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Significance of CRP in pediatric Hodgkin disease aim: To determine usage of CRP in Hodgkin disease as a prognostic and diagnostic parameter

Year 2005, Volume 36, Issue 3, 139 - 141, 01.04.2005

Abstract

Materials and Methods: We evaluated the relationship of CRP, with disease stage, presence of B symptom and prognosis in our 20 patients with the diagnosis of Hodgkin disease retrospectively. Results: CRP was high in 10 (50 %) of our cases. None of the patients with the disease stage I, had high CRP. CRP values were above 5 mg/L in 37 %, 83 %, 67 % of the patients stages II, III and IV respectively. It was determined that elevated CRP values and the presence of B symptoms correlated statistically. Three of the cases showed progression and received second line treatment. In all of the cases with progressive disease, CRP values were elevated at the first diagnose. Conclusion: CRP can be a useful marker at diagnosis and follow up of pediatric Hodgkin disease.

References

  • Balou SP, Lozanski G. Introduction of inflammatory cytokines release from cultured human monocytes by C-reactive protein.Cytokine 1992-4.361-368
  • Fassbender K, Dempfle CE, Mielke O, et al
  • Proinflammatorycytokines: Indicators of infection in high risk patients.J Lab Clin Med 1997;130:535- 539. Franke S, Herrmann D, Hein G, et al. Interleukin 6, soluble interleukin-2-receptor, and soluble interleukin-6-receptor in sera of patients with rheumatoid arthritis:Infkuences of disease activity and drug therapy, Eur J Med Res 1997;2:401-406 Herrmann JL, Blanchard H, Brunengo P, et al
  • TNF alpha, IL-1 beta, and IL-6 plasma levels in neutropenic patients after onset of fever and correlation with C reactive protein(CRP) kinetic values.Infection 1994; 22:309-315 Kutukculer N, Çağlayan S, Aydogdu F. Study of proinflammatory (TNF-alpha, IL-1 alpha, IL-6) and T-cefl drived (IL-2JL-4) cytokines in plasma and synoyial fluid of patients with juvenile chronic arthritis: Correlations with clinical and labratory parameters. Clin Rheumatol 1998,17:288-292
  • Child JA, Cooper EH, Illingworth S, et al
  • Biochemical markers in Hodgkin's disease and non-Hogkin's lymphoma. Recent Results Cancer Res 197 8,64.180-189 Legouffe E, Rodroguez C, Picot MC, et al. C reaciive protein serum level is a valuable and simple prognostic marker in non hodgkin's lymphoma.Leuk Lymphoma 1998;31:351-357 Child JA, Spati B, Illingworth S, et al. Serum beta 2 microgloblin and C-reactive protein in monitoring öf lymphomas: Findings in multicenter study and experience in selected patients. Cancer 1980;45:318-326 Tartour E,Deneux L, Mosseri V,et al. Soluble inteleukin-2 receptor serum level as predictor of locoreginal control and survival for patients with head and neck carcinomas: Results of a multivariate prospective study.Cancer 1997;79: 1401-1408 Maccio A, Lai P, Santona MC,et al. High serum levels of soluble IL-2 receptors, cytokines , and C- reactive protein correlate with impairment of T cell response in patients with advanced epithelial ovarian cancer. Gynecol Oncol 1998; 69:248-252 Nozoe T,Matsumata T,Kitamura M, et al. Significance of preoperative elevation of serum C-reactive protein as an indicator for prognosos in colorectal cancer. Am J surg 1998;176:335-338 Zaloudik J,Lauerova L, Janakova L, et al
  • Significance of pretreatment immunological parameters in colorectal cancer patients with unresectable metastases to the liver
  • Hepatogastroenterelogy 1999;46:220-227 Inoue T, Hashimura T, Iwamura H, et al
  • Multivariate analysis of prognostic determinants after surgery for renal cell carcinoma at Himeji National Hospital. Hinyokika Kiyo 200;46:229-234
  • Masuda H, Kurita Y, Fukuta K, etal. Significant prognostic factors for %-year survival after curative resection of renal cell carcinoma. Int J Urol 1998,5:418-422
  • Wieland A, Kerbl R, Berghold A, Schwinger W, Mann G, Urban C. C-reactive protein (CRP) as tumor marker in pediatric and adolescent patients with Hodgkin disease. Med Pediatr Oncol 2003,41:21-25

