Akut Lösemilerde Minimal Residüel Hastalığın Akım Sitometrisi Yöntemiyle Araştırılması ve Relaps ile Korelasyonu

Cilt: 30 Sayı: 3 1 Eylül 2004
  • Ülkü Ozan
  • Fahir Özkalemkaş
  • Rıdvan Ali
  • Ferah Budak
  • Güher Göral
  • Vildan Özkocaman
  • Tülay Özçelik
  • Ahmet Tunalı
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Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It's Correlation with Relapse

Öz

It's known that many acute leukemia patients in morphologic remission would eventually relapse due to the persistence of residual leukemic cells. The aim of this study was to evaluate the use of flow cytometry (FC) to detect minimal residual disease (MRD) and the correlation between MRD and relapse-free survival. We have first evaluated the immunophenotypic outcomes of 89 acute leukemia patients during admission and rarely seen coexpressions (UC) were found in 73% of them. Then the initial levels of UC were compared with the levels during complete remission (CR) in 16 alive cases and a significant decrease was observed in 8 cases who have remained in CR for 28-40 weeks of follow-up. However, in 3 cases, coexpression levels in remission were almost the same with the initial levels and 2 of them relapsed after 19 and 30 weeks. These results confirm that FC would be useful in the assessment of MRD and a gradual increase of leukemic cells would be suggestive for subsequent relapse.

Anahtar Kelimeler

Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

-

Yazarlar

Ülkü Ozan Bu kişi benim

Fahir Özkalemkaş Bu kişi benim

Rıdvan Ali Bu kişi benim

Ferah Budak Bu kişi benim

Güher Göral Bu kişi benim

Vildan Özkocaman Bu kişi benim

Tülay Özçelik Bu kişi benim

Ahmet Tunalı Bu kişi benim

Yayımlanma Tarihi

1 Eylül 2004

Gönderilme Tarihi

1 Eylül 2004

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2004 Cilt: 30 Sayı: 3

IZ

https://izlik.org/JA83CM46YK

Kaynak Göster

RIS / Bibtex
APA
Ozan, Ü., Özkalemkaş, F., Ali, R., Budak, F., Göral, G., Özkocaman, V., Özçelik, T., & Tunalı, A. (2004). Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse. Journal of Uludağ University Medical Faculty, 30(3), 181-187. https://izlik.org/JA83CM46YK
AMA
1.Ozan Ü, Özkalemkaş F, Ali R, vd. Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse. Uludağ Tıp Derg. 2004;30(3):181-187. https://izlik.org/JA83CM46YK
Chicago
Ozan, Ülkü, Fahir Özkalemkaş, Rıdvan Ali, vd. 2004. “Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse”. Journal of Uludağ University Medical Faculty 30 (3): 181-87. https://izlik.org/JA83CM46YK.
EndNote
Ozan Ü, Özkalemkaş F, Ali R, Budak F, Göral G, Özkocaman V, Özçelik T, Tunalı A (01 Eylül 2004) Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse. Journal of Uludağ University Medical Faculty 30 3 181–187.
IEEE
[1]Ü. Ozan vd., “Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse”, Uludağ Tıp Derg, c. 30, sy 3, ss. 181–187, Eyl. 2004, [çevrimiçi]. Erişim adresi: https://izlik.org/JA83CM46YK
ISNAD
Ozan, Ülkü - Özkalemkaş, Fahir - Ali, Rıdvan - Budak, Ferah - Göral, Güher - Özkocaman, Vildan - Özçelik, Tülay - Tunalı, Ahmet. “Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse”. Journal of Uludağ University Medical Faculty 30/3 (01 Eylül 2004): 181-187. https://izlik.org/JA83CM46YK.
JAMA
1.Ozan Ü, Özkalemkaş F, Ali R, Budak F, Göral G, Özkocaman V, Özçelik T, Tunalı A. Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse. Uludağ Tıp Derg. 2004;30:181–187.
MLA
Ozan, Ülkü, vd. “Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse”. Journal of Uludağ University Medical Faculty, c. 30, sy 3, Eylül 2004, ss. 181-7, https://izlik.org/JA83CM46YK.
Vancouver
1.Ülkü Ozan, Fahir Özkalemkaş, Rıdvan Ali, Ferah Budak, Güher Göral, Vildan Özkocaman, Tülay Özçelik, Ahmet Tunalı. Determination of Minimal Residual Disease in Acute Leukaemia Using Flow Cytometry and It’s Correlation with Relapse. Uludağ Tıp Derg [Internet]. 01 Eylül 2004;30(3):181-7. Erişim adresi: https://izlik.org/JA83CM46YK

ISSN: 1300-414X, e-ISSN: 2645-9027

Uludağ Üniversitesi Tıp Fakültesi Dergisi "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License" ile lisanslanmaktadır.


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Journal of Uludag University Medical Faculty is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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