The Effect of Aglepriston on Some Hematological and Biochemical Parameters Used in Termination of Unwanted Pregnancies in Cats

Abstract

In this study the effect of aglepristone in order to create abortion was investigated on some haematological and biochemical parameters on 22-30 days of pregnant cats. Twenty cats that their pregnancy is determined by ultrasonography were randomly divided into two groups. The experimental group (n:15) was formed by giving aglepristone at a dose of 15 mg/kg subcutaneously twice every 24 hours in the first group and the control group (n: 5) was formed by giving the same dose of 0.9% sodium chloride (NaCl) at the same time to the second group. All of the animals in both groups were examined as clinical every day. A complete blood count (CBC) on blood count device and biochemistry parameters Blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), bilirubin, glucose on a Reflotron device were made every 2 days during 15 days. In our study it was observed that 14 of the 15 animals (94.4%) in the experimental group were aborted and 1 of them gave birth healthy at the end of the normal gestational period. In the biochemical analyzes although there were some statistical differences between the experimental and control groups it was observed that all values remained within the range of normal reference values. Consequently it was concluded that aglepristone can be used successfully for terminated of unwanted pregnancies on 22 - 30 days of pregnant cats and do not have negative effects on hematological and biochemical parameters.

Keywords

• Aglepristone,Cat,Hematological,Biochemical,Parameter

Kedilerde İstenmeyen Gebeliklerin Sona Erdirilmesinde Kullanılan Aglepristonun Bazı Hematolojik ve Biyokimyasal Parametreler Üzerine Etkisi

Abstract

Bu çalışmada 22-30 günlük gebe kedilerde abort oluşturmak amacıyla kullanılan aglepristonun bazı hematolojik ve biyokimyasal parametreler üzerine etkisi araştırıldı. Gebelikleri ultrasonografi ile belirlenen 20 adet kedi rastgele iki gruba ayrıldı 1. gruba (n:15) 24 saat ara ile iki kez 15mg/kg dozda aglepriston subcutan uygulanarak deney grubu, 2. gruba (n:5) aynı anda aynı dozda serum fizyolojik uygulanarak kontrol grubu oluşturuldu. Her iki gruptaki hayvanların tamamı her gün klinik muayeneden geçirildi. 15 gün boyunca 2 günde bir kan örnekleri alınarak kan sayım cihazında hemoglobin miktarı (Hb), hematokrit oranı (HCT), akyuvar sayısı (WBC) belirlendi. Kan üre azotu (BUN), kreatinin, Aspartat aminotransferaz (AST), Alanin aminotransferaz (ALT), bilirubin, glukoz ölçümleri Reflotron cihazında yapıldı. Çalışmamızda aglepriston uygulanan deney grubundaki 15 hayvandan 14 tanesinin abort yaptığı (% 94.4), 1 tanesinin normal gebelik süresi sonunda sağlıklı doğum yaptığı gözlendi. Yapılan biyokimyasal analizlerde deney ve kontrol grupları arasında istatistiksel açıdan bazı farklar bulunsada tüm değerlerin normal referans değerleri aralığında kaldığı gözlendi. Sonuç olarak aglepristonun 22-30 günlük gebe kedilerde istenmeyen gebeliklerin sona erdirilmesinde başarı ile kullanılabileceği, hematolojik ve biyokimyasal parametreler üzerinde olumsuz etki oluşturmadığı kanısına varıldı.

Keywords

• Aglepriston,Kedi,Hematolojik,Biyokimyasal,Parametre

References

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