Comparison of Estrogen and Progesterone Receptors in Endometrial Polyps and Normal Endometrium

Year 2019, , 13 - 16, 14.03.2019

Şahin Yüksek Önder Sakin , Bülent Kars Muzaffer Seyhan Çıkman Ali Doğukan Anğın Engin Ersin Şimşek

https://doi.org/10.16948/zktipb.392542

Abstract

INTRODUCTION: The pathogenesis of endometrial polyps is still
unknown. Our aim in this research is to examine steroid receptors in
endometrial polyps.

METHODS: This study immunohistochemically stained estrogen and progesterone
receptors of both polyp and intact endometrium tissues of 28 patients who
underwent hysteroscopic polypectomy between February 2008 and December 2011 in
our hospital.

RESULTS: The coloring
scores were recorded as 3 positive for strong dyes, 2 positive for medium dyes
and 1 positive for weak dyes. In endometrial polyp gland estrogen receptors
were weak in 1 (3.6%) patient and strong in 17 (60.7%) patient. In the stroma,
5 (17.9%) patients were weak and 12 (52.8%) patients were strongly stained. The
endometrial tissues adjacent to the polyp 13 (46.4%) patients were weak and 5
(17.6%) patients were strong stained. In the stroma, 14 (50.0%) patients were
weak and 3 (10.7%) patients were strongly stained.

Progesterone receptors did not show weak staining on the endometrial polyp gland. Strong staining was observed in 27 patients (96.4%). There was no weak staining in stroma. Strong staining was observed in 25 patients (89.3%). The gland of the endometrial tissue adjacent to polyp; 4 (14.3%) patients weak, 18 (64.3%) moderate, and 6 (21.4%) patients were strong stained. In the stroma, 3 (10.7%) patients weak, 18 (64.3%) patients moderate and 7 (%25.0) patients were strongly stained.

CONCLUSION: Our findings support the importance
of steroid receptors on the development of endometrial polyps. Therapeutic
treatments for these receptors may be useful in preventing the development of
polyps, as well as in treatment and prevention of complaints. 

Keywords

Polyps, estrogen receptor, progesterone receptor

Endometrial Polipler ile Normal Endometriumda Estrogen ve Progesteron Reseptörlerinin Karşılaştırılması

Abstract

AMAÇ: Endometrial poliplerin patogenezi halen tam
olarak bilinmemektedir. Bu araştırmada amacımız endometrial poliplerdeki
steroid reseptörlerini incelemektir.

YÖNTEM: Bu
araştırmada Şubat 2008 ile Aralık 2011 tarihleri arasında hastanemizde histeroskopik polipektomi
yapılan 28 hastanın poliplerine ve sağlam endometrium dokularına ait östrojen
ve progesteron reseptörleri immunohistokimyasal olarak boyandı. Boyanma
skorları kuvvetli boyananlar için 3 pozitif, orta boyananlar için 2 pozitif ve
zayıf boyananlar için 1 pozitif olarak kaydedildi.

BULGULAR: Östrojen reseptörleri
endometriyal polip glandında 1 (%3.6) hastada zayıf, 17 (%60.7) hastada
kuvvetli boyandı.  Stromasında ise 5
(%17.9) hastada zayıf,  12 (%52.8)
hastada kuvvetli olarak boyandı. Polipin hemen yanındaki endometrial dokunun
glandında 13 (%46.4) hastada zayıf, 5 (%17.6) hastada kuvvetli boyandı.
Stromasında ise 14 (%50.0) hastada zayıf, 3 (%10.7) hastada kuvvetli boyandı.

Progesteron
reseptörleri için endometriyal polip glandında zayıf boyanma olmadı. Kuvvetli
boyanma 27 (%96.4) hastada görüldü. Stromasında da zayıf boyanma olmadı.
Kuvvetli boyanma 25 (%89.3) hastada görüldü. Endometriyal polipin hemen
yanındaki endometrium dokusunun glandında 4 (%14.3) hastada zayıf, 18 (%64.3)
hastada orta, 6 (%21.4) hastada kuvvetli boyandı. Stromasında ise 3 (%10.7)
hastada zayıf, 18 (%64.3) hastada orta, 7 (%25.0) hastada kuvvetli
boyandı. 

SONUÇ: Bulgularımız steroid
reseptörlerinin endometrial poliplerin gelişimi üzerine olan önemini destekler
niteliktedir. Bu reseptörlere yönelik geliştirilecek tedaviler hem poliplerin
gelişiminin önlenmesinde, hem tedavisinde, hem de sebep olduğu şikâyetlerin
engellenmesinde faydalı olabilecektir.

Keywords

Polipler, östrojen reseptörü, progesteron reseptörü

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