Obstrüktif Uyku Apne Sendromlu Hastalarda Lipoliz Enzim Düzeyleri; Özellikle Perilipin-1

Yıl 2025, Cilt: 18 Sayı: 2, 123 - 130, 30.08.2025

Saliha Yıldız , Hülya Günbatar , Ahmet Ufuk Kömüroğlu , Aysel Sünnetçioğlu , Murat Alay

https://doi.org/10.52976/vansaglik.1711771

Öz

Giriş: Obstrüktif uyku apne sendromunda (OSAS) obezite önemli bir risk faktörü olduğundan, hücre içi ve damar içi lipoliz enzimleri ile OSAS arasındaki ilişkiyi belirlemek önemli olacaktır. Bu çalışmada OSAS'lı hastalarda lipoliz enzimleri Perilipin-1 (Plin-1), yağ trigliserit lipaz (ATGL), hormon duyarlı lipaz (HSL) ve lipoprotein lipaz (LPL) düzeylerini ve bu enzimler ile OSAS arasındaki ilişkiyi araştırdık.
Materyal ve Yöntem: Obstrüktif uyku apne sendromu olan 51 OSAS hastası ve kontrol grubu olarak basit horlama tanısı almış 25 gönüllü çalışmaya dahil edildi. Her katılımcının polisomnografik değerlendirmesi, yaşı, cinsiyeti ve vücut kitle indeksi kaydedildi. Enzimleri analiz etmek için katılımcılardan aynı gün kan alındı.
Bulgular: OSAS grubu (n:51) ile kontrol grubu (n:25) arasında yaş (ortalama: 45,3±10 vs 40,9±9,1, p değeri: 0,065), cinsiyet (hasta ve kontrol grubunda kadın/erkek, sırasıyla: 5/46, 3/22, p değeri: 0,76) ve VKİ (sırasıyla min-maks 23,3-40,1 vs 24-44,1, p değeri: 0,21) benzerdi. ATGL, HSL, LPL için gruplar arasında anlamlı fark saptanmadı (sırasıyla medyan değerler: 65,9 vs 68,3, 7,30 vs 7,33, 484,2 vs 485,3, p değerleri: 0,33, 0,69, 0,33). Plin-1 düzeyinin OSAS grubunda anlamlı olarak daha yüksek olduğu bulundu (ortanca değer: 5,34'e karşı 4,87 ng/ml, p:0,038). Plin-1'in WASO (uyku başlangıcından sonra uyanma) ile pozitif korelasyona ve toplam uyku süresi ile negatif korelasyona sahip olduğu belirlendi (sırasıyla p değeri: 0,003, 0,006, r değeri: 0,41, -0,38). OSAS grubu için yapılan doğrusal regresyon analizinde, WASO'nun Plin-1 yükselmesi için bir risk faktörü olduğu tespit edildi (p: 0,003, B: 0,012).
Tartışma: Obstrüktif Uyku Apnesi Sendromu'na sahip hastalarda Plin-1 düzeylerinin obeziteye bağlı olmaksızın uyku bozukluklarına bağlı olarak arttığını bulduk.

Anahtar Kelimeler

Obstrüktif Uyku Apnesi Sendromu , Perilipin-1 , Lipoliz

Proje Numarası

TSA-2018-6846

Lipolyse Enzyms Levels in Patients with Obstructive Sleep Apnea Syndrome; Especially Perilipin-1

Öz

Introduction: Since obesity is an important risk factor in obstructive sleep apnea syndrome (OSAS), it will be important to determine the relationship between intracellular and intravascular lipolysis enzymes and OSAS. In this study we investigated the levels of lipolysis enzymes Perilipin-1 (Plin-1), adipose triglyceride lipase (ATGL), hormon sensitive lipase (HSL) and lipoprotein lipase (LPL) in patients with OSAS and the relationship between these enzymes and OSAS.
Material method: 51 OSAS patients with obstructive sleep apnea syndrome and 25 volunteers diagnosed with simple snoring as a control group were included in the study. Polysomnographic evaluation, age, gender, and body mass index of each participant were recorded. Blood was taken from the participants on the same day to analyze enzymes.
Results: Between the OSAS group (n:51) and the control group (n:25), age (mean: 45.3±10 vs 40.9±9.1, p value: 0.065), gender (female/male in the patient and control group, respectively: 5/46, 3/22, p value: 0.76) and BMI (min-max 23.3-40.1 vs 24-44.1, p value: 0.21, respectively) were similar. For ATGL, HSL, LPL, no significant difference was detected between the groups (median values: 65.9 vs 68.3, 7.30 vs 7.33, 484.2 vs 485.3, p values: 0.33, 0.69, 0.33, respectively). Plin-1 level was found to be significantly higher in the OSAS group (median value: 5.34 vs 4.87 ng/ml, p:0.038). It was determined that Plin-1 had a positive correlation with WASO (wake after sleep onset) and a negative correlation with total sleep time (p value: 0.003, 0.006, r value: 0.41, -0.38, respectively). In the linear regression analysis performed for the OSAS group, WASO was detected as a risk factor for Plin-1 elevation (p: 0.003, B: 0.012).
Conclusion: We found that Plin-1 levels increased secondary to sleep disruptions in patients with OSAS, independent of obesity.

Anahtar Kelimeler

Obstructive Sleep Apnea Syndrome , Perilipin-1 , Lipolysis

Destekleyen Kurum

Van Yüzüncü Yıl Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Proje Numarası

TSA-2018-6846

Teşekkür

Van Yüzüncü Yıl Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimime desteğinden ötürü teşekkür ederiz.

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