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The Effect of Intraperitoneal Administration of Dichlorvos on The Activity Glucose 6-Phosphate Dehydrogenase and Malate Dehydrogenase in Some Tissues of Rats (Rattus norvegicus)
Abstract
In this study, rats (Rattus norvegicus) were intraperitoneally injected with 4 mg kg-1 dose of dichlorvos (DDVP), a toxic agent widely used
for agricultural purposes. Physiological saline was administered to each control group. Changes in the glucose 6-phosphate dehydrogenase
(G6PD) and malate dehydrogenase (MDH) activities in the liver, kidney, brain and small intestine of male and female rats were investigated
at 0, 2, 4, 8, 16, 32, 64 and 72 hours following injection. Enzyme activities were measured spectrophotometrically. Statistical analysis
was performed using the SPSS program. As a result, dichlorvos which primarily inhibits acetylcholinesterase (AChE) activity in the
nervous system causes significant (p<0.05) changes in both enzyme activities in studied tissues of male and female rats.
Keywords
Details
Primary Language
English
Subjects
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Journal Section
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Publication Date
March 1, 2007
Submission Date
March 1, 2007
Acceptance Date
-
Published in Issue
Year 2007 Volume: 33 Number: 1
APA
Dere, E., Özdikicioğlu, F., & Tosunoğlu, H. (2007). The Effect of Intraperitoneal Administration of Dichlorvos on The Activity Glucose 6-Phosphate Dehydrogenase and Malate Dehydrogenase in Some Tissues of Rats (Rattus norvegicus). Journal of Uludağ University Medical Faculty, 33(1), 5-10. https://izlik.org/JA23AS66LB
AMA
1.Dere E, Özdikicioğlu F, Tosunoğlu H. The Effect of Intraperitoneal Administration of Dichlorvos on The Activity Glucose 6-Phosphate Dehydrogenase and Malate Dehydrogenase in Some Tissues of Rats (Rattus norvegicus). Journal of Uludağ University Medical Faculty. 2007;33(1):5-10. https://izlik.org/JA23AS66LB
Chicago
Dere, Egemen, Ferda Özdikicioğlu, and Hakan Tosunoğlu. 2007. “The Effect of Intraperitoneal Administration of Dichlorvos on The Activity Glucose 6-Phosphate Dehydrogenase and Malate Dehydrogenase in Some Tissues of Rats (Rattus Norvegicus)”. Journal of Uludağ University Medical Faculty 33 (1): 5-10. https://izlik.org/JA23AS66LB.
EndNote
Dere E, Özdikicioğlu F, Tosunoğlu H (March 1, 2007) The Effect of Intraperitoneal Administration of Dichlorvos on The Activity Glucose 6-Phosphate Dehydrogenase and Malate Dehydrogenase in Some Tissues of Rats (Rattus norvegicus). Journal of Uludağ University Medical Faculty 33 1 5–10.
IEEE
[1]E. Dere, F. Özdikicioğlu, and H. Tosunoğlu, “The Effect of Intraperitoneal Administration of Dichlorvos on The Activity Glucose 6-Phosphate Dehydrogenase and Malate Dehydrogenase in Some Tissues of Rats (Rattus norvegicus)”, Journal of Uludağ University Medical Faculty, vol. 33, no. 1, pp. 5–10, Mar. 2007, [Online]. Available: https://izlik.org/JA23AS66LB
ISNAD
Dere, Egemen - Özdikicioğlu, Ferda - Tosunoğlu, Hakan. “The Effect of Intraperitoneal Administration of Dichlorvos on The Activity Glucose 6-Phosphate Dehydrogenase and Malate Dehydrogenase in Some Tissues of Rats (Rattus Norvegicus)”. Journal of Uludağ University Medical Faculty 33/1 (March 1, 2007): 5-10. https://izlik.org/JA23AS66LB.
JAMA
1.Dere E, Özdikicioğlu F, Tosunoğlu H. The Effect of Intraperitoneal Administration of Dichlorvos on The Activity Glucose 6-Phosphate Dehydrogenase and Malate Dehydrogenase in Some Tissues of Rats (Rattus norvegicus). Journal of Uludağ University Medical Faculty. 2007;33:5–10.
MLA
Dere, Egemen, et al. “The Effect of Intraperitoneal Administration of Dichlorvos on The Activity Glucose 6-Phosphate Dehydrogenase and Malate Dehydrogenase in Some Tissues of Rats (Rattus Norvegicus)”. Journal of Uludağ University Medical Faculty, vol. 33, no. 1, Mar. 2007, pp. 5-10, https://izlik.org/JA23AS66LB.
Vancouver
1.Egemen Dere, Ferda Özdikicioğlu, Hakan Tosunoğlu. The Effect of Intraperitoneal Administration of Dichlorvos on The Activity Glucose 6-Phosphate Dehydrogenase and Malate Dehydrogenase in Some Tissues of Rats (Rattus norvegicus). Journal of Uludağ University Medical Faculty [Internet]. 2007 Mar. 1;33(1):5-10. Available from: https://izlik.org/JA23AS66LB