EN
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Chemoradiotherapy in the Head and Neck Squamous Cell Cancer
Abstract
The treatment of head and neck squmaous cell cancer (HNSSC) requires a multidisciplinary management. Postoperative chemoradiotherapy (CRT) has been the gold standart in the patients with early stage HNSSC with poor prognostic factors. The treatment of locally advanced HNSSC includes surgery and adjuvant CRT, induction chemotherapy followed by definitive CRT or CRT alone. Induction chemotherapy followed by definitive CRT has been a successful approach for organ preservation, in particularly operable HNSSC. It has been demonstrated that the greatest survival benefit over radiotherapy (RT) alone is seen with the CRT in several trials. Specifically, to improve the efficacy of the treatment for organ preservation, it has been explored new induction combination regimens with taxanes and found to be more efficient comparing with the cisplatin-5 fluorouracil regimens. The favorable efficiency of the concomitantly usage of taxans with RT, has been demonstrated in only Phase II studies. More recently, the improving efficacy of epidermal growth factor receptor inhibitor (Cetuximab) combined with RT has been determined on survival in several trials. In this review, we overviewed the current literatures within the future role of new agents on the base of clinical trials.
Keywords
Details
Primary Language
English
Subjects
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Journal Section
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Publication Date
March 1, 2011
Submission Date
March 1, 2011
Acceptance Date
-
Published in Issue
Year 2011 Volume: 37 Number: 1
APA
Demiröz, C., & Özşahin, E. M. (2011). Chemoradiotherapy in the Head and Neck Squamous Cell Cancer. Journal of Uludağ University Medical Faculty, 37(1), 61-65. https://izlik.org/JA48HE24PH
AMA
1.Demiröz C, Özşahin EM. Chemoradiotherapy in the Head and Neck Squamous Cell Cancer. Journal of Uludağ University Medical Faculty. 2011;37(1):61-65. https://izlik.org/JA48HE24PH
Chicago
Demiröz, Candan, and Esat Mahmut Özşahin. 2011. “Chemoradiotherapy in the Head and Neck Squamous Cell Cancer”. Journal of Uludağ University Medical Faculty 37 (1): 61-65. https://izlik.org/JA48HE24PH.
EndNote
Demiröz C, Özşahin EM (March 1, 2011) Chemoradiotherapy in the Head and Neck Squamous Cell Cancer. Journal of Uludağ University Medical Faculty 37 1 61–65.
IEEE
[1]C. Demiröz and E. M. Özşahin, “Chemoradiotherapy in the Head and Neck Squamous Cell Cancer”, Journal of Uludağ University Medical Faculty, vol. 37, no. 1, pp. 61–65, Mar. 2011, [Online]. Available: https://izlik.org/JA48HE24PH
ISNAD
Demiröz, Candan - Özşahin, Esat Mahmut. “Chemoradiotherapy in the Head and Neck Squamous Cell Cancer”. Journal of Uludağ University Medical Faculty 37/1 (March 1, 2011): 61-65. https://izlik.org/JA48HE24PH.
JAMA
1.Demiröz C, Özşahin EM. Chemoradiotherapy in the Head and Neck Squamous Cell Cancer. Journal of Uludağ University Medical Faculty. 2011;37:61–65.
MLA
Demiröz, Candan, and Esat Mahmut Özşahin. “Chemoradiotherapy in the Head and Neck Squamous Cell Cancer”. Journal of Uludağ University Medical Faculty, vol. 37, no. 1, Mar. 2011, pp. 61-65, https://izlik.org/JA48HE24PH.
Vancouver
1.Candan Demiröz, Esat Mahmut Özşahin. Chemoradiotherapy in the Head and Neck Squamous Cell Cancer. Journal of Uludağ University Medical Faculty [Internet]. 2011 Mar. 1;37(1):61-5. Available from: https://izlik.org/JA48HE24PH