BibTex RIS Cite

Risk factors associated with antepartum intrauterine fetal death

Year 2010, Volume: 41 Issue: 3, 115 - 121, 01.04.2010

Abstract

Objective: To investigate the frequency, etiology, management of intrauterine fetal death and to determine risk of pregnancies and to predict necessary precautions to provide increased healthy maternal and newborn rate. Material and Methods: From January 2006-January 2009, a total of 514 fetal deaths were identified through the Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital registries of labor units. The principal criteria of selecting variables intrauterine fetal death between 22-42 weeks of gestation. In this period, 40 fetal deaths referred for autopsy. The patients had intrauterine fetal deaths were accepted as group 1. 153 singletons live born were randomly selected as a control group in the same population and accepted as group 2. Results: In this study, intrauterine fetal death rate was 1.2% in 3 years in group 1 gestational age, median birth weight was significantly lower than group 2 (p: 0.001). Systolic and diastolic blood pressure at diagnosis, maternal hypertension, maternal systemic disease, intrauterine growth restriction rate and anhydramniosis ingmup 1 was significantly higher than group 2 (p

References

  • 1. Silver RM, Varner MW, Reddy U, Goldberg R, Pinar H, Conway D, Bukowski R Carpenter M, Houge C, Willinger M, Dudley D, Sade G, StollB. Work-up of stillbirth: a rewiew of the evidence. Am J Obstet Gynecol 2007 ; 196: 433-44
  • 2. Edmond KM, Quigley MA, Zandoh C, Danso S, Hurt C, Agyei SO, Kirkwood BR. Aetiology of stillbirths and neonatal deaths in rural Ghada: implications for health programming in developing countries. Paediatr Perinat Epidemiol 2008 ;22:430-7
  • 3. Sims MA, Collins KA. Fetal Death: A 10-Year Retrospective Study. Am J Forensic Med Pathol 2001; 22:261-5
  • 4. Morrison I, Olsen J. Weight-specific stillbirths and associated causes of detahs.an analysis of 765 stillbirths. Am J Obstet Gynecol 1985; 152:975-80
  • 5. Piktin RM,.Fetal death: diagnosis and management. Am J Obstet Gynecol 1987;157:583-9
  • 6. Bernischke K, Robb JA. Infectious causes of fetal death. Clin Obstet Gynecol 1987;30:284-94
  • 7. Oshiro BT, Silver RM, Scott JR, Yu H, Branch DW. Antiphospholipid antibodies and fetal death. Obstet Gynecol 1996;87: 489-93
  • 8. Salle DN, Lesser KB, Harrel U, Rogers BB, Oyer CE. The clinical utility of the perinatal autopsy. JAMA 1995; 273:663-5
  • 9. Kale A, Akdeniz N, Erdemoğlu M, Yalinkaya A, Yayla M. On yıllık 660 Ölü Doğum Olgusunun Retrospektif Analizi. Perinatoloji Dergisi 2005; 13:101-4
  • 10. Cunningham FG, Gant NF, Leveno KJ, Gilstap LC, Hauth JC, Wenstrom KD. Fetal Death. Williams Obstetrics. Mc Graw-Hill, 21nd ed. New York 2001;p:1073-8
  • 11. Fretts RC. Etiology andpreventation of stillbirth. Am J Obstet Gynecol 2005;193:1923-35
  • 12. Jacobson B, Landfords L, Milsom I. Advanced maternal age and adverse perinatal outcome. Obstet Gynecol 2004; 104:727-33
  • 13. Luna F, Polo V, Fernandez-Santander A, Moral P. StillbirthPattern in an Isolated Meditterranean Population: La Alpujarra, Spain. Human Biology 2001; 73:561-73
  • 14. Fretts JC, Usher RH. Causes of fetal death in women of advanced maternal age. Obstet Gynecol 1997; 89:40-5
