Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It's Correlation with Relapse

Volume: 30 Number: 3 September 1, 2004
  • Ülkü Ozan
  • Fahir Özkalemkaş
  • Rıdvan Ali
  • Ferah Budak
  • Güher Göral
  • Vildan Özkocaman
  • Tülay Özçelik
  • Ahmet Tunalı
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Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It's Correlation with Relapse

Abstract

It's known that many acute leukemia patients in morphologic remission would eventually relapse due to the persistence of residual leukemic cells. The aim of this study was to evaluate the use of flow cytometry (FC) to detect minimal residual disease (MRD) and the correlation between MRD and relapse-free survival. We have first evaluated the immunophenotypic outcomes of 89 acute leukemia patients during admission and rarely seen coexpressions (UC) were found in 73% of them. Then the initial levels of UC were compared with the levels during complete remission (CR) in 16 alive cases and a significant decrease was observed in 8 cases who have remained in CR for 28-40 weeks of follow-up. However, in 3 cases, coexpression levels in remission were almost the same with the initial levels and 2 of them relapsed after 19 and 30 weeks. These results confirm that FC would be useful in the assessment of MRD and a gradual increase of leukemic cells would be suggestive for subsequent relapse.

Keywords

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Ülkü Ozan This is me

Fahir Özkalemkaş This is me

Rıdvan Ali This is me

Ferah Budak This is me

Güher Göral This is me

Vildan Özkocaman This is me

Tülay Özçelik This is me

Ahmet Tunalı This is me

Publication Date

September 1, 2004

Submission Date

September 1, 2004

Acceptance Date

-

Published in Issue

Year 2004 Volume: 30 Number: 3

IZ

https://izlik.org/JA83CM46YK

Cite

RIS / Bibtex
APA
Ozan, Ü., Özkalemkaş, F., Ali, R., Budak, F., Göral, G., Özkocaman, V., Özçelik, T., & Tunalı, A. (2004). Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse. Journal of Uludağ University Medical Faculty, 30(3), 181-187. https://izlik.org/JA83CM46YK
AMA
1.Ozan Ü, Özkalemkaş F, Ali R, et al. Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse. Journal of Uludağ University Medical Faculty. 2004;30(3):181-187. https://izlik.org/JA83CM46YK
Chicago
Ozan, Ülkü, Fahir Özkalemkaş, Rıdvan Ali, et al. 2004. “Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation With Relapse”. Journal of Uludağ University Medical Faculty 30 (3): 181-87. https://izlik.org/JA83CM46YK.
EndNote
Ozan Ü, Özkalemkaş F, Ali R, Budak F, Göral G, Özkocaman V, Özçelik T, Tunalı A (September 1, 2004) Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse. Journal of Uludağ University Medical Faculty 30 3 181–187.
IEEE
[1]Ü. Ozan et al., “Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse”, Journal of Uludağ University Medical Faculty, vol. 30, no. 3, pp. 181–187, Sept. 2004, [Online]. Available: https://izlik.org/JA83CM46YK
ISNAD
Ozan, Ülkü - Özkalemkaş, Fahir - Ali, Rıdvan - Budak, Ferah - Göral, Güher - Özkocaman, Vildan - Özçelik, Tülay - Tunalı, Ahmet. “Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation With Relapse”. Journal of Uludağ University Medical Faculty 30/3 (September 1, 2004): 181-187. https://izlik.org/JA83CM46YK.
JAMA
1.Ozan Ü, Özkalemkaş F, Ali R, Budak F, Göral G, Özkocaman V, Özçelik T, Tunalı A. Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse. Journal of Uludağ University Medical Faculty. 2004;30:181–187.
MLA
Ozan, Ülkü, et al. “Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation With Relapse”. Journal of Uludağ University Medical Faculty, vol. 30, no. 3, Sept. 2004, pp. 181-7, https://izlik.org/JA83CM46YK.
Vancouver
1.Ülkü Ozan, Fahir Özkalemkaş, Rıdvan Ali, Ferah Budak, Güher Göral, Vildan Özkocaman, Tülay Özçelik, Ahmet Tunalı. Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse. Journal of Uludağ University Medical Faculty [Internet]. 2004 Sep. 1;30(3):181-7. Available from: https://izlik.org/JA83CM46YK

ISSN: 1300-414X, e-ISSN: 2645-9027

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