Pediatrik Hodgkin hastalığı'nda CRP'nin önemi

Year 2005, Volume 36, Issue 3, 139 - 141, 01.04.2005

Abstract

Amaç: CRP'nin pediatrik Hodgkin hastalığında prognostik ve tanısal bir parametre olarak kullanılabilirliliğini değerlendirmek. Gereç ve Yöntem: 20 Hodgkin olgumuzda tanı sırasındaki CRP değerleri ile hastalığın evresi, B semptomlarının varlığı ve prognozu arasındaki ilişkiyi retrospektif olarak irdeledik. Bulgular: Olgularımızdan 10'unda (% 50) CRP'nin yüksek olduğu saptandı. Evre I'de hiçbir hastada CRP yüksek değildi. Evre II'de ise hastaların % 37'inde, evre III'de % 83'ünde, evre IV'de % 67'sinde CRP değeri 5 mg/L'nin üzerinde idi. İstatistiksel olarak irdelendiğinde CRP yüksekliğinin ileri evre ve B septomlarının varlığı ile paralellik gösterdiği görüldü. Olgularımızın 3'ü progrese olmuşlar ve ikinci seçim tedaviye alınmışlardır. Progrese olguların tamamında tanı sırasında CRP yüksek olarak bulunmuştur. Sonuç: CRP çocukluk çağı Hodgkin hastalığında tanı ve izlemde bir biyomarker olarak yararlı olabilir.

References

  • Balou SP, Lozanski G. Introduction of inflammatory cytokines release from cultured human monocytes by C-reactive protein.Cytokine 1992-4.361-368
  • Fassbender K, Dempfle CE, Mielke O, et al
  • Proinflammatorycytokines: Indicators of infection in high risk patients.J Lab Clin Med 1997;130:535- 539. Franke S, Herrmann D, Hein G, et al. Interleukin 6, soluble interleukin-2-receptor, and soluble interleukin-6-receptor in sera of patients with rheumatoid arthritis:Infkuences of disease activity and drug therapy, Eur J Med Res 1997;2:401-406 Herrmann JL, Blanchard H, Brunengo P, et al
  • TNF alpha, IL-1 beta, and IL-6 plasma levels in neutropenic patients after onset of fever and correlation with C reactive protein(CRP) kinetic values.Infection 1994; 22:309-315 Kutukculer N, Çağlayan S, Aydogdu F. Study of proinflammatory (TNF-alpha, IL-1 alpha, IL-6) and T-cefl drived (IL-2JL-4) cytokines in plasma and synoyial fluid of patients with juvenile chronic arthritis: Correlations with clinical and labratory parameters. Clin Rheumatol 1998,17:288-292
  • Child JA, Cooper EH, Illingworth S, et al
  • Biochemical markers in Hodgkin's disease and non-Hogkin's lymphoma. Recent Results Cancer Res 197 8,64.180-189 Legouffe E, Rodroguez C, Picot MC, et al. C reaciive protein serum level is a valuable and simple prognostic marker in non hodgkin's lymphoma.Leuk Lymphoma 1998;31:351-357 Child JA, Spati B, Illingworth S, et al. Serum beta 2 microgloblin and C-reactive protein in monitoring öf lymphomas: Findings in multicenter study and experience in selected patients. Cancer 1980;45:318-326 Tartour E,Deneux L, Mosseri V,et al. Soluble inteleukin-2 receptor serum level as predictor of locoreginal control and survival for patients with head and neck carcinomas: Results of a multivariate prospective study.Cancer 1997;79: 1401-1408 Maccio A, Lai P, Santona MC,et al. High serum levels of soluble IL-2 receptors, cytokines , and C- reactive protein correlate with impairment of T cell response in patients with advanced epithelial ovarian cancer. Gynecol Oncol 1998; 69:248-252 Nozoe T,Matsumata T,Kitamura M, et al. Significance of preoperative elevation of serum C-reactive protein as an indicator for prognosos in colorectal cancer. Am J surg 1998;176:335-338 Zaloudik J,Lauerova L, Janakova L, et al
  • Significance of pretreatment immunological parameters in colorectal cancer patients with unresectable metastases to the liver
  • Hepatogastroenterelogy 1999;46:220-227 Inoue T, Hashimura T, Iwamura H, et al
  • Multivariate analysis of prognostic determinants after surgery for renal cell carcinoma at Himeji National Hospital. Hinyokika Kiyo 200;46:229-234
  • Masuda H, Kurita Y, Fukuta K, etal. Significant prognostic factors for %-year survival after curative resection of renal cell carcinoma. Int J Urol 1998,5:418-422
  • Wieland A, Kerbl R, Berghold A, Schwinger W, Mann G, Urban C. C-reactive protein (CRP) as tumor marker in pediatric and adolescent patients with Hodgkin disease. Med Pediatr Oncol 2003,41:21-25

