Effects of Puerperal Metritis on Uterine Blood Flow, Acute Phase Proteins and Selected Biochemical Parameters in Aleppo Goats

Year 2025, Volume: 36 Issue: 3, 187 - 193, 30.11.2025

Ömer Yaprakcı , Tuğra Akkuş

https://doi.org/10.36483/vanvetj.1717699

Abstract

The aim of this study was to determine the effects of puerperal metritis on uterine blood flow, acute-phase proteins, and certain biochemical parameters in Aleppo goats. In the study, researchers divided 30 multiparous Aleppo goats, which were in the first 10 days postpartum and had not been exposed to any medical treatment, into two equal groups: Group 1 (n=15) included goats with a healthy uterus throughout the postpartum period, whereas Group 2 (n=15) consisted of goats diagnosed with puerperal metritis. Before any intervention, Pulsatility Index (PI) and Resistance Index (RI) were measured using Doppler ultrasonography. Blood samples were then collected to analyze White Blood Cell (WBC) count, Interleukin-6 (IL-6), Tumor Necrosis Factor-Alpha (TNF-α), Serum Amyloid A (SAA), Procalcitonin (PCT), Aspartate Aminotransferase (AST), Gamma-Glutamyl Transferase (GGT), urea, and creatinine levels. The obtained data were evaluated using an independent samples t-test. Body temperature, respiratory rate, heart rate, and WBC values were significantly higher in the puerperal metritis group compared to the control group (p<0.001). In goats with metritis, comparison with the control group revealed that PI and RI values were low (p<0.001), and IL-6, TNF-α, SAA, PCT, AST, GGT, urea and creatinine levels were high (p<0.001). In conclusion, puerperal metritis induces substantial alterations in uterine blood flow and results in marked variations in acute-phase proteins and biochemical markers in goats.

Keywords

Doppler , Goat , Metritis

Ethical Statement

This study was approved by the Local Ethics Committee for Animal Experiments of Harran University under permit number 2025/003/10.

Halep Keçilerinde Puerperal Metritisin Uterus Kan Akımı, Akut Faz Proteinleri ve Seçilmiş Biyokimyasal Parametreler Üzerine Etkileri

Abstract

Bu çalışmanın amacı, Halep keçilerinde puerpreal metritisin uterus kan akımı, akut faz proteinleri ve bazı biyokimyasal parametreler üzerine etkilerini belirlemektir. Çalışmada, postpartum ilk 10 gün içerisinde bulunan ve herhangi medikal tedaviye maruz kalmamış multipar 30 Halep keçisi eşit iki gruba ayrıldı: Grup 1 (n=15), doğum sonrası dönemde sağlıklı uterusa sahip keçileri içerirken, Grup 2 (n=15), doğum sonrası puerperal metritis tanısı koyulan keçilerden oluşturuldu. Herhangi bir uygulama yapılmadan önce, Doppler ultrasonografi muayenesi yapılarak Pulsatilite İndeksi (PI) ve Rezistans İndeksi (RI) ölçüldü. Daha sonra Beyaz Kan Hücresi (WBC) sayımı, İnterlökin-6 (IL-6), Tümör Nekroz Faktör Alfa (TNF-α), Serum Amiloid A (SAA), Prokalsitonin (PCT), Aspartat Aminotransferaz (AST), Gama-Glutamil Transferaz (GGT), üre ve kreatinin düzeylerini analiz etmek için kan örnekleri toplandı. Elde edilen veriler bağımsız örnekler t-testi kullanılarak değerlendirildi. Vücut sıcaklığı, solunum hızı, kalp hızı ve WBC değerleri puerperal metritis grubunda kontrol grubuna kıyasla anlamlı derecede yüksek belirlendi (p<0.001). Metritisli keçilerde kontrol grubuna kıyasla PI ve RI değerlerinin düşük (p<0.001), IL-6, TNF-α, SAA, PCT, AST, GGT, üre ve kreatinin düzeylerinin yüksek olduğu belirlendi (p<0.001). Sonuç olarak puerperal metritisin keçilerde uterus kan akımında önemli değişikliklere neden olduğu ve akut faz proteinleri ile biyokimyasal belirteçlerde belirgin varyasyonlara yol açtığı görüldü.

Keywords

Doppler , Keçi , Metritis

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