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Helicobacter Pylori and Gastric Carcinogenesis
Abstract
Association between H.pylori and gastric carcinoma was defined through retrospective and prospective epidemiological studies following the discovery of H.pylori, and it was described as a first-degree risk factor for gastric cancer by International Agency for Research on Cancer, a WHO Study Group, in 1994. However, the role of H.pylori in carcinogenesis remains unclear. A proposed mechanism is as follows: H.pylori associated chronic gastritis causes mutagenic free oxygen radicals to increase in the epithelial tissue and antioxidants acting in mucosal defence system to decrease. This in turn leads to mutagenic free oxygen radicals eventually causing DNA damage. It was also demonstrated that H. pylori results in hyperproliferation by changing epithelial kinetics. Thus, it can be concluded that the association of hyperproliferation with free radicals causes damages in the cell which could play a significant role in triggering carcinogenesis.
Keywords
Details
Primary Language
English
Subjects
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Journal Section
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Publication Date
June 1, 2003
Submission Date
June 1, 2003
Acceptance Date
-
Published in Issue
Year 2003 Volume: 29 Number: 2
APA
Demiray, M., & Manavoğlu, O. (2003). Helicobacter Pylori and Gastric Carcinogenesis. Journal of Uludağ University Medical Faculty, 29(2), 29-33. https://izlik.org/JA84AT33NC
AMA
1.Demiray M, Manavoğlu O. Helicobacter Pylori and Gastric Carcinogenesis. Journal of Uludağ University Medical Faculty. 2003;29(2):29-33. https://izlik.org/JA84AT33NC
Chicago
Demiray, Mutlu, and Osman Manavoğlu. 2003. “Helicobacter Pylori and Gastric Carcinogenesis”. Journal of Uludağ University Medical Faculty 29 (2): 29-33. https://izlik.org/JA84AT33NC.
EndNote
Demiray M, Manavoğlu O (June 1, 2003) Helicobacter Pylori and Gastric Carcinogenesis. Journal of Uludağ University Medical Faculty 29 2 29–33.
IEEE
[1]M. Demiray and O. Manavoğlu, “Helicobacter Pylori and Gastric Carcinogenesis”, Journal of Uludağ University Medical Faculty, vol. 29, no. 2, pp. 29–33, June 2003, [Online]. Available: https://izlik.org/JA84AT33NC
ISNAD
Demiray, Mutlu - Manavoğlu, Osman. “Helicobacter Pylori and Gastric Carcinogenesis”. Journal of Uludağ University Medical Faculty 29/2 (June 1, 2003): 29-33. https://izlik.org/JA84AT33NC.
JAMA
1.Demiray M, Manavoğlu O. Helicobacter Pylori and Gastric Carcinogenesis. Journal of Uludağ University Medical Faculty. 2003;29:29–33.
MLA
Demiray, Mutlu, and Osman Manavoğlu. “Helicobacter Pylori and Gastric Carcinogenesis”. Journal of Uludağ University Medical Faculty, vol. 29, no. 2, June 2003, pp. 29-33, https://izlik.org/JA84AT33NC.
Vancouver
1.Mutlu Demiray, Osman Manavoğlu. Helicobacter Pylori and Gastric Carcinogenesis. Journal of Uludağ University Medical Faculty [Internet]. 2003 Jun. 1;29(2):29-33. Available from: https://izlik.org/JA84AT33NC