Details

Primary Language Turkish
Journal Section Articles
Authors

Gülnur TOKUÇ This is me


Sedat ÖKTEM This is me


Şihmir ŞİMŞEK This is me


Serdar YILMAZ This is me

Publication Date April 1, 2005
Published in Issue Year 2005, Volume 36, Issue 3

Cite

Bibtex @ { zktipb236838, journal = {Zeynep Kamil Tıp Bülteni}, issn = {1300-7971}, eissn = {2148-4864}, address = {}, publisher = {Zeynep Kamil Kadın ve Çocuk Hastalıkları EAH}, year = {2005}, volume = {36}, number = {3}, pages = {139 - 141}, doi = {10.16948/zktb.65479}, title = {Pediatrik Hodgkin hastalığı'nda CRP'nin önemi}, key = {cite}, author = {Tokuç, Gülnur and Öktem, Sedat and Şimşek, Şihmir and Yılmaz, Serdar} }
APA Tokuç, G. , Öktem, S. , Şimşek, Ş. & Yılmaz, S. (2005). Pediatrik Hodgkin hastalığı'nda CRP'nin önemi . Zeynep Kamil Tıp Bülteni , 36 (3) , 139-141 . Retrieved from https://dergipark.org.tr/en/pub/zktipb/issue/22056/236838
MLA Tokuç, G. , Öktem, S. , Şimşek, Ş. , Yılmaz, S. "Pediatrik Hodgkin hastalığı'nda CRP'nin önemi" . Zeynep Kamil Tıp Bülteni 36 (2005 ): 139-141 <https://dergipark.org.tr/en/pub/zktipb/issue/22056/236838>
Chicago Tokuç, G. , Öktem, S. , Şimşek, Ş. , Yılmaz, S. "Pediatrik Hodgkin hastalığı'nda CRP'nin önemi". Zeynep Kamil Tıp Bülteni 36 (2005 ): 139-141
RIS TY - JOUR T1 - Significance of CRP in pediatric Hodgkin disease aim: To determine usage of CRP in Hodgkin disease as a prognostic and diagnostic parameter AU - GülnurTokuç, SedatÖktem, ŞihmirŞimşek, SerdarYılmaz Y1 - 2005 PY - 2005 N1 - DO - T2 - Zeynep Kamil Tıp Bülteni JF - Journal JO - JOR SP - 139 EP - 141 VL - 36 IS - 3 SN - 1300-7971-2148-4864 M3 - UR - Y2 - 2022 ER -
EndNote %0 Medical Bulletin of Zeynep Kamil Pediatrik Hodgkin hastalığı'nda CRP'nin önemi %A Gülnur Tokuç , Sedat Öktem , Şihmir Şimşek , Serdar Yılmaz %T Pediatrik Hodgkin hastalığı'nda CRP'nin önemi %D 2005 %J Zeynep Kamil Tıp Bülteni %P 1300-7971-2148-4864 %V 36 %N 3 %R %U
ISNAD Tokuç, Gülnur , Öktem, Sedat , Şimşek, Şihmir , Yılmaz, Serdar . "Pediatrik Hodgkin hastalığı'nda CRP'nin önemi". Zeynep Kamil Tıp Bülteni 36 / 3 (April 2005): 139-141 .
AMA Tokuç G. , Öktem S. , Şimşek Ş. , Yılmaz S. Pediatrik Hodgkin hastalığı'nda CRP'nin önemi. Zeynep Kamil Tıp Bülteni. 2005; 36(3): 139-141.
Vancouver Tokuç G. , Öktem S. , Şimşek Ş. , Yılmaz S. Pediatrik Hodgkin hastalığı'nda CRP'nin önemi. Zeynep Kamil Tıp Bülteni. 2005; 36(3): 139-141.
IEEE G. Tokuç , S. Öktem , Ş. Şimşek and S. Yılmaz , "Pediatrik Hodgkin hastalığı'nda CRP'nin önemi", Zeynep Kamil Tıp Bülteni, vol. 36, no. 3, pp. 139-141, Apr. 2005, doi:10.16948/zktb.65479