The role of microRNA-124 in early diagnosis, prognosis and treatment of cancer

Abstract

Nutrition, lifestyle, genetics, exposure to a carcinogenic substance causing cancer is one of the common causes of death. Especially in recent years some of the studies to reduce cancer mortality have focused on biomarkers that will provide early detection. MicroRNAs are included in the non-coding RNA groups containing about 25 nucleotides and discovered over the last 25 years, which are considered to be one of these biomarkers. Studies on the use of microRNAs as markers have gained momentum in recent years due to the fact that microRNAs can be detected by conventional molecular methods in blood and tissue samples.

Keywords

• mir-124
• cancer
• microRNA

Kanserin erken teşhisi, prognozu ve tedavisinde mikroRNA-124’ün yeri

Öz

Beslenme, yaşam tarzı, genetik, kanserojen bir maddeye maruziyet gibi sebeplerle ortaya çıkan kanser yaygın ölüm nedenlerinden biridir. Kanser mortalitesini azaltmak için yapılan çalışmalardan bir kısmı son yıllarda özellikle erken teşhisi sağlayacak biyobelirteçler üzerine yoğunlaşmıştır. Bu biyobelirteçlerden biri olarak değerlendirilen mikroRNA’lar, son 25 yıl içerisinde keşfedilmiş yaklaşık 25 nükleotid uzunluğunda kodlanmayan RNA grubuna dâhildir. Kan ve doku örneklerinden geleneksel moleküler yöntemlerle tespit edilebiliyor oluşları sayesinde mikroRNA’ların belirteç olarak kullanılmasına yönelik çalışmalar son yıllarda hız kazanmıştır.

Anahtar Kelimeler

• mir-124
• kanser
• mikroRNA

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