Some 2,5-Disubstitue-1,3,4-Oxadiazoles as New Antioxidants

Yıl 2019, Cilt: 9 Sayı: 1, 10 - 15, 30.06.2019

Nurhan Gümrükçüoğlu , Bahar Bilgin Sökmen

https://doi.org/10.31466/kfbd.528553

Öz

Many heterocyclic compound, a pharmacologically
used as the starting compound for the synthesis of new structures which are
important. Groups of these azole compounds, due to their various biological
activities, in recent years have become common classes of compounds
synthesized. Heterocyclic compounds containing five-membered ring, compounds of
pharmacological class have entered popular in recent years due to properties. In
this study, antioxidant activities of some 2,5-disubstitue-1,3,4-oxadiazoles (1-3) were evaluated for according to ABTS
(2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt), 2,2-diphenyl-1-picrylhydrazyl
(DPPH) radical scavenging activities and iron reducing
power capacity. The obtained results showed that the synthesized
compounds (1-3) had effective
antioxidant activities.

Anahtar Kelimeler

2.5-Disubstitue-1.3.4-oxadiazoles, Antioxidant, ABTS Radical Scavenging Activity

Yeni Antioksidanlar Olarak Bazı 2,5-Disübstitüye-1,3,4-Oksadiazoller

Öz

Birçok heterosiklik bileşik, farmakolojik açıdan
önemli olan yeni yapıların sentezi için başlangıç bileşiği olarak
kullanılmaktadır. Bunlardan azol gurubu bileşikler, sahip oldukları değişik
biyolojik aktivitelerden dolayı son yıllarda sıklıkla sentezlenen bileşik
sınıfları haline gelmiştir. Beş üyeli halka içeren heterosiklik bileşikler,
farmakolojik özelliklere sahip olmasından dolayı son yıllarda popüler
bileşikler sınıfına girmiştir. Bu çalışmada, bazı 2,5-disübstitüye-1,3,4-oksadiazollerin
(1-3) antioksidan aktiviteleri, ABTS
(2,2’-Azino-bis(3-etilbenzenothiazoline-6-sülfonik asid), DPPH
(1,1-difenil-2-pikrilhidrazil) radikal giderme aktiviteleri ve demir indirgeme
gücü kapasitesine göre incelendi. Elde edilen sonuçlar,
sentezlenen bileşiklerin (1-3)
etkili antioksidan aktiviteye sahip olduğunu gösterdi.

Anahtar Kelimeler

2.5-Disübstitüye-1.3.4-oksadiazoller, Antioksidan, ABTS Radikal Giderme Aktivitesi

Kaynakça

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