine 2021;146:155648.
• 45. Cahn BR, Goodman MS, Peterson CT, Maturi R, Mills PJ. Yoga, meditation and mind-body health: increased BDNF, cortisol awakening response, and altered inflammatory marker expression after a 3-month yoga and meditation retreat. Front. Hum. Neurosci. 2017;11:315.
• 46. Anderson-Hanley C, Barcelos NM, Zimmerman EA et al. The aerobic and cognitive exercise study (ACES) for community-dwelling older adults with or at-risk for mild cognitive impairment (MCI): neuropsychological, neurobiological and neuroimaging outcomes of a randomized clinical trial. Front. Aging Neurosci. 2018;10: 76.
• 47. Byun JE, Kang EB. The effects of senior brain health exercise program on basic physical fitness, cognitive function and BDNF of elderly women-a feasibility study. J. Exerc. Nutrition Biochem. 2016;20(2):8-18.
• 48. McGurk SR, Otto MW, Fulford D et al. A randomized controlled trial of exercise on augmenting the effects of cognitive remediation in persons with severe mental illness. J. Psychiatr Res. 2021;139:38-46.
• 49. Gourgouvelis J, Yielder P, Clarke ST, Behbahani H, Murphy BA. Exercise leads to better clinical outcomes in those receiving medication plus cognitive behavioral therapy for major depressive disorder. Front. Psychiatry 2018;9:37.
• 50. Szuhany KL, Otto MW. Assessing BDNF as a mediator of the effects of exercise on depression. J. Psychiatr. Res. 2020;123:114-8.
• 51. Szuhany KL, Bugatti M, Otto MW. A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. J. Psychiatr. Res. 2015;60:56-64.
• 52. Marquez CMS, Vanaudenaerde B, Troosters T, Wenderoth N. High-intensity interval training evokes larger serum BDNF levels compared with intense continuous exercise. J. Appl. Physiol. 2015;119:1363-73.
• 53. Rentería I, García-Suárez PC, Martínez-Corona DO, et al. Short-term high-Intensity interval training increases systemic brain-derived neurotrophic factor (BDNF) in healthy women. Eur. J. Sport Sci. 2020;20(4):516-24.
• 54. Lommatzsch M, Zingler D, Schuhbaeck K et al. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol. Aging 2005;26(1):115-23.