  • 15. Samuelo? A, Xenakis EM, Berkus MD, Hu? RW, Langer O. Recurrent stillbirth. Signifi cance and characteristics. J Reprod Med 1993; 38: 883-86
  • 16. Froen JF, Arnestad M, Frey K, VegeA, Saugstad OD, Stray-Pedersen B. Risk factors for sudden intrauterine unexplained death:epidemiologic characteristics of singleton cases in Oslo, Norway, 1986-1995. Am J Obstet Gynecol 2001; 184:694-702
  • 17. FrettsRC, BoydME, Usher RH, Usher HA. The cahngirıg pattern of fetal death, 1961-1988. Obstet Gynecol 1992; 79:35-9
  • 18. Petitti D. The epidemiology of fetal death. Clin Obstet Gynecol 1987;30:253-8
  • 19. Huang DY, Usher RH, Kramer MS, Yang H, Morjiin L, Fretts RC. Determinants of unexplained antepartum fetal deaths. Obstet Gynecol 2000; 95:215-21
  • 20. Pauli RM, Reiser CA. Wisconsin Stillbirth Service Program:II. Analyses of diagnosis and diagnostic categories in the first 1000 referrals. Am J Med Genet 1994; 50:135-53
  • 21. Copper RL, Goldenberg RL, DuBard MD, Davis RO. Risk factors of fetal death in white, black and Hispanic women. Collaborative Group on Preterm Birth Prevention. Obstet Gynecol 1994; 94:490-5
  • 22. Lammer EJ, Brown LE, Anderka MT, Guyer B. Classification and analysis of fetal deaths in Massachusetts. JAMA 1989; 261:1757-62
  • 23. Cartlidge PHT, Stewart JH. Effect of changing the stillbirth definition on evaluation of perinatal mortality rates. Lancet 1995; 346:486
  • 24. Faye-Petersen OM, Guinn Da, Wenstrom KD. Value of perinatal autopsy. Obstet Gynecol 1999; 94:915-20
  • 25. Aguiar MI, Campos AS, Aguiar RA, Lana AM, Magalhaes RL, Babeto LT. neural tube defects and associated factors in liveborn and stillborn infants. J Pediatr 2003; 79:129-34
  • 26. Madazlı R, Uludağ S, Aksoy F, Şen C, Ocak V. Cerrahpaşa Tıp Fakültesi Kadın Hastalıkları ve Doğum Kliniğinde 1986-1992 Yılları Arasındaki Perinatal Otopsi Olgularının İrdelenmesi. Perinatoloji Dergisi 1994; 2: 94-100
  • 27. Özkan F, Cesur S, Bilgiç R, Yorgancı C. Onüç yıllık fetal otopsilerimizin geriye dönük olarak incelenmesi. Türk Pediatri Arşivi 2006; 41:46-50
  • 28. Yudkin PL, Wood L, Redman CW. Risk of unexplained stillbirth at different gestational ages. Lancet 1987; 23:1192-4
  • 29. Onderoğlu L, Tuncer ZS. The clinical predictors of intrauterine fetal death. Turk J Pediatr 1998; 40:543-7
  • 30. Fretts JC, Usher RH. Causes of fetal death in women of advanced maternal age. Obstet Gynecol 1997; 89:40-5
  • 31. Kesim MD, Karlık A, Yalçın A, Çalışkan K. Kliniğimizdeki Perinatal Mortalite Oranlarının Değerlendirilmesi, Perinatoloji Dergisi 1996;4
  • 32. SmulianJC, Ananth CV, Vintzileos AM, Scorza WE, Knüppel RA. Fetal deaths in the United States. Infi uence of high-risk conditions and implications for management. Obstet Gynecol 2002; 100: 1183-89
  • 33. Macintosh MC, Fleming KM, Bailey JA, et al. Perinatal mortality and congenital anomalies in babies of women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland: population based study. BMJ 2006; 333: 177
  • 34. Fretts RC, Schmittdiel J, Mclean FH, Usher RH, Goldman MB. Increased maternal age and the risk of fetal death. N Engl J Med 1995; 333:953-57
  • 35. Gürel H, Güerl SA, Kamacı M. Evaluation of perinatal mortality in our clinic. T Clin J Gynecol Obst 1998;8:69-73

