EN
TR
Helicobacter Pylori and Gastric Carcinogenesis
Öz
Association between H.pylori and gastric carcinoma was defined through retrospective and prospective epidemiological studies following the discovery of H.pylori, and it was described as a first-degree risk factor for gastric cancer by International Agency for Research on Cancer, a WHO Study Group, in 1994. However, the role of H.pylori in carcinogenesis remains unclear. A proposed mechanism is as follows: H.pylori associated chronic gastritis causes mutagenic free oxygen radicals to increase in the epithelial tissue and antioxidants acting in mucosal defence system to decrease. This in turn leads to mutagenic free oxygen radicals eventually causing DNA damage. It was also demonstrated that H. pylori results in hyperproliferation by changing epithelial kinetics. Thus, it can be concluded that the association of hyperproliferation with free radicals causes damages in the cell which could play a significant role in triggering carcinogenesis.
Anahtar Kelimeler
Ayrıntılar
Birincil Dil
İngilizce
Konular
-
Bölüm
-
Yayımlanma Tarihi
1 Haziran 2003
Gönderilme Tarihi
1 Haziran 2003
Kabul Tarihi
-
Yayımlandığı Sayı
Yıl 2003 Cilt: 29 Sayı: 2
APA
Demiray, M., & Manavoğlu, O. (2003). Helicobacter Pylori and Gastric Carcinogenesis. Journal of Uludağ University Medical Faculty, 29(2), 29-33. https://izlik.org/JA84AT33NC
AMA
1.Demiray M, Manavoğlu O. Helicobacter Pylori and Gastric Carcinogenesis. Uludağ Tıp Derg. 2003;29(2):29-33. https://izlik.org/JA84AT33NC
Chicago
Demiray, Mutlu, ve Osman Manavoğlu. 2003. “Helicobacter Pylori and Gastric Carcinogenesis”. Journal of Uludağ University Medical Faculty 29 (2): 29-33. https://izlik.org/JA84AT33NC.
EndNote
Demiray M, Manavoğlu O (01 Haziran 2003) Helicobacter Pylori and Gastric Carcinogenesis. Journal of Uludağ University Medical Faculty 29 2 29–33.
IEEE
[1]M. Demiray ve O. Manavoğlu, “Helicobacter Pylori and Gastric Carcinogenesis”, Uludağ Tıp Derg, c. 29, sy 2, ss. 29–33, Haz. 2003, [çevrimiçi]. Erişim adresi: https://izlik.org/JA84AT33NC
ISNAD
Demiray, Mutlu - Manavoğlu, Osman. “Helicobacter Pylori and Gastric Carcinogenesis”. Journal of Uludağ University Medical Faculty 29/2 (01 Haziran 2003): 29-33. https://izlik.org/JA84AT33NC.
JAMA
1.Demiray M, Manavoğlu O. Helicobacter Pylori and Gastric Carcinogenesis. Uludağ Tıp Derg. 2003;29:29–33.
MLA
Demiray, Mutlu, ve Osman Manavoğlu. “Helicobacter Pylori and Gastric Carcinogenesis”. Journal of Uludağ University Medical Faculty, c. 29, sy 2, Haziran 2003, ss. 29-33, https://izlik.org/JA84AT33NC.
Vancouver
1.Mutlu Demiray, Osman Manavoğlu. Helicobacter Pylori and Gastric Carcinogenesis. Uludağ Tıp Derg [Internet]. 01 Haziran 2003;29(2):29-33. Erişim adresi: https://izlik.org/JA84AT33NC
