Year 2019, Volume 9, Issue 1, Pages 10 - 15 2019-06-30

Yeni Antioksidanlar Olarak Bazı 2,5-Disübstitüye-1,3,4-Oksadiazoller
Some 2,5-Disubstitue-1,3,4-Oxadiazoles as New Antioxidants

Nurhan GÜMRÜKÇÜOĞLU [1] , Bahar BİLGİN SÖKMEN [2]

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Birçok heterosiklik bileşik, farmakolojik açıdan önemli olan yeni yapıların sentezi için başlangıç bileşiği olarak kullanılmaktadır. Bunlardan azol gurubu bileşikler, sahip oldukları değişik biyolojik aktivitelerden dolayı son yıllarda sıklıkla sentezlenen bileşik sınıfları haline gelmiştir. Beş üyeli halka içeren heterosiklik bileşikler, farmakolojik özelliklere sahip olmasından dolayı son yıllarda popüler bileşikler sınıfına girmiştir. Bu çalışmada, bazı 2,5-disübstitüye-1,3,4-oksadiazollerin (1-3) antioksidan aktiviteleri, ABTS (2,2’-Azino-bis(3-etilbenzenothiazoline-6-sülfonik asid), DPPH (1,1-difenil-2-pikrilhidrazil) radikal giderme aktiviteleri ve demir indirgeme gücü kapasitesine göre incelendi. Elde edilen sonuçlar, sentezlenen bileşiklerin (1-3) etkili antioksidan aktiviteye sahip olduğunu gösterdi.

Many heterocyclic compound, a pharmacologically used as the starting compound for the synthesis of new structures which are important. Groups of these azole compounds, due to their various biological activities, in recent years have become common classes of compounds synthesized. Heterocyclic compounds containing five-membered ring, compounds of pharmacological class have entered popular in recent years due to properties. In this study, antioxidant activities of some 2,5-disubstitue-1,3,4-oxadiazoles (1-3) were evaluated for according to ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities and iron reducing power capacity. The obtained results showed that the synthesized compounds (1-3) had effective antioxidant activities.

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Primary Language en
Subjects Basic Sciences
Journal Section Articles
Authors

Orcid: 0000-0002-9669-6318
Author: Nurhan GÜMRÜKÇÜOĞLU (Primary Author)
Institution: Karadeniz Technical University
Country: Turkey


Author: Bahar BİLGİN SÖKMEN
Institution: Giresun University

Dates

Publication Date: June 30, 2019

Bibtex @research article { kfbd528553, journal = {Karadeniz Fen Bilimleri Dergisi}, issn = {1309-4726}, eissn = {2564-7377}, address = {Giresun University}, year = {2019}, volume = {9}, pages = {10 - 15}, doi = {10.31466/kfbd.528553}, title = {Some 2,5-Disubstitue-1,3,4-Oxadiazoles as New Antioxidants}, key = {cite}, author = {GÜMRÜKÇÜOĞLU, Nurhan and BİLGİN SÖKMEN, Bahar} }
APA GÜMRÜKÇÜOĞLU, N , BİLGİN SÖKMEN, B . (2019). Some 2,5-Disubstitue-1,3,4-Oxadiazoles as New Antioxidants. Karadeniz Fen Bilimleri Dergisi, 9 (1), 10-15. DOI: 10.31466/kfbd.528553
MLA GÜMRÜKÇÜOĞLU, N , BİLGİN SÖKMEN, B . "Some 2,5-Disubstitue-1,3,4-Oxadiazoles as New Antioxidants". Karadeniz Fen Bilimleri Dergisi 9 (2019): 10-15 <http://dergipark.org.tr/kfbd/issue/45378/528553>
Chicago GÜMRÜKÇÜOĞLU, N , BİLGİN SÖKMEN, B . "Some 2,5-Disubstitue-1,3,4-Oxadiazoles as New Antioxidants". Karadeniz Fen Bilimleri Dergisi 9 (2019): 10-15
RIS TY - JOUR T1 - Some 2,5-Disubstitue-1,3,4-Oxadiazoles as New Antioxidants AU - Nurhan GÜMRÜKÇÜOĞLU , Bahar BİLGİN SÖKMEN Y1 - 2019 PY - 2019 N1 - doi: 10.31466/kfbd.528553 DO - 10.31466/kfbd.528553 T2 - Karadeniz Fen Bilimleri Dergisi JF - Journal JO - JOR SP - 10 EP - 15 VL - 9 IS - 1 SN - 1309-4726-2564-7377 M3 - doi: 10.31466/kfbd.528553 UR - https://doi.org/10.31466/kfbd.528553 Y2 - 2019 ER -
EndNote %0 The Black Sea Journal of Sciences Some 2,5-Disubstitue-1,3,4-Oxadiazoles as New Antioxidants %A Nurhan GÜMRÜKÇÜOĞLU , Bahar BİLGİN SÖKMEN %T Some 2,5-Disubstitue-1,3,4-Oxadiazoles as New Antioxidants %D 2019 %J Karadeniz Fen Bilimleri Dergisi %P 1309-4726-2564-7377 %V 9 %N 1 %R doi: 10.31466/kfbd.528553 %U 10.31466/kfbd.528553
ISNAD GÜMRÜKÇÜOĞLU, Nurhan , BİLGİN SÖKMEN, Bahar . "Some 2,5-Disubstitue-1,3,4-Oxadiazoles as New Antioxidants". Karadeniz Fen Bilimleri Dergisi 9 / 1 (June 2019): 10-15. https://doi.org/10.31466/kfbd.528553
AMA GÜMRÜKÇÜOĞLU N , BİLGİN SÖKMEN B . Some 2,5-Disubstitue-1,3,4-Oxadiazoles as New Antioxidants. KFBD. 2019; 9(1): 10-15.
Vancouver GÜMRÜKÇÜOĞLU N , BİLGİN SÖKMEN B . Some 2,5-Disubstitue-1,3,4-Oxadiazoles as New Antioxidants. Karadeniz Fen Bilimleri Dergisi. 2019; 9(1): 15-10.