Anteparum intrauterin fetal ölüm ile ilişkili risk faktörleri

Year 2010, Volume: 41 Issue: 3, 115 - 121, 01.04.2010

Abstract

Amaç: Zeynep Kamil Hastanesi doğum kliniğinde intrauterin fetal ölüm nedeniyle yatan hastaların oranını, neden olabilecek etyolojik faktörleri, bu hastalara yapılan klinik yaklaşımı, riskli gebelikleri belirlemek ve sağlıklı anne ve yenidoğan oranını arttırmak için gerekli önlemleri önceden tahmin etmek amaçlanmıştır. Gereç ve Yöntem: Ocak 2006- Ocak 2009 tarihleri arasında kliniğimizde intrauterin fetal ölüm nedeniyle yatmış 514 hastanın dosyaları incelenmiştir. 22-42. haftalar arasında doğum yapmış hastalar çalışmaya dahil edilmiştir. Bu hastaların 40 da istek üzerine bebeklerine otopsi yapılmıştır. Antepartum tekil, ölü doğum yapan bu hasta grubu, grup 1 olarak kabul edilirken, 153 tekil, sağlıklı doğumla sonuçlanan hasta grubu, grup 2 olarak kabul edilmiştir. Bulgular: Antepartum ölü doğum oranı %1.2 olarak bulunmuştur. Ortalama doğum haftası ve ortalama bebek doğum ağırlığı 1. grubta istatiksel olarak anlamlı düzeyde düşük saptanırken, yatıştaki ortalama sistolik diastolıkkan basıncı, maternal hipertansiyon, maternal sistemık hastalık, intrauterin gelişme geriliği ve anhidroamnios görülme oranı 1. grubta istatiksel olarak anlamlı düzeyde yüksek bulunmuştur(p

References

  • 1. Silver RM, Varner MW, Reddy U, Goldberg R, Pinar H, Conway D, Bukowski R Carpenter M, Houge C, Willinger M, Dudley D, Sade G, StollB. Work-up of stillbirth: a rewiew of the evidence. Am J Obstet Gynecol 2007 ; 196: 433-44
  • 2. Edmond KM, Quigley MA, Zandoh C, Danso S, Hurt C, Agyei SO, Kirkwood BR. Aetiology of stillbirths and neonatal deaths in rural Ghada: implications for health programming in developing countries. Paediatr Perinat Epidemiol 2008 ;22:430-7
  • 3. Sims MA, Collins KA. Fetal Death: A 10-Year Retrospective Study. Am J Forensic Med Pathol 2001; 22:261-5
  • 4. Morrison I, Olsen J. Weight-specific stillbirths and associated causes of detahs.an analysis of 765 stillbirths. Am J Obstet Gynecol 1985; 152:975-80
  • 5. Piktin RM,.Fetal death: diagnosis and management. Am J Obstet Gynecol 1987;157:583-9
  • 6. Bernischke K, Robb JA. Infectious causes of fetal death. Clin Obstet Gynecol 1987;30:284-94
  • 7. Oshiro BT, Silver RM, Scott JR, Yu H, Branch DW. Antiphospholipid antibodies and fetal death. Obstet Gynecol 1996;87: 489-93
  • 8. Salle DN, Lesser KB, Harrel U, Rogers BB, Oyer CE. The clinical utility of the perinatal autopsy. JAMA 1995; 273:663-5
  • 9. Kale A, Akdeniz N, Erdemoğlu M, Yalinkaya A, Yayla M. On yıllık 660 Ölü Doğum Olgusunun Retrospektif Analizi. Perinatoloji Dergisi 2005; 13:101-4
  • 10. Cunningham FG, Gant NF, Leveno KJ, Gilstap LC, Hauth JC, Wenstrom KD. Fetal Death. Williams Obstetrics. Mc Graw-Hill, 21nd ed. New York 2001;p:1073-8
  • 11. Fretts RC. Etiology andpreventation of stillbirth. Am J Obstet Gynecol 2005;193:1923-35
  • 12. Jacobson B, Landfords L, Milsom I. Advanced maternal age and adverse perinatal outcome. Obstet Gynecol 2004; 104:727-33
  • 13. Luna F, Polo V, Fernandez-Santander A, Moral P. StillbirthPattern in an Isolated Meditterranean Population: La Alpujarra, Spain. Human Biology 2001; 73:561-73
  • 14. Fretts JC, Usher RH. Causes of fetal death in women of advanced maternal age. Obstet Gynecol 1997; 89:40-5
  • 15. Samuelo? A, Xenakis EM, Berkus MD, Hu? RW, Langer O. Recurrent stillbirth. Signifi cance and characteristics. J Reprod Med 1993; 38: 883-86
  • 16. Froen JF, Arnestad M, Frey K, VegeA, Saugstad OD, Stray-Pedersen B. Risk factors for sudden intrauterine unexplained death:epidemiologic characteristics of singleton cases in Oslo, Norway, 1986-1995. Am J Obstet Gynecol 2001; 184:694-702
  • 17. FrettsRC, BoydME, Usher RH, Usher HA. The cahngirıg pattern of fetal death, 1961-1988. Obstet Gynecol 1992; 79:35-9
  • 18. Petitti D. The epidemiology of fetal death. Clin Obstet Gynecol 1987;30:253-8
  • 19. Huang DY, Usher RH, Kramer MS, Yang H, Morjiin L, Fretts RC. Determinants of unexplained antepartum fetal deaths. Obstet Gynecol 2000; 95:215-21
  • 20. Pauli RM, Reiser CA. Wisconsin Stillbirth Service Program:II. Analyses of diagnosis and diagnostic categories in the first 1000 referrals. Am J Med Genet 1994; 50:135-53
  • 21. Copper RL, Goldenberg RL, DuBard MD, Davis RO. Risk factors of fetal death in white, black and Hispanic women. Collaborative Group on Preterm Birth Prevention. Obstet Gynecol 1994; 94:490-5
  • 22. Lammer EJ, Brown LE, Anderka MT, Guyer B. Classification and analysis of fetal deaths in Massachusetts. JAMA 1989; 261:1757-62
  • 23. Cartlidge PHT, Stewart JH. Effect of changing the stillbirth definition on evaluation of perinatal mortality rates. Lancet 1995; 346:486
  • 24. Faye-Petersen OM, Guinn Da, Wenstrom KD. Value of perinatal autopsy. Obstet Gynecol 1999; 94:915-20
  • 25. Aguiar MI, Campos AS, Aguiar RA, Lana AM, Magalhaes RL, Babeto LT. neural tube defects and associated factors in liveborn and stillborn infants. J Pediatr 2003; 79:129-34
  • 26. Madazlı R, Uludağ S, Aksoy F, Şen C, Ocak V. Cerrahpaşa Tıp Fakültesi Kadın Hastalıkları ve Doğum Kliniğinde 1986-1992 Yılları Arasındaki Perinatal Otopsi Olgularının İrdelenmesi. Perinatoloji Dergisi 1994; 2: 94-100
  • 27. Özkan F, Cesur S, Bilgiç R, Yorgancı C. Onüç yıllık fetal otopsilerimizin geriye dönük olarak incelenmesi. Türk Pediatri Arşivi 2006; 41:46-50
  • 28. Yudkin PL, Wood L, Redman CW. Risk of unexplained stillbirth at different gestational ages. Lancet 1987; 23:1192-4
  • 29. Onderoğlu L, Tuncer ZS. The clinical predictors of intrauterine fetal death. Turk J Pediatr 1998; 40:543-7
  • 30. Fretts JC, Usher RH. Causes of fetal death in women of advanced maternal age. Obstet Gynecol 1997; 89:40-5
  • 31. Kesim MD, Karlık A, Yalçın A, Çalışkan K. Kliniğimizdeki Perinatal Mortalite Oranlarının Değerlendirilmesi, Perinatoloji Dergisi 1996;4
  • 32. SmulianJC, Ananth CV, Vintzileos AM, Scorza WE, Knüppel RA. Fetal deaths in the United States. Infi uence of high-risk conditions and implications for management. Obstet Gynecol 2002; 100: 1183-89
  • 33. Macintosh MC, Fleming KM, Bailey JA, et al. Perinatal mortality and congenital anomalies in babies of women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland: population based study. BMJ 2006; 333: 177
  • 34. Fretts RC, Schmittdiel J, Mclean FH, Usher RH, Goldman MB. Increased maternal age and the risk of fetal death. N Engl J Med 1995; 333:953-57
  • 35. Gürel H, Güerl SA, Kamacı M. Evaluation of perinatal mortality in our clinic. T Clin J Gynecol Obst 1998;8:69-73
There are 35 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Derya Başar This is me

Oya Demirci This is me

Yeşim Akdemir This is me

Hamdullah Sözen This is me

Aktuğ Ertekin This is me

Publication Date April 1, 2010
Published in Issue Year 2010 Volume: 41 Issue: 3

Cite

APA Başar, D., Demirci, O., Akdemir, Y., Sözen, H., et al. (2010). Anteparum intrauterin fetal ölüm ile ilişkili risk faktörleri. Zeynep Kamil Tıp Bülteni, 41(3), 115-121. https://doi.org/10.16948/zktb.61076
AMA Başar D, Demirci O, Akdemir Y, Sözen H, Ertekin A. Anteparum intrauterin fetal ölüm ile ilişkili risk faktörleri. Zeynep Kamil Tıp Bülteni. April 2010;41(3):115-121. doi:10.16948/zktb.61076
Chicago Başar, Derya, Oya Demirci, Yeşim Akdemir, Hamdullah Sözen, and Aktuğ Ertekin. “Anteparum Intrauterin Fetal ölüm Ile ilişkili Risk faktörleri”. Zeynep Kamil Tıp Bülteni 41, no. 3 (April 2010): 115-21. https://doi.org/10.16948/zktb.61076.
EndNote Başar D, Demirci O, Akdemir Y, Sözen H, Ertekin A (April 1, 2010) Anteparum intrauterin fetal ölüm ile ilişkili risk faktörleri. Zeynep Kamil Tıp Bülteni 41 3 115–121.
IEEE D. Başar, O. Demirci, Y. Akdemir, H. Sözen, and A. Ertekin, “Anteparum intrauterin fetal ölüm ile ilişkili risk faktörleri”, Zeynep Kamil Tıp Bülteni, vol. 41, no. 3, pp. 115–121, 2010, doi: 10.16948/zktb.61076.
ISNAD Başar, Derya et al. “Anteparum Intrauterin Fetal ölüm Ile ilişkili Risk faktörleri”. Zeynep Kamil Tıp Bülteni 41/3 (April 2010), 115-121. https://doi.org/10.16948/zktb.61076.
JAMA Başar D, Demirci O, Akdemir Y, Sözen H, Ertekin A. Anteparum intrauterin fetal ölüm ile ilişkili risk faktörleri. Zeynep Kamil Tıp Bülteni. 2010;41:115–121.
MLA Başar, Derya et al. “Anteparum Intrauterin Fetal ölüm Ile ilişkili Risk faktörleri”. Zeynep Kamil Tıp Bülteni, vol. 41, no. 3, 2010, pp. 115-21, doi:10.16948/zktb.61076.
Vancouver Başar D, Demirci O, Akdemir Y, Sözen H, Ertekin A. Anteparum intrauterin fetal ölüm ile ilişkili risk faktörleri. Zeynep Kamil Tıp Bülteni. 2010;41(3):115-21.