Research Article

Serum Neurogranin and PNF-H Level in the Early Period in Rats with Experimental Head Trauma

Volume: 52 July 8, 2026
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Serum Neurogranin and PNF-H Level in the Early Period in Rats with Experimental Head Trauma

Abstract

This study investigates the course of Neurogranin and Phosphorylated Neurofilament Heavy Chain in serum samples taken from rats experimentally induced with mild traumatic brain injury during the first five hours after injury. This experimental animal study was based on 32 female Sprague-Dawley rats. Each group consisted of 8 rats (n=8), 3 experimental groups and 1 control group. Traumatic brain injury was induced in the rats by dropping a 50 mg metal object from a height of 80 cm. Neurogranin and Phosphorylated Neurofilament Heavy Chain ratios in serum samples taken from the rats 1, 3, and 5 hours after trauma were compared with the control group. It was determined that the neurogranin values measured in serum samples taken from rats after traumatic brain injury were statistically higher at 3 and 5 hours compared to the control group. Comparing the 3rd and 5th hour values, it was found that the 5th hour value was lower than the 3rd hour value. Regarding pNF-H levels, it was observed to be significantly higher at 1 and 3 hours, and a significant decrease at 5 hours. Increasing serum neurogranin and pNF-H levels may be beneficial in the diagnosis and treatment of patients with mild traumatic brain injury, but more comprehensive studies are needed to determine its benefit in humans.

Keywords

References

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Details

Primary Language

English

Subjects

Emergency Medicine

Journal Section

Research Article

Publication Date

July 8, 2026

Submission Date

February 16, 2026

Acceptance Date

May 27, 2026

Published in Issue

Year 2026 Volume: 52

APA
Aydoğan, G., Çıkrıklar, H. İ., Durak, V. A., Çakır, A., Aydoğan, A. A., Karesioğlu, E., & Aydin, B. (2026). Serum Neurogranin and PNF-H Level in the Early Period in Rats with Experimental Head Trauma. Journal of Uludağ University Medical Faculty, 52. https://doi.org/10.32708/uutfd.1890739
AMA
1.Aydoğan G, Çıkrıklar Hİ, Durak VA, et al. Serum Neurogranin and PNF-H Level in the Early Period in Rats with Experimental Head Trauma. Journal of Uludağ University Medical Faculty. 2026;52. doi:10.32708/uutfd.1890739
Chicago
Aydoğan, Göksel, Halil İbrahim Çıkrıklar, Vahide Aslıhan Durak, et al. 2026. “Serum Neurogranin and PNF-H Level in the Early Period in Rats With Experimental Head Trauma”. Journal of Uludağ University Medical Faculty 52 (July). https://doi.org/10.32708/uutfd.1890739.
EndNote
Aydoğan G, Çıkrıklar Hİ, Durak VA, Çakır A, Aydoğan AA, Karesioğlu E, Aydin B (July 1, 2026) Serum Neurogranin and PNF-H Level in the Early Period in Rats with Experimental Head Trauma. Journal of Uludağ University Medical Faculty 52
IEEE
[1]G. Aydoğan et al., “Serum Neurogranin and PNF-H Level in the Early Period in Rats with Experimental Head Trauma”, Journal of Uludağ University Medical Faculty, vol. 52, July 2026, doi: 10.32708/uutfd.1890739.
ISNAD
Aydoğan, Göksel - Çıkrıklar, Halil İbrahim - Durak, Vahide Aslıhan - Çakır, Ayşen - Aydoğan, Ayşe Armağan - Karesioğlu, Emine - Aydin, Birnur. “Serum Neurogranin and PNF-H Level in the Early Period in Rats With Experimental Head Trauma”. Journal of Uludağ University Medical Faculty 52 (July 1, 2026). https://doi.org/10.32708/uutfd.1890739.
JAMA
1.Aydoğan G, Çıkrıklar Hİ, Durak VA, Çakır A, Aydoğan AA, Karesioğlu E, Aydin B. Serum Neurogranin and PNF-H Level in the Early Period in Rats with Experimental Head Trauma. Journal of Uludağ University Medical Faculty. 2026;52. doi:10.32708/uutfd.1890739.
MLA
Aydoğan, Göksel, et al. “Serum Neurogranin and PNF-H Level in the Early Period in Rats With Experimental Head Trauma”. Journal of Uludağ University Medical Faculty, vol. 52, July 2026, doi:10.32708/uutfd.1890739.
Vancouver
1.Göksel Aydoğan, Halil İbrahim Çıkrıklar, Vahide Aslıhan Durak, Ayşen Çakır, Ayşe Armağan Aydoğan, Emine Karesioğlu, Birnur Aydin. Serum Neurogranin and PNF-H Level in the Early Period in Rats with Experimental Head Trauma. Journal of Uludağ University Medical Faculty. 2026 Jul. 1;52. doi:10.32708/uutfd.1890739

ISSN: 1300-414X, e-ISSN: 2645-9027

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