Normal, hiperplastik ve kanserli endometriumda galektin-3, östrojen, progesteron ekspresyonu ve FIGO evre ile ilişkisi

Nevra Dursun; Meltem Öznur; Cem Leblebici; Tuğçe Güzel Çay; İlker Arıkan; H.Serpil Bozkurt; Fadime Bahadır

doi:10.16948/zktb.18134

The relationship of gallectin-3, estrogen and progesteron expression and FIGO staging in normal, hyperplastic and carcinomatous endometrium

Year 2007, Volume: 38 Issue: 1, 1 - 6, 01.02.2007

Nevra Dursun Meltem Öznur Cem Leblebici Tuğçe Güzel Çay İlker Arıkan H.Serpil Bozkurt Fadime Bahadır

Abstract

The Relationship Of Galectin-3, Estrogen And Progesteron Expression And FIGO Staging In Normal, Hyperplastic And Carcinomatous Endometrium Endometrium carcinoma is the most common gynecological malignancy in developed countries. Hormone receptor expression in endometrium carcinoma is one of the prognostic factors. It is thought that galectin-3, one of the member ofbetagalactozide- binding lectin family, binds to basal membrane glycoprotein and has a role in many biological events. Galectin-3's role in tumor progression is not completely understood. In our study, we examined estrogen, progesteron, and galectin-3 expression in normal functional (n=I2), hyperplastic (with or without atypia) (n=7), carcinomatous endometrial tissues (n-25) and also examined immunohistochemically the relationship of expression with FIGO staging. Estrogen, progesteron expressionin normal cases was more meaningful statistically than the one in carcinoma cases. (p

Keywords

Endometrium, Galectin 3, Estrogens, Progesterone, Immunohistochemistry, Hysterectomy, Adenocarcinoma, Mixed Tumor, Mesodermal, Endometrial Neoplasms

References

KAYNAKLAR 1. Tavasolli FA, Devilee P. World Health Organition Classification of Tumours. Pathology and Genetics of the Breast and Female Genital Organs. Lyon , I ARC Press,2003 ;217-259
2. Kurman RJ. Blaustein's Pathology of the Female Genital Tract. 5th ed. New York, Springer-Verlag, 2001 ;501 -561
3. Fukuda K, Mori M, Uchiyama M. Prognostic significance of progesterone receptor immunohistochemistry in endometrial cancer
Gynecologic Oncology 1998; 69:220-225.4. 4.Bonfitto VLL, Angelo Andrade LAL. P53, estrogen and progesterone receptors in diagnostic curretage for endometrial adenocarcinoma and their correlation with morphological data and disease stage at hysterectomy. Sao Paulo Medical Journal 2003; 121:163-166 5. Lax SF, Piıer ES, Ronnett BM, Kurman RJ
Comparison of estrogen and progesterone receptor, ki67, and p53 immunoreactivity in uterine endometrioid carcinoma and endometrioid carcinoma with squamous, mucinous, secretory, and ciliated differentiation
Hum Pathol 1998;29:924-930 6. Sivridis E, Giatromanolaki A, Koukourakis M, Anastasiadis P. Endometrial carcinoma: association of steroid hormone receptor expression with low angiogenesis and bcl-2 expression. Virchows Arch 2001 ;438:470-477
7. Yang RY, Liu FT. Galectins in cell growth and apoptosis. Cell Mol Life Sci. 2003;60:267-276
8. Seyrek K, Çulhacı N, Kıral Kargın F, Bildik A, Saraçoğlu HA. Meme Karsinomlarında Galektin-3 Ekspresyonu ve Lokalizasyonu. Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi 2004;5(l):ll-15
9. Miyazaki J, Hokari R, Kato S, Tsuzuki Y, Kawaguchi A, Nagao S, Itoh K, Miura S
Increased expression of galectin-3 in primary gastric cancer and the metastatic lymph nodes
Oncol Rep,2002;9(6):1307-1312
10. Namura M, Inufusa H, Adachi T, Aga M, Kurimoto M, Nakatani Y, Wakano T, Nakajima A, Hida JI, Miyake M, Shindo K, Yasutomi M
Involvement of galectin-3 expression in color ectal cancer progression and metastasis. Int J Oncol
1999;15(1):143-148., 11.Xu XC, el_Naggar AK, Lotan R. Differential expression of galectin-1 and galectin-3 in thyroid tumors: Potential diagnostic implications. Am J Pathol.1995 ;147:815-822 12. van den Brule FA;Buicu C, Berchuck A, Bast RC, Deprez M. Expression of the 67kD laminin receptor, galectin-1, and galectin-3 in advenced human uterin carcinoma. Hum Pathol. 1996; 27:1185-1191
13. Brustman H, Riss D, Naude S. Galectin-3 expression in normal hyperplastic, and neoplastic endometrial tissues. Pathol Res Pract.2003;199(3):151-158
14. Perillo NL, Marcus ME, Baum LC. Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death. J Mol Med.l998;76:402-412
15. Hikita C, Vijayakumar S, Tkito J,Erdjument- Bromage H, TempstP, Al-Awgati Q. introduction terminal differentiation in epithelial cells reqires polymerezation of hensin by galectin-3. J Cell Biol. 2001; 151:1235-1246

Normal, hiperplastik ve kanserli endometriumda galektin-3, östrojen, progesteron ekspresyonu ve FIGO evre ile ilişkisi

Year 2007, Volume: 38 Issue: 1, 1 - 6, 01.02.2007

Nevra Dursun Meltem Öznur Cem Leblebici Tuğçe Güzel Çay İlker Arıkan H.Serpil Bozkurt Fadime Bahadır

Abstract

Endometrium karsinomu gelişmiş ülkelerde jinekolojik kanserler içinde en sık görülenidir. Endometrium karsinomlarındaki hormon reseptör ekspresyonu, yerleşmiş prognostik faktörler arasında yer almaya başlamıştır. Galektin-3, _- galaktozid bağlayan lektin ailesinin bir üyesidir; bazal membran glikoproteinlerine bağlanarak pek çok biyolojik olayda rol oynadığı düşünülmektedir. Tümör progresyonunda galektin-3' ün rolü tam olarak bilinmemektedir. Çalışmamızda normal fonksiyonel (n=12), hiperplastik (atipili ve atipisiz) (n=7) ve kanserli (n=25) endometrial dokuda östrojen, progesteron ve galektin-3 ekspresyonunu ayrıca kanserli olgularda, ekspresy onların FIGO Evre'si ile ilişkisini immunhistokimyasal yöntemle inceledik. Normal endometrial dokudaki östrojenprogesteron ekspresyonu kanserli dokulara göre ileri derecede anlamlı saptandı(p

Keywords

Endometriyum, Galektin 3, Östrojenler, Progesteron, İmmünohistokimya, Histerektomi, Adenokarsinom, Karma tümör, mezodermal, Endometriyum neoplazmları

References

KAYNAKLAR 1. Tavasolli FA, Devilee P. World Health Organition Classification of Tumours. Pathology and Genetics of the Breast and Female Genital Organs. Lyon , I ARC Press,2003 ;217-259
2. Kurman RJ. Blaustein's Pathology of the Female Genital Tract. 5th ed. New York, Springer-Verlag, 2001 ;501 -561
3. Fukuda K, Mori M, Uchiyama M. Prognostic significance of progesterone receptor immunohistochemistry in endometrial cancer
Gynecologic Oncology 1998; 69:220-225.4. 4.Bonfitto VLL, Angelo Andrade LAL. P53, estrogen and progesterone receptors in diagnostic curretage for endometrial adenocarcinoma and their correlation with morphological data and disease stage at hysterectomy. Sao Paulo Medical Journal 2003; 121:163-166 5. Lax SF, Piıer ES, Ronnett BM, Kurman RJ
Comparison of estrogen and progesterone receptor, ki67, and p53 immunoreactivity in uterine endometrioid carcinoma and endometrioid carcinoma with squamous, mucinous, secretory, and ciliated differentiation
Hum Pathol 1998;29:924-930 6. Sivridis E, Giatromanolaki A, Koukourakis M, Anastasiadis P. Endometrial carcinoma: association of steroid hormone receptor expression with low angiogenesis and bcl-2 expression. Virchows Arch 2001 ;438:470-477
7. Yang RY, Liu FT. Galectins in cell growth and apoptosis. Cell Mol Life Sci. 2003;60:267-276
8. Seyrek K, Çulhacı N, Kıral Kargın F, Bildik A, Saraçoğlu HA. Meme Karsinomlarında Galektin-3 Ekspresyonu ve Lokalizasyonu. Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi 2004;5(l):ll-15
9. Miyazaki J, Hokari R, Kato S, Tsuzuki Y, Kawaguchi A, Nagao S, Itoh K, Miura S
Increased expression of galectin-3 in primary gastric cancer and the metastatic lymph nodes
Oncol Rep,2002;9(6):1307-1312
10. Namura M, Inufusa H, Adachi T, Aga M, Kurimoto M, Nakatani Y, Wakano T, Nakajima A, Hida JI, Miyake M, Shindo K, Yasutomi M
Involvement of galectin-3 expression in color ectal cancer progression and metastasis. Int J Oncol
1999;15(1):143-148., 11.Xu XC, el_Naggar AK, Lotan R. Differential expression of galectin-1 and galectin-3 in thyroid tumors: Potential diagnostic implications. Am J Pathol.1995 ;147:815-822 12. van den Brule FA;Buicu C, Berchuck A, Bast RC, Deprez M. Expression of the 67kD laminin receptor, galectin-1, and galectin-3 in advenced human uterin carcinoma. Hum Pathol. 1996; 27:1185-1191
13. Brustman H, Riss D, Naude S. Galectin-3 expression in normal hyperplastic, and neoplastic endometrial tissues. Pathol Res Pract.2003;199(3):151-158
14. Perillo NL, Marcus ME, Baum LC. Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death. J Mol Med.l998;76:402-412
15. Hikita C, Vijayakumar S, Tkito J,Erdjument- Bromage H, TempstP, Al-Awgati Q. introduction terminal differentiation in epithelial cells reqires polymerezation of hensin by galectin-3. J Cell Biol. 2001; 151:1235-1246

There are 17 citations in total.

Details

Primary Language	Turkish
Journal Section	Articles
Authors	Nevra Dursun This is me Meltem Öznur This is me Cem Leblebici This is me Tuğçe Güzel Çay This is me İlker Arıkan This is me H.Serpil Bozkurt This is me Fadime Bahadır This is me
Publication Date	February 1, 2007
Published in Issue	Year 2007 Volume: 38 Issue: 1

Cite

APA	Dursun, N., Öznur, M., Leblebici, C., Çay, T. G., et al. (2007). Normal, hiperplastik ve kanserli endometriumda galektin-3, östrojen, progesteron ekspresyonu ve FIGO evre ile ilişkisi. Zeynep Kamil Tıp Bülteni, 38(1), 1-6. https://doi.org/10.16948/zktb.18134
AMA	Dursun N, Öznur M, Leblebici C, Çay TG, Arıkan İ, Bozkurt H, Bahadır F. Normal, hiperplastik ve kanserli endometriumda galektin-3, östrojen, progesteron ekspresyonu ve FIGO evre ile ilişkisi. Zeynep Kamil Tıp Bülteni. February 2007;38(1):1-6. doi:10.16948/zktb.18134
Chicago	Dursun, Nevra, Meltem Öznur, Cem Leblebici, Tuğçe Güzel Çay, İlker Arıkan, H.Serpil Bozkurt, and Fadime Bahadır. “Normal, Hiperplastik Ve Kanserli Endometriumda Galektin-3, östrojen, Progesteron Ekspresyonu Ve FIGO Evre Ile ilişkisi”. Zeynep Kamil Tıp Bülteni 38, no. 1 (February 2007): 1-6. https://doi.org/10.16948/zktb.18134.
EndNote	Dursun N, Öznur M, Leblebici C, Çay TG, Arıkan İ, Bozkurt H, Bahadır F (February 1, 2007) Normal, hiperplastik ve kanserli endometriumda galektin-3, östrojen, progesteron ekspresyonu ve FIGO evre ile ilişkisi. Zeynep Kamil Tıp Bülteni 38 1 1–6.
IEEE	N. Dursun, M. Öznur, C. Leblebici, T. G. Çay, İ. Arıkan, H. Bozkurt, and F. Bahadır, “Normal, hiperplastik ve kanserli endometriumda galektin-3, östrojen, progesteron ekspresyonu ve FIGO evre ile ilişkisi”, Zeynep Kamil Tıp Bülteni, vol. 38, no. 1, pp. 1–6, 2007, doi: 10.16948/zktb.18134.
ISNAD	Dursun, Nevra et al. “Normal, Hiperplastik Ve Kanserli Endometriumda Galektin-3, östrojen, Progesteron Ekspresyonu Ve FIGO Evre Ile ilişkisi”. Zeynep Kamil Tıp Bülteni 38/1 (February 2007), 1-6. https://doi.org/10.16948/zktb.18134.
JAMA	Dursun N, Öznur M, Leblebici C, Çay TG, Arıkan İ, Bozkurt H, Bahadır F. Normal, hiperplastik ve kanserli endometriumda galektin-3, östrojen, progesteron ekspresyonu ve FIGO evre ile ilişkisi. Zeynep Kamil Tıp Bülteni. 2007;38:1–6.
MLA	Dursun, Nevra et al. “Normal, Hiperplastik Ve Kanserli Endometriumda Galektin-3, östrojen, Progesteron Ekspresyonu Ve FIGO Evre Ile ilişkisi”. Zeynep Kamil Tıp Bülteni, vol. 38, no. 1, 2007, pp. 1-6, doi:10.16948/zktb.18134.
Vancouver	Dursun N, Öznur M, Leblebici C, Çay TG, Arıkan İ, Bozkurt H, Bahadır F. Normal, hiperplastik ve kanserli endometriumda galektin-3, östrojen, progesteron ekspresyonu ve FIGO evre ile ilişkisi. Zeynep Kamil Tıp Bülteni. 2007;38(1):1-6.