Year 2017, Volume 28 , Issue 3, Pages 127 - 130 2017-12-20

Farklı Doz Ellajik Asitin Rat Serum Lipit Profili ve Total Antioksidan Üzerine Etkisi
The Effect of Different Doses of Ellagic Acid on the Serum Lipid Profile and Total Antioxidant of Rat

Songül AKKUŞ [1] , Yeter DEĞER [2]


Bu çalışma, ellajik asitin, lipit, lipoprotein ve total antioksidan kapasite üzerine optimum etkiyi hangi dozda gösterdiğini tespit etmek amacıyla planlandı. Bu amaçla 40 adet,  200-250 gr ağırlığında erkek rat (Wistar- albino) kullanıldı. Kontrol, 1. grup (EA 3 mg/kg), 2. grup (EA 10 mg/kg), 3. grup (EA 12 mg/kg)  ve 4. grup (EA 20 mg/kg) olmak üzere her biri 8 rattan oluşan 5 grup oluşturuldu. Sekiz hafta boyunca, gün aşırı olarak ellajik asitin (EA) oral olarak uygulanmasını takiben, alınan kan örneklerinde, trigliserit, kolesterol, HDL ve LDL ölçümleri ticari kit kullanılarak modüler oto-anlizör cihazında yapıldı. VLDL düzeyleri formülle hesaplandı.  TAS ölçümü ticari kit kullanılarak spektrofotometrede gerçekleştirildi. Kontrol grubu ile karşılaştırıldığında, EA verilen tüm gruplarda, TAS, HDL,  VLDL ve trigliserit seviyelerinin artarken,  LDL ve kolesterol seviyelerinin azaldığı tespit edildi. Bu değişiklikler istatistik olarak anlamlı değildi (p˃0.05). Sonuç olarak, bu çalışmada elde edilen verilere dayanarak, yapılacak çalışmalarda, ellajik asitin koruyucu dozunun 20 mg/kg/gün düzeyinden yüksek olması ve uzun süre kullanılması önerilir

This study was planned to  determine in which dose of ellagic acid  it shows the optimum effect on lipid, lipoprotein and total antioxidant capacity. For this purpose, 40 male rats (Wistar-albino) weighing 200- 250 g were used. Control, group 1 (EA 3 mg/kg), group 2 (EA 10 mg/kg), group 3 (EA 12 mg/kg) and group 4 (EA 20 mg /kg) were designated, each containing 8 rats.  Following orally application ofellagic acid  (EA) every other day for eight weeks, from the blood samples taken; the measurement of triglyceride, cholesterol, LDL and HDL were determined by modular auto-analyzer using commercial kit. VLDL levels were calculated by formula. The total antioxidant capacity (TAS) was measured through spectrophotometer using the commercial kit. When compared with the control group, it was found that while TAS, triglyceride, HDL and VLDL levels were increased, LDL and cholesterol levels were decreased in the all EA applied groups. These changes weren’t important statistically (P˃0.05). Consequently, with regard to the data acquired in this study, it is recommended that in further research, the protective dose of ellagic acid is higher than 20 mg/kg/day and prolonged use
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Primary Language tr
Journal Section Articles
Authors

Author: Songül AKKUŞ (Primary Author)
Institution: YÜZÜNCÜ YIL ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ

Author: Yeter DEĞER
Institution: YÜZÜNCÜ YIL ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ

Dates

Application Date : February 17, 2017
Acceptance Date : July 6, 2017
Publication Date : December 20, 2017

Bibtex @research article { vanvetj435249, journal = {Van Veterinary Journal}, issn = {2149-3359}, eissn = {2149-8644}, address = {YYÜ Veteriner Fakültesi Dergi Editörlüğü Kampüs Van Turkey}, publisher = {Yuzuncu Yil University}, year = {2017}, volume = {28}, pages = {127 - 130}, doi = {}, title = {Farklı Doz Ellajik Asitin Rat Serum Lipit Profili ve Total Antioksidan Üzerine Etkisi}, key = {cite}, author = {Akkuş, Songül and Değer, Yeter} }
APA Akkuş, S , Değer, Y . (2017). Farklı Doz Ellajik Asitin Rat Serum Lipit Profili ve Total Antioksidan Üzerine Etkisi . Van Veterinary Journal , 28 (3) , 127-130 . Retrieved from https://dergipark.org.tr/en/pub/vanvetj/issue/37671/435249
MLA Akkuş, S , Değer, Y . "Farklı Doz Ellajik Asitin Rat Serum Lipit Profili ve Total Antioksidan Üzerine Etkisi" . Van Veterinary Journal 28 (2017 ): 127-130 <https://dergipark.org.tr/en/pub/vanvetj/issue/37671/435249>
Chicago Akkuş, S , Değer, Y . "Farklı Doz Ellajik Asitin Rat Serum Lipit Profili ve Total Antioksidan Üzerine Etkisi". Van Veterinary Journal 28 (2017 ): 127-130
RIS TY - JOUR T1 - Farklı Doz Ellajik Asitin Rat Serum Lipit Profili ve Total Antioksidan Üzerine Etkisi AU - Songül Akkuş , Yeter Değer Y1 - 2017 PY - 2017 N1 - DO - T2 - Van Veterinary Journal JF - Journal JO - JOR SP - 127 EP - 130 VL - 28 IS - 3 SN - 2149-3359-2149-8644 M3 - UR - Y2 - 2017 ER -
EndNote %0 Van Veterinary Journal Farklı Doz Ellajik Asitin Rat Serum Lipit Profili ve Total Antioksidan Üzerine Etkisi %A Songül Akkuş , Yeter Değer %T Farklı Doz Ellajik Asitin Rat Serum Lipit Profili ve Total Antioksidan Üzerine Etkisi %D 2017 %J Van Veterinary Journal %P 2149-3359-2149-8644 %V 28 %N 3 %R %U
ISNAD Akkuş, Songül , Değer, Yeter . "Farklı Doz Ellajik Asitin Rat Serum Lipit Profili ve Total Antioksidan Üzerine Etkisi". Van Veterinary Journal 28 / 3 (December 2017): 127-130 .
AMA Akkuş S , Değer Y . Farklı Doz Ellajik Asitin Rat Serum Lipit Profili ve Total Antioksidan Üzerine Etkisi. Van Vet J. 2017; 28(3): 127-130.
Vancouver Akkuş S , Değer Y . Farklı Doz Ellajik Asitin Rat Serum Lipit Profili ve Total Antioksidan Üzerine Etkisi. Van Veterinary Journal. 2017; 28(3): 127-130.
IEEE S. Akkuş and Y. Değer , "Farklı Doz Ellajik Asitin Rat Serum Lipit Profili ve Total Antioksidan Üzerine Etkisi", Van Veterinary Journal, vol. 28, no. 3, pp. 127-130, Dec